Saccharin is an artificial sweetener that is 300-400 times sweeter than sucrose. It was discovered in 1879 and first introduced commercially in 1885. While saccharin was shown to induce bladder cancer in rats in the 1970s, resulting in a warning label, the label was removed in 2000 after further studies found it to be safe for human consumption. Saccharin is a non-caloric sweetener that is used as a sugar substitute, especially for those watching their weight or with diabetes. In moderate and approved doses, it provides benefits but can cause allergic reactions in some individuals.

1. Group 4
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2. Group’s members
• Ngo Cam Huynh
• Bui Thi Y Nhu
• Hoang Thi Anh
• Phan Hoai Diem
• Pham Minh Tuan
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3.  Saccharin is an
artificial sweetener.
 Used as a non-
caloric sweetener
 300–400 times as sweet as sucrose.
 Used to sweeten products such as drinks,
candies, cookies, medicines, and toothpaste.
INTRODUCTION
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4. • In 1879, Saccharin discovered by C. Fahlberg who is a chemist
working coal tar derivatives in Remsen’s laboratory, Johns
Hopkins University.
• In 1885 Saccharin first introduced at Antwerp Trade Fair as a
cheap and readily-available substitute for sugar.
• In 1907, An illegal substitution of a valuable ingredient (sugar)
by a less valuable ingredient.
• In 1912, Food Inspection Decision 142 stated that saccharin
was not harmful.
• In 1960, saccharin was used
by diabetics at the United
States, saccharin is often
found in restaurants with
brand is " Sweet'n Low ".
HISTORY
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5. • 1970s, saccharine induces bladder cancer in
rats warning label addition
• In 2000, warning label was removed
•  safe for consumption
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HISTORY
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6.  Saccharin is a cyclic sulfimide.
 Molecular formula: 𝑪 𝟕 𝑯 𝟓 𝑵𝑶 𝟑 𝐒
 Another name: “benzoic
sunfimit” or “ortho
sunphobenzamit”.
 The free acid of saccharin has a
low pKa of 1.6
FORMULA AND PROPERTIES
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7.  Molecular weight: 183.17g / mol
 Specific Gravity: 0.828g / 𝑐𝑚3
 Melting temperature: 228.8 - 229.7℃
 Water solubility: 1g / 270ml water
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8. Odorless white crystals or crystalline powder
Intensely sweet taste. It can have an
unpleasant, bitter aftertaste
Slightly soluble in benzene,
ethyl ether, chloroform;
soluble in acetone and ethanol
heat stable
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9. APPLICATION OF SACCHARINE
• Saccharine is often featured in various vitamin
supplements and medicines and it can be used
for the baking as a substitute for sugar.
• Saccharine has been used to sweeten foods and
beverages without calories.
• Saccharine provides products with increased
stability, improved taste, lower production
costs and more choices for the consumer.
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10. • Saccharin is especially beneficial to people
with diabetes and the obese, and reduce dental
cavities.
• The use of saccharin is particularly important
to those whose diets require a restriction of
caloric or carbohydrate intake, such as people
with diabetes
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11. APPROVED OR NON-APPROVED ?
• Saccharine is now one of five FDA-approved
artificial sweeteners, and is also an approved
food additive in Europe and most countries
around the world
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12. • Positive effects:
Replacing sugar with a low-calorie
sweetener may benefit weight loss and
protect against obesity
Saccharin is often recommended as a sugar
substitute for people with diabetes
reduce the risk of cavities
SIDE EFFECTS ON HUMAN HEALTH
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13. • Negative effects:
 Acute( short-term) health effects: irritate the
skin
 Chronic(long-term) health effects:
Cancer hazard: not classifiable as to its potential to
cause cancer
Reproduction hazard: not affect reproduction
Other long-term effects: In very high concentration,
cause a skin allergy itching and a skin rash
SIDE EFFECTS ON HUMAN HEALTH
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The FDA: the daily allowance (ADI) is 5mg / kg body weight
The WHO: 0-15mg / kg body weight.
DOSING FOR USE
For example:
A person weighing 50kg, the maximum
amount of saccharin taken into the body
is 50 kg x 15mg / kg = 750mg / day.
It is best to use only 30% ADI sugar,
which is
only 250mg / day.

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• Saccharin is considered as a functional food that is no
toxin to human health. However, there are some
problem that relate to using of Saccharin.
• Allergic reactions ( sulfonamide) in people taking
sulfa drugs.
• Symptoms with allergies include headache, difficulty
breathing, rash, diarrhea.
• Saccharin was found in milk is also a risk factor for
muscle dysfunction. For objects such as pregnant
women, infants and especially infants should not use
products containing saccharin
CONCLUSION

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