This document discusses the various roles of computers in clinical pharmacy. It describes how computers can be used for patient record management, medication order entry, generating medication profiles and lists, screening for drug interactions, maintaining drug information databases, aiding research, managing inventories, and generating administrative reports. The document also discusses several specific computer systems and software programs that are used to support clinical pharmacy activities and optimize patient care.
The document discusses pharmacokinetics of multiple dosing. It defines dosage regimen as how a drug is taken when treatment duration is longer than a single dose's therapeutic effect. The objectives of dosage regimen design are to achieve target drug concentrations. Multiple dosing is used when treatment duration is larger than a single dose's effect, leading to drug accumulation. Loading and maintenance doses are discussed to quickly reach the desired plasma concentration and maintain it.
This document discusses the role of computers in clinical pharmacy. It describes how computers can be used for patient record management, medication order entry, generating medication profiles and lists, screening for drug interactions, and applications in areas like research, education, and inventory management. Computers help improve efficiency and accuracy in monitoring patient drug therapy and free up pharmacists to spend more time on direct patient care activities.
This document discusses various approaches used to model pharmacokinetics. It describes compartment models, physiological models, and distributed parameter models that can be used to mathematically describe drug absorption, distribution, metabolism and excretion over time. It also discusses model-independent or non-compartmental analysis, which does not require assumptions about specific compartment models. Compartment models include mammillary and catenary models. Physiological models group tissues into compartments based on similar perfusion properties. Distributed parameter models account for variations in organ blood flow and drug diffusion.
Hospital pharmacists are experts in medicines who work as part of healthcare teams to manage medication use in hospitals. Their responsibilities include procurement, storage, dispensing, manufacturing, testing, and distribution of drugs. They provide patient-centered care through individualized patient monitoring and evaluation. Hospital pharmacists require administrative, technical, and academic abilities to plan pharmacy operations, ensure quality control, provide training, and participate in research. Their roles include working in central dispensing areas, patient care units, and direct patient care through counseling, monitoring therapy, and obtaining medication histories. Beyond clinical care, hospital pharmacists also serve on committees, conduct drug trials, provide education, and influence hospital formularies.
Clinical pharmacokinetics and its application--
1)definition
2) APPLICATIONS OF CLINICAL PHARMACOKINETICS
Design of dosage regimens:
a) Nomograms and Tabulations in designing dosage regimen,
b) Conversion from intravenous to oral dosing,
c) Determination of dose and dosing intervals,
d) Drug dosing in the elderly and pediatrics and obese patients.
Pharmacokinetics of Drug Interaction:
a) Pharmacokinetic drug interactions
b) Inhibition and Induction of Drug metabolism
c) Inhibition of Biliary Excretion.
Therapeutic Drug monitoring:
a) Introduction
b) Individualization of drug dosage regimen (Variability – Genetic, Age and Weight, disease, Interacting drugs).
c) Indications for TDM. Protocol for TDM.
d) Pharmacokinetic/Pharmacodynamic Correlation in drug therapy.
e) TDM of drugs used in the following disease conditions: cardiovascular disease, Seizure disorders, Psychiatric conditions, and Organ transplantations
Dosage adjustment in Renal and Hepatic Disease.
a. Renal impairment
b. Pharmacokinetic considerations
c. General approach for dosage adjustment in renal disease.
d. Measurement of Glomerular Filtration rate and creatinine clearance.
e. Dosage adjustment for uremic patients.
f. Extracorporeal removal of drugs.
g. Effect of Hepatic disease on pharmacokinetics.
Population Pharmacokinetics.
a) Introduction to Bayesian Theory.
b) Adaptive method or Dosing with feedback.
c) Analysis of Population pharmacokinetic Data
The presentation gives you a bird eye's view regarding basics of PK-PD modeling, its applications, types, limitations and various softwares used for the same.
The document discusses hospital formularies, which are lists of approved medications used in hospitals. A hospital formulary is developed and revised by the Pharmacy and Therapeutics Committee to reflect the current views of medical staff. It includes generic drugs when possible to help control costs. The formulary provides essential information on approved medications to guide doctors' prescribing and aid rational drug use. It undergoes annual revisions to add new drugs and remove outdated ones.
This document provides an overview of therapeutic drug monitoring (TDM). It defines TDM as the measurement of drug concentrations in blood or plasma to guide dosage adjustments for effective and safe treatment. The goals of TDM are to ensure maximal therapeutic benefit and minimal toxicity by achieving appropriate drug concentrations at the site of action. Several factors can cause variability in individual drug response, including pharmacokinetic factors like absorption and clearance, as well as pharmacodynamic factors like genetic polymorphisms and drug interactions. TDM is indicated for drugs with a narrow therapeutic index, a lack of clinical endpoints, or significant inter-individual variability. It involves collecting samples at standardized times, measuring drug levels, and interpreting the results with clinical context to optimize individual patient dos
The document discusses pharmacokinetics of multiple dosing. It defines dosage regimen as how a drug is taken when treatment duration is longer than a single dose's therapeutic effect. The objectives of dosage regimen design are to achieve target drug concentrations. Multiple dosing is used when treatment duration is larger than a single dose's effect, leading to drug accumulation. Loading and maintenance doses are discussed to quickly reach the desired plasma concentration and maintain it.
This document discusses the role of computers in clinical pharmacy. It describes how computers can be used for patient record management, medication order entry, generating medication profiles and lists, screening for drug interactions, and applications in areas like research, education, and inventory management. Computers help improve efficiency and accuracy in monitoring patient drug therapy and free up pharmacists to spend more time on direct patient care activities.
This document discusses various approaches used to model pharmacokinetics. It describes compartment models, physiological models, and distributed parameter models that can be used to mathematically describe drug absorption, distribution, metabolism and excretion over time. It also discusses model-independent or non-compartmental analysis, which does not require assumptions about specific compartment models. Compartment models include mammillary and catenary models. Physiological models group tissues into compartments based on similar perfusion properties. Distributed parameter models account for variations in organ blood flow and drug diffusion.
