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Revised National Tuberculosis Control
Programme
What is Tuberculosis?
Tuberculosis (TB) is an infectious
disease caused by the bacterium
Mycobacterium tuberculosis
(MTB)
Tuberculosis generally affects the
lungs, but can also affect other
parts of the body
One patient with infectious
pulmonary TB if untreated can
infect 10-15 persons in a year
Risk factors
o Malnutrition
o Diabetes
o HIV infection
o Low body weight
o Severe kidney disease
o Other lung diseases (silicosis)
o Substance abuse etc.
o Overcrowding
o Inadequate ventilation
o Enclosed living/working
conditions
o Occupational risks
Environmental
Medical
Possible TB Disease Symptoms
Night Sweats Fever Chills
Weakness or
fatigue
Weight loss No appetite
Cough lasting
longer than
3 weeks
Pain in
the chest
Coughing up
blood or sputum
(phlegm from inside the
lungs)
4
Global TB Burden -2018
Global India
Incidence
1,00,00,000
(132/lakh)
26,90,000
(199/lakh)
Deaths
15,00,000
(16/lakh)
4,40,000
(32/lakh)
HIV TB
cases
8,62,000
(11/lakh)
92,000
(6.8/lakh)
HIV TB
deaths
3,74,000
(5.0/lakh)
12,000
(0.7/lakh)
Estimated
MDR/RR
cases
484000
(6.4/lakh
population)
1,30,000
(9.6/ lakh
population)
ā—¾ India has highest burden of both TB and MDR
TB and second highest of HIV associated TB
based on estimates reported in Global TB report
2015.
ā—¾ An estimated 71,000 cases of MDR TB emerge
annually from the notified cases of Pulmonary
TB in India.
ā—¾ 3% among new TB cases, 12-17% among
previously treated TB cases have MDR TB.
ā—¾ An estimated 1.1 Lac HIV associated TB
occurred in 2014 & 31,000 estimated number of
patient died among them.
āš«TB kills more adults in India than any other
infectious disease.
āš«In India every day ā€“
āš«More than 6000 develop TB disease
āš«More than 600 people die of TB (i.e. 2 deaths
every 5 minutes)
EVOLUTION OF TB CONTROL IN INDIA
āš« 1950s-60s
āš« 1962
āš« 1992
Important TB research at TRC and NTI
National TB Programme (NTP)
Programme Review
āš« 1993
āš« 1998
āš« 2001
āš« 2004
āš« 2006
ā€¢ only 30% of patients diagnosed;
ā€¢ of these, only 30% treated successfully
RNTCP pilot began
RNTCP scale-up
450 million population covered
>80% of country covered
Entire country covered by RNTCP
STOP TB STRATEGY, 2006
āš«Vision:A world free of TB
āš«Goal: To dramatically reduce the global burden of
TB by 2015 in line with Millennium Development
Goals and the Stop TB Partnership targets
STOP TB PARTNERSHIP TARGETS
āš«By 2005:
āš«At least 70% people with sputum smear positive TB will be
diagnosed.
āš«At least 85% cured.
āš«By 2015:
āš«Global burden of TB (prevalence and death rates) will be
reduced by 50% relative to 1990 levels.
āš« Reduce prevalence to <150 per lakh population
āš« Reduce deaths to <15 per lakh population
āš«Number of people dying from TB in 2015 should be less
than 1 million, including those co-infected with HIV
āš«By 2035:
āš«Global incidence of TB disease will be less than or equal to
1 case per million population per year
Government of India preponed END TB Strategy
āš«Revised National TB Control
Programme (RNTCP) nomenclature
changed
To
āš«National TB Elimination Programme
(NTEP)
from January 2020
ā€¢ At the start of 2020 the
central government of
India renamed
the RNTCP the
National
Tuberculosis
Elimination
Program (NTEP).
12
OBJECTIVES OF THE PROGRAM
NATIONAL STRATEGIC PLAN 2017
- 2025
ā€¢ The MOHFW in consultation with over 150
national and international experts working
in the field of public health, program
managers, donor agencies, technical
partners, civil societies, affected community
representatives and other stakeholders of
TB control both from public as well as
private sector finalized the new National
Strategic Plan for TB 2017-2025 (NSP).
14
WHAT IS NSP?
ā€¢ The NSP for TB elimination 2017ā€“25 is a framework to
guide the activities of all stakeholders including the
national and state governments, development partners,
civil society organizations, international agencies,
research institutions, private sector, and many others
whose work is relevant to TB elimination in India . It is a
3 year costed plan and a 8 year strategy document.
ā€¢ It provides goals and strategies for the countryā€™s
response to the disease during the period 2017 to 2025
and aims to direct the attention of all stakeholders on
the most important interventions or activities that the
RNTCP believes will bring about significant changes in
the incidence, prevalence and mortality of TB . ā€¢ The
NSP will guide the development of the national project
implementation plan (PIP) and state PIPs, as well as
district health action plans (DHAP) under the national
health mission (NHM).
15
VISION,GOALS and TARGETS
ā€¢ VISION:- TB-Free India with zero deaths,
disease and poverty due to tuberculosis.
ā€¢ GOALS:- To achieve a rapid decline in
burden of TB, morbidity and mortality while
working towards elimination of TB in India
by 2025.
ā€¢ TARGETS:- The requirements for moving
towards TB elimination have been
integrated into the four strategic pillars of
ā€œDetect ā€“ Treat ā€“ Prevent ā€“ Buildā€ (DTPB).
16
DETECT
ā€¢ Early identification of presumptive TB cases,
at the first point of care be it private or
public sectors, and prompt diagnosis using
high sensitivity diagnostic tests to provide
universal access to quality TB diagnosis
including drug resistant TB in the country.
17
How it can be achieved?
ā€¢ 1. LABORATORY SYSTEMS 2. CASE
FINDINGS 3. PATIENTS IN PRIVATE
SECTORS
18
TREAT
ā€¢ What does it mean? Provide sustained,
equitable access to high quality TB
treatment, care and support services
responsive to the community needs
without financial loss thereby protecting
the population especially the poor and
vulnerable from TB related morbidity,
mortality and poverty.
19
What does it entail?
ā€¢ 1. Providing daily regimen using FDCs to all
TB patients. 2. DST guided treatment for DR
TB. 3. Patient centric approach to treatment.
4. Prevent loss at cascade of TB care . How
it can be achieved? 1. Treatment services 2.
Key affected populations 3. Patient support
system
20
STRATEGIES
ā€¢ 1. Initiation of appropriate treatment for all
diagnosed TB patients. ā€¢ 2. Implementation
of TB treatment services in health facilities
and communities. ā€¢ Regular and long term
follow up and rehabilitation of all treated
TB patients.
21
The principles of treatment
for TB
1. Screen all patients for Rifampicin
resistance and additional drugs wherever
indicated. 2. For drug sensitive TB,
administer daily fixed dose combinations of
first line Antituberculosis drugs in
appropriate weight bands for all forms of TB
and in all ages, including four drug FDC in
the intensive phase and three drug FDCs in
the continuation phase. 3. All Rifampicin
Resistant /Multi Drug Resistant TB patients
are subjected to baseline Kanamycin and
Levofloxacin all across the country. In
addition country has introduced extended
DST to all second line drugs in a phased 22
4. RR/MDR TB patients without additional
drug resistance are treated with standard
short course treatment regimen for MDR TB.
And in those with mixed patterns of
resistance, standard MDR TB regimens were
modified as per revised guidelines. 5. Where
DST patterns for extended DST are available,
the management protocol will follow
essential optimized regimen for patients
diagnosed with drug resistance other than
MDR and XDR TB. 6. Minimize leakage across
the care cascade and maximize adherence
through innovative patient support
strategies and real time monitoring. 23
PREVENT
ā€¢ What does it entail? 1. Scale up air-borne
infection control measures at health care
facilities. 2. Treatment for latent TB
infection in contacts of bacteriologically-
confirmed cases . 3. Addressing social
determinants of TB through intersectoral
approach .
24
How it can be achieved?
ā€¢ 1. AIR BORNE INFECTION CONTROL 2.
CONTACT TRACING 3. LTBI TREATMENT
25
AIR BORNE INFECTION
CONTROL
ā€¢ CHALLENGES AT COMMUNITY LEVEL
- Social habits ā€¢ Cough etiquettes not being
followed ā€¢ Indiscriminate spitting ā€¢ Sneezing
without covering face ā€¢ Alcoholics and
mentally challenged patients ā€¢ Delay in
reaching health facility for specific diagnosis
Special groups ā€¢ Migrant population, back
ward areas and tribal pockets Old age
homes, poor homes, children homes, jails,
hard to reach areas ā€¢ Delay in diagnosis in
co-morbid conditions like Diabetes, HIV,
Cancers, etc.
