This document discusses important compounds of sodium including sodium carbonate, sodium chloride, and sodium hydroxide. Sodium carbonate is produced via the Solvay process and is used for water softening, laundering, and cleaning. Sodium chloride is obtained from sea water or salt mines and is used as table salt. Sodium hydroxide is produced commercially via electrolysis of sodium chloride and is used to make soap, paper, and chemicals.
3 modren sodium hydroxide manufacturing methodsrita martin
Sodium hydroxide also known as caustic soda with chemical formula NaOH found in many forms caustic soda lye, flakes, granules and solid. Produced using three different process Mercury Cell, Diaphragm cell, Membrane Cell methods
This is a presentation file that will provide you notes, proper diagrams, short tips, mnemonics about the alkali metals.. This course is of High School of grades 11 and 12. I think it will help every type of student. Similarly, you can find some repeated and important questions.
3 modren sodium hydroxide manufacturing methodsrita martin
Sodium hydroxide also known as caustic soda with chemical formula NaOH found in many forms caustic soda lye, flakes, granules and solid. Produced using three different process Mercury Cell, Diaphragm cell, Membrane Cell methods
This is a presentation file that will provide you notes, proper diagrams, short tips, mnemonics about the alkali metals.. This course is of High School of grades 11 and 12. I think it will help every type of student. Similarly, you can find some repeated and important questions.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
3. SOME IMPORTANT COMPOUNDS OF SODIUM
Sodium Carbonate (Washing Soda), Na2CO3·10H2O
• Sodium carbonate is generally prepared by Solvay Process.
• In this process, as sodium hydrogencarbonate has low solubility it gets
precipitated in the reaction of sodium chloride with ammonium
hydrogencarbonate.
• The latter is prepared by passing CO2 to a concentrated solution of sodium
chloride saturated with ammonia, where ammonium carbonate followed
by ammonium hydrogencarbonate are formed. The equations for the
complete process may be written as :
4. Sodium hydrogencarbonate crystal separates. These are heated to
give sodium carbonate
In this process NH3 is recovered when the solution containing
NH4Cl is treated with Ca(OH)2. Calcium chloride is obtained as a
by-product.
Solvay process cannot be used to manufacture potassium
carbonate because, potassium hydrogencarbonate is too soluble
to be precipitated.
5. Properties :
• Sodium carbonate is a white crystalline solid which exists as a decahydrate,
Na2CO3·10H2O.
• This is also called washing soda.
• It is readily soluble in water.
• On heating, the decahydrate loses its water of crystallisation to form monohydrate.
Above 373K, the monohydrate becomes completely anhydrous and changes to a
white powder called soda ash.
• Carbonate part of sodium carbonate gets hydrolysed by water to
form an alkaline solution
6. Uses:
(i) It is used in water softening, laundering and cleaning.
(ii) It is used in the manufacture of glass, soap, borax and caustic soda.
(iii) It is used in paper, paints and textile industries.
(iv) It is an important laboratory reagent both in qualitative and
quantitative analysis.
7. Sodium Chloride, NaCl
• The most abundant source of sodium chloride is sea water which
contains 2.7 to 2.9% by mass of the salt.
• In tropical countries like India, common salt is generally obtained by
evaporation of sea water. Approximately 50 lakh tons of salt are
produced annually in India by solar evaporation.
• Crude sodium chloride, generally obtained by crystallization of brine
solution, contains sodium sulphate, calcium sulphate, calcium chloride
and magnesium chloride as impurities
• Calcium chloride and magnesium chloride, are impurities because they
are deliquescent (absorb moisture easily from the atmosphere).
• To obtain pure sodium chloride, the crude salt is dissolved in minimum
amount of water and filtered to remove insoluble impurities.
8. • Sodium chloride melts at 1081K.
• It has a solubility of 36.0 g in 100 g of water at 273 K.
• The solubility does not increase appreciably with
increase in temperature.
Uses :
(i) It is used as a common salt or table salt for domestic
purpose.
(ii) It is used for the preparation of Na2O2, NaOH and Na2CO3.
• The solution is then saturated with hydrogen chloride
gas. Crystals of pure sodium chloride separate out.
• Calcium and magnesium chloride, being more soluble
than sodium chloride, remain in solution.
9. Sodium Hydroxide (Caustic Soda), NaOH
• Sodium hydroxide is generally
prepared commercially by the
electrolysis of sodium chloride in
Castner-Kellner cell.
• A brine solution is electrolysed using a
mercury cathode and a carbon anode.
• Sodium metal discharged at the
cathode combines with mercury to
form sodium amalgam. Chlorine gas is
evolved at the anode.
10. • The amalgam is treated with water to give
sodium hydroxide and hydrogen gas.
properties
• Sodium hydroxide is a white, translucent
solid.
• It melts at 591 K.
• It is readily soluble in water to give a strong
alkaline solution.
• Crystals of sodium hydroxide are
deliquescent.
• The sodium hydroxide solution at the surface
reacts with the CO2 in the atmosphere to
form Na2CO3.
Uses:
(i) the manufacture of soap, paper,
artificial silk and a number of chemicals,
(ii) in petroleum refining,
(iii) in the purification of bauxite,
(iv) in the textile industries for mercerising
cotton fabrics,
(v) for the preparation of pure fats and oils,
(vi) as a laboratory reagent.
