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Melbia Shiny
Introduction
Major salivary glands
 Parotid
 Submandibular
 Sublingual
Minor salivary glands
 Labial glands
 Lingual glands
Von Ebner’s gland.
Glands of Blandin’s and Nuhn’s.
 Buccal glands
 Palatine glands (weber’s gland)
Evaluation of salivary glands
 Main salivary gland complaints and causes
1)Acute intermittent generalized swelling.
 Sialolithiasis
 Stricture/stenosis
 Recurrent juvenile parotitis
2)Acute generalized swelling
 Infection – Viral,Bacterial
3)Chronic generalised swelling
 Sjogren’s syndrome
 Sialosis
 Cystic fibrosis
 Sarcoidosis
4)Discrete swelling
 Intrinsic tumor – benign,malignant.
 Extrinsic tumor
 Cyst
 Lymph nodes
5)Dry mouth
 Sjogren’s syndrome
 Post radiation
 Mouth breathing
 Dehydration
 Drugs
 Systemic diseases
6)Excess salivation
 Reflex
 Heavy metal poisoning
 Systemic diseases
 Parkinsonism
 Epilepsy
Physical examination
Inspection
 Intra oral inspection – duct orifice
 Extra oral inspection –
Colour,symmetry,pulsation,sinus discharge.
Palpation
 Extra oral -
 Intra oral
 Bimanual palpation
Differential diagnosis of
enlargement in salivary gland
1)Parotid area:
Unilateral
 Bacterial sialadenitis
 Sialodochitis
 Cyst
 Benign neoplasm
 Malignant neoplasm
 Intraglandular lymph node
 Masseter muscle hypertrophy
 Lesions of adjacent osseous structures
Bilateral
 Bacterial sialadenitis
 Viral sialadenitis
 Sjogren syndrome
 Alcoholic hypertrophy
 Medication induced hypertrophy(I, heavymetal)
 HIV
 Masseter muscle hypertrophy
 Accessory salivary gland
 TMJ related
2)Submandibular area
Unilateral
 Bacterial sialdenitis
 Sialodochitis
 Fibrosis
 Cyst
 Benign neoplasm
 Malignant neoplasm
Bilateral
 Bacterial sialadenitis
 Sjogren’s syndrome
 lymphadenitis
 Branchial cleft cyst
 Space infection
Imaging modalities
1)Plain radiography.
Parotid - Intra oral view of cheek.
Lateral oblique.
Panoramic.
Submandibular - lower 90 degree occlusal.
lower oblique occlusal.
Lateral oblique.
Panoramic.
2)Sialography.
Conventional sialography.
MR sialography.
CBCT sialography.
3)Ultrasound.
4)Computed Tomography.
5)Multidetector computed tomographic imaging
5)Magnetic resonance.
6)Radioisotope imaging.
7)Sialendoscopy.
Intra oral radiography
For Wharton’s duct sialolith
In anterior 2/3 rd
of submandibular
duct
Mandibular occlusal view
Extraoral radiography
 Panoramic view – both parotid & submandibular duct
sialolith.
 Lateral oblique view of submandibular gland (modified)
Parotid calculi
AP view with cheek blown out. – sialolith in distal
portion
Conventional Sialography
Defined as radiographic demonstration of major salivary
glands by introducing a radiopaque contrast medium into
their ductal system.
Stones & strictures.
First - 1902
 The preoperative phase
 The filling phase.
 The emptying phase.
Preoperative phase:
 scout radiographs.
 Position of radiopaque obstruction.
 Position of normal anatomical structures.
 Exposure factors.
 Filling Phase :
Filling
phase:
Techniques:
1)Simple injection.
2)Hydrostatic.
3)Continuous infusion pressure monitored.
Filling phase radiographs at two different views at right
angles to each other.
Simple injection technique:
 oil based /aqueous contrast media .
 Gentle hand pressure till tightness /discomfort is felt.
 Parotid – 1 ml,submandibular – 0.8 ml.
 Simple & cheap.
 Arbitary pressure - under or over filling due to patient
response.
Hydrostatic technique
 Aqueous contrast media – overhead reservoir under
force of gravity.
 Simple ,inexpensive.
 Pt lying position and position for filling phase
radiographs.