Hospital pharmacists are experts in medicines who work as part of healthcare teams to manage medication use in hospitals. Their responsibilities include procurement, storage, dispensing, manufacturing, testing, and distribution of drugs. They provide patient-centered care through individualized patient monitoring and evaluation. Hospital pharmacists require administrative, technical, and academic abilities to plan pharmacy operations, ensure quality control, provide training, and participate in research. Their roles include working in central dispensing areas, patient care units, and direct patient care through counseling, monitoring therapy, and obtaining medication histories. Beyond clinical care, hospital pharmacists also serve on committees, conduct drug trials, provide education, and influence hospital formularies.
Clinical pharmacokinetics and its application--
1)definition
2) APPLICATIONS OF CLINICAL PHARMACOKINETICS
Design of dosage regimens:
a) Nomograms and Tabulations in designing dosage regimen,
b) Conversion from intravenous to oral dosing,
c) Determination of dose and dosing intervals,
d) Drug dosing in the elderly and pediatrics and obese patients.
Pharmacokinetics of Drug Interaction:
a) Pharmacokinetic drug interactions
b) Inhibition and Induction of Drug metabolism
c) Inhibition of Biliary Excretion.
Therapeutic Drug monitoring:
a) Introduction
b) Individualization of drug dosage regimen (Variability – Genetic, Age and Weight, disease, Interacting drugs).
c) Indications for TDM. Protocol for TDM.
d) Pharmacokinetic/Pharmacodynamic Correlation in drug therapy.
e) TDM of drugs used in the following disease conditions: cardiovascular disease, Seizure disorders, Psychiatric conditions, and Organ transplantations
Dosage adjustment in Renal and Hepatic Disease.
a. Renal impairment
b. Pharmacokinetic considerations
c. General approach for dosage adjustment in renal disease.
d. Measurement of Glomerular Filtration rate and creatinine clearance.
e. Dosage adjustment for uremic patients.
f. Extracorporeal removal of drugs.
g. Effect of Hepatic disease on pharmacokinetics.
Population Pharmacokinetics.
a) Introduction to Bayesian Theory.
b) Adaptive method or Dosing with feedback.
c) Analysis of Population pharmacokinetic Data
The presentation gives you a bird eye's view regarding basics of PK-PD modeling, its applications, types, limitations and various softwares used for the same.
The document discusses hospital formularies, which are lists of approved medications used in hospitals. A hospital formulary is developed and revised by the Pharmacy and Therapeutics Committee to reflect the current views of medical staff. It includes generic drugs when possible to help control costs. The formulary provides essential information on approved medications to guide doctors' prescribing and aid rational drug use. It undergoes annual revisions to add new drugs and remove outdated ones.
This document provides an overview of therapeutic drug monitoring (TDM). It defines TDM as the measurement of drug concentrations in blood or plasma to guide dosage adjustments for effective and safe treatment. The goals of TDM are to ensure maximal therapeutic benefit and minimal toxicity by achieving appropriate drug concentrations at the site of action. Several factors can cause variability in individual drug response, including pharmacokinetic factors like absorption and clearance, as well as pharmacodynamic factors like genetic polymorphisms and drug interactions. TDM is indicated for drugs with a narrow therapeutic index, a lack of clinical endpoints, or significant inter-individual variability. It involves collecting samples at standardized times, measuring drug levels, and interpreting the results with clinical context to optimize individual patient dos
This document discusses linear and non-linear pharmacokinetics. Linear pharmacokinetics follows first-order kinetics where the rate of change in drug concentration depends only on the current concentration. In non-linear pharmacokinetics, the rate depends on carrier enzymes that can become saturated at high drug concentrations, causing the kinetics to follow mixed or zero-order processes and parameters to change with dose. Non-linearity can be caused by saturation of absorption, distribution, metabolism or excretion processes. The Michaelis-Menten equation describes non-linear kinetics and parameters. Km and Vmax can be estimated from plasma concentration data using Lineweaver-Burk, Eadie-Hofstee or Han
The document discusses nonlinear pharmacokinetics and chronopharmacokinetics. Nonlinear pharmacokinetics occurs when the body's absorption, distribution, metabolism, or excretion of a drug becomes saturated at higher doses. This can cause the rate of drug elimination to decrease. Examples of processes that can become saturated include drug metabolism and renal excretion. Circadian rhythms can also impact drug pharmacokinetics by influencing absorption, distribution, metabolism, and excretion over 24-hour periods. Accounting for these temporal changes can improve drug therapy for circadian phase-dependent diseases.
This document discusses the design of dosage regimens and controlled release drug delivery systems based on pharmacokinetic principles. It begins with an introduction to pharmacokinetics and then covers factors to consider in designing dosage regimens such as dose size, dose frequency, and approaches like empirical or population-based modeling. It also discusses concepts like loading and maintenance doses, drug accumulation, and fluctuation for multiple dosing. Finally, it discusses using pharmacokinetic parameters to design controlled release formulations to optimize therapeutic effects and reduce side effects.
This document discusses physiological pharmacokinetic models, which describe drug movement and disposition in the body based on organ blood flow and organ spaces penetrated by the drug. It presents different types of models, including blood flow-limited models, models incorporating drug binding, and membrane-limited models. It discusses key concepts like mean residence time, mean absorption time, and mean dissolution time. Physiological pharmacokinetic models provide a more exact description of drug concentrations over time compared to non-physiological models.
This presentation is about the process by which prolonged therapeutic activity of drug is achieved and it's importance. By this presentation you will learn about dosage regimen, steady state concentration, principle of superposition, drug accumulation, repetitive intravenous injections etc. By this you will also learn how to adjust the dose to the patient.
Prescribed Medication Order and Communication Skills.pptxSangam Kanthale
Prescribed medication orders must contain specific information to effectively communicate treatment regimens to pharmacists. This includes the patient's name, drug name, strength, dose, form, administration route, quantity, prescriber information, and date. PRN orders require additional details like maximum daily dose and signs/symptoms prompting administration. Proper interpretation of prescriptions by pharmacists can prevent medication errors by understanding abbreviations and Latin terms used. Effective communication between all healthcare professionals is critical for safe and accurate patient care.
