A research article HbA1c:A Biomarker of Anti Aging By Prof Dr Bashir Ahmed Dar Chinki Pora Sopore Kashmir
Glycosylated hemoglobin (HbA1c) is a marker of evaluation of long-term glycemic control in diabetic patients that predict risks for the development and progression of diabetic complications. The aim of this study is to evaluate the significance of Glycosylated hemoglobin (HbA1c) in relation to aging
OBESITY AND WEIGHT LOSS SURGERY, HOW MUCH BENEFICIAL AND SAFE?BY DR MANZOOR A...Prof Dr Bashir Ahmed Dar
Obesity is recognized as a global health crisis. Weight loss surgery offers a treatment that can reduce weight, induce remission of obesity-related diseases, and improve the quality of life. This review summarizes recent evidence related to the safety, efficacy, and metabolic outcomes of weight loss surgery for morbid obesity. The article also highlights various issues when lifestyle modifications and weight loss medications have failed to provide significant weight loss in the majority of obese people.
Dietary Lifestyle, Way of Life Practices and Corpulence: Towards Present Day Science by Alok Raghav, Aditi, Sneha Gupta, Pratibha Singh, Aman Nikhil, Saba Noor and Jamal Ahmad in Examines in Physical Medicine & Rehabilitation
Obesity is defined as excessive unhealthy accumulation of body fat. India has the third largest obese population in the world after United States of America and China. Prevalence of obesity has reached epidemic proportions in parts of India. In some urban areas, up to a third of the population is either overweight or obese. Childhood and adolescent obesity is also rising rapidly. If this trend continues, certain sections of Indian society may start seeing declining life expectancy in India after many decades of steady progress. Early diagnosis of overweight and obesity may prevent progression to more severe forms associated with complications. In this review, we examine the usefulness of Body Mass Index in diagnosis of obesity in Asian Indian population and the debate surrounding the call for a downward revision of “normal” range in this population.
The influence of regular physical exercise on the advanced glycation end prod...Dr. Anees Alyafei
What are the advanced glycated end products, underline metabolism, and health-related effects? How could physical exercise affect them?
review on the different mechanisms involved in how the exercise reduces the advanced glycated end products.
Oxidative stress and lipid peroxidation may be risk factors for metabolic car...IOSR Journals
Metabolic cardiovascular syndrome is a combination of factors that augment a person's risk
for heart disease, diabetes and stroke. Features of which are obesity, insulin resistance, dyslipidemia [including
increased triglycerides and decreased HDL], impaired glucose tolerance, and hypertension. Obesity has the
central role in this syndrome. The prevalence of obesity in children has increased dramatically over the last 20
years, leading to higher health risk associated with complications such as type 2 diabetes, high blood pressure
and cardiovascular disease.
Aim: The aim of this study is to search for a possible relationship between oxidative stress (as interpreted by
lipid peroxidation) and risk factors for metabolic cardiovascular syndrome in obese prepubertal children, in an
attempt to overcome the increased health risk associated with obesity in children.
Subjects and methods: Eighty prepubertal children aged (5-11) years were enrolled in this study. According to
their body mass index (BMI) they were divided into two groups:
1. Obese group of which 50 subjects were selected
2. Lean group consisted 30 aged matched subjects.
Random cholesterol, high density lipoproteins (HDL) and malondialdehyde were measured in sera
spectrophotometricaly
Results: Both cholesterol and MDA serum concentrations were significantly higher in obese children than leans
( P < 0.000 ). However HDL was lower in obese children and no significant value was found when compared to
leans.
Conclusion: Obese children exhibited hypercholesterolemia and increased lipid peroxidation. This might be a
potential risk of hypertension and cardiovascular diseases especially when HDL decreases as was found. These
findings might shed a light on a possible relationship between oxidative stress metabolic cardiovascular
syndrome. A case where interventional measures might be necessary to prevent excessive weight gain during
childhood.
OBESITY AND WEIGHT LOSS SURGERY, HOW MUCH BENEFICIAL AND SAFE?BY DR MANZOOR A...Prof Dr Bashir Ahmed Dar
Obesity is recognized as a global health crisis. Weight loss surgery offers a treatment that can reduce weight, induce remission of obesity-related diseases, and improve the quality of life. This review summarizes recent evidence related to the safety, efficacy, and metabolic outcomes of weight loss surgery for morbid obesity. The article also highlights various issues when lifestyle modifications and weight loss medications have failed to provide significant weight loss in the majority of obese people.
Dietary Lifestyle, Way of Life Practices and Corpulence: Towards Present Day Science by Alok Raghav, Aditi, Sneha Gupta, Pratibha Singh, Aman Nikhil, Saba Noor and Jamal Ahmad in Examines in Physical Medicine & Rehabilitation
Obesity is defined as excessive unhealthy accumulation of body fat. India has the third largest obese population in the world after United States of America and China. Prevalence of obesity has reached epidemic proportions in parts of India. In some urban areas, up to a third of the population is either overweight or obese. Childhood and adolescent obesity is also rising rapidly. If this trend continues, certain sections of Indian society may start seeing declining life expectancy in India after many decades of steady progress. Early diagnosis of overweight and obesity may prevent progression to more severe forms associated with complications. In this review, we examine the usefulness of Body Mass Index in diagnosis of obesity in Asian Indian population and the debate surrounding the call for a downward revision of “normal” range in this population.
The influence of regular physical exercise on the advanced glycation end prod...Dr. Anees Alyafei
What are the advanced glycated end products, underline metabolism, and health-related effects? How could physical exercise affect them?
review on the different mechanisms involved in how the exercise reduces the advanced glycated end products.