Continuous infusion pressure monitored
technique:
 Aqueous contrast media and ductal pressure monitored.
 No damage/overfilling of gland.
 Independent of pt response.
 Complex equipment.
 Time consuming.
Emptying phase:
 Removal of cannula & pt asked to rinse.
 Lemon juice aids in excretion.
 Emptying phase radiographs.
Submandibular gland
Contrast agents in sialography
Iodine based
 Ionic aqueous solution
Diatrizoate(urografin).
Metrizoate(triosil).
 Non ionic aqueous solution
Iohexol (omniopaque).
Oil based solution
 Iodized oil (lipiodol)
 Water insoluble organic iodine compounds(pantopaque).
Indications:
1)The presence of calculi
2)To assess extent of ductal & glandular destruction.
3)To determine the extend of glandular breakdown and
crude assessment of function.
Contraindication:
1)Allergic to iodine compounds.
2)Acute infections
3)Calculus close to the ductal opening.
 The main pathological changes are:
Ductal changes associated with –
 Calculi
 Sialodochitis (ductal inflammation).
Glandular changes associated with –
 Sialadenitis.(glandular inflammation).
 Sjogren syndrome.
 Intrinsic tumours.
Sialographic appearance of calculi
Sialographic appearance of
sialodochitis
Sialographic appearance of
sialadenitis
Sialectasis – blobs /dots
Sialographic appearance in
sjogren syndrome
Intercalated ductule & acinus
Sialographic appearance of intrinsic
tumors
CBCT imaging
 Useful for evaluating structures in & adjacent to
salivary gland
 Cannot resolve soft tissue densities.
 Minimal calcified sialolith well depicted.
 Three D visualization possible.
CBCT SIALOGRAPHY IMAGING
 3D reconstruction can be performed and the ductal
architecture viewed in all possible dimensions.
 Information about measurements and location of
sialoliths.
 Highly reliable technique for identifying both
radiopaque as well as radiolucent sialoliths and ductal
strictures.
 Less exposure dose and cost effective.
Lateral and axial view
Computer tomography
 Useful for evaluating salivary
gland pathology,adjacent
structures and proximity to
facial nerve.
 Calcified structures are
visualized.
 Abscess – hypervascular wall is
evident.
 Definition of cystic walls and
contents.
 Osseous erosions and sclerosis
are visualized.
Sialolith
CT (contrast) images of enlarged
parotid
Multidetector computed
tomographic imaging
MRI
 Provides superior soft tissue contrast resolution than
CT.
 Fewer problems with streak artifacts from metallic
dental restoration.
 Image – multiplanar reconstruction software
algorithm.
 iv contrast(gadolinium) – Differentiate cystic & solid
masses.
MRI revealing lymphoepithelial
cyst involving right parotid
MR sialography
 MRI with evoked
salivation.
 Lemon juice – stimulate
salivation.
 Reveal ductal morphology
accurately ,sialolith
identification
 Alternative to conventional
sialography.
Advantages
 Ionizing radiation not used.
 Excellent soft tissue details.
 Differentiate benign & malignant.
 Identify facial n.
 Images in all planes.
 Co- localization with PET scans.
 MR sialography – no contrast.
 MR spectroscopy – differentiate tissues by chemical
constituents.
 In acute stage & cannulation not possible.
Disadvantages
 Salivary gland function cannot be determined.
 Limited adjacent hard tissue information.
Ultrasound
 High resolution scanners produce excellent images.
Indications:
 Discrete & generalised swelling both intrinsic and
extrinsic to gland.
 Salivary obstruction.
 Differentiate solid masses from cystic ones.
 Guided fine needle aspiration biopsy.
*
Benign tumour Sialolith
Advantages
 Ionisation radiation not used.
 Good imaging of superficial masses.
 Differentiates solid & cystic masses.
 Different echo signals from different tumours
 Blood flow assessment using colour doppler.
 Identify radiolucent stones.
 Lithotripsy of salivary stones.
 Ultra sound aided fine needle aspiration.
 Intraoral US possible with small probes.
 Differentiates intra and extra glandular masses.
Disadvantages
 Limited area for investigation.
 No information on fine architecture.
Scintigraphy (Nuclear medicine, PET)
 Functional study of salivary glands.