26
CHALLENGES AT
INSTITUTIONAL LEVEL
ā€¢ Outpatient facility ā€¢ Patients with chest
infection at outpatient settings ā€¢
Overcrowding - mixing of patients in
queues and waiting areas ā€¢ Poor ventilation
in the facilities In patient facility ā€¢ Cough
screening, separation, fast-tracking, mask
and counseling provision missing ā€¢
Infectious patients getting admitted at
General wards ā€¢ Cough etiquettes not
followed in wards ā€¢ Overcrowding in the
wards ā€“ no restricted entries
27
SOLUTIONS AT
INSTITUTIONAL LEVEL
ā€¢ 1. Certification of Health facility for AIC
Compliance 2. Develop cough
corners/counters - Cough screening,
separation, fast-tracking, mask and counseling
3. Posting of specific staff for fast tracking and
providing masks 4. Providing N 95 masks to
the Hospital staff in High risk settings 5. ACSM
at OPD and other settings like Posters,
Clippings etc 6. Implementation of AIC in all
settings 7. In house AIC complaint facility for
treating nomads, destitutes, homeless patients
8. Separate IP facility for bacteriological
positive DS/DR TB patients and other airborne
infectious patients in major institutions
28
ā€¢ 9. Proper infection control measures in ART
centres. 10. Proper follow up of daily
reported cases 11. Proper disposal of
sputum and infected materials 12. Early
diagnosis and initiation of treatment 13.
PPE for concerned staff 14. Wet mopping
and disinfection 15. Periodic screening of
staff 16. Proper ventilation, renovation if
necessary 17. Facility risk assessment and
reporting 18. Periodic trainings 19.
Ongoing monitoring dashboards/checklist
for AIC practices at all levels .
29
ā€¢ CONTACT TRACING;- In RNTCP contact
screening has been a clinical function with
cursory programmatic monitoring. In this
NSP contact tracing will be made more
rigorous, expansive and accountable. The
end result expected is that most TB pts will
have their contacts screened, with
secondary cases detected and treated.
30
ā€¢ PREVENTIVE THERAPY/ LATENT TB
INFECTION TREATMENT :- TB infection is
the seed bed for developing TB disease and
continued transmission. The lifetime risk of
reactivation of LTBI in healthy HIV-
uninfected individuals is 10%, with 5%
developing TB disease during the first 2 to
5 years after infection. ART reduces the risk
of TB by approximately two thirds.
31
BUILD
ā€¢ What does it means in term of NSP?
Undertake critical management reforms,
restructuring of HR and financial norms,
pathways for private sector participation, in
order to improve efficiency, effectiveness
and accountability of the health system for
an improved response to the TB epidemic.
32
ā€¢ What does it entail? 1. Build synergies with
existing health service delivery mechanism
under Urban Health Mission and plan for
integration of services 2. Reform and
restructure HR in TB programme to align with
the enhanced programme needs for
surveillance, participation of private sector and
community participation. 3. Strengthen
RNTCPā€™s regulatory capacity to control TB
drugs through appropriate laws, regulations,
and policies. 4. Position TB high on the health
and development agenda of the nation to
ensure adequate resources, greater demand
for and universal access to TB care services
33
ā€¢ How it can be achieved? ā€¢ URBAN TB
CONTROL SYSTEMS ā€¢ HEALTH SYSTEM
STRENGTHENING ā€¢ ADVOCACY,
COMMUNICATIONS AND SOCIAL
MOBILIZATION ā€¢ SURVEILLANCE,
MONITORING AND EVALUATION ā€¢
RESEARCH AND TECHNICAL ASSISTANCE
34
Tuberculosis unit
āš«It is the nodal point for TB control activities in the
sub-district.
āš«In urban areas 1 TU per 2,00,000 population
(range 1.5-2.5laks)
āš«Manned by designated
1. Medical Officer ā€“Tuberculosis Control (MO-TC)
2. Senior Treatment Supervisor (STS)
3. Senior TB Laboratory Supervisor (STLS per 5
lakh population
4. 1 TBHV per 1 lakh urban population
Continuedā€¦..
āš«TU will have one Designated Microscopy Centre
(DMC) for every 1 lakh population (50,000 in
tribal, desert, remote and hilly region)
āš«Microscopy centres are also located in Medical
Colleges, Corporate Hospitals, ESI, Railways,
NGOs, private hospitals.
PRESUMPTIVE TB CASES
ā€¢ Presumptive Pulmonary TB ā€“
ā€“ Cough for > 2 weeks
ā€“ Fever for > 2 weeks
ā€“ Significant weight loss
ā€“ Haemoptysis
ā€“ Any abnormality in Chest Radiograph
Note ā€“ Contacts of Microbiologically confirmed TB patients,
PLHIV, Diabetics, Malnourished, Cancer patients, patients
on immune ā€“suppressants or steroid should be regularly
screen for signs and symptoms of TB
Presumptive Extra Pulmonary TB
āš«Organ specific symptoms and signs like swelling
of Lymph node, pain and swelling in joints, neck
stiffness, disorientation.
āš«Constitutional symptoms like ā€“ significant weight
loss, persistent fever for ā‰„ 2 weeks, night sweats.
Presumptive Paediatric TB
āš«Persistent fever > 2 weeks
āš«Cough > 2 weeks
āš«Loss of weight / no weight gain
āš«History of contact with infectious TB case
Loss of weight is define as loss of > 5% body weight
as compared to highest weight recorded in last 3
months
Presumptive DRTB (As per TOG
2016)
āš«Patients who are found positive on any follow up
sputum smear examination during treatment with
FLD, previously treated TB cases
āš« TB patients with HIV coā€“infection
āš«TB patients who failed treatment with FLD
āš«Paediatric TB non responders
āš«TB patients who are contact of DR-TB (or Rif
resistance)
CASE DEFINITIONS
āš«Microbiologically confirm TB case ā€“ Biological
specimen positive for AFB or positive for
Mycobacterium tuberculosis on culture or positive
for tuberculosis through quality assured rapid
diagnostic molecular test.
Clinically diagnosed TB case
āš«A presumptive TB patients who is not
microbiologically confirmed but diagnosed with a
active TB by a clinician on the basis of X-ray
abnormalities, Histopathology or Clinical signs
with a decision to treat the patient with a full
course of ATD.
It is same as the old one
Previously called relapse
Previously called only failure
New Pyramid of TB diagnostics
Characteristic
Symptom
Microbiologic
confirmation
with U-DST
Conventional
Radiology
Tuberculosi
s Skin Test/
IGRA
Specificit
y
Sensitivit
y
Yield of test and robustness of diagnosis can be improved by
better characterisation of symptoms and interpretation of radiology!!
NTEP Implementation
Arrangement
45
46
99DOTS
2
pills
5
4
3
pills
99DOTS Envelopes
99DOTS: Accurate Monitoring at Very Low Cost
101
How can the Patient data be
accessed?
Different ways of accessing the patient data ā€“
āš«Web dashboard (www.99dots.org)
āš«Every center will be given their own login ID and
Password to access their patients
āš«Different logins for ART center, DTC and field staff (with
limited permissions)
āš«SMS Alerts for Staff and Treatment Supporters to
take immediate action in case of default.