Oxidative stress and lipid peroxidation may be risk factors for metabolic car...IOSR Journals
Metabolic cardiovascular syndrome is a combination of factors that augment a person's risk
for heart disease, diabetes and stroke. Features of which are obesity, insulin resistance, dyslipidemia [including
increased triglycerides and decreased HDL], impaired glucose tolerance, and hypertension. Obesity has the
central role in this syndrome. The prevalence of obesity in children has increased dramatically over the last 20
years, leading to higher health risk associated with complications such as type 2 diabetes, high blood pressure
and cardiovascular disease.
Aim: The aim of this study is to search for a possible relationship between oxidative stress (as interpreted by
lipid peroxidation) and risk factors for metabolic cardiovascular syndrome in obese prepubertal children, in an
attempt to overcome the increased health risk associated with obesity in children.
Subjects and methods: Eighty prepubertal children aged (5-11) years were enrolled in this study. According to
their body mass index (BMI) they were divided into two groups:
1. Obese group of which 50 subjects were selected
2. Lean group consisted 30 aged matched subjects.
Random cholesterol, high density lipoproteins (HDL) and malondialdehyde were measured in sera
spectrophotometricaly
Results: Both cholesterol and MDA serum concentrations were significantly higher in obese children than leans
( P < 0.000 ). However HDL was lower in obese children and no significant value was found when compared to
leans.
Conclusion: Obese children exhibited hypercholesterolemia and increased lipid peroxidation. This might be a
potential risk of hypertension and cardiovascular diseases especially when HDL decreases as was found. These
findings might shed a light on a possible relationship between oxidative stress metabolic cardiovascular
syndrome. A case where interventional measures might be necessary to prevent excessive weight gain during
childhood.
REGULAR YOGURT CONSUMPTION MAY HELP PREVENT CARDIOMETABOLIC DISEASES - Andre ...Yogurt in Nutrition #YINI
Growing evidence for the benefits of yogurt consumption in preventing type 2 diabetes and other cardiometabolic risk factors. The importance of dairy as part of a balanced and healthy diet is widely recognised by health authorities and scientific experts worldwide. Now, evidence is mounting that consuming yogurt in particular as part of a healthy diet helps to prevent type 2 diabetes and other cardiometabolic risk factors, with one of the most recent studies suggesting that people who regularly eat yogurt are almost 30% less likely to develop type 2 diabetes than those who do not (1). Speaking to public health officials at the III World Congress of Public Health Nutrition in Spain, Dr André Marette from the Heart and Lung Institute of Laval Hospital in Quebec, Canada, said it was time to recognize the all-round health benefits of yogurt and encourage more people to eat yogurt on a daily basis.
Physical Fitness and Physical Activity in Children and Adolescences with Type...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
ABSTRACT- Background: Obesity is rising in medical students due to their stressful academic calendar and sparse time for sports. Obesity is aggravated by the regular drinking of alcohol, a recreational and stress-busting activity, particularly for the male students. Obesity leads to insulin resistance. Homeostasis model assessment-estimated insulin resistance (HOMA-IR) >2 has been reported to independently predict cardiovascular risk. Although many studies are there on obesity of medical students, few studies exist in Central India on the prevalence of insulin resistance in medical students. Therefore, prevalence of insulin resistance and its association with obesity and alcoholism was investigated in the first year male medical students of LN Medical College, Bhopal, India.
Methods: 50 male medical students of first year were investigated and considered overweight/obese if BMI>=23 or centrally obese if waist circumference (WC)>=90cm. Alcohol intake of more than 20gm per day was considered as high alcohol intake. HOMA-IR was calculated from fasting glucose and fasting insulin, whereas HOMA-IR>=2 was regarded as high.
Results: Insulin resistance measured by HOMA-IR>=2 was found in 40%, central obesity as per waist circumference in 20%, overall obesity/overweight as per BMI in 60% and alcoholism in 42%. Significant association was found between insulin resistance and central obesity measured by waist circumference (p value 0.001), but not with BMI and alcoholism. Conclusion: Prevalence of insulin resistance in first year male medical students was high and insulin resistance was significantly associated with central obesity.
Key-words- BMI, Waist circumference, HOMA-IR, Insulin resistance, Alcoholism
As a chronic disease it is prevalent in both developed and developing countries, and affecting children(10-20%) as well as adults(20-40%).Excess weight gain invites many associated diseases.
REGULAR YOGURT CONSUMPTION MAY HELP PREVENT CARDIOMETABOLIC DISEASES - Andre ...Yogurt in Nutrition #YINI
Growing evidence for the benefits of yogurt consumption in preventing type 2 diabetes and other cardiometabolic risk factors. The importance of dairy as part of a balanced and healthy diet is widely recognised by health authorities and scientific experts worldwide. Now, evidence is mounting that consuming yogurt in particular as part of a healthy diet helps to prevent type 2 diabetes and other cardiometabolic risk factors, with one of the most recent studies suggesting that people who regularly eat yogurt are almost 30% less likely to develop type 2 diabetes than those who do not (1). Speaking to public health officials at the III World Congress of Public Health Nutrition in Spain, Dr André Marette from the Heart and Lung Institute of Laval Hospital in Quebec, Canada, said it was time to recognize the all-round health benefits of yogurt and encourage more people to eat yogurt on a daily basis.
Physical Fitness and Physical Activity in Children and Adolescences with Type...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
ABSTRACT- Background: Obesity is rising in medical students due to their stressful academic calendar and sparse time for sports. Obesity is aggravated by the regular drinking of alcohol, a recreational and stress-busting activity, particularly for the male students. Obesity leads to insulin resistance. Homeostasis model assessment-estimated insulin resistance (HOMA-IR) >2 has been reported to independently predict cardiovascular risk. Although many studies are there on obesity of medical students, few studies exist in Central India on the prevalence of insulin resistance in medical students. Therefore, prevalence of insulin resistance and its association with obesity and alcoholism was investigated in the first year male medical students of LN Medical College, Bhopal, India.