 Iv injection of technetium 99m pertechnetate –
concentrated in and excreated by glandular structures
(salivary, thyroid,mammary ).
 Appearance in ducts max. 30 to 45 min.
 Sialagogue administered to evaluate secretory capacity.
 major salivary glands studied at once.
 High diagnostic sensitivity but lacks specificity.
 Pathosis – increased/decreased/absent radionuclide
uptake.
• PET – greater resolution .
• Not used as such.
•Increased uptake of
radioisotope in right
parotid.
Sialendoscopy
Sialendoscopy is a
relatively new procedure
that allows endoscopic
transluminal
visualization of major
salivary gland ductal
system and offers a
mechanism for
diagnosing and treating
both inflammatory and
obstructive pathology
related to ductal system
Image interpretation of salivary
gland disorders
SIALOLITHIASIS
 radiopaque / radiolucent.(mucous plugs).
 occlusal view, IOPA, Sialography.
 Radiolucent sialolith – ductal filling defect.
 MDCT – minimally calcified sialoliths.
 Ultrasound - > 2mm as echo dense spots with acoustic
shadow.
Submandibular calculi
Sialolith from phleboliths
Sialolith from tonsillolith
Sialolith from calcified
lymphnode
Bacterial sialadenitis
 Sialography contraindicated in acute infections.
 Chronic cases – Sialectasia
(sac like acinar areas).
 Abscess - seen in
MDCT,US,MRI.
Sialodochitis
 Ductal sialadenitis.
 Sialography – sausage string appearance (interstitial
fibrosis).
 Seen in MRI.
 Scintigraphy & CT not indicated.
Autoimmune Sialadenitis
 Sialography is helpful.
 Early stage – punctate (<1 mm) & globular (1-2 mm)
collection of contrast media – sialectasia.
 Cavitary sialectases - larger & irregular suggestive of
advanced stage.
 MRI – multiple punctate sialectases.
 US – multiple hypoechoic areas.
Sialadenosis
 It is a non neoplastic,noninflammatory
enlargment of parotid gland.
 Sialography - enlargement /normal appearance.
 CT & MRI – straightforward depiction but are
nonspecific.
Cystic lesions
 Ultrasound - cyst are sharply marginated and echo
free areas.
 Well circumscribed ,high signal areas on T 2 weighted
MRI.
Benign tumors
 Well defined radiolucency - in CT & MRI.
 Contrast agents in CT - >radiopaque due to increased
vascularity of tumor.
 MRI - for submandibular gland neoplasm due to
superior soft tissue resolution.
 USG – benign masses are less echogenic than
parenchyma.
 Sialography – ball in hand.
Pleomorphic adenoma
 MDCT – sharply circumscribed ,round homogenous
lesion with high density than adjacent tissue.
 MRI - dark in T 1 weighted images, intermediate in
proton density weighted images & homogenous high
intensity in T 2 weighted images.
 Signal voids – calcification present.
Pleomorphic adenoma
Warthin’s tumor
 MDCT – soft tissue
/cystic density.
 MRI – heterogenous
with hemorhagic foci.
 USG – solid anechoic.
Hemangioma
 Associated with phleboliths
 Plain radiographs and MDCT images.
 MDCT – well defined soft tissue mass.
 MRI – T1 (muscle adjacent)
 T2 – high signal.
 US – hypoechoic hemangioma,phleboliths as multiple
hyperechoic areas .
Malignant tumors
 Indicators – illdefined margins,invasion of adjacent
soft tissues,destruction of osseous structures and
perivascular involvement.
Mucoepidermoid carcinoma
 Low grade similar to benign.
 High grade – in CT (irregular
homogenous mass).
 In MRI – homogenous & dark
(T1)
 Heterogenous & bright (T2).
Other malignant & metastatic tumors
 Adenoid cystic carcinoma
Conclusion
 Imaging of the salivary glands uses many different
modalities .
 no established absolute algorithm as to which study
should be performed.
 Depends upon the radiologist preference.
References
1)Oral Radiology Principles and Interpretation.Stuart
White,Micheal Pharoah.
2)Salivary gland disorders.Eugene Myers,Robert Ferris.
3)Oral and Maxillo facial radiology. Freny Karjodkar.