Benefits of 99DOTS
ā€¢ Less travel
ā€¢ Increased convenience
Patients
ā€¢ Focused and more
efficient care
Field
Staff/Supervisors
ā€¢ Easy monitoring
ā€¢ Accurate reports
Program Officers
Nikshay
Niksh
ay
Nikshay is an Integrated ICT (Information Communication
Technology) system for TB patient management and care in India
Real-time, case-based, web-based surveillance tool
Unified interface for public and private sector health care providers
Nikshay webpage - https://Nikshay.in
Android mobileApp - Google Play Store
Demo site ā€“ https://beta.nikshay.in
Modalities of
notification
Submission of
hardcopies to
DTO
Reporting into Nikshay web
portal/mobile application
Reporting via
Nikshay
Sampark
(1800 11
6666)
Incentives to Patients for Social Protection
āš«ā€œNikshay Poshan
Yojanaā€-
āš«Launched from 01st April
2018
āš«Nutritional support through
Direct Benefit Transfer of
500 INR per month
āš«For all patients on TB
treatment throughout
duration of treatment
āš«Patient need to be
registered in the Nikshay
portal
āš«Tribal patient incentive
Incentives to
Providers
āš«Private Provider Incentive
āš«500 INR at notification & 500 INR on reporting
treatment outcome
āš«Informant incentive
āš«Incentive of 500 INR to informant for notification of
patients in public sector
āš«Incentive for Treatment support
āš«New Case: 1000 INR at completion of treatment
āš«Drug Resistant Case: 2000 INR at completion of
intensive phase, 3000 INR at completion of treatment
Take Home Messageā€¦ā€¦ā€¦
āš«For microbiologically confirmed TB cases we
must follow Universal DST (Drug Susceptibility
Testing)
āš«For clinically diagnosed TB casesā€“ it is the test of
experts not to over diagnose TB as well as not to
under diagnose TB cases
āš«Repeated counselling for regular adherence and
completion of ATD course is necessary
NIKSHAY
ā€¢ Nikshay is an integrated Information and
Communication Technology system for
tuberculosis patient management and care in
India. Nikshay was launched in 2012 and has
evolved significantly to make patient
management easier and more effective for
health care providers and their support staff.
ā€¢ NI-KSHAY-(Ni=End, Kshay=TB) is the web enabled
patient management system for TB control under
the National Tuberculosis Elimination
Programme (NTEP).
59
ā€¢ It is developed and maintained by the Central TB
Division (CTD), Ministry of Health and Family Welfare,
Government of India, in collaboration with the National
Informatics Centre (NIC), and the World Health
Organization Country office for India.
ā€¢ Ni-kshay is used by health functionaries at various
levels across the country both in the public and private
sector, to register cases under their care, order various
types of tests from Labs across the country, record
treatment details, monitor treatment adherence and to
transfer cases between care providers. It also functions
as the National TB Surveillance System and enables
reporting of various surveillance data to the
Government of India.
60
Salient Features of Nikshay 2.0
Nikshay is an Integrated ICT system for TB patient
management and care in India.
Nikshay was launched in 2012 and since then, various
improvements have been made in the system
Nikshay Version 2 has been launched in September 2018.
Nikshay provides-
1. A Unified interface for public and private sector health
care providers
2. Different types of Logins like State, District, TU, PHI,
Staff logins, Private providers, Chemist, Labs and
PPSA/JEET Logins
3. Integrates all adherence technologies such as 99DOTS
and MERM
4. Unified DSTB and DRTB data entry forms
5. Mobile friendly website with mobile app
Nikshay 2 is accessible either via web browser
(https://Nikshay.in ) or mobile App called ā€˜Nikshayā€™ that
can be downloaded from Google Play Store
( log in page in web browser) ( log in page in mobileApp)
Diagnostic work up
āš«Based on CBNAAT result patient will be
categorized as Microbiologically
confirmed drug sensitive TB or RIF
resistance TB
āš«In case of RIF indeterminate result an
additional CBNAAT will be done to get a
valid result. If indeterminate on second
occasion an additional specimen will be
sent to nearest IRL or C &DST centre for
LPA or liquid culture and DST as
appropriate
66
DIAGNOSTIC ALOGRYTHM FOR EXTRA PULMONARY TB
Recommendations for LTBI interventions under NTEP
3rd National Technical Working Group(TWG) on Latent TB
Infection Management in India held
on 12th May, 2020
Eligible population Strategy Treatment option
ā€¢ People living with HIV
(Adults and children >12 months)
ā€¢ Infants <12 months in contact
with active TB
ā€¢ Household contacts below 5 years of
pulmonary TB patients
Treating all
after ruling out
active TB
ā€¢ 6-months daily
isoniazid
ā€¢ Three months of daily
rifampicin plus isoniazid
(Alternative in household
contacts 0 - 14 years (up to
25 kg weight) in limited
geographies)
ā€¢ Household contacts 5 years
and above of pulmonary TB patients
(testing would be offered whenever
available)
Treating all
after ruling out
active TB
3-month weekly Isoniazid
and Rifapentine
ā€¢ Children/Adult on
immunosuppressive therapy Testing and
3-month weekly Isoniazid
and Rifapentine
HIV & Tuberculosis
Ideally all presumptive TB patients have to
undergo HIV screening.
This is important to ensure all HIV positive TB
patients receive ART irrespective of CD4 count
and Chemo Prophylaxis (CPT).
HIV & Tuberculosis
First Line ART for HIV - TB
Second LineART for HIV - TB
TB-HIV Collaboration ā€“ Single
Window
Delivery of HIV-TB care at ART centres
Rapid molecular
diagnosis
CBNAAT
Daily FDC for HIV
and TB
ICT based
adherence support
(99 DOTS)
Pharmacovigilance
(AMC)
Isoniazid
Preventive Therapy
Progress
ā€¢ Training completed by NACO and CTD
ā€¢ Drugs supplied in Oct-Novā€™16
ā€¢ 10,031 HIV-TB patients initiated on treatment
Adjustment of Anti TB drugs in renal insufficiency
Drugs Recommended dose and frequency for patients with creatinine
clearance <30 ml/min or for patients receiving haemodialysis (unless
otherwise indicated dose after dialysis)
Isoniazid No adjustment necessary
Refiampicin No adjustment necessary
Pyrazinamide 25-35 mg/kg per dose three times per week ( not daily)
Ethambutol 15-25 mg/kg per dose three times per week ( not daily)
Rifabutin Normal dose can be used, if possible monitor drug concentrations to avoid
toxicity.
Streptomycin 12-15mg/kg per dose two or three times per week (not daily)
Capreomycin 12-15mg/kg per dose two or three times per week (not daily)
Kanamycin 12-15mg/kg per dose two or three times per week (not daily)
Amikacin 12-15mg/kg per dose two or three times per week (not daily)
Ofloxacin 600-800mg/kg per dose three times per week (not daily)
Levofloxacin 750-1000mg per dose three times per week (not daily)
Moxifloxacin No adjustment necessary
Cycloserine 250mg once daily or 500mg/ dose three times per week
Terizidone Recommendations not available
Torizidone Recommendations not available
Prothinamide No adjustment necessary
Ethionamide No adjustment necessary
Para-
aminosalicylicaci
d
4g/dose twice daily maximum dose
Bedaquiline No dosage adjustments required in patients with mild to moderate renal
impairment (dosing not established in severe renal impairment, use with
caution)
Linezolid No adjustment necessary
Clofazimine No adjustment necessary
Amoxicilin
/clavulanate
For creatinine clearance 10-30ml/min dose 1000mg as amoxiciline
component twice daily
For creatinine clearance <10ml/min dose 1000mg as amoxicilin
component once daily
Imipenem
/cilastin
For creatinine clearance 20-40ml/min dose 500mg every hours
For creatinine clearance <20-40ml/min dose 500mg every 12 hours
Meropenem For creatinine clearance 20-40/ml/min dose 750mg every 12 hours
For creatinine clearance <20/ml/min dose 500mg every 12 hours
High dose
isoniazid
Recommendations not available
Adjustment of Anti TB drugs in renal insufficiency
75
40 crore infected
35 lakh estimated
TB patients annually
4.2 lakh deaths
Due to TB annually
In Indiaā€¦ā€¦.