Methods: 50 male medical students of first year were investigated and considered overweight/obese if BMI>=23 or centrally obese if waist circumference (WC)>=90cm. Alcohol intake of more than 20gm per day was considered as high alcohol intake. HOMA-IR was calculated from fasting glucose and fasting insulin, whereas HOMA-IR>=2 was regarded as high.
Results: Insulin resistance measured by HOMA-IR>=2 was found in 40%, central obesity as per waist circumference in 20%, overall obesity/overweight as per BMI in 60% and alcoholism in 42%. Significant association was found between insulin resistance and central obesity measured by waist circumference (p value 0.001), but not with BMI and alcoholism. Conclusion: Prevalence of insulin resistance in first year male medical students was high and insulin resistance was significantly associated with central obesity.
Key-words- BMI, Waist circumference, HOMA-IR, Insulin resistance, Alcoholism
As a chronic disease it is prevalent in both developed and developing countries, and affecting children(10-20%) as well as adults(20-40%).Excess weight gain invites many associated diseases.
ABSTRACT- Introduction: Importance of measurement of glycated hemoglobin (HbA1c) has been recommended for
the diagnosis of diabetes and pre-diabetes. However, various epidemiological studies conducted different parts of the
universe have shown significant discordance between HbA1c and glucose-based tests. Glycated hemoglobin (HbA1c) is
assumed to be the gold standard for monitoring glycemic control in patients with diabetes mellitus disorder. The Glycated
hemoglobin (HbA1c) assay provided an accurate, precise measure of chronic glycemic levels, and associates with the risk
of diabetes complications.
Materials and Methods: This is a cross sectional prospective study. A total of 868 individuals attended to the medicine
outpatient clinic at Lord Buddha Koshi Medical College, Saharsa, Bihar between Jan 2016 to Dec 2016 were selected for
the study after screening a large cohort visited OPD. The results of FPG, OGTT, and HbA1c for 868 individual were
analyzed as well as all grouped as diabetic patients, glucose intolerant (pre-diabetes) patients, and non-diabetic patients
according to new ADA criteria for the diagnosis of diabetes.
Results: Diagnostic sensitivity of all diabetic criteria were 80.33% for A1c; 75% for OGTT and only 41.87% for FPG
respectively.
Conclusion: The proposed A1c diagnostic criteria have greater diagnostic than FPG and 2-h OGTT regarding a diagnosis
of diabetes mellitus disorder.
Key-words- Glycated Hemoglobin, Fasting Plasma Glucose, Oral glucose tolerances test (OGTT), Diabetes Mellitus,
and Pre- diabetes
O R I G I N A L R E S E A R C HLived experience of diabete.docxcherishwinsland
O R I G I N A L R E S E A R C H
Lived experience of diabetes among older, rural people
Sharon R. George & Sandra P. Thomas
Accepted for publication 16 January 2010
Correspondence to S.R. George:
e-mail: [email protected]
Sharon R. George PhD RN CNL
Assistant Professor, Graduate Faculty
College of Nursing, The University of
Alabama in Huntsville, USA
Sandra P. Thomas PhD RN FAAN
Coordinator for Doctoral Program,
and Co-Director
Cooperating Site, International Institute for
Qualitative Methodology, The University of
Tennessee, USA
G E O R G E S . R . & T H O M A S S . P . ( 2 0 1 0 )G E O R G E S . R . & T H O M A S S . P . ( 2 0 1 0 ) Lived experience of diabetes among older,
rural people. Journal of Advanced Nursing 66(5), 1092–1100.
doi: 10.1111/j.1365-2648.2010.05278.x
Abstract
Title. Lived experience of diabetes among older, rural people.
Aim. This paper is a report of a study conducted to elucidate experiences and
perceptions of self-management of diabetes as narrated by older people diagnosed
with insulin-dependent diabetes living in a rural area.
Background. Older people worldwide are disproportionately affected by diabetes
and are more likely to have co-morbidities and disabilities. Guidelines for
management, developed by the American Diabetes Association, are not targeted for
this population. A plethora of quantitative research has investigated self-manage-
ment issues, with little change to outcomes. This pleads for consideration of a new
diabetes education model, which includes consideration of experiences within
clients’ worldviews.
Method. Unstructured interviews starting with an open question were conducted
from a purposive sample in 2005. Interviews were transcribed and analysed
according to the tenets of existential phenomenology, a process which began with
bracketing the researcher’s biases.
Findings. Living with poorly controlled diabetes led participants to introspection
and existential questioning. Four connected themes were identified: ‘Your Body Will
Let You Know’; ‘I Thought I Was Fine, But I Wasn’t’; ‘The Only Way Out is to Die’;
and ‘You Just Go On’.
Conclusion. Currently designed from a medical perspective, diabetes education
should be based on a nursing model incorporating the client’s insights and experi-
ences. When managing diabetes is viewed from a client’s perspective, the focus
becomes solving problems that arise in self-regulation of one’s own regimen rather
than in complying with doctor’s orders. Nurses need to reframe the problem by
excluding the compliance/noncompliance model and developing a conceptual
perspective on self-management that is grounded in world and body.
Keywords: diabetes, gerontology, nursing, older people, phenomenology, rural
health, self-management
1092 � 2010 The Authors. Journal compilation � 2010 Blackwell Publishing Ltd
J A N JOURNAL OF ADVANCED NURSING
Introduction
Every 10 seconds, two people develop diabetes and someone
dies from.