4)Textbook of colour atlas of salivary gland
pathology.Eric Carlson,Robert Ford.
5)Atlas of oral diagnostic imaging.Tomomitsu Higashi.
6) Taneja et al. Salivary gland imaging.IJMDS.
7)Yousem et al.Major salivary gland imaging.Radiology.

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Salivary gland imaging

  • 2. Introduction Major salivary glands  Parotid  Submandibular  Sublingual Minor salivary glands  Labial glands  Lingual glands Von Ebner’s gland. Glands of Blandin’s and Nuhn’s.  Buccal glands  Palatine glands (weber’s gland)
  • 3. Evaluation of salivary glands  Main salivary gland complaints and causes 1)Acute intermittent generalized swelling.  Sialolithiasis  Stricture/stenosis  Recurrent juvenile parotitis 2)Acute generalized swelling  Infection – Viral,Bacterial
  • 4. 3)Chronic generalised swelling  Sjogren’s syndrome  Sialosis  Cystic fibrosis  Sarcoidosis 4)Discrete swelling  Intrinsic tumor – benign,malignant.  Extrinsic tumor  Cyst  Lymph nodes
  • 5. 5)Dry mouth  Sjogren’s syndrome  Post radiation  Mouth breathing  Dehydration  Drugs  Systemic diseases
  • 6. 6)Excess salivation  Reflex  Heavy metal poisoning  Systemic diseases  Parkinsonism  Epilepsy
  • 7. Physical examination Inspection  Intra oral inspection – duct orifice  Extra oral inspection – Colour,symmetry,pulsation,sinus discharge. Palpation  Extra oral -  Intra oral  Bimanual palpation
  • 8. Differential diagnosis of enlargement in salivary gland 1)Parotid area: Unilateral  Bacterial sialadenitis  Sialodochitis  Cyst  Benign neoplasm  Malignant neoplasm  Intraglandular lymph node  Masseter muscle hypertrophy  Lesions of adjacent osseous structures
  • 9. Bilateral  Bacterial sialadenitis  Viral sialadenitis  Sjogren syndrome  Alcoholic hypertrophy  Medication induced hypertrophy(I, heavymetal)  HIV  Masseter muscle hypertrophy  Accessory salivary gland  TMJ related
  • 10. 2)Submandibular area Unilateral  Bacterial sialdenitis  Sialodochitis  Fibrosis  Cyst  Benign neoplasm  Malignant neoplasm
  • 11. Bilateral  Bacterial sialadenitis  Sjogren’s syndrome  lymphadenitis  Branchial cleft cyst  Space infection
  • 12. Imaging modalities 1)Plain radiography. Parotid - Intra oral view of cheek. Lateral oblique. Panoramic. Submandibular - lower 90 degree occlusal. lower oblique occlusal. Lateral oblique. Panoramic.
  • 13. 2)Sialography. Conventional sialography. MR sialography. CBCT sialography. 3)Ultrasound. 4)Computed Tomography. 5)Multidetector computed tomographic imaging 5)Magnetic resonance. 6)Radioisotope imaging. 7)Sialendoscopy.
  • 14. Intra oral radiography For Wharton’s duct sialolith In anterior 2/3 rd of submandibular duct
  • 16. Extraoral radiography  Panoramic view – both parotid & submandibular duct sialolith.  Lateral oblique view of submandibular gland (modified)
  • 17. Parotid calculi AP view with cheek blown out. – sialolith in distal portion
  • 18. Conventional Sialography Defined as radiographic demonstration of major salivary glands by introducing a radiopaque contrast medium into their ductal system. Stones & strictures. First - 1902  The preoperative phase  The filling phase.  The emptying phase.
  • 19. Preoperative phase:  scout radiographs.  Position of radiopaque obstruction.  Position of normal anatomical structures.  Exposure factors.
  • 22. Techniques: 1)Simple injection. 2)Hydrostatic. 3)Continuous infusion pressure monitored. Filling phase radiographs at two different views at right angles to each other.
  • 23. Simple injection technique:  oil based /aqueous contrast media .  Gentle hand pressure till tightness /discomfort is felt.  Parotid – 1 ml,submandibular – 0.8 ml.  Simple & cheap.  Arbitary pressure - under or over filling due to patient response.