This document discusses bioavailability and bioequivalence concepts including definitions, objectives of bioavailability studies, types of bioavailability studies, and methods of measuring bioavailability. It also covers bioequivalence experimental study designs including completely randomized, randomized block, repeated measures, and Latin square designs. In vitro dissolution studies and developing in vitro-in vivo correlations to help assess bioavailability without human studies are also summarized.
Individualisation and optimization of drug dosing regimenJyoti Nautiyal
Drug dosing regimen, dosing frequency, individualisation, Steps Involved in Individualization of Dosage Regimen, optimization, variability, Clinical experience with individualization and optimization based on plasma drug levels.
Pharmacovigilance is the science of detecting, assessing, understanding, and preventing adverse effects of medicines. The goals of pharmacovigilance include early detection of unknown safety problems, quantifying risks, and preventing patients from being harmed. Adverse drug reactions are a major cause of mortality and healthcare costs worldwide. Ongoing pharmacovigilance is needed to monitor drug safety after approval and promote rational, safer drug use. Healthcare professionals play a key role by thoroughly investigating and reporting any suspected adverse drug reactions.
This document discusses drug use in special situations including geriatric, pediatric, and pregnancy/lactation. For geriatric drug therapy, it notes that the elderly use more medications due to more disease symptoms and that aging affects drug pharmacokinetics through changes in absorption, distribution, metabolism and elimination. For pediatric drug therapy, it describes the developmental changes that influence drug response in infants and children. For drugs in pregnancy and lactation, it emphasizes avoiding non-essential drugs during pregnancy due to risks to the fetus, and that some drugs can pass through the placenta as a potential teratogen.
Transdermal Drug Delivery System [TDDS]Sagar Savale
Management of illness through medication has entered an era of rapid growth. A variety of means by which drugs are delivered to the human body for the therapy such as tablets, capsules, injections, aerosols, creams, ointments, suppositories, liquids etc. are referred as a conventional drug formulations. Among many pharmaceutical dosage forms, continuous intravenous infusion at preprogrammed rate has been recognized as a superior mode of drug delivery. At present, the most common form of delivery of drugs is the oral route. It has the notable advantage of easy administration.
Pharmacy Practice- ADVERSE DRUG REACTION BY Khusboo DebnathGvDurgamani
PHARMACY PRACTICE BY KHUSBOO DEBNATH.
CLASSIFICATION OF ADVERSE DRUG REACTION.
definition ,adverse drug reaction, adverse drug effect, classification, side effect, application.
Therapeutic drug monitoring (TDM) refers to measuring drug levels in the blood to optimize drug therapy and ensure concentrations remain in the therapeutic range to maximize efficacy and minimize toxicity. TDM is used for drugs with a narrow therapeutic index, non-linear kinetics, or high inter-individual variability in metabolism. It allows clinicians to individualize dosing regimens to maintain therapeutic concentrations and avoid sub-therapeutic or toxic levels. Common drugs monitored include digoxin, theophylline, aminoglycosides, and anti-epileptics.
Detection, reporting and management of adverse eventsKatla Swapna
This document discusses adverse drug reactions (ADRs), including definitions, classifications, detection, reporting, and management. It notes that ADRs are a major clinical problem that can cause suffering and increased healthcare costs. It emphasizes the importance of monitoring and reporting ADRs to improve patient safety. Pharmacists can play an important role by monitoring high-risk patients and drugs, educating on ADR reporting, and assisting in the detection and assessment of ADRs. Timely reporting of ADRs is crucial to help prevent human suffering and unnecessary costs from drug-related injuries.
This document discusses various methods of drug dispensing to inpatients in hospitals. It describes four main systems: individual drug order system, floor stock system, combined individual/floor stock system, and unit dose distribution system. The floor stock system involves storing drugs on patient floors while the unit dose system dispenses single doses from a central pharmacy. Newer methods like automated dispensing cabinets aim to improve efficiency by electronically transmitting orders and dispensing medications directly from computerized cabinets. Overall the document provides an overview of traditional and emerging approaches to delivering medications to hospitalized patients.
This document discusses dosage regimens for drugs administered through multiple doses. It defines key concepts like maintenance dose, loading dose, and accumulation index. The loading dose is given to quickly reach the steady state concentration, while the maintenance dose is used to maintain that concentration by replacing eliminated drug. The accumulation index describes the extent of drug accumulation in the body during multiple dosing as a function of dosing interval and elimination half-life. Designing optimal dosage regimens requires considering factors like dose size, dosing frequency, and pharmacokinetic parameters.
INTRODUCTION TO PHARMACOKINETIC MODELS, ONE COMPARTMENT OPEN MODEL IV BOLUS, IV INFUSION, EXTRAVASCULAR ADMINISTRATION, WAGNER NELSON METHOD, METHOD OF RESIDUALS
OTC drugs are medications that can be purchased without a prescription. They include pain relievers like acetaminophen and ibuprofen, cough and cold medicines, antacids, and allergy medications. OTC drugs are widely used in India, accounting for 55% of drugs consumed. While convenient and cheaper than prescription drugs, OTC medications still carry risks if not taken as directed or if combining multiple products with the same active ingredients. Proper use of OTC drugs requires carefully reading and following all label instructions.
Role of computers in clinical pharmacy simi joju k.simisheeja
Computers play a vital role in clinical pharmacy practice by assisting with patient record management, medication order entry, patient medication profiles, drug interaction screening, and other functions. Clinical computer systems update patient records and can produce information like diagnoses, allergies, physician details. They allow pharmacists to enter and retrieve medication orders, prepare labels and reports, and screen for potential drug interactions. Overall, computers improve efficiency, accuracy, and safety in key areas of clinical pharmacy work.
biostats use of computers in pharmacy.pptxShaistaSumayya
Hospital pharmacy is the health care service, which comprises the art, practice, and profession of choosing, preparing, storing, compounding, and dispensing medicines and medical devices, advising healthcare professionals and patients on their safe, effective and efficient use.
The computer has become a very common tool in all the areas of science and technology.
The field of pharmacy has immensely benefitted by the use of computers and will continue to do so.
The complete field of pharmacy requires computers.
This document discusses linear and non-linear pharmacokinetics. Linear pharmacokinetics follows first-order kinetics where the rate of change in drug concentration depends only on the current concentration. In non-linear pharmacokinetics, the rate depends on carrier enzymes that can become saturated at high drug concentrations, causing the kinetics to follow mixed or zero-order processes and parameters to change with dose. Non-linearity can be caused by saturation of absorption, distribution, metabolism or excretion processes. The Michaelis-Menten equation describes non-linear kinetics and parameters. Km and Vmax can be estimated from plasma concentration data using Lineweaver-Burk, Eadie-Hofstee or Han
The document discusses nonlinear pharmacokinetics and chronopharmacokinetics. Nonlinear pharmacokinetics occurs when the body's absorption, distribution, metabolism, or excretion of a drug becomes saturated at higher doses. This can cause the rate of drug elimination to decrease. Examples of processes that can become saturated include drug metabolism and renal excretion. Circadian rhythms can also impact drug pharmacokinetics by influencing absorption, distribution, metabolism, and excretion over 24-hour periods. Accounting for these temporal changes can improve drug therapy for circadian phase-dependent diseases.
This document discusses the design of dosage regimens and controlled release drug delivery systems based on pharmacokinetic principles. It begins with an introduction to pharmacokinetics and then covers factors to consider in designing dosage regimens such as dose size, dose frequency, and approaches like empirical or population-based modeling. It also discusses concepts like loading and maintenance doses, drug accumulation, and fluctuation for multiple dosing. Finally, it discusses using pharmacokinetic parameters to design controlled release formulations to optimize therapeutic effects and reduce side effects.
This document discusses physiological pharmacokinetic models, which describe drug movement and disposition in the body based on organ blood flow and organ spaces penetrated by the drug. It presents different types of models, including blood flow-limited models, models incorporating drug binding, and membrane-limited models. It discusses key concepts like mean residence time, mean absorption time, and mean dissolution time. Physiological pharmacokinetic models provide a more exact description of drug concentrations over time compared to non-physiological models.
This presentation is about the process by which prolonged therapeutic activity of drug is achieved and it's importance. By this presentation you will learn about dosage regimen, steady state concentration, principle of superposition, drug accumulation, repetitive intravenous injections etc. By this you will also learn how to adjust the dose to the patient.
Prescribed Medication Order and Communication Skills.pptxSangam Kanthale
Prescribed medication orders must contain specific information to effectively communicate treatment regimens to pharmacists. This includes the patient's name, drug name, strength, dose, form, administration route, quantity, prescriber information, and date. PRN orders require additional details like maximum daily dose and signs/symptoms prompting administration. Proper interpretation of prescriptions by pharmacists can prevent medication errors by understanding abbreviations and Latin terms used. Effective communication between all healthcare professionals is critical for safe and accurate patient care.
This document discusses bioavailability and bioequivalence concepts including definitions, objectives of bioavailability studies, types of bioavailability studies, and methods of measuring bioavailability. It also covers bioequivalence experimental study designs including completely randomized, randomized block, repeated measures, and Latin square designs. In vitro dissolution studies and developing in vitro-in vivo correlations to help assess bioavailability without human studies are also summarized.
Individualisation and optimization of drug dosing regimenJyoti Nautiyal
Drug dosing regimen, dosing frequency, individualisation, Steps Involved in Individualization of Dosage Regimen, optimization, variability, Clinical experience with individualization and optimization based on plasma drug levels.
Pharmacovigilance is the science of detecting, assessing, understanding, and preventing adverse effects of medicines. The goals of pharmacovigilance include early detection of unknown safety problems, quantifying risks, and preventing patients from being harmed. Adverse drug reactions are a major cause of mortality and healthcare costs worldwide. Ongoing pharmacovigilance is needed to monitor drug safety after approval and promote rational, safer drug use. Healthcare professionals play a key role by thoroughly investigating and reporting any suspected adverse drug reactions.
This document discusses drug use in special situations including geriatric, pediatric, and pregnancy/lactation. For geriatric drug therapy, it notes that the elderly use more medications due to more disease symptoms and that aging affects drug pharmacokinetics through changes in absorption, distribution, metabolism and elimination. For pediatric drug therapy, it describes the developmental changes that influence drug response in infants and children. For drugs in pregnancy and lactation, it emphasizes avoiding non-essential drugs during pregnancy due to risks to the fetus, and that some drugs can pass through the placenta as a potential teratogen.
Transdermal Drug Delivery System [TDDS]Sagar Savale
Management of illness through medication has entered an era of rapid growth. A variety of means by which drugs are delivered to the human body for the therapy such as tablets, capsules, injections, aerosols, creams, ointments, suppositories, liquids etc. are referred as a conventional drug formulations. Among many pharmaceutical dosage forms, continuous intravenous infusion at preprogrammed rate has been recognized as a superior mode of drug delivery. At present, the most common form of delivery of drugs is the oral route. It has the notable advantage of easy administration.
Pharmacy Practice- ADVERSE DRUG REACTION BY Khusboo DebnathGvDurgamani
PHARMACY PRACTICE BY KHUSBOO DEBNATH.
CLASSIFICATION OF ADVERSE DRUG REACTION.
definition ,adverse drug reaction, adverse drug effect, classification, side effect, application.
Therapeutic drug monitoring (TDM) refers to measuring drug levels in the blood to optimize drug therapy and ensure concentrations remain in the therapeutic range to maximize efficacy and minimize toxicity. TDM is used for drugs with a narrow therapeutic index, non-linear kinetics, or high inter-individual variability in metabolism. It allows clinicians to individualize dosing regimens to maintain therapeutic concentrations and avoid sub-therapeutic or toxic levels. Common drugs monitored include digoxin, theophylline, aminoglycosides, and anti-epileptics.
Detection, reporting and management of adverse eventsKatla Swapna
This document discusses adverse drug reactions (ADRs), including definitions, classifications, detection, reporting, and management. It notes that ADRs are a major clinical problem that can cause suffering and increased healthcare costs. It emphasizes the importance of monitoring and reporting ADRs to improve patient safety. Pharmacists can play an important role by monitoring high-risk patients and drugs, educating on ADR reporting, and assisting in the detection and assessment of ADRs. Timely reporting of ADRs is crucial to help prevent human suffering and unnecessary costs from drug-related injuries.
This document discusses various methods of drug dispensing to inpatients in hospitals. It describes four main systems: individual drug order system, floor stock system, combined individual/floor stock system, and unit dose distribution system. The floor stock system involves storing drugs on patient floors while the unit dose system dispenses single doses from a central pharmacy. Newer methods like automated dispensing cabinets aim to improve efficiency by electronically transmitting orders and dispensing medications directly from computerized cabinets. Overall the document provides an overview of traditional and emerging approaches to delivering medications to hospitalized patients.
This document discusses dosage regimens for drugs administered through multiple doses. It defines key concepts like maintenance dose, loading dose, and accumulation index. The loading dose is given to quickly reach the steady state concentration, while the maintenance dose is used to maintain that concentration by replacing eliminated drug. The accumulation index describes the extent of drug accumulation in the body during multiple dosing as a function of dosing interval and elimination half-life. Designing optimal dosage regimens requires considering factors like dose size, dosing frequency, and pharmacokinetic parameters.
INTRODUCTION TO PHARMACOKINETIC MODELS, ONE COMPARTMENT OPEN MODEL IV BOLUS, IV INFUSION, EXTRAVASCULAR ADMINISTRATION, WAGNER NELSON METHOD, METHOD OF RESIDUALS
OTC drugs are medications that can be purchased without a prescription. They include pain relievers like acetaminophen and ibuprofen, cough and cold medicines, antacids, and allergy medications. OTC drugs are widely used in India, accounting for 55% of drugs consumed. While convenient and cheaper than prescription drugs, OTC medications still carry risks if not taken as directed or if combining multiple products with the same active ingredients. Proper use of OTC drugs requires carefully reading and following all label instructions.
Role of computers in clinical pharmacy simi joju k.simisheeja
Computers play a vital role in clinical pharmacy practice by assisting with patient record management, medication order entry, patient medication profiles, drug interaction screening, and other functions. Clinical computer systems update patient records and can produce information like diagnoses, allergies, physician details. They allow pharmacists to enter and retrieve medication orders, prepare labels and reports, and screen for potential drug interactions. Overall, computers improve efficiency, accuracy, and safety in key areas of clinical pharmacy work.
biostats use of computers in pharmacy.pptxShaistaSumayya
Hospital pharmacy is the health care service, which comprises the art, practice, and profession of choosing, preparing, storing, compounding, and dispensing medicines and medical devices, advising healthcare professionals and patients on their safe, effective and efficient use.
The computer has become a very common tool in all the areas of science and technology.
The field of pharmacy has immensely benefitted by the use of computers and will continue to do so.
The complete field of pharmacy requires computers.
Use of computers in hospital pharmacy, biostatistics and research methodology...shaistasumayya2
Computers in pharmacy are used for the information of drug data, records and files, drug management (creating, modifying, adding and deleting data in patient files to generate reports), business details.
Use of computers in pharmacy, biostatistics and research methodology, Shaista...shaistasumayya2
Patient record database management
Medication order entry
Drug labels
Drug lists
Electronic medication administration record
Patient medication profiles
Inventory control
Management report and statistics
APPLICATION OF COMPUTER IN HOPITAL PHARMACY.pptxMonishaReddy31
Computer applications have numerous benefits in hospital pharmacy including maintaining accurate patient and drug records, aiding in purchase and inventory control, facilitating therapeutic drug monitoring, enabling efficient drug information retrieval, assisting in drug dispensing, and helping reduce medication errors. Specifically, computerized systems allow easy storage and updating of patient information, automated purchase ordering based on inventory levels, statistical analysis to optimize individual drug dosages, rapid searching of medical literature, electronic prescribing and verification of orders, and integration of health records across providers and locations.
Medication order entry introduction, Medication order management system, steps involved, clinical decision support system, entering information in computers, drug labels and drug lists
Hospital Pharmacy Chapter -7 Applications of computer in Hospital PharmacyNikita Gupta
Here is notes of Hospital Pharmacy Chapter -7 Applications of computer in Hospital Pharmacy - practice electronic health records, softwares used in hospital pharmacy.
The document discusses pharmacy automation and computerized provider order entry (CPOE) in healthcare. It describes the large and growing market for pharmacy automation technologies like tablet counters, IV compounders, and automated dispensing machines. It also outlines key terms related to CPOE systems, their importance for improving safety and reducing errors, and factors that can lead to issues like e-iatrogenesis during computer downtimes.
This document summarizes a project to improve the medication order and dispensing process at an inpatient pharmacy to reduce risks of medication errors. It describes the current process which involves electronic medication orders, printed labels, and medication administration records (MAR). A process map identified 23 steps and 48 gaps. Root cause analysis found issues like human error, technical problems, lack of training and non-compliance with policies. Recommendations include ensuring policy compliance, updating the health information system, modifying behaviors like only printing one label at a time for verification, and performing failure mode effects analysis when modifying the process.
Errors are every doctor's nightmare. Adverse drug events are the most common error in hospitals, especially in intensive care units, emergency rooms, operating theaters, and at night. Reducing errors requires improving various aspects of the medication system such as computerized physician order entry, unit dose packaging, automated dispensing, bar code scanning, look-alike/sound-alike drug names, administration processes, intravenous medications, and health information technology alerts. A systems approach is needed to redesign processes and implement checks, rather than blaming individuals, in order to significantly reduce medication errors.
