This randomized controlled trial evaluated the effects of periurethral cleaning with 10% povidone-iodine, 0.05% chlorhexidine, or sterile water in preventing catheter-associated urinary tract infections (CAUTIs) prior to urinary catheter insertion in pediatric intensive care patients. 112 children were randomly assigned to one of the three cleaning groups. Fewer CAUTIs occurred in the chlorhexidine group compared to the povidone-iodine and sterile water groups, though the results were not statistically significant. The study concluded that chlorhexidine may reduce CAUTI rates in pediatric intensive care patients.