  • 24. Hydrostatic technique  Aqueous contrast media – overhead reservoir under force of gravity.  Simple ,inexpensive.  Pt lying position and position for filling phase radiographs.
  • 25. Continuous infusion pressure monitored technique:  Aqueous contrast media and ductal pressure monitored.  No damage/overfilling of gland.  Independent of pt response.  Complex equipment.  Time consuming.
  • 26. Emptying phase:  Removal of cannula & pt asked to rinse.  Lemon juice aids in excretion.  Emptying phase radiographs.
  • 28. Contrast agents in sialography Iodine based  Ionic aqueous solution Diatrizoate(urografin). Metrizoate(triosil).  Non ionic aqueous solution Iohexol (omniopaque). Oil based solution  Iodized oil (lipiodol)  Water insoluble organic iodine compounds(pantopaque).
  • 29. Indications: 1)The presence of calculi 2)To assess extent of ductal & glandular destruction. 3)To determine the extend of glandular breakdown and crude assessment of function. Contraindication: 1)Allergic to iodine compounds. 2)Acute infections 3)Calculus close to the ductal opening.
  • 30.  The main pathological changes are: Ductal changes associated with –  Calculi  Sialodochitis (ductal inflammation). Glandular changes associated with –  Sialadenitis.(glandular inflammation).  Sjogren syndrome.  Intrinsic tumours.
  • 36. Sialographic appearance of intrinsic tumors
  • 37. CBCT imaging  Useful for evaluating structures in & adjacent to salivary gland  Cannot resolve soft tissue densities.  Minimal calcified sialolith well depicted.  Three D visualization possible.
  • 38.
  • 39. CBCT SIALOGRAPHY IMAGING  3D reconstruction can be performed and the ductal architecture viewed in all possible dimensions.  Information about measurements and location of sialoliths.  Highly reliable technique for identifying both radiopaque as well as radiolucent sialoliths and ductal strictures.  Less exposure dose and cost effective.
  • 41. Computer tomography  Useful for evaluating salivary gland pathology,adjacent structures and proximity to facial nerve.  Calcified structures are visualized.  Abscess – hypervascular wall is evident.  Definition of cystic walls and contents.  Osseous erosions and sclerosis are visualized.
  • 43. CT (contrast) images of enlarged parotid
  • 45. MRI  Provides superior soft tissue contrast resolution than CT.  Fewer problems with streak artifacts from metallic dental restoration.  Image – multiplanar reconstruction software algorithm.  iv contrast(gadolinium) – Differentiate cystic & solid masses.
  • 46. MRI revealing lymphoepithelial cyst involving right parotid
  • 47. MR sialography  MRI with evoked salivation.  Lemon juice – stimulate salivation.  Reveal ductal morphology accurately ,sialolith identification  Alternative to conventional sialography.
  • 48.
  • 49.
  • 50. Advantages  Ionizing radiation not used.  Excellent soft tissue details.  Differentiate benign & malignant.  Identify facial n.  Images in all planes.  Co- localization with PET scans.  MR sialography – no contrast.  MR spectroscopy – differentiate tissues by chemical constituents.  In acute stage & cannulation not possible.
  • 51. Disadvantages  Salivary gland function cannot be determined.  Limited adjacent hard tissue information.
  • 52. Ultrasound  High resolution scanners produce excellent images. Indications:  Discrete & generalised swelling both intrinsic and extrinsic to gland.  Salivary obstruction.  Differentiate solid masses from cystic ones.  Guided fine needle aspiration biopsy.
  • 53. *
  • 55. Advantages  Ionisation radiation not used.  Good imaging of superficial masses.  Differentiates solid & cystic masses.  Different echo signals from different tumours  Blood flow assessment using colour doppler.  Identify radiolucent stones.  Lithotripsy of salivary stones.  Ultra sound aided fine needle aspiration.  Intraoral US possible with small probes.  Differentiates intra and extra glandular masses.
  • 56. Disadvantages  Limited area for investigation.  No information on fine architecture.
  • 57. Scintigraphy (Nuclear medicine, PET)  Functional study of salivary glands.  Iv injection of technetium 99m pertechnetate – concentrated in and excreated by glandular structures (salivary, thyroid,mammary ).  Appearance in ducts max. 30 to 45 min.  Sialagogue administered to evaluate secretory capacity.  major salivary glands studied at once.  High diagnostic sensitivity but lacks specificity.  Pathosis – increased/decreased/absent radionuclide uptake.