Prevalence of Chronic Kidney disease in Patients with Metabolic Syndrome in S...asclepiuspdfs
Background and Objective: Chronic kidney disease (CKD) which is an increasingly important clinical and public health issue is associated with cardiovascular disease. Epidemiologic studies have also linked metabolic syndrome (MetS) with an increased risk of incident CKD. Therefore, the present study was designed retrospectively to find the prevalence and potential risk factors of CKD in patients with MetS in Saudi Arabia.
Diabetes is a rapidly and serious health problem in Pakistan. This chronic condition is associated with serious long-term complications, including higher risk of heart disease and stroke. Aggressive treatment of hypertension and hyperlipideamia can result in a substantial reduction in cardiovascular events in patients with diabetes 1. Consequently pharmacist-led diabetes cardiovascular risk (DCVR) clinics have been established in both primary and secondary care sites in NHS Lothian during the past five years. An audit of the pharmaceutical care delivery at the clinics was conducted in order to evaluate practice and to standardize the pharmacists’ documentation of outcomes. Pharmaceutical care issues (PCI) and patient details were collected both prospectively and retrospectively from three DCVR clinics. The PCI`s were categorized according to a triangularised system consisting of multiple categories. These were ‘checks’, ‘changes’ (‘change in drug therapy process’ and ‘change in drug therapy’), ‘drug therapy problems’ and ‘quality assurance descriptors’ (‘timer perspective’ and ‘degree of change’). A verified medication assessment tool (MAT) for patients with chronic cardiovascular disease was applied to the patients from one of the clinics. The tool was used to quantify PCI`s and pharmacist actions that were centered on implementing or enforcing clinical guideline standards. A database was developed to be used as an assessment tool and to standardize the documentation of achievement of outcomes. Feedback on the audit of the pharmaceutical care delivery and the database was received from the DCVR clinic pharmacist at a focus group meeting.
Guidelines in Obesity management
By Dr. Usama Ragab Youssif
Obesity-related counseling should be offered to those with BMI ≥25 kg/m2
A 3% to 5% weight loss can result in meaningful reductions in triglycerides, blood glucose, hemoglobin A1c, and the risk of developing type 2 diabetes
Set an initial weight loss goal of 5% to 10% of current body weight over 6 mo
After 6 mo, focus on weight maintenance before attempting further weight loss
Participating in a weight loss program long-term can help improve weight maintenance
Resurge - The Godzilla Of Offers - Resurge weight loss.Med Gaith
Resurge- The Godzilla Offers is a blend of natural products that are helpful to losing weight, boosting the immune system, increasing metabolism, and relieving stress. it is effective against problems that in one way or another are related to weight gain. It is made in the USA and approved by the Food and Drug Administration (FDA).
Dyslipidemia:
Among the total sample, 55.3% of patients had dyslipidemia.
11.7% of patients had high cholesterol,
28.6% had high triglyceride,
32.7% had high LDL, and
18.0% had low HDL.
Waist circumference was significantly associated with having dyslipidemia.
With every unit increase (1 cm), the odds of having dyslipidemia significantly increases by 1.020
In this mini-review benefits and risks of Growth Hormone (GH) replacement therapy in adults with GH deficiency are discussed. In addition, a cost-benefit analysis will be made and the inevitable illicit use and doping of growth hormone will be considered. Global human growth hormone market is expected to rise to USD 7,1 billion in 2025 and is the fastest growing market segment in Pharma due to extending GH treatment indications and investments of large players. Growth hormone use in anti-aging is highly controversial but booming. New guidelines are discussed as well as the recently FDA approved ghrelin oral GH stimulation test. The very recent horizon view of the Growth Hormone Research Society is discussed as well as the proteomic search for putative new biomarkers for detecting GH defiency in patients and doping in athletes. GH replacement therapy in children remains a costly treatment with USD 35.000-50.000 for each gained inch in height.
Comparative Studies of Diabetes in Adult Nigerians Lipid Profile and Antioxid...YogeshIJTSRD
The study sought to determine the extent to which the usage of social media in the marketing of agricultural products in South West Nigeria can enhance farmers turnover. It employed the survey research design to collect data with the help of a structured questionnaire to elicit information from respondents selected from six 6 south western states. Research data were analysed using structural equation modelling. The results showed that the use of social media WhatsApp and Facebook in marketing of agricultural products significantly enhances farmers turnover. The managerial implication is that use of Whatsapp and Facebook in the marketing of agricultural products for the enhancement of farmers’ turnover was found to have significant influence on the enhancement in farmers’ turnover from agricultural products. Policy makers in government should provide the enabling environment for the telecommunication companies to enhance their reach by installing their facilities across the length and breadth of the country so that the network coverage will be strong at all times so that the benefits of social media usage will not be constrained. Egejuru, Leonard O | Akubugwo, Emmanuel I | Ugorji, Beatrice N "Comparative Studies of Diabetes in Adult Nigerians: Lipid Profile and Antioxidants Vitamins (A and C)" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd45021.pdf Paper URL: https://www.ijtsrd.com/biological-science/biochemistry/45021/comparative-studies-of-diabetes-in-adult-nigerians-lipid-profile-and-antioxidants-vitamins-a-and-c/egejuru-leonard-o
My STSH Scholary Article about TREATMENT of PRE-DIABETES with SSDDDr. Sutanu Patra
I had done research on "Scope of Individualistic treatment with Serially Succussed and Diluted Drugs in treating Pre-diabetic condition: an Open-label Exploratory trial – in search of Prevention of Diabetes" and this was got awarded in Short Term Studentship in Homeopathy (STSH) 2014 by Central Council for Research in Homeopathy (CCRH), Ministry of AYUSH, Govt. of India.