This document discusses the need for and organization of drug information centers. It notes that the number and complexity of drugs has increased, making it difficult for medical professionals to stay up to date. Drug information centers aim to provide objective, documented data about drugs to support rational drug use and improve patient care. They gather, organize and distribute drug information to health professionals and consumers. The document outlines the functions, sources of information, staffing, funding, and operations of drug information centers.
This document describes the features and modules of a Hospital Management System (HMS). It discusses key modules like the laboratory module, pharmacy module, and nurse module. The laboratory module allows for test management and tracking samples. The pharmacy module facilitates dispensing medications and inventory management. The nurse module supports tasks like medication requests, patient observations, and shift scheduling. Overall, the HMS aims to improve operations, record keeping, and clinical decision making through integrated management of hospital departments and patient data.
Successful treatment of hypertension is possible with limited side effects
given the availability of multiple antihypertensive drug classes. The translation of
pharmacological research to the treatment of hypertension has been a continuous
process, starting with drugs discovered 60 years ago, such as thiazide diuretics
(1958) and currently finishing with the newest antihypertensive agent available
on the market, the orally active direct renin-inhibitor aliskiren, discovered more
than 10 years ago (2000) (Laurent, 2017).
In between, there has been a continuous rate of discovery, including
spironolactone (1957), beta-blockers (propranolol, 1973), centrally acting alpha-
2 adrenergic receptor agonists (clonidine, 1970s), alpha1- adrenergic receptor
blocker (prazosin, 1975), angiotensin converting enzyme inhibitors (captopril,
1977), calcium channel blockers (verapamil, 1977), and angiotensin II receptor
blockers (losartan, 1993) (Kotchen, 2011).
Therapeutic considerations regarding the treatment of hypertension in
patients with diabetes mellitus are reviewed. Good blood pressure control is
essential in diabetic patients to prevent morbidity and mortality associated with
The document discusses healthcare information technology and its evolution. It defines common terms like EMR, EHR, HIS, HL7, DICOM and PACS. It states that computerized physician order entry (CPOE) can significantly reduce medication errors and preventable adverse drug events. The hospital information system (HIS) is described as an integrated system that manages administrative, financial and clinical data across different departments. Several standards organizations are working to develop standards for interoperability between different health IT tools and electronic medical records.
The document discusses pharmacy management information systems (PMIS). It explains that a PMIS integrates pharmaceutical data collection and processing to provide information to help manage pharmacy services. A PMIS performs functions like clinical screening, prescription management, inventory management, and report generation. It also discusses the information system pyramid with operational, management, and executive levels. Finally, it lists popular PMIS vendors and software products.
Application of computers in Pharmacy.pptxsana916816
Computers and data processing techniques have made possible the high-speed, selective retrieval of large amount of information for government, commercial and academic purposes.
- Drug information involves providing unbiased and well-referenced information on pharmacy practice either verbally or in writing.
- A drug information center aims to enhance effective drug use, educate students, provide specialized drug databases, and expand the pharmacist's role in providing drug information services.
- A drug information center provides information on therapeutic drug use, dosing, safety, interactions, and focuses on patient care, counseling, and monitoring adverse drug reactions. It uses primary sources like clinical studies, secondary sources like reviews, and tertiary sources like textbooks.
A healthcare information system enables the collection, storage, management and analysis of patient treatment histories and other key data. It has several potential benefits including more efficient administration, improved monitoring of drug usage, reduced errors and increased information integrity. There are different types of healthcare information systems such as electronic medical records, practice management software, patient portals and clinical decision support systems. Each system serves an important role like storing patient records, managing daily operations, enabling patient access to health data and assisting healthcare providers in clinical decision making. Overall, healthcare information systems can improve quality of care, reduce costs and improve coordination across the healthcare system.
Similar to Role of computers in clinical pharmacy (20)
LAND USE LAND COVER AND NDVI OF MIRZAPUR DISTRICT, UPRAHUL
This Dissertation explores the particular circumstances of Mirzapur, a region located in the
core of India. Mirzapur, with its varied terrains and abundant biodiversity, offers an optimal
environment for investigating the changes in vegetation cover dynamics. Our study utilizes
advanced technologies such as GIS (Geographic Information Systems) and Remote sensing to
analyze the transformations that have taken place over the course of a decade.
The complex relationship between human activities and the environment has been the focus
of extensive research and worry. As the global community grapples with swift urbanization,
population expansion, and economic progress, the effects on natural ecosystems are becoming
more evident. A crucial element of this impact is the alteration of vegetation cover, which plays a
significant role in maintaining the ecological equilibrium of our planet.Land serves as the foundation for all human activities and provides the necessary materials for
these activities. As the most crucial natural resource, its utilization by humans results in different
'Land uses,' which are determined by both human activities and the physical characteristics of the
land.
The utilization of land is impacted by human needs and environmental factors. In countries
like India, rapid population growth and the emphasis on extensive resource exploitation can lead
to significant land degradation, adversely affecting the region's land cover.
Therefore, human intervention has significantly influenced land use patterns over many
centuries, evolving its structure over time and space. In the present era, these changes have
accelerated due to factors such as agriculture and urbanization. Information regarding land use and
cover is essential for various planning and management tasks related to the Earth's surface,
providing crucial environmental data for scientific, resource management, policy purposes, and
diverse human activities.
Accurate understanding of land use and cover is imperative for the development planning
of any area. Consequently, a wide range of professionals, including earth system scientists, land
and water managers, and urban planners, are interested in obtaining data on land use and cover
changes, conversion trends, and other related patterns. The spatial dimensions of land use and
cover support policymakers and scientists in making well-informed decisions, as alterations in
these patterns indicate shifts in economic and social conditions. Monitoring such changes with the
help of Advanced technologies like Remote Sensing and Geographic Information Systems is
crucial for coordinated efforts across different administrative levels. Advanced technologies like
Remote Sensing and Geographic Information Systems
9
Changes in vegetation cover refer to variations in the distribution, composition, and overall
structure of plant communities across different temporal and spatial scales. These changes can
occur natural.
it describes the bony anatomy including the femoral head , acetabulum, labrum . also discusses the capsule , ligaments . muscle that act on the hip joint and the range of motion are outlined. factors affecting hip joint stability and weight transmission through the joint are summarized.
