Secondary Immunodeficiency

SECONDARY IMMUNE DEFICIENCY w.pongsak,MD

scope ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Introduction ,[object Object],[object Object],[object Object],[object Object]

Extreme Age ,[object Object],[object Object]

Newborn peroid ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Advanced age ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Robert R Rich . Clinical immunology 3 rd edition

Innate immunity & aging ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Adaptive immunity & aging ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],CD 28 - CD8 T cells may be CD 27 + or - but CD 28 - CD4 T cells limit to CD 27 - =>loss of CD 40L =Loss of co-stimulatory molecule Thymic involution

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Vaccine in elderly ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

1.12 1.12 Increase threshold to respond to danger signal Functional defect of APC Progressive loss of naïve T cell Reduce naïve B cell isotype switching and Somatic Hypermutation Increase effector T cell , restrict diversity of T cell Aging of BM caused short duration of protection

Stratergies to reverse or delay immunosenescence ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Malnutrition ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],J Allergy Clin Immunol 2005 ;1151119-28

Robert R Rich . Clinical immunology 3 rd edition ?

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],J Allergy Clin Immunol 2005 ;1151119-28

J Allergy Clin Immunol 2005 ;1151119-28

Conclusion: CD4 T and B cell decrease in malnutrition with infectious pt.

Metabolic diseases ,[object Object],[object Object]

Diabetes Mellitus ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Defect in innate immunity

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Uremia ,[object Object],[object Object],[object Object],[object Object],[object Object]

Surgery and Trauma ,[object Object],[object Object],[object Object],[object Object]

splenectomy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Environmental condition ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

conclusion ,[object Object],[object Object],[object Object],[object Object],[object Object]

Nature Reviews Immunology 2008;8:685-98

Secondary Immunodeficiency

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Secondary Immunodeficiency