Similar to Research article on anti aging tool by Prof Dr Bashir Ahmed Dar Sopore Kashmir (20)
Localization of brainstem lesion by Prof Dr Bashir Ahmed Dar Sopore KashmirProf Dr Bashir Ahmed Dar
Localizing neurological lesions in the brainstem can be very precise, it relies on a clear understanding on the functions of brainstem .Brainstem lesions usually produce cranial nerve palsy one one side and hemiplegia or hemiparesis on other side
The main aim of this slide presentation is to localize abnormal neurological findings to their main site of origin within the nervous system. After reading the presentation the doctor should be able to localise neurological disorders to their main site of origin.if you fail to identify the clinical signs correctly, then you will be unable to identify where the problem is.Read my slide presentation on localization of brainstem lesion which i will upload very soon
Taking the patient's history is traditionally the first step in virtually every clinical encounter. A thorough neurologic history allows the clinician to define the patient's problem and, along with the result of physical examination, assists in formulating an etiologic and/or pathologic diagnosis
Taking the patient's history is traditionally the first step in virtually every clinical encounter. A thorough neurologic history allows the clinician to define the patient's problem and, along with the result of physical examination, assists in formulating an etiologic and/or pathologic diagnosis
Doctors need to be aware of a rare, hard to diagnose condition called Porphyria. To reach an accurate diagnosis of Porphyria a crystal clear understanding is needed
Doctors need to be aware of a rare, hard to diagnose condition called Porphyria. To reach an accurate diagnosis of Porphyria a crystal clear understanding is needed
Thalassemia (British English: thalassaemia), also called Mediterranean anemia, is a form of inherited autosomal recessive blood disorder characterized by abnormal formation of hemoglobin
Facial nerve disorders can be caused by infection, injury or other conditions.Facial nerve disorders can cause weakness on one or both sides of the face. Those affected may experience loss of facial expression and also difficulties with eating, drinking and clarity of speech. Closing of the eye and blinking can also become difficult.
Facial nerve disorders can be caused by infection, injury or other conditions.Facial nerve disorders can cause weakness on one or both sides of the face. Those affected may experience loss of facial expression and also difficulties with eating, drinking and clarity of speech. Closing of the eye and blinking can also become difficult
Systemic lupus erythematosus (SLE) is an autoimmune disease and as we know immune
system is vast and complex and presents an enormous challenge to scientists working in this field as well as presents a challenge to anyone seeking to explain where pathogenesis research stands at the end of 2011
A research article Fountain of Youth by Prof Dr Bashir Ahmed Dar Sopore KashmirProf Dr Bashir Ahmed Dar
Calorie restriction (CR) is as close to a real fountain of youth as any known technique is. Caloric restriction known to extend the human lifespan by up to five years has quietly become accepted among leading researchers. Even scientists who are cautious about anti-aging hype say it works
HYPERTHYROIDISM PART-2 BY DR BASHIR ASSOCIATE PROFESSOR MEDICINE SOPORE KASHMIRProf Dr Bashir Ahmed Dar
Read hyperthyroidism part-1 and part-2 for better understanding of the subject.Consulted many books and available litrature on the subject
brought their points together to produce precise simple easy to understand slide presentation.Thankful to all these masters.If you need a copy to download just message me on the email drbashir123@gmail.com.Your comments on the site is highly appreciable and welcome, gives me some feedback to improve my work in future
HYPERTHYROIDISM PART-1 BY DR BASHIR ASSOCIATE PROFESSOR MEDICINE SOPORE KASHMIRProf Dr Bashir Ahmed Dar
This slide presentation on hyperthyroidism is divided into two parts.Part-1 deals with causes of hyperthyroidism.I have tried to explain and give clear understanding about the causes of hyperthyroidism which to my knowledge is made very simple and easily understandable.
Part-2 deals with signs symptoms and treatment.Treatment part has been explained in detail.I hope you will enjoy reading it.
ANTI THYROID DRUGS BY DR BASHIR ASSOCIATE PROFESSOR MEDICINE SOPORE KASHMIRProf Dr Bashir Ahmed Dar
The thyroid gland is the biggest gland in the neck. It is situated in the anterior part of the neck below the skin and muscle layers. The thyroid gland takes the shape of a butterfly with the two wings being represented by the left and right thyroid lobes which wrap around the trachea. The sole function of the thyroid is to make thyroid hormone. This hormone has an effect on nearly all tissues of the body where it increases cellular activity. The function of the thyroid, therefore, is to regulate the body's metabolism
UNDERSTANDING THYROID & ITS DISORDERS PART 2 BY DR BASHIR ASSOCIATE PROFESSOR...Prof Dr Bashir Ahmed Dar
The thyroid gland is the biggest gland in the neck. It is situated in the anterior part of the neck below the skin and muscle layers. The thyroid gland takes the shape of a butterfly with the two wings being represented by the left and right thyroid lobes which wrap around the trachea. The sole function of the thyroid is to make thyroid hormone. This hormone has an effect on nearly all tissues of the body where it increases cellular activity. The function of the thyroid, therefore, is to regulate the body's metabolism
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journey
Research article on anti aging tool by Prof Dr Bashir Ahmed Dar Sopore Kashmir
1. ARTICLE INFO ABSTRACT
Keywords:
Hemoglobin A1C and aging,
Hemoglobin A1C anti aging tool,
HBA1C,
HBA1C Biomarker
Original Article
BioMedSciDirect
Publications
Introduction
Copyright 2010 BioMedSciDirect Publications IJBMR - ISSN: 0976:6685. All rights reserved.
c
Int J Biol Med Res.2015;6(3):5084-5086
Contents lists available at BioMedSciDirect Publications
Journal homepage: www.biomedscidirect.com
International Journal of Biological & Medical Research
Glycosylated hemoglobin (HbA1c): A Biomarker of Anti Aging
a b c d e f
Bashir Ahmed Dar, Manzoor Ahmed Dar, Sheeba Bashir, Saima Nazir, Shania Bashir, Yawer Bashir
a
Department of Medicine, Melaka Manipal Medical College, Melaka, Malaysia
b
Department of Surgery, Sohar Hospital Oman
c
Srinagar Kashmir
d
Department of Community Medicine GMC Srinagar Kashmir
e
Obstetrics and Gynaecology SKIMS Soura Srinagar Kashmir India
f
Intern oral maxillofacial surgery ITS Dental College greater Noida Delhi (NCR) India
Glycation
Aging is a multi dimensional process of becoming older and
remains one of the most mysterious areas of biological research. It
represents the accumulation of changes in a person over time
[1][2].