This presentation includes basic of PCOS their pathology and treatment and also Ayurveda correlation of PCOS and Ayurvedic line of treatment mentioned in classics.
How to Manage Your Lost Opportunities in Odoo 17 CRMCeline George
Odoo 17 CRM allows us to track why we lose sales opportunities with "Lost Reasons." This helps analyze our sales process and identify areas for improvement. Here's how to configure lost reasons in Odoo 17 CRM
How to Build a Module in Odoo 17 Using the Scaffold MethodCeline George
Odoo provides an option for creating a module by using a single line command. By using this command the user can make a whole structure of a module. It is very easy for a beginner to make a module. There is no need to make each file manually. This slide will show how to create a module using the scaffold method.
Main Java[All of the Base Concepts}.docxadhitya5119
This is part 1 of my Java Learning Journey. This Contains Custom methods, classes, constructors, packages, multithreading , try- catch block, finally block and more.
2. Clinical pharmacy is the branch of Pharmacy where
pharmacists provide patient care that optimizes the
use of medication and promotes health, wellness, and
disease prevention.
Clinical pharmacists often collaborate with physicians
and other healthcare professionals.
Drug information retrieval system and special
therapeutic programs are available to further assist in
patient care role
CLINICAL PHARMACY
3. • Prescription monitoring
• Prescribing advice to medical and nursing staff
• Medication errors and adverse drug reaction
reporting
• History Taking
• Patient education and counseling
• Pharmacokinetics and therapeutic drug level
monitoring
• Professional and Clinical Audit
ROLES OF CLINICAL PHARMACIST :
4. Computers have played a vital role in the development of
clinical pharmacy practice and basic pharmacy research :-
• Patient record Management
• Entries of Medication Orders
• Patient Medication Profile
• Drug Therapy Monitoring & Problem Detection
• Record Drug-Drug Interactions & ADR’S
• Pharmacy Automated drug interaction screening (PADIS)
system
• Teaching Techniques
• Building Data Base
• Inventory control
• Medical Research
• Computerizing Drug Information System
• Uses Of Computers In Other Fields Of Pharmacy
ROLE OF COMPUTERS IN CLINICAL PHARMACY
5. The Clinical computer system must assure the patients record
database is continually updated to reflect the current status of
all patients. This updating is done by assessing the database of
admitting department to determine the information about
recent admissions, discharges, patient transfers. Pharmacist
should be present to check the details regularly.The computer
system should be capable of producing other information such
as
• Present diagnosis
• Allergies
• Weight
• Height
• Name of Attending physician
• And any special note about the patient.
Patient record management
6. Medication orders should be entered regularly and the
Pharmacist must be able to retrieve orders prior to
administration to patient. Date must be entered by use
of codes for drug names, dose scheduling. All drug
orders should contain following :
• Drug Name
• Drug Generic Name & Strength
• Route of administration
• Dosage schedule
• Physician Data or Code
Entries of Medication Orders
7.
8. The computer systems should be capable of
producing the labels and reports in the form of
• Patient Medication Profile
• “Fill Lists” for preparations of Individual doses
• Lists of medications charged
• Drug order renewal lists for the prescriber
• Medication administration Record (MAR)
• The computer system should have the functions to
prepare separate lists of TPN, IV Solutions and
admixtures.
Preparations of Lists
9. Computer systems helps in diagnosing DRUG
Interactions & warns potentially dangerous
combinations of medications along with
Drug-drug, Drug- lab, Drug-Allergy interactions
& Wrong Diagnosis automatically.
DRUG INTERACTIONS
10. RECORD DATA BASE MANAGEMENT
AUOMATED AMBULATORY MEDICAL RECORD
SYSTEMS (AAMRS)-
• Billing,accounting,patient scheduling immunization
etc. Identifying high risk conditions
• Providing patient with personal records
11. • MEDICATION ADMINISTRATON RECORD (MAR)-printed
list of medication orders for each patient on nursing unit
e.g name ,bed number,diagnosis,sex,weight,height
,allergies
• DRUG UTILIZATION REVIEW-monitoring of drug use &
also cost.it is designed to investigate suspected problem
• DRUG THERAPY PROBLEM DETECTION-automatic
screening of medication order for possible drug
interaction for new or changed drug order is enteru into
patient profile
12. • DRUG THERAPY MONITORING-improves individualized
dosing decision ,allow multiple storage,precise dosing
• PATIENT BILLING
• MANAGEMENT REPORTS AND STATICS
• RATIONAL DRUG PRESCRIPTION-computer based
consultation system assist in rational prescribing.one such
system is MYCIN
13. ADMINISTRATIVE APPLICATIONS
• PATIENT BILLING-bills for no. of doses of each item
is supplied
• DRUG UTILIZATION-monitor use of specific drug for
cost analysis , budgeting, or quality assurance
• WORK LOAD ANALYSIS-frequency of specific
activities, average time for specific function,
determining staffing needs, productivity estimates
are also possible
14. • COST AND REVENUE ANALYSIS-department costs,
expected revenue,inventory turn over,wastage,lost
charges etc. Applicable in budget development,drug
control,inventory management
• GROUP WORKING-accessible for multi users
• NETWORKING-making sharing easy
< INTRANET-presenting information in a way every 1 can
see it
<EXTRANET-extending infornation outside work group
15. IN-HOUSE PREPERATION
• Schedualing,calculating quantity of additives and
correct concentration,label,record maitenance,TPN
,sterile solution,radio pharmaceuticals
• STABILITY studies
extrapolated stability curves for expiry date
calculation,test schedule,shelf life calculation.serves as
calender,data analyser,report writer.
17. • HELP :
The Program HELP ( Health Evaluation Through
Logical Processing ) is used to allow experts in a
medical specialty for defining the criteria of medical
decision making. The broad base and flexibility of
HELP permits complete drug monitoring. After
receiving the Warning from computer the pharmacist
contact the nursing staff and the physician. This
system makes the pharmacist more efficient and
accurate in monitoring patient drug therapy. The
system issues warning more quickly than manual
methods.
Software's & Programs For Clinical Monitoring
18. • Messages are presented in the form of
pharmacological summary.
• The drug interaction messages are integrated with
computerized drug profile systems.
• All drug interactions which may occur in current
drug therapy of the patient are reported by this
system.
• The information received from the system is to be
used by either a physician or pharmacist in the
clinical area
• The system is useful in reducing drug interactions.
features of HELP system
19. Monitoring Evaluation Of Drug Interactions By A
Pharmacy Oriented Reporting.
This system issues a warning when potentially
interacting drugs are prescribed for a patient
MEDIPHOR
20. • If a prescription containing
many drugs is entered in the
computer for billing purpose,
immediately the computer scans
the drug and issues the warning
if there is possibility of drug
interaction. Thus the computer
helps in avoiding the drug
interactions.
• The computer also warns when
two or more drugs of same
generic are entered. Avoid
duplication.
Data Base
21. • A pharmacy automated drug interaction screening
(PADIS) system is described which detects possible
drug interactions by screening patient medication
profiles. The data base contains approximately
24,000 drug interaction combinations of drugs
marketed in the U.S
• The PADIS system operates as a batch run program
which screens all patient medication profiles on a
daily schedule. A patient drug interaction profile is
printed by the computer for use by the pharmacist
to suggest alternative therapy to the physician. The
computer detects potential drug interactions
Pharmacy Automated Drug Interaction Screening (PADIS)
22. • Computerized Listing Of Abnormal And Unsual
Drug Effects
• Containing 17,500 abnormal effects on laboratory
tests of 1500 drugs may be computerized to match
the laboratory test effects of drugs with patient
because scanning manually for every patient is
time consuming
COSTAR
• COmputer STored Ambulatory Record
(COSTAR) is an electronic medical record using
the MUMPS programming language
CLAUDE
23. • COSTAR(computer stored ambulatory record)-manages
office, clinical functions, patient registration, scheduling
billing, revenue analalysis , medical records , chart review
• MUMPS-supports database maintaining complete medical
record
• SCAMP-comprehensive ambulatory record-billing,
appontments, patient care reports, lab data, health
maintenance, general/medical management
• AUTOMED-complete financial,administrative, clinical
computer package
• FMIS(family medicine information system)
24. • MARTINDALE’S Extra Pharmacopoeia is now
available online
• MEDLAR’S ( Medical literature Analysis And
Retrieval system )
• MEDLINE ( Medlars Online )
• NLM ( National library of Medicine )
• PNI ( Pharmaceutical News Index ) Contained
news about devices and health industries.
Other Computer Software's
26. • Computers have two types of applications in
Medical research :
I) Computerized testing equipments ( Blood
chemistry n gas analysers, Ultra sound scanners
and CT scanners
II) Data collection, storage retrieval and research
planning & Statistics
Medical Research
27. • Multimedia refers to the presentation of information in
formats other than text alone. Included in these format
types are: sounds, images, graphics, animations and
videos
• Computers help a great deal in pharmacy training and
education
• X.RAYS , Electrocardiograms and other interpretations
and values with reference to cases can be shown on
multimedia and taught to the students.
• E-Books, Websites and Wikipedia are also a great source
of help for the Clinical pharmacists and students to
gather information and data.
• Computer simulations are helpful in teaching techniques
i.e Demonstration of complete physiological or
pharmacological process.
Use Of Computers In
Clinical Education
28. HOSPITAL INFORMATION SYSTEMS
• hospital information-intensive istitution where lot of time and
budget involved inacquiring,recording,processing,retrieving and
communicating information.
• Computer based information system available icluding
AUTOMATED HEALTH INFORMATION SYSTEM,clinical
informatin system,medical information system
• COMPONENTS:
• 1.patient registration/admission/transfer/discharge
• 2.patient clinical data base(history/physical
examination/labortory/progress notes)
• 3.dignosis and treatment desion support
• 4.order entery/execution/confirmation
29. • 5.Lab/diagnostic report
• 6.Pharmacy support
• 7.Food and nutrition services
• 8.quality servillience
• 9.billing/insurance/collection
• 10.administrative report
computer based information system allows multi user
accessd,provides ongoing monitoring, programs to detect risk
situations,alert patieny senstivity, interactions.inapropriate
dosing,medication strength, frequency of administration
However traditional paper based system is disorganized/illegible
and can be used by only one person,at one location
30. • DRUG SUPPLYING & DISPENCING: label printing for
individual patient,keep tracks of dosing,correct
medication,dug list,charge information
• DRUG INFORMATION: keep up to date with new
development,all library contents can be available
• Computer bases resources of information are available to
provide rapid,efficient,current,compact inf( electronic
journals,CDs,electronic bullitien ,world wide webs)
• Receiving of inquiry
• Literature search
• Delivering the responce
31. PUBLISHING
• Formulary
• Procedural manual
• research report
• Drug bullitien
• ADR report
• REPORT GENERATION-for retrospective data analysis
• PATIENT DRUG PROFILE-prescribed drug , dose , age ,
allergy , height, weight and dignosis
• PATIENT LOCATION
• MEDICATION ADMINISTRATION
• AUTOMATIC DATA COLLECTION
32. • Maintenance of perpetual inventory control :
Whenever an item is added to stock or removed from
stock immediately the position of stock can be updated
by the computer. This operation of the computer is
intimately linked to other operations such as receipt of
good, dispensing of goods, billing of goods, return of
goods etc
• Maintaining the inventory records :
For annual auditing of pharmacy department , records
of numerous items are required ,
They can be easily obtained by the computer database
records.
Purchasing and
inventory control
33. 1. Reduced book keeping
2. Fewer transcription and medication error
3. Reduce duplicate medication order
4. Lowering cost in preparing bill
5. Improves efficiency in order processing
6. Improved detection of drug allergies, interactions
7. Improved managing reports
8. Improved inventory management
9. Reduced ordering cost
ADVANTAGES OF COMPUTERS IN CLINICAL
PHARMACY