Cell injuryadaptation 6
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Cell injuryadaptation 6
- 2. SDUMC-Path-CSBRP Hyaline changeHyaline change (HC)(HC) Def: Homogeneous glassy pink material in H&E stained sections which can occur both intra and extracellularly Hyaline derived from Greek word ‘HyalosHyalos’ HyalosHyalos = Glass HC can result from accumulation of a variety different substances It’s a descriptive histologic term not aIt’s a descriptive histologic term not a specific marker of cell injuryspecific marker of cell injury
- 3. SDUMC-Path-CSBRP Hyaline changeHyaline change (HC)(HC) Intracellular hyaline change: Mallory bodies Hyaline droplets in Renal tubular cells in NS Alcoholic hyaline in Liver Viral inclusions Russel bodies
- 4. SDUMC-Path-CSBRP Hyaline changeHyaline change (Russel bodies)(Russel bodies)
- 5. SDUMC-Path-CSBRP Hyaline changeHyaline change (glomerular sclerosis)(glomerular sclerosis)
- 6. SDUMC-Path-CSBRP Hyaline changeHyaline change (Protein droplets in(Protein droplets in renal tubular cells in NS)renal tubular cells in NS)
- 7. SDUMC-Path-CSBRP Hyaline changeHyaline change (Mallory hyaline)(Mallory hyaline)
- 8. SDUMC-Path-CSBRP Hyaline changeHyaline change (Mallory hyaline - IF)(Mallory hyaline - IF)
- 9. SDUMC-Path-CSBRP Pituitary adenoma with Crooke's hyaline changePituitary adenoma with Crooke's hyaline change
- 10. SDUMC-Path-CSBRP Hyaline changeHyaline change (A1AT deficiency)(A1AT deficiency)
- 11. SDUMC-Path-CSBRP Hyaline changeHyaline change (Viral inclusions)(Viral inclusions) Molluscum contagiosum
- 12. SDUMC-Path-CSBRP Hyaline changeHyaline change • Extracellular hyalin: occurs in connective tissue • Collagenous fibrous tissue in old scars may appear hyalinized, but the physiochemical mechanism underlying this change is not clear. • Hyaline arteriosclerosis of renal vessels in HTN • Hyalinization of glomeruli of kidney in chronic renal disease • Also seen in RA, aging, chronic infection et.c.
- 13. SDUMC-Path-CSBRP Hyaline changeHyaline change • Extracellular hyalin: occurs in connective tissue NOTE: • Amyloid should not be included under this category as it’s a well studied different entity
Editor's Notes
- This PAS stain demonstrates diffuse glomerulosclerosis associated with long-standing diabetes mellitus. There is an increase in mesangial matrix, a slight increase in mesangial cellularity, and capillary basement membrane thickening. These changes gradually advance until the entire glomerulus is sclerotic.
- Figure 1-34 A, The liver of alcohol abuse (chronic alcoholism). Hyaline inclusions in the hepatic parenchymal cell in the center appear as eosinophilic networks disposed about the nuclei (arrow). B, Electron micrograph of alcoholic hyalin. The material is composed of intermediate (prekeratin) filaments and an amorphous matrix.
- In long-standing hypertension and diabetes mellitus, the walls of arterioles, especially in the kidney, become hyalinized, owing to extravasated plasma protein and deposition of basement membrane material. Hyaline arteriosclerosis in HTN.
- Although some authors include amyloid as an example of hyaline change, it has been so well studied and charecterized, and appears to lead to such well-defined clinical conditions, hence to be treated as a separate entity. REF: Anderson’s pathology.