It is among the largest known risk factors for most human
diseases.[3] Roughly 100,000 people worldwide die each day of
age-relatedcauses.[4]
Since ageing is a cause or major risk factor of the age related
diseases and mortality, there are growing efforts in ageing
research to slow ageing and extend healthy lifespan. Ageing
processescan be fasterbecause ofaccumulation oftoxic metabolic
products.
These products could be rogue Advanced Glycation end
products formed from reducing sugars such as glucose, that react
non enzymatically with amino groups in proteins, lipids and
nucleicacidsthroughaseriesofreactionsformingSchiffbasesand
AmadoriproductstoproduceAGE.
This process, also known as the Maillard reaction was
described in the early 1900s, when it was noted that amino acids
heated in presence of reducing sugars developed a characteristic
yellowbrowncolour.[5]
These Advanced Glycation end products corrode our body the
same way rust damages metal in a machine. AGEs as they build up
in the body, they bombard the body's cells like a meteor shower
and continue to cause more damage and rusting that becomes
noticedovermanyyears.
This Glycation, make cells stiffer, less pliable and subject to
damage and premature aging. This is one reason why joints,
muscles and tendons become stiff and inflexible over time.
Glycation thus plays an important role in ageing and has been
implicatedinthepathophysiologyofnumberofdiseases
For most people with normal levels of glucose, the Glycation
process is something that happens gradually over the course of a
lifetime, and it's really not that big of a deal, However people with
highsugarlevelsinbodyleadtoquickandmoreformationofAGEs,
thathastensdamagetocellsofbodyandearlyaging.
When you're younger, your body has more resources to ward
off damage, and you're producing more collagen, says New York
and Miami-based dermatologist Fredric Brandt, who in 2007 was
one of the first to launch an anti-aging skin-care line specifically
addressing glycation.When you reach a certain age, these
Glycation products begin to build up at the same time that your
thresholdfordamageisgettinglower.
Glycation is a fact of life. It's happening right now, to all of us. It
can even be measured. There are number of biomarkers shown to
be related with the ageing process. One of these biomarkers is
glycated hemoglobin (HbA1c).The A1C test is based on non-
enzymatic Glycation pathway by hemoglobin's exposure to plasma
glucose. Therefore Glycation measurement can give idea how fast
it is happening in our body to lead to aging and various age related
diseases.
International Journal of
BIOLOGICAL AND MEDICAL RESEARCH
www.biomedscidirect.comInt J Biol Med Res
Volume 6, Issue 2, April 2015
Glycosylated hemoglobin (HbA1c) is a marker of evaluation of long-term glycemic control in
diabetic patients that predict risks for the development and progression of diabetic
complications. The aim of this study is to evaluate the significance of Glycosylated hemoglobin
(HbA1c) in relation to aging. After going through number of research papers have come to
conclusion that such relationship do exist and Glycosylated hemoglobin (HbA1c) does increase
with advancing age independent of glycemia.It also clearly shows association with premature
aging and increased mortality. Review Criteria: We systematically searched number of articles,
webpages, and major textbooks for writing this article. All papers identified were in English
language and full manuscripts. I also searched the reference lists of identified articles for
additional relevant papers A search for reference data for this purpose was also performed
using the Google search engine. In this short review we summarize the findings given by
different researchers on the subject and bring it in our support to prove HBA1C should also be
usedasantiagingtool.
* Corresponding Author : Dr Bashir Ahmed Dar
Associate Professor Medicine
Department of Medicine, Melaka Manipal Medical College
Melaka Malaysia 75150
Email:drbashir123@gmail.com
Copyright 2010 BioMedSciDirect Publications. All rights reserved.c
2. Bashir Ahmed Dar Int J Biol Med Res. 2015; 6(3): 5084-5086
5085
HemoglobinA1Candaging
The hemoglobin A1C test also called HbA1c, glycated
hemoglobin test, or glycohemoglobin test is an important blood
test used to determine how well diabetes is being controlled.
HemoglobinA1Cprovidesan averageofbloodsugarcontrolovera
sixto12weekperiod.[6]
However, the same blood test also helps identify age-
accelerating Glycation reactions in the body. The hemoglobin A1C
blood test is thus being considered as useful in non-diabetics who
wanttoguardagainstthedestructiveGlycationprocess.
The hemoglobin A1C test identifies the potential for age-
accelerating Glycation reactions in our bodies. However, this
valuable tool has been dramatically underutilized in the context of
aging.
Scientists believe that it is not only those with diabetes or pre-
diabetes who should be concerned about the damaging effects of
Glycation in the body, but all of us should be concerned as the
damage inflicted by advanced Glycation end-products (AGEs) is
moreastheageadvances.
