Repetