This lecture help the students such as medical ,nursing , and any health care provider to understand the basic information about anatomy of respiratory system.
The respiratory system (also respiratory apparatus, ventilatory system) is a biological system consisting of specific organs and structures used for gas exchange in animals and plants. The anatomy and physiology that make this happen varies greatly, depending on the size of the organism, the environment in which it lives and its evolutionary history. In land animals the respiratory surface is internalized as linings of the lungs.[1] Gas exchange in the lungs occurs in millions of small air sacs called alveoli in mammals and reptiles, but atria in birds. These microscopic air sacs have a very rich blood supply, thus bringing the air into close contact with the blood.[2] These air sacs communicate with the external environment via a system of airways, or hollow tubes, of which the largest is the trachea, which branches in the middle of the chest into the two main bronchi. These enter the lungs where they branch into progressively narrower secondary and tertiary bronchi that branch into numerous smaller tubes, the bronchioles. In birds the bronchioles are termed parabronchi. It is the bronchioles, or parabronchi that generally open into the microscopic alveoli in mammals and atria in birds. Air has to be pumped from the environment into the alveoli or atria by the process of breathing which involves the muscles of respiration.
This lecture help the students such as medical ,nursing , and any health care provider to understand the basic information about anatomy of skeletomuscular system.
The respiratory system (also respiratory apparatus, ventilatory system) is a biological system consisting of specific organs and structures used for gas exchange in animals and plants. The anatomy and physiology that make this happen varies greatly, depending on the size of the organism, the environment in which it lives and its evolutionary history. In land animals the respiratory surface is internalized as linings of the lungs.[1] Gas exchange in the lungs occurs in millions of small air sacs called alveoli in mammals and reptiles, but atria in birds. These microscopic air sacs have a very rich blood supply, thus bringing the air into close contact with the blood.[2] These air sacs communicate with the external environment via a system of airways, or hollow tubes, of which the largest is the trachea, which branches in the middle of the chest into the two main bronchi. These enter the lungs where they branch into progressively narrower secondary and tertiary bronchi that branch into numerous smaller tubes, the bronchioles. In birds the bronchioles are termed parabronchi. It is the bronchioles, or parabronchi that generally open into the microscopic alveoli in mammals and atria in birds. Air has to be pumped from the environment into the alveoli or atria by the process of breathing which involves the muscles of respiration.
This lecture help the students such as medical ,nursing , and any health care provider to understand the basic information about anatomy of skeletomuscular system.
This lecture help the students such as medical ,nursing , and any health care provider to understand the basic information about anatomy of Genitourinary system
This lecture help the students such as medical ,nursing , and any health care provider to understand the basic information about anatomy of nervous system
This lecture help the students such as medical ,nursing , and any health care provider to understand the basic information about Cardiac system anatomy.
This lecture help the students such as medical ,nursing , and any health care provider to understand the basic information about musculoskeletal system.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
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Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
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Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
4. NOSE AND NASAL CAVITY
Position and structure: The nasal cavity is the first of the
respiratory organs and consists of a large irregular cavity
divided into two equal passages by a septum.
5. Lining of the nose : The nose is lined with very vascular ciliated columnar
epithelium (ciliated mucous membrane) which contains mucus-secreting cells.
Openings into the nasal cavity The anterior nares, or nostrils, this blends with
the skin, are the openings from the exterior into the nasal cavity. Hairs are
present in this area. The posterior nares are the openings from the nasal cavity
into the pharynx. The paranasal sinuses are cavities in the bones of the face
and the cranium which contain air.
6. PHARYNX
Position : The pharynx is a tube. It lies behind the nose, mouth and
larynx. the pharynx is divided into three parts: nasopharynx,
oropharynx and laryngopharynx.
Nasopharynx: On its lateral walls are the two openings of the
auditory tubes, one leading to each middle ear. On the posterior
wall there are the pharyngeal tonsils (adenoids), consisting of
lymphoid tissue.
Oropharynx: lymphoid tissue called the palatine tonsil. During
swallowing, the nasal and oral parts are separated by the soft
palate and the uvula.
Laryngopharynx: The laryngeal part of the pharynx extends from the
oropharynx above and continues as the oesophagus below.
Structure: Mucous membrane lining, Fibrous tissue, and Muscle
tissue.
7. LARYNX
Position: The larynx or 'voice box'
extends from the root of the tongue and
the hyoid bone to the trachea. It is
called 'Adam's apple' and responses on
the generally deeper voice.
Structure: Cartilages: The larynx is
composed of several irregularly shaped
cartilages attached to each other by
ligaments and membranes. The main
cartilages are:
8.