India: MDG6 TB target
TB REVERSED
Rate
per
100,000
population
50%
35 lakh
additional
lives saved
50%
New cases
declining
All cases reduced
by half
Deaths reduced
by half
HIV
WHO Global TB Report 2016
465 ļƒ  195 per lakh pop
(58% reduction) 38 ļƒ  17 per lakh pop
(55% reduction)
216 ļƒ  167 per lakh pop
(23% reduction)
Vision: A world free of TB
Zero TB deaths, Zero TB disease, and Zero TB suffering
Goal: End the Global TB Epidemic (<10 cases per 100,000 population)
Sustainable Development Goals (SDG)
INDICATORS
TARGETS
SDG 2030
Reduction in number of TB deaths
compared with 2015 (%)
90%
Reduction in TB incidence (new case) rate
compared with 2015 (%)
80%
TB-affected families facing catastrophic
expenditures due to TB (%)
Zero
TB Free India
ā€¢ India has committed to End
TB by 2025, 5 years ahead of
the global SDG target
ā€¢ Prime Minister of India
launched TB Free India
campaign at ā€˜Delhi End TB
Summitā€™ on 13th March,
2018
ā€¢ The campaign calls for a
social movement focused on
patient-centric and holistic
care driven by integrated
actions for TB Free India
79
Strategies
Private
sector
engagement
Active Case
Finding
TB
Co-
morbidities
Multi-
sectoral
response
Drug
Resistant TB
ICT Tools for
adherence
and
monitoring
Preventive
Measures
Community
Engagemen
t
National
Strategic Plan
(2017-25)
Organizational
structure
Ministry of Health & Family Welfare
Central TB Division
State TB Cell
36 States / UTs
District TB Centre
733 Districts
TB Unit
One per 1.5 ā€“ 2.5 lakh
population
Designated Microscopy
Centre
One per 1 lakh
population
Peripheral Health Institute
Supporting Facilities
ļ‚§ National Institutes (6)
ļ‚§ National Reference Laboratories (6)
ļ‚§ Intermediate Reference Laboratories (29)
ļ‚§ State TB Training and Demonstration Centres (26)
ļ‚§ Culture and DST Laboratories (49)
ļ‚§ DR-TB Centres (148)
ļ‚§ CBNAAT Laboratories (1180)
Key Services
1. Free diagnosis and treatment for TB patient
2. Provision of rapid diagnostics
3. Testing of all TB patients for drug resistance
and HIV
4. Management of associated diseases
5. Treatment adherence support
6. Nutrition assistance to TB patients
7. Preventive measures
Strategy to find
Active TB
Case Finding
Reaching
patients
seeking care
in Private
Sector
High
Sensitive
Diagnostic
tool
Treat
Treatment
Patient Centric Care
Reduce Out-of-pocket
Expenditure
ā€¢ Daily Regimen
ā€¢ Shorter Regimen
ā€¢ Newer Drugs
ā€¢ IT Enabled Adherence
Support
ā€¢ Comorbidity
management
ā€¢ Financial incentives
ā€¢ Direct Benefit Transfer
Direct Benefit Transfer (DBT) schemes
Existing schemes:
1. Honorarium to Treatment Supporters ā€“ For provision of
treatment support to TB patients (Adherence, ADR
monitoring, counselling @Rs.1000/- to Rs.5000/-)
2. Patient Support to Tribal TB Patients (Financial Patient
Support @Rs750/-)
New Schemes:
1. Nutritional Support to All TB patients (Financial Support to
Patients @Rs.500/-month)
2. Incentives to Private Providers (Rs.500/- for Notification &
Rs.500/- for Follow-up with Treatment Outcome @Rs. 500)
3. Incentives to Informant (Rs. 500/- is given on diagnosis of TB
among referrals from community to public sector health
facility)
Prevent
ā€¢ Air borne infection control measures
ā€¢ Strengthen Contact Investigation
ā€¢ Preventive treatment in high risk groups
ā€¢ Manage Latent TB Infection
ā€¢ Address determinants of disease
Increased Access to Diagnostic
Services
ļƒØ Expansion of microscopy centres to improve
access
ļ‚§ Phase 1 - PHCs where a Laboratory Technician (LT) is
available
ļ‚§ Phase 2 ā€“ Other PHCs
ļƒØCurrent Status ā€“
Policy Update in RNTCP, 2018
14,576
16758
Microscopy Centres in 2018
Microscopy Centres in 2017
16.1 lakh TB patients notified in
public sector (ļƒ©12% in 2018)
1 microscopy centre at ~75,000
population
Universal Drug Susceptibility
Testing
ļƒØ All TB patients to be tested for Rifampicin Resistance
ļƒØCurrent Status ā€“ 60% of target
ļƒØ DR-TB patients diagnosed
(ļƒ©54% from 2017)
Testing for Rifampicin to All
Rif
Resistance
MDR-TB
Testing for INH
Mono/Poly
DR-TB
Testing for Second line
FQ/SLI Resistance XDR
38,605
59544
2018 2017
Policy Update in RNTCP, 2018
Paradigm shift in management of Drug
Resistant TB
ļ‚§> 20,000 patients on Shorter regimen
ļ‚§> 4,600 patients on BDQ containing regimen
ļ‚§62 patients on DLM containing regimen
Shorter
Regimen
ā€¢ All
MDR/RR-
TB
patients
without
resistant
to addl.
SLD
BDQ
ā€¢ MDR/RR-
TB
patients
with
resistance
to addl.
SLD &
eligible
DLM
ā€¢ 7 States
ā€¢ Children 6
to 17
years in all
States
Policy Update in RNTCP, 2018
Injection Free Regimen
2HRZES
1HRZE
3HRE
Injection Free
regimen for
4,20,000
patients
2HRZE
4HRE
Policy Update in RNTCP, 2018
(3-6) Km Lfx R E Z
Injection Free regimen
for ~1,00,000 patients Lfx R E Z
Treatment for Previously Treated TB Patients
Treatment for INH Resistant TB Patients
Gazette on TB Notification
ļƒØMandatory Notification of TB
patients
ļƒØ Public Health Actions
ļƒØProvisions of Sections 269 and 270 of the
Indian Penal Code (IPC)
Pharmac
ies
Laborato
ries
Clinics /
Hospital
s
FIR
1
Notices
519 Policy Update in RNTCP, 2018
Provider
RNTCP
Patient
48 Cities in JEET & others
90 Cities approved in PIP
Multi-sectoral Engagement
TB care services in
health
infrastructure
Socio-economic
support &
Empowerment
Infection
Prevention
Address
Determinants
Information
Education
Communication
Prevention and
Care at Work Place
Corporate Social
Responsibility
Policy Update in RNTCP, 2018
TB - A social problem & needs multi-sectoral approach
Community Engagement
ļƒ˜Transformation of TB survivors to
TB champions
ļƒ˜Capacity building and mentoring
programme
ļƒ˜Engagement of existing
community groups like PRI, SHG,
VHSNC, MAS, Youth Club
ļƒ˜Grievance redressal mechanism
ļƒ˜Involvement of community
representatives in different
forums
National
22 States
351 Districts
TB Patients | Community
4 lakh Treatment supporters
Call Centre
ļ‚§ 1800-11-6666
ļ‚§ Outbound & Inbound
ļ‚§ Time ā€“ 7 to 11
ļ‚§ Languages ā€“ 14
ļ‚§ 100 call centre agents
ļ‚§ Pan-India coverage
ļ‚§ Citizen ā€“ Patient - Providers
Counselli
ng Treatme
nt
Adheren
ce
Grievance
Redressal
Follow
Up
TB
Notificati
on
Informat
ion
Nikshay
Poshan
Yojana
Policy Update in RNTCP, 2018
Subnational Certification for TB
Free District / State
ļ‚§ Accelerate efforts
ļ‚§ Contextual strategies
ļ‚§ Generate healthy competition
ļ‚§ Recognition for achieving ā€œDisease Freeā€ status through
monetary and non-monetary awards
Policy Update in RNTCP, 2018
TB
Free
Award Categories Criteria
Decline in incidence rate
compared to 2015
Monetary Award for
District (in Rs.)