  • 58. • PET – greater resolution . • Not used as such. •Increased uptake of radioisotope in right parotid.
  • 59. Sialendoscopy Sialendoscopy is a relatively new procedure that allows endoscopic transluminal visualization of major salivary gland ductal system and offers a mechanism for diagnosing and treating both inflammatory and obstructive pathology related to ductal system
  • 60.
  • 61. Image interpretation of salivary gland disorders SIALOLITHIASIS  radiopaque / radiolucent.(mucous plugs).  occlusal view, IOPA, Sialography.  Radiolucent sialolith – ductal filling defect.  MDCT – minimally calcified sialoliths.  Ultrasound - > 2mm as echo dense spots with acoustic shadow.
  • 66. Bacterial sialadenitis  Sialography contraindicated in acute infections.  Chronic cases – Sialectasia (sac like acinar areas).  Abscess - seen in MDCT,US,MRI.
  • 67. Sialodochitis  Ductal sialadenitis.  Sialography – sausage string appearance (interstitial fibrosis).  Seen in MRI.  Scintigraphy & CT not indicated.
  • 68. Autoimmune Sialadenitis  Sialography is helpful.  Early stage – punctate (<1 mm) & globular (1-2 mm) collection of contrast media – sialectasia.  Cavitary sialectases - larger & irregular suggestive of advanced stage.  MRI – multiple punctate sialectases.  US – multiple hypoechoic areas.
  • 69.
  • 70. Sialadenosis  It is a non neoplastic,noninflammatory enlargment of parotid gland.  Sialography - enlargement /normal appearance.  CT & MRI – straightforward depiction but are nonspecific.
  • 71. Cystic lesions  Ultrasound - cyst are sharply marginated and echo free areas.  Well circumscribed ,high signal areas on T 2 weighted MRI.
  • 72.
  • 73. Benign tumors  Well defined radiolucency - in CT & MRI.  Contrast agents in CT - >radiopaque due to increased vascularity of tumor.  MRI - for submandibular gland neoplasm due to superior soft tissue resolution.  USG – benign masses are less echogenic than parenchyma.  Sialography – ball in hand.
  • 74. Pleomorphic adenoma  MDCT – sharply circumscribed ,round homogenous lesion with high density than adjacent tissue.  MRI - dark in T 1 weighted images, intermediate in proton density weighted images & homogenous high intensity in T 2 weighted images.  Signal voids – calcification present.
  • 76. Warthin’s tumor  MDCT – soft tissue /cystic density.  MRI – heterogenous with hemorhagic foci.  USG – solid anechoic.
  • 77. Hemangioma  Associated with phleboliths  Plain radiographs and MDCT images.  MDCT – well defined soft tissue mass.  MRI – T1 (muscle adjacent)  T2 – high signal.  US – hypoechoic hemangioma,phleboliths as multiple hyperechoic areas .
  • 78. Malignant tumors  Indicators – illdefined margins,invasion of adjacent soft tissues,destruction of osseous structures and perivascular involvement.
  • 79. Mucoepidermoid carcinoma  Low grade similar to benign.  High grade – in CT (irregular homogenous mass).  In MRI – homogenous & dark (T1)  Heterogenous & bright (T2).
  • 80.
  • 81. Other malignant & metastatic tumors  Adenoid cystic carcinoma
  • 82.
  • 83. Conclusion  Imaging of the salivary glands uses many different modalities .  no established absolute algorithm as to which study should be performed.  Depends upon the radiologist preference.
  • 84. References 1)Oral Radiology Principles and Interpretation.Stuart White,Micheal Pharoah. 2)Salivary gland disorders.Eugene Myers,Robert Ferris. 3)Oral and Maxillo facial radiology. Freny Karjodkar. 4)Textbook of colour atlas of salivary gland pathology.Eric Carlson,Robert Ford. 5)Atlas of oral diagnostic imaging.Tomomitsu Higashi. 6) Taneja et al. Salivary gland imaging.IJMDS. 7)Yousem et al.Major salivary gland imaging.Radiology.

Editor's Notes

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