9. TRAC
HEA
Position: The trachea or windpipe is a
continuation of the larynx and
extends downwards where it divides
at the carina into the right and left
bronchi, one bronchus going to each
lung.
Structure: The trachea is composed
of from incomplete (C-shaped) rings
of hyaline cartilages. Connective
tissue and involuntary muscle join
the cartilages and form the posterior
wall where The soft tissue posterior
wall is in contact with the
oesophagus.
11. BRONCHI AND SMALLER AIR
PASSAGES
The right bronchus. This is
wider, shorter and more
vertical than the left
bronchus and is therefore
the more likely of the two to
become obstructed by an
inhaled foreign body.
The left bronchus. This is
long and is narrower than
the right.
12. Bronchi and
bronchioles
Structure : The bronchi are composed of the same tissues as the
trachea. The bronchi progressively subdivide into bronchioles,
terminal bronchioles, respiratory bronchioles, alveolar ducts and
finally, alveoli.
Respiratory bronchioles and
alveoli
Structure: the respiratory tract consisting of respiratory
bronchioles, alveolar ducts and alveoli (tiny air sacs).
the cells of alveoli secrete surfactant, a phospholipid
fluid which prevents the alveoli from drying out. In
addition, surfactant reduces surface tension and prevents
alveolar walls collapsing during expiration. Secretion of
surfactant into the distal air passages and alveoli begins
about the 35th week of fetal life
13. LUN
G
Position: there are two lungs, one lying on each side of the midline in the thoracic
cavity. They are cone-shaped and are described as having an apex, a base, costal
surface and medial surface.
Structures: the apex. This is rounded and rises into the root of the neck, about 25
mm (1 inch) above the level of the middle third of the clavicle. The structures
associated with it are the first rib and the blood vessels and nerves in the root of
the neck.
The base. This is concave and semilunar in shape and is closely associated with
the thoracic surface of the diaphragm.
The costal surface. This surface is convex and is closely associated with the costal
cartilages, the ribs and the intercostal muscles.
The medial surface. This surface is concave and has a roughly triangular-shaped
area, called the hilum, at the level of the 5th, 6th and 7th thoracic vertebrae.
Structures which form the root of the lung enter and leave at the hilum. These
include the primary bronchus, the pulmonary artery supplying the lung and the
two pulmonary veins draining it, the bronchial artery and veins, and the lymphatic
and nerve supply.
14.
15. ORGANISA
TION OF
THE
LUNGS
The right lung is divided
into three distinct lobes:
superior, middle and
inferior.
The left lung is smaller
as the heart is situated
left of the midline. It is
divided into only two
lobes: superior and
inferior.
16. PLEURA AND
PLEURAL CAVITY
The pleura consists of a closed sac of serous membrane (one for each
lung) which contains a small amount of serous fluid.
The visceral pleura. This is adherent to the lung, covering each lobe and
passing into the fissures which separate them.
The parietal pleura. This is adherent to the inside of the chest wall and
the thoracic surface of the diaphragm.
The pleural cavity. This is only a potential space. In health, the two layers
of pleura are separated by only a thin film of serous fluid which allows
them to glide over each other, preventing friction between them during
breathing. The serous fluid is secreted by the epithelial cells of the
membrane. The two layers of pleura, with serous fluid between them. If
either layer of pleura is punctured, the underlying lung collapses due to
17.
18. MUSCLES OF
RESPIRATION
The expansion of the chest during inspiration
occurs as a result of muscular activity, partly
voluntary and partly involuntary. The main
muscles of respiration in normal quiet
breathing are the intercostal muscles and the
diaphragm. During difficult or deep breathing
they are assisted by the muscles of the neck,
shoulders and abdomen.
Intercostal muscles:There are 11 pairs of
intercostal muscles that occupy the spaces
between the 12 pairs of ribs. They are
arranged in two layers, the external and
internal intercostal muscles.
19. The external intercostal muscle fibers. These extend in a downwards
and forwards direction from the lower border of the rib above to the
upper border of the rib below.
The internal intercostal muscle fibers. These extend in a downwards and
backwards direction from the lower border of the rib above to the upper
border of the rib below, crossing the external intercostal muscle fibers
at right angles.
The intercostal muscles are stimulated to contract by the intercostal
nerves.
Diaphragm:
The diaphragm is a dome-shaped structure separating the thoracic and
abdominal cavities. It forms the floor of the thoracic cavity and the roof
of the abdominal cavity and consists of a central tendon from which
muscle fibers radiate to be attached to the lower ribs and sternum and
to the vertebral column by two crura.
The diaphragm is supplied by the phrenic nerves. The intercostal