Non-Monetary
Recognition
Bronze 20% 2 lakhs Certification and
Felicitation at the
National Level
Silver 40% 3 lakhs
Gold 60% 5 lakhs
TB Free Status 80% 10 lakhs
State
District
Award
Categories
State/Uts with
population <50 lakh
State/Uts with
population 50 lakh ā€“
5 Cr
State/Uts with
population >5 Cr
Non-Monetary
Recognition
Bronze 10 lakhs 15 lakhs 25 lakhs Certification and
Felicitation at
the National
Level
Silver 20 lakhs 35 lakhs 50 lakhs
Gold 40 lakhs 60 lakhs 75 lakhs
TB Free Status 60 lakhs 75 lakhs 1 Crore
State TB Index
Policy Update in RNTCP, 2018
1. Under reporting and uncertain care of TB patients in
private sector
2. Reaching the unreached ā€“ Slums, Tribal, vulnerable
3. Drug Resistant TB
4. Co-morbidities ā€“ HIV, Diabetes
5. Undernutrition, overcrowding
6. Lack of awareness and poor health seeking behaviour lead
to delay in diagnosis
Key Challenges
Key Take Away
ā€¢ Improve TB notification rate Ensure mandatory TB
notification from private sector
ā€¢ Active TB Case Finding to reach the unreached
ā€¢ Optimum utilization of CBNAAT machines
ā€¢ Expand Universal Drug Susceptibility Testing coverage
ā€¢ Expansion of newer treatment regimens (daily regimen,
bedaquiline, delamanid, shorter MDR TB regimen)
ā€¢ NIKSHAY Poshan Yojana to every TB patients
ā€¢ 100% reporting through NIKSHAY
ā€¢ Collaboration with Line Ministries to tackle social
determinants of TB
ā€¢ Community participation for TB Elimination
Thank You
Bending the Curve
Accelerating towards a TB free India
Thank You

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Revised National Tuberculosis Control Programme (RNTCP

  • 1. Revised National Tuberculosis Control Programme
  • 2. What is Tuberculosis? Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis (MTB) Tuberculosis generally affects the lungs, but can also affect other parts of the body One patient with infectious pulmonary TB if untreated can infect 10-15 persons in a year
  • 3. Risk factors o Malnutrition o Diabetes o HIV infection o Low body weight o Severe kidney disease o Other lung diseases (silicosis) o Substance abuse etc. o Overcrowding o Inadequate ventilation o Enclosed living/working conditions o Occupational risks Environmental Medical
  • 4. Possible TB Disease Symptoms Night Sweats Fever Chills Weakness or fatigue Weight loss No appetite Cough lasting longer than 3 weeks Pain in the chest Coughing up blood or sputum (phlegm from inside the lungs) 4
  • 5. Global TB Burden -2018 Global India Incidence 1,00,00,000 (132/lakh) 26,90,000 (199/lakh) Deaths 15,00,000 (16/lakh) 4,40,000 (32/lakh) HIV TB cases 8,62,000 (11/lakh) 92,000 (6.8/lakh) HIV TB deaths 3,74,000 (5.0/lakh) 12,000 (0.7/lakh) Estimated MDR/RR cases 484000 (6.4/lakh population) 1,30,000 (9.6/ lakh population)
  • 6. ā—¾ India has highest burden of both TB and MDR TB and second highest of HIV associated TB based on estimates reported in Global TB report 2015. ā—¾ An estimated 71,000 cases of MDR TB emerge annually from the notified cases of Pulmonary TB in India. ā—¾ 3% among new TB cases, 12-17% among previously treated TB cases have MDR TB. ā—¾ An estimated 1.1 Lac HIV associated TB occurred in 2014 & 31,000 estimated number of patient died among them.
  • 7. āš«TB kills more adults in India than any other infectious disease. āš«In India every day ā€“ āš«More than 6000 develop TB disease āš«More than 600 people die of TB (i.e. 2 deaths every 5 minutes)
  • 8. EVOLUTION OF TB CONTROL IN INDIA āš« 1950s-60s āš« 1962 āš« 1992 Important TB research at TRC and NTI National TB Programme (NTP) Programme Review āš« 1993 āš« 1998 āš« 2001 āš« 2004 āš« 2006 ā€¢ only 30% of patients diagnosed; ā€¢ of these, only 30% treated successfully RNTCP pilot began RNTCP scale-up 450 million population covered >80% of country covered Entire country covered by RNTCP
  • 9. STOP TB STRATEGY, 2006 āš«Vision:A world free of TB āš«Goal: To dramatically reduce the global burden of TB by 2015 in line with Millennium Development Goals and the Stop TB Partnership targets
  • 10. STOP TB PARTNERSHIP TARGETS āš«By 2005: āš«At least 70% people with sputum smear positive TB will be diagnosed. āš«At least 85% cured. āš«By 2015: āš«Global burden of TB (prevalence and death rates) will be reduced by 50% relative to 1990 levels. āš« Reduce prevalence to <150 per lakh population āš« Reduce deaths to <15 per lakh population āš«Number of people dying from TB in 2015 should be less than 1 million, including those co-infected with HIV āš«By 2035: āš«Global incidence of TB disease will be less than or equal to 1 case per million population per year Government of India preponed END TB Strategy
  • 11. āš«Revised National TB Control Programme (RNTCP) nomenclature changed To āš«National TB Elimination Programme (NTEP) from January 2020
  • 12. ā€¢ At the start of 2020 the central government of India renamed the RNTCP the National Tuberculosis Elimination Program (NTEP). 12
  • 13. OBJECTIVES OF THE PROGRAM
  • 14. NATIONAL STRATEGIC PLAN 2017 - 2025 ā€¢ The MOHFW in consultation with over 150 national and international experts working in the field of public health, program managers, donor agencies, technical partners, civil societies, affected community representatives and other stakeholders of TB control both from public as well as private sector finalized the new National Strategic Plan for TB 2017-2025 (NSP). 14
  • 15. WHAT IS NSP? ā€¢ The NSP for TB elimination 2017ā€“25 is a framework to guide the activities of all stakeholders including the national and state governments, development partners, civil society organizations, international agencies, research institutions, private sector, and many others whose work is relevant to TB elimination in India . It is a 3 year costed plan and a 8 year strategy document. ā€¢ It provides goals and strategies for the countryā€™s response to the disease during the period 2017 to 2025 and aims to direct the attention of all stakeholders on the most important interventions or activities that the RNTCP believes will bring about significant changes in the incidence, prevalence and mortality of TB . ā€¢ The NSP will guide the development of the national project implementation plan (PIP) and state PIPs, as well as district health action plans (DHAP) under the national health mission (NHM). 15
  • 16. VISION,GOALS and TARGETS ā€¢ VISION:- TB-Free India with zero deaths, disease and poverty due to tuberculosis. ā€¢ GOALS:- To achieve a rapid decline in burden of TB, morbidity and mortality while working towards elimination of TB in India by 2025. ā€¢ TARGETS:- The requirements for moving towards TB elimination have been integrated into the four strategic pillars of ā€œDetect ā€“ Treat ā€“ Prevent ā€“ Buildā€ (DTPB). 16
  • 17. DETECT ā€¢ Early identification of presumptive TB cases, at the first point of care be it private or public sectors, and prompt diagnosis using high sensitivity diagnostic tests to provide universal access to quality TB diagnosis including drug resistant TB in the country. 17
  • 18. How it can be achieved? ā€¢ 1. LABORATORY SYSTEMS 2. CASE FINDINGS 3. PATIENTS IN PRIVATE SECTORS 18
  • 19. TREAT ā€¢ What does it mean? Provide sustained, equitable access to high quality TB treatment, care and support services responsive to the community needs without financial loss thereby protecting the population especially the poor and vulnerable from TB related morbidity, mortality and poverty. 19
  • 20. What does it entail? ā€¢ 1. Providing daily regimen using FDCs to all TB patients. 2. DST guided treatment for DR TB. 3. Patient centric approach to treatment. 4. Prevent loss at cascade of TB care . How it can be achieved? 1. Treatment services 2. Key affected populations 3. Patient support system 20
  • 21. STRATEGIES ā€¢ 1. Initiation of appropriate treatment for all diagnosed TB patients. ā€¢ 2. Implementation of TB treatment services in health facilities and communities. ā€¢ Regular and long term follow up and rehabilitation of all treated TB patients. 21
  • 22. The principles of treatment for TB 1. Screen all patients for Rifampicin resistance and additional drugs wherever indicated. 2. For drug sensitive TB, administer daily fixed dose combinations of first line Antituberculosis drugs in appropriate weight bands for all forms of TB and in all ages, including four drug FDC in the intensive phase and three drug FDCs in the continuation phase. 3. All Rifampicin Resistant /Multi Drug Resistant TB patients are subjected to baseline Kanamycin and Levofloxacin all across the country. In addition country has introduced extended DST to all second line drugs in a phased 22
