The document summarizes various toxicity studies including male fertility studies, female reproduction and developmental toxicity studies, and carcinogenicity studies. It discusses the key aspects of each study such as the species and number of animals used, dosing duration and levels, and parameters assessed. For example, it notes that female reproduction and developmental toxicity studies (segments I-III) are carried out in two species, usually rats and rabbits, to study effects on fertility, embryo-fetal development, and perinatal/postnatal development. It also describes carcinogenicity studies using two rodent species dosed for most of their lifespan to evaluate cancer potential.