Lydie N. Pani, Leslie Korenda and others published a research
"Effect of Aging on A1C Levels in Individuals without Diabetes
“they found that A1C was associated with age in nondiabetic
subjects and in subjects with normal glucose tolerance (NGT) in
twopopulation-basedcohorts.[7]
They performed cross-sectional analyses of A1C across age
categories in 2,473 nondiabetic participants of the Framingham
Offspring Study (FOS) and in 3,270 nondiabetic participants from
the National Health and Nutrition Examination Survey (NHANES)
2001–2004.The results in their study showed positive association
of AIC with age in nondiabetic subjects. The 97.5th percentiles for
A1C were 6.0% and 5.6% for nondiabetic individuals aged <40
years in FOS and NHANES, respectively, compared with 6.6% and
6.2%forindividualsaged=70years.
They further concluded that the studies that have failed to
demonstrate an association between age and A1C used diagnostic
criteria to exclude diabetes that are now outdated or were small
andpossiblyunderpowered.[8–10]
In another study researchers concluded that Glycemic control
deteriorates with age in healthy, non-diabetic individuals. Age-
related rises in haemoglobin A1C result from a small but steady
declineinpancreaticbetacellfunction.[11]
Similarly Frank Q. Nuttall, in the study found that there was a
modestage-relatedincreasein%HbA1c.[12]
While as in another study on Japanese Population showed the
same results. This study on Japanese population was done to
evaluate whether there is any change in HbA1c with age and to
determine the effects of body mass index (BMI), exercise, and
familyhistoryofdiabetesonthischange.
A cross-sectional survey of 7,664 male Japanese workers aged
20–59 years was performed. All subjects received a physical
examination that included measurement of HbA1c as an indicator
of plasma glucose level. The subjects were classified according to
their ages and BMIs, and any relationship with HbA1c levels was
evaluated.[13]
Results showed that in all BMI groups, HbA1c increased with
age. The greatest increase in HbA1c was observed in the 40 to 49
year-oldage-groupinsubjectswithaBMI=26kg/m2andinthe30
to39yearoldagegroupinsubjectswithaBMI>26.
HbA1c in the subjects aged 20 to 29 years did not change with
BMI. In contrast, HbA1c in subjects aged 30 to 59 years was
significantly higher in those with a BMI >26 when compared with
thosewithBMI=20.
The age dependent increase in HbA1c was greater in subjects
with a positive rather than negative family history of diabetes.
They further concluded that the age dependent increase in HbA1c
maybeaconsequenceoftheagingprocessitself.[13]
Therefore monitoring of hemoglobin A1c levels is essential for
all adults who wish to identify excess glycation processes in their
bodies and take measures to control and minimize glycation
induced damage, as the favourable glucose metabolism and its
control has been identified as a central key factor for longevity.
[14]
A Community-based cross-sectional study involving 2368
subjects aged = 20 years was done from Chandigarh, India and all
had normal glucose tolerance. In this study there was a significant
positive correlation between mean HbA1c and age in these
subjects.
The increase in HbA1c with each advancing year was 0.01%
above the age of 20 years. A significantly higher number (6.5%,
21/325) of subjects had HbA1c of = 6.5% (48 mmol/mol) in those
above the age of 50 years compared with those below the age of 50
years and it was concluded that HbA1c increases with advancing
ageindependentofglycaemia.[15]
A1C levels are positively associated with age in nondiabetic
populations. The age-dependent increase in HbA1c may be a
consequence of the aging process itself independent of glycaemia.
Age therefore should be taken into consideration when using
HbA1c for the diagnosis and management of diabetes and
prediabetes.
The HBA1C test which is being used primarily to monitor
blood sugar control in diabetics also helps to identify the level of
age-acceleratingGlycationinourbody.
Therefore being important factor in aging makes the
hemoglobin HBA1C test important tool for anti aging program to
preventacceleratedagingduetovariousproblems.
HBA1C level is an indirect measure of how fast you are aging
and how much damage is likely being done to your cells by the
agingprocess.
Together with other key anti aging tests, the HBA1C blood test
is a marker for potential accelerated aging, and can help to clear
theproblemsandcomplicationsofhighbloodsugarandGlycation.
Knowing your HBA1C levels and responding accordingly will
ensureamuchlongerandhealthierlife
Conclusions
REFERENCES
1. Bowen, Richard L.; Atwood, Craig S. (2004). "Living and Dying
f o r S e x " . G e ro n t o l o g y 5 0 ( 5 ) : 2 6 5 – 9 0 . D o i :
1 0 . 1 1 5 9 / 0 0 0 0 7 9 1 2 5 . P M I D 1 5 3 3 1 8 5 6
http://agingresearch.wisc.edu/pdf/AGING%20THEORY.pdf
2. Birbrair, A.; Zhang, T.; Wang, Z.-M.; Messi, M. L.; Mintz, A.;
Delbono, O. (2013). "Type-1 pericytes participate in fibrous
tissue deposition in aged skeletal muscle". AJP: Cell Physiology
305 (11): C1098. doi:10.1152/ajpcell.00171.2013.
http://ajpcell.physiology.org/content/ajpcell/305/11/C109
8.full.pdf
3. 5086
http://www.sciencedirect.com/science/journal/00222143/
134/5# http://www.translationalres.com/article/S0022-
2 1 4 3 ( 9 9 ) 9 0 1 6 5 - 8 / a b s t r a c t . D O I :
http://dx.doi.org/10.1016/S0022-2143(99)90165-8
13.Yoshiaki Hashimoto, Azusa Futamura, and Miharu
Ikushima,"Effect of Aging on HbA1c in a Working Male
Japanese Population", Diabetes Care October 1995 18:1337-
1 3 4 0 . d o i : 1 0 . 2 3 3 7 / d i a c a r e . 1 8 . 1 0 . 1 3 3 7 .