  • 23. 4. RR/MDR TB patients without additional drug resistance are treated with standard short course treatment regimen for MDR TB. And in those with mixed patterns of resistance, standard MDR TB regimens were modified as per revised guidelines. 5. Where DST patterns for extended DST are available, the management protocol will follow essential optimized regimen for patients diagnosed with drug resistance other than MDR and XDR TB. 6. Minimize leakage across the care cascade and maximize adherence through innovative patient support strategies and real time monitoring. 23
  • 24. PREVENT ā€¢ What does it entail? 1. Scale up air-borne infection control measures at health care facilities. 2. Treatment for latent TB infection in contacts of bacteriologically- confirmed cases . 3. Addressing social determinants of TB through intersectoral approach . 24
  • 25. How it can be achieved? ā€¢ 1. AIR BORNE INFECTION CONTROL 2. CONTACT TRACING 3. LTBI TREATMENT 25
  • 26. AIR BORNE INFECTION CONTROL ā€¢ CHALLENGES AT COMMUNITY LEVEL - Social habits ā€¢ Cough etiquettes not being followed ā€¢ Indiscriminate spitting ā€¢ Sneezing without covering face ā€¢ Alcoholics and mentally challenged patients ā€¢ Delay in reaching health facility for specific diagnosis Special groups ā€¢ Migrant population, back ward areas and tribal pockets Old age homes, poor homes, children homes, jails, hard to reach areas ā€¢ Delay in diagnosis in co-morbid conditions like Diabetes, HIV, Cancers, etc. 26
  • 27. CHALLENGES AT INSTITUTIONAL LEVEL ā€¢ Outpatient facility ā€¢ Patients with chest infection at outpatient settings ā€¢ Overcrowding - mixing of patients in queues and waiting areas ā€¢ Poor ventilation in the facilities In patient facility ā€¢ Cough screening, separation, fast-tracking, mask and counseling provision missing ā€¢ Infectious patients getting admitted at General wards ā€¢ Cough etiquettes not followed in wards ā€¢ Overcrowding in the wards ā€“ no restricted entries 27
  • 28. SOLUTIONS AT INSTITUTIONAL LEVEL ā€¢ 1. Certification of Health facility for AIC Compliance 2. Develop cough corners/counters - Cough screening, separation, fast-tracking, mask and counseling 3. Posting of specific staff for fast tracking and providing masks 4. Providing N 95 masks to the Hospital staff in High risk settings 5. ACSM at OPD and other settings like Posters, Clippings etc 6. Implementation of AIC in all settings 7. In house AIC complaint facility for treating nomads, destitutes, homeless patients 8. Separate IP facility for bacteriological positive DS/DR TB patients and other airborne infectious patients in major institutions 28
  • 29. ā€¢ 9. Proper infection control measures in ART centres. 10. Proper follow up of daily reported cases 11. Proper disposal of sputum and infected materials 12. Early diagnosis and initiation of treatment 13. PPE for concerned staff 14. Wet mopping and disinfection 15. Periodic screening of staff 16. Proper ventilation, renovation if necessary 17. Facility risk assessment and reporting 18. Periodic trainings 19. Ongoing monitoring dashboards/checklist for AIC practices at all levels . 29
  • 30. ā€¢ CONTACT TRACING;- In RNTCP contact screening has been a clinical function with cursory programmatic monitoring. In this NSP contact tracing will be made more rigorous, expansive and accountable. The end result expected is that most TB pts will have their contacts screened, with secondary cases detected and treated. 30
  • 31. ā€¢ PREVENTIVE THERAPY/ LATENT TB INFECTION TREATMENT :- TB infection is the seed bed for developing TB disease and continued transmission. The lifetime risk of reactivation of LTBI in healthy HIV- uninfected individuals is 10%, with 5% developing TB disease during the first 2 to 5 years after infection. ART reduces the risk of TB by approximately two thirds. 31
  • 32. BUILD ā€¢ What does it means in term of NSP? Undertake critical management reforms, restructuring of HR and financial norms, pathways for private sector participation, in order to improve efficiency, effectiveness and accountability of the health system for an improved response to the TB epidemic. 32
  • 33. ā€¢ What does it entail? 1. Build synergies with existing health service delivery mechanism under Urban Health Mission and plan for integration of services 2. Reform and restructure HR in TB programme to align with the enhanced programme needs for surveillance, participation of private sector and community participation. 3. Strengthen RNTCPā€™s regulatory capacity to control TB drugs through appropriate laws, regulations, and policies. 4. Position TB high on the health and development agenda of the nation to ensure adequate resources, greater demand for and universal access to TB care services 33
  • 34. ā€¢ How it can be achieved? ā€¢ URBAN TB CONTROL SYSTEMS ā€¢ HEALTH SYSTEM STRENGTHENING ā€¢ ADVOCACY, COMMUNICATIONS AND SOCIAL MOBILIZATION ā€¢ SURVEILLANCE, MONITORING AND EVALUATION ā€¢ RESEARCH AND TECHNICAL ASSISTANCE 34
  • 35. Tuberculosis unit āš«It is the nodal point for TB control activities in the sub-district. āš«In urban areas 1 TU per 2,00,000 population (range 1.5-2.5laks) āš«Manned by designated 1. Medical Officer ā€“Tuberculosis Control (MO-TC) 2. Senior Treatment Supervisor (STS) 3. Senior TB Laboratory Supervisor (STLS per 5 lakh population 4. 1 TBHV per 1 lakh urban population
  • 36. Continuedā€¦.. āš«TU will have one Designated Microscopy Centre (DMC) for every 1 lakh population (50,000 in tribal, desert, remote and hilly region) āš«Microscopy centres are also located in Medical Colleges, Corporate Hospitals, ESI, Railways, NGOs, private hospitals.
  • 37. PRESUMPTIVE TB CASES ā€¢ Presumptive Pulmonary TB ā€“ ā€“ Cough for > 2 weeks ā€“ Fever for > 2 weeks ā€“ Significant weight loss ā€“ Haemoptysis ā€“ Any abnormality in Chest Radiograph Note ā€“ Contacts of Microbiologically confirmed TB patients, PLHIV, Diabetics, Malnourished, Cancer patients, patients on immune ā€“suppressants or steroid should be regularly screen for signs and symptoms of TB
  • 38. Presumptive Extra Pulmonary TB āš«Organ specific symptoms and signs like swelling of Lymph node, pain and swelling in joints, neck stiffness, disorientation. āš«Constitutional symptoms like ā€“ significant weight loss, persistent fever for ā‰„ 2 weeks, night sweats.
  • 39. Presumptive Paediatric TB āš«Persistent fever > 2 weeks āš«Cough > 2 weeks āš«Loss of weight / no weight gain āš«History of contact with infectious TB case Loss of weight is define as loss of > 5% body weight as compared to highest weight recorded in last 3 months
  • 40. Presumptive DRTB (As per TOG 2016) āš«Patients who are found positive on any follow up sputum smear examination during treatment with FLD, previously treated TB cases āš« TB patients with HIV coā€“infection āš«TB patients who failed treatment with FLD āš«Paediatric TB non responders āš«TB patients who are contact of DR-TB (or Rif resistance)
  • 41. CASE DEFINITIONS āš«Microbiologically confirm TB case ā€“ Biological specimen positive for AFB or positive for Mycobacterium tuberculosis on culture or positive for tuberculosis through quality assured rapid diagnostic molecular test.
  • 42. Clinically diagnosed TB case āš«A presumptive TB patients who is not microbiologically confirmed but diagnosed with a active TB by a clinician on the basis of X-ray abnormalities, Histopathology or Clinical signs with a decision to treat the patient with a full course of ATD.
  • 43. It is same as the old one Previously called relapse Previously called only failure
  • 44. New Pyramid of TB diagnostics Characteristic Symptom Microbiologic confirmation with U-DST Conventional Radiology Tuberculosi s Skin Test/ IGRA Specificit y Sensitivit y Yield of test and robustness of diagnosis can be improved by better characterisation of symptoms and interpretation of radiology!!
  • 46. 46
  • 48.
  • 50. 99DOTS: Accurate Monitoring at Very Low Cost 101
  • 51. How can the Patient data be accessed? Different ways of accessing the patient data ā€“ āš«Web dashboard (www.99dots.org) āš«Every center will be given their own login ID and Password to access their patients āš«Different logins for ART center, DTC and field staff (with limited permissions) āš«SMS Alerts for Staff and Treatment Supporters to take immediate action in case of default.
  • 52. Benefits of 99DOTS ā€¢ Less travel ā€¢ Increased convenience Patients ā€¢ Focused and more efficient care Field Staff/Supervisors ā€¢ Easy monitoring ā€¢ Accurate reports Program Officers
  • 54. Niksh ay Nikshay is an Integrated ICT (Information Communication Technology) system for TB patient management and care in India Real-time, case-based, web-based surveillance tool Unified interface for public and private sector health care providers Nikshay webpage - https://Nikshay.in Android mobileApp - Google Play Store Demo site ā€“ https://beta.nikshay.in
  • 55. Modalities of notification Submission of hardcopies to DTO Reporting into Nikshay web portal/mobile application Reporting via Nikshay Sampark (1800 11 6666)
  • 56. Incentives to Patients for Social Protection āš«ā€œNikshay Poshan Yojanaā€- āš«Launched from 01st April 2018 āš«Nutritional support through Direct Benefit Transfer of 500 INR per month āš«For all patients on TB treatment throughout duration of treatment āš«Patient need to be registered in the Nikshay portal āš«Tribal patient incentive
  • 57. Incentives to Providers āš«Private Provider Incentive āš«500 INR at notification & 500 INR on reporting treatment outcome āš«Informant incentive āš«Incentive of 500 INR to informant for notification of patients in public sector āš«Incentive for Treatment support āš«New Case: 1000 INR at completion of treatment āš«Drug Resistant Case: 2000 INR at completion of intensive phase, 3000 INR at completion of treatment
  • 58. Take Home Messageā€¦ā€¦ā€¦ āš«For microbiologically confirmed TB cases we must follow Universal DST (Drug Susceptibility Testing) āš«For clinically diagnosed TB casesā€“ it is the test of experts not to over diagnose TB as well as not to under diagnose TB cases āš«Repeated counselling for regular adherence and completion of ATD course is necessary
  • 59. NIKSHAY ā€¢ Nikshay is an integrated Information and Communication Technology system for tuberculosis patient management and care in India. Nikshay was launched in 2012 and has evolved significantly to make patient management easier and more effective for health care providers and their support staff. ā€¢ NI-KSHAY-(Ni=End, Kshay=TB) is the web enabled patient management system for TB control under the National Tuberculosis Elimination Programme (NTEP). 59
  • 60. ā€¢ It is developed and maintained by the Central TB Division (CTD), Ministry of Health and Family Welfare, Government of India, in collaboration with the National Informatics Centre (NIC), and the World Health Organization Country office for India. ā€¢ Ni-kshay is used by health functionaries at various levels across the country both in the public and private sector, to register cases under their care, order various types of tests from Labs across the country, record treatment details, monitor treatment adherence and to transfer cases between care providers. It also functions as the National TB Surveillance System and enables reporting of various surveillance data to the Government of India. 60
  • 61. Salient Features of Nikshay 2.0 Nikshay is an Integrated ICT system for TB patient management and care in India. Nikshay was launched in 2012 and since then, various improvements have been made in the system Nikshay Version 2 has been launched in September 2018. Nikshay provides- 1. A Unified interface for public and private sector health care providers 2. Different types of Logins like State, District, TU, PHI, Staff logins, Private providers, Chemist, Labs and PPSA/JEET Logins 3. Integrates all adherence technologies such as 99DOTS and MERM 4. Unified DSTB and DRTB data entry forms 5. Mobile friendly website with mobile app
  • 62. Nikshay 2 is accessible either via web browser (https://Nikshay.in ) or mobile App called ā€˜Nikshayā€™ that can be downloaded from Google Play Store ( log in page in web browser) ( log in page in mobileApp)
  • 63.
  • 64. Diagnostic work up āš«Based on CBNAAT result patient will be categorized as Microbiologically confirmed drug sensitive TB or RIF resistance TB
  • 65. āš«In case of RIF indeterminate result an additional CBNAAT will be done to get a valid result. If indeterminate on second occasion an additional specimen will be sent to nearest IRL or C &DST centre for LPA or liquid culture and DST as appropriate
  • 66. 66 DIAGNOSTIC ALOGRYTHM FOR EXTRA PULMONARY TB
  • 67. Recommendations for LTBI interventions under NTEP 3rd National Technical Working Group(TWG) on Latent TB Infection Management in India held on 12th May, 2020 Eligible population Strategy Treatment option ā€¢ People living with HIV (Adults and children >12 months) ā€¢ Infants <12 months in contact with active TB ā€¢ Household contacts below 5 years of pulmonary TB patients Treating all after ruling out active TB ā€¢ 6-months daily isoniazid ā€¢ Three months of daily rifampicin plus isoniazid (Alternative in household contacts 0 - 14 years (up to 25 kg weight) in limited geographies) ā€¢ Household contacts 5 years and above of pulmonary TB patients (testing would be offered whenever available) Treating all after ruling out active TB 3-month weekly Isoniazid and Rifapentine ā€¢ Children/Adult on immunosuppressive therapy Testing and 3-month weekly Isoniazid and Rifapentine
  • 69. Ideally all presumptive TB patients have to undergo HIV screening. This is important to ensure all HIV positive TB patients receive ART irrespective of CD4 count and Chemo Prophylaxis (CPT). HIV & Tuberculosis
  • 70.
  • 71. First Line ART for HIV - TB Second LineART for HIV - TB
  • 72. TB-HIV Collaboration ā€“ Single Window Delivery of HIV-TB care at ART centres Rapid molecular diagnosis CBNAAT Daily FDC for HIV and TB ICT based adherence support (99 DOTS) Pharmacovigilance (AMC) Isoniazid Preventive Therapy Progress ā€¢ Training completed by NACO and CTD ā€¢ Drugs supplied in Oct-Novā€™16 ā€¢ 10,031 HIV-TB patients initiated on treatment
  • 73. Adjustment of Anti TB drugs in renal insufficiency Drugs Recommended dose and frequency for patients with creatinine clearance <30 ml/min or for patients receiving haemodialysis (unless otherwise indicated dose after dialysis) Isoniazid No adjustment necessary Refiampicin No adjustment necessary Pyrazinamide 25-35 mg/kg per dose three times per week ( not daily) Ethambutol 15-25 mg/kg per dose three times per week ( not daily) Rifabutin Normal dose can be used, if possible monitor drug concentrations to avoid toxicity. Streptomycin 12-15mg/kg per dose two or three times per week (not daily) Capreomycin 12-15mg/kg per dose two or three times per week (not daily) Kanamycin 12-15mg/kg per dose two or three times per week (not daily) Amikacin 12-15mg/kg per dose two or three times per week (not daily) Ofloxacin 600-800mg/kg per dose three times per week (not daily) Levofloxacin 750-1000mg per dose three times per week (not daily) Moxifloxacin No adjustment necessary Cycloserine 250mg once daily or 500mg/ dose three times per week Terizidone Recommendations not available
  • 74. Torizidone Recommendations not available Prothinamide No adjustment necessary Ethionamide No adjustment necessary Para- aminosalicylicaci d 4g/dose twice daily maximum dose Bedaquiline No dosage adjustments required in patients with mild to moderate renal impairment (dosing not established in severe renal impairment, use with caution) Linezolid No adjustment necessary Clofazimine No adjustment necessary Amoxicilin /clavulanate For creatinine clearance 10-30ml/min dose 1000mg as amoxiciline component twice daily For creatinine clearance <10ml/min dose 1000mg as amoxicilin component once daily Imipenem /cilastin For creatinine clearance 20-40ml/min dose 500mg every hours For creatinine clearance <20-40ml/min dose 500mg every 12 hours Meropenem For creatinine clearance 20-40/ml/min dose 750mg every 12 hours For creatinine clearance <20/ml/min dose 500mg every 12 hours High dose isoniazid Recommendations not available Adjustment of Anti TB drugs in renal insufficiency
  • 75. 75 40 crore infected 35 lakh estimated TB patients annually 4.2 lakh deaths Due to TB annually In Indiaā€¦ā€¦.