http://care.diabetesjournals.org/content/18/10/1337
14.Rozing MP, Westendorp RGJ, De Craen AJM, Frölich M, De Goeij
MCM, Heijmans BT, et al, "Favorable Glucose Tolerance and
Lower Prevalence of Metabolic Syndrome in Offspring without
Diabetes Mellitus of Nonagenarian Siblings: The Leiden
Longevity Study", Journal of the American Geriatrics Society
2010 Volume 58, Issue 3 March 2010 Pages 564–569.
http://onlinelibrary.wiley.com/doi/10.1111/j.1532-
5415.2010.02725.x/full
15. P. Ravi Kumar, A. Bhansali, R. Walia, G. Shanmugasundar and M.
Ravikiran,"Alterations in HbA1c with advancing age in subjects
with normal glucose tolerance: Chandigarh Urban Diabetes
Study (CUDS)",Diabetic Medicine Volume 28, Issue 5, pages
590–594, May 2011. DOI: 10.1111/j.1464-5491.2011.03242.x
http://onlinelibrary.wiley.com/doi/10.1111/j.1464-
5491.2011.03242.x/abstract
3. Dillin A, Gottschling DE, Nyström T; Gottschling; Nyström
(2014). "The good and the bad of being connected: the
integronsofaging".CurrentOpinioninCellBiology:Volume26,
F e b r u a r y 2 0 1 4 , P a g e s 1 0 7 – 1 1 2 .
doi:10.1016/j.ceb.2013.12.003. PMC 3927154. PMID
24529252. http://www.ncbi.nlm.nih.gov/pmc/
articles/PMC3927154/
4. De Grey, Aubrey D.N.J (2007). "Life Span Extension Research
and Public Debate: Societal Considerations". Studies in Ethics,
Law, and Technology 1doi:10.2202/1941-6008.1011
http://www.sens.org/files/pdf/ENHANCE-PP.pdf
5. R.Singh, A.Barden, T.Mori, L.Beilin,"Advanced glycation end
products: a review", Diabetologia (2001)44:129-146
h t t p : / / a g e f o u n d a t i o n . c o m / w p -
content/uploads/2013/01/SpringerBookArchivesStudy.pdf
6. Raval DK, Shah H K, Meghani NM, Bhut VG," Hemoglobin A1C:
biomarker for diabetes prediction?",INTERNATIONAL
JOURNAL OF PHARMACOLOGY AND THERAPEUTICS, Issue 1 :
2011. http://www.earthjournals.org/ijpt-1.pdf.
http://www.earthjournals.org/ijpt_issue1.html
7.Lydie N. Pani,Leslie Korenda, James B. Meigs,Cynthia
Driver,Shadi Chamany,Caroline S. Fox,Lisa Sullivan,Ralph B.
D.Agostino and David M. Nathan."Effect of Aging on A1C Levels
in Individuals without Diabetes: Evidence from the
Framingham Offspring Study and the National Health and
Nutrition Examination Survey 2001–2004", Diabetes Care
October 2008 31:1991-1996. Doi: 10.2337/dc08-0577.
http://care.diabetesjournals.org/content/31/10/1991.full
8. K.Wiener,N.B.Roberts,“AgedoesnotinfluencelevelsofHbA1c
in normal subject", QJM: An International Journal of Medicine
V o l u m e 9 2 , I s s u e 3 P p . 1 6 9 - 1 7 3 . D O I :
h t t p : / / d x . d o i . o r g / 1 0 . 1 0 9 3 / q j m e d / 9 2 . 3 . 1 6 9 .
http://qjmed.oxfordjournals.org/content/92/3/169
9. Sandrine Vallée Polneau, Virginie Lasserre, Michèle Fonfrède,
Jacques Delattre, Simone Bénazeth,"A different approach to
analyzing age-related HbA1c values in non-diabetic
subjects",ClinicalChemistryandLaboratoryMedicine:CCLM/
F E S C C [ 2 0 0 4 , 4 2 ( 4 ) : 4 2 3 - 4 2 8 ] . D O I :
1 0 . 1 5 1 5 / C C L M . 2 0 0 4 . 0 7 4 ( P M I D : 1 5 1 4 7 1 5 3 ) .
http://www.degruyter.com/view/j/cclm.2004.42.issue-
4 / c c l m . 2 0 0 4 . 0 7 4 / c c l m . 2 0 0 4 . 0 7 4 . x m l .
http://europepmc.org/abstract/MED/15147153
10. Udaya M Kabadi,"Glycosylation of Proteins: Lack of Influence of
Aging", Diabetes Care May 1988 vol. 11 no. 5 429-432 .
d o i : 1 0 . 2 3 3 7 / d i a c a r e . 1 1 . 5 . 4 2 9 .
http://care.diabetesjournals.org/content/11/5.toc
11.A. P. Yates andI Laing,"Age-related increase in haemoglobin A1c
and fasting plasma glucose is accompanied by a decrease in ß
cell function without change in insulin sensitivity: evidence
from a cross-sectional study of hospital personnel Article first
published online: 26 MAR 2002", Diabetic Medicine Vol 19
Issue 3DOI: 10.1046/j.1464-5491.2002.00644.
http://onlinelibrary.wiley.com/doi/10.1111/dme.2002.19.is
sue-3/issuetoc. http://onlinelibrary.wiley.com
/doi/10.1046/j.1464-5491.2002.00644.x/abstract.
http://www.ncbi.nlm.nih.gov/pubmed/11918628
12. Frank Q. Nuttal,"Effect of age on the percentage of hemoglobin
A1c and the percentage of total glycohemoglobin in non-
diabetic persons Original", Journal of Laboratory and Clinical
Medicine, Volume 134, Issue 5, November 1999, Pages
451–453
Copyright 2010 BioMedSciDirect Publications IJBMR - ISSN: 0976:6685.
All rights reserved.
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Bashir Ahmed Dar Int J Biol Med Res. 2015; 6(3): 5084-5086