  • 76. India: MDG6 TB target TB REVERSED Rate per 100,000 population 50% 35 lakh additional lives saved 50% New cases declining All cases reduced by half Deaths reduced by half HIV WHO Global TB Report 2016 465 ļƒ  195 per lakh pop (58% reduction) 38 ļƒ  17 per lakh pop (55% reduction) 216 ļƒ  167 per lakh pop (23% reduction)
  • 77. Vision: A world free of TB Zero TB deaths, Zero TB disease, and Zero TB suffering Goal: End the Global TB Epidemic (<10 cases per 100,000 population) Sustainable Development Goals (SDG) INDICATORS TARGETS SDG 2030 Reduction in number of TB deaths compared with 2015 (%) 90% Reduction in TB incidence (new case) rate compared with 2015 (%) 80% TB-affected families facing catastrophic expenditures due to TB (%) Zero
  • 78. TB Free India ā€¢ India has committed to End TB by 2025, 5 years ahead of the global SDG target ā€¢ Prime Minister of India launched TB Free India campaign at ā€˜Delhi End TB Summitā€™ on 13th March, 2018 ā€¢ The campaign calls for a social movement focused on patient-centric and holistic care driven by integrated actions for TB Free India
  • 79. 79 Strategies Private sector engagement Active Case Finding TB Co- morbidities Multi- sectoral response Drug Resistant TB ICT Tools for adherence and monitoring Preventive Measures Community Engagemen t National Strategic Plan (2017-25)
  • 80. Organizational structure Ministry of Health & Family Welfare Central TB Division State TB Cell 36 States / UTs District TB Centre 733 Districts TB Unit One per 1.5 ā€“ 2.5 lakh population Designated Microscopy Centre One per 1 lakh population Peripheral Health Institute Supporting Facilities ļ‚§ National Institutes (6) ļ‚§ National Reference Laboratories (6) ļ‚§ Intermediate Reference Laboratories (29) ļ‚§ State TB Training and Demonstration Centres (26) ļ‚§ Culture and DST Laboratories (49) ļ‚§ DR-TB Centres (148) ļ‚§ CBNAAT Laboratories (1180)
  • 81. Key Services 1. Free diagnosis and treatment for TB patient 2. Provision of rapid diagnostics 3. Testing of all TB patients for drug resistance and HIV 4. Management of associated diseases 5. Treatment adherence support 6. Nutrition assistance to TB patients 7. Preventive measures
  • 82. Strategy to find Active TB Case Finding Reaching patients seeking care in Private Sector High Sensitive Diagnostic tool
  • 83. Treat Treatment Patient Centric Care Reduce Out-of-pocket Expenditure ā€¢ Daily Regimen ā€¢ Shorter Regimen ā€¢ Newer Drugs ā€¢ IT Enabled Adherence Support ā€¢ Comorbidity management ā€¢ Financial incentives ā€¢ Direct Benefit Transfer
  • 84. Direct Benefit Transfer (DBT) schemes Existing schemes: 1. Honorarium to Treatment Supporters ā€“ For provision of treatment support to TB patients (Adherence, ADR monitoring, counselling @Rs.1000/- to Rs.5000/-) 2. Patient Support to Tribal TB Patients (Financial Patient Support @Rs750/-) New Schemes: 1. Nutritional Support to All TB patients (Financial Support to Patients @Rs.500/-month) 2. Incentives to Private Providers (Rs.500/- for Notification & Rs.500/- for Follow-up with Treatment Outcome @Rs. 500) 3. Incentives to Informant (Rs. 500/- is given on diagnosis of TB among referrals from community to public sector health facility)
  • 85. Prevent ā€¢ Air borne infection control measures ā€¢ Strengthen Contact Investigation ā€¢ Preventive treatment in high risk groups ā€¢ Manage Latent TB Infection ā€¢ Address determinants of disease
  • 86. Increased Access to Diagnostic Services ļƒØ Expansion of microscopy centres to improve access ļ‚§ Phase 1 - PHCs where a Laboratory Technician (LT) is available ļ‚§ Phase 2 ā€“ Other PHCs ļƒØCurrent Status ā€“ Policy Update in RNTCP, 2018 14,576 16758 Microscopy Centres in 2018 Microscopy Centres in 2017 16.1 lakh TB patients notified in public sector (ļƒ©12% in 2018) 1 microscopy centre at ~75,000 population
  • 87. Universal Drug Susceptibility Testing ļƒØ All TB patients to be tested for Rifampicin Resistance ļƒØCurrent Status ā€“ 60% of target ļƒØ DR-TB patients diagnosed (ļƒ©54% from 2017) Testing for Rifampicin to All Rif Resistance MDR-TB Testing for INH Mono/Poly DR-TB Testing for Second line FQ/SLI Resistance XDR 38,605 59544 2018 2017 Policy Update in RNTCP, 2018
  • 88. Paradigm shift in management of Drug Resistant TB ļ‚§> 20,000 patients on Shorter regimen ļ‚§> 4,600 patients on BDQ containing regimen ļ‚§62 patients on DLM containing regimen Shorter Regimen ā€¢ All MDR/RR- TB patients without resistant to addl. SLD BDQ ā€¢ MDR/RR- TB patients with resistance to addl. SLD & eligible DLM ā€¢ 7 States ā€¢ Children 6 to 17 years in all States Policy Update in RNTCP, 2018
  • 89. Injection Free Regimen 2HRZES 1HRZE 3HRE Injection Free regimen for 4,20,000 patients 2HRZE 4HRE Policy Update in RNTCP, 2018 (3-6) Km Lfx R E Z Injection Free regimen for ~1,00,000 patients Lfx R E Z Treatment for Previously Treated TB Patients Treatment for INH Resistant TB Patients
  • 90. Gazette on TB Notification ļƒØMandatory Notification of TB patients ļƒØ Public Health Actions ļƒØProvisions of Sections 269 and 270 of the Indian Penal Code (IPC) Pharmac ies Laborato ries Clinics / Hospital s FIR 1 Notices 519 Policy Update in RNTCP, 2018 Provider RNTCP Patient 48 Cities in JEET & others 90 Cities approved in PIP
  • 91. Multi-sectoral Engagement TB care services in health infrastructure Socio-economic support & Empowerment Infection Prevention Address Determinants Information Education Communication Prevention and Care at Work Place Corporate Social Responsibility Policy Update in RNTCP, 2018 TB - A social problem & needs multi-sectoral approach
  • 92. Community Engagement ļƒ˜Transformation of TB survivors to TB champions ļƒ˜Capacity building and mentoring programme ļƒ˜Engagement of existing community groups like PRI, SHG, VHSNC, MAS, Youth Club ļƒ˜Grievance redressal mechanism ļƒ˜Involvement of community representatives in different forums National 22 States 351 Districts TB Patients | Community 4 lakh Treatment supporters
  • 93. Call Centre ļ‚§ 1800-11-6666 ļ‚§ Outbound & Inbound ļ‚§ Time ā€“ 7 to 11 ļ‚§ Languages ā€“ 14 ļ‚§ 100 call centre agents ļ‚§ Pan-India coverage ļ‚§ Citizen ā€“ Patient - Providers Counselli ng Treatme nt Adheren ce Grievance Redressal Follow Up TB Notificati on Informat ion Nikshay Poshan Yojana Policy Update in RNTCP, 2018
  • 94. Subnational Certification for TB Free District / State ļ‚§ Accelerate efforts ļ‚§ Contextual strategies ļ‚§ Generate healthy competition ļ‚§ Recognition for achieving ā€œDisease Freeā€ status through monetary and non-monetary awards Policy Update in RNTCP, 2018 TB Free
  • 95. Award Categories Criteria Decline in incidence rate compared to 2015 Monetary Award for District (in Rs.) Non-Monetary Recognition Bronze 20% 2 lakhs Certification and Felicitation at the National Level Silver 40% 3 lakhs Gold 60% 5 lakhs TB Free Status 80% 10 lakhs State District Award Categories State/Uts with population <50 lakh State/Uts with population 50 lakh ā€“ 5 Cr State/Uts with population >5 Cr Non-Monetary Recognition Bronze 10 lakhs 15 lakhs 25 lakhs Certification and Felicitation at the National Level Silver 20 lakhs 35 lakhs 50 lakhs Gold 40 lakhs 60 lakhs 75 lakhs TB Free Status 60 lakhs 75 lakhs 1 Crore
  • 96. State TB Index Policy Update in RNTCP, 2018
  • 97. 1. Under reporting and uncertain care of TB patients in private sector 2. Reaching the unreached ā€“ Slums, Tribal, vulnerable 3. Drug Resistant TB 4. Co-morbidities ā€“ HIV, Diabetes 5. Undernutrition, overcrowding 6. Lack of awareness and poor health seeking behaviour lead to delay in diagnosis Key Challenges
  • 98. Key Take Away ā€¢ Improve TB notification rate Ensure mandatory TB notification from private sector ā€¢ Active TB Case Finding to reach the unreached ā€¢ Optimum utilization of CBNAAT machines ā€¢ Expand Universal Drug Susceptibility Testing coverage ā€¢ Expansion of newer treatment regimens (daily regimen, bedaquiline, delamanid, shorter MDR TB regimen) ā€¢ NIKSHAY Poshan Yojana to every TB patients ā€¢ 100% reporting through NIKSHAY ā€¢ Collaboration with Line Ministries to tackle social determinants of TB ā€¢ Community participation for TB Elimination
  • 99. Thank You Bending the Curve Accelerating towards a TB free India Thank You

Editor's Notes

  1. Anyone can become infected with TB simply by breathing in the germs Once infected, the chances of developing active disease increases when the immunity goes down due to Babies and young children often have weak immune systems which increases their susceptibility to TB
  2. Pulmonary TB disease develops in the lungs while extrapulmonary TB disease can develop in other parts of the body. Symptoms can vary depending on the type of TB Disease. For more information: https://www.cdc.gov/tb/topic/basics/signsandsymptoms.htm
  3. In RNTCP, one of the first health programs to move to DBT, will be using it to transfer monetary benefits to eligible patients and providers. We would be using Nikshay to identify the beneficiaries and the transfer of funds will be through the Public Financial Management System or PFMS
  4. Number of DR-TB diagnosed in 2017 ā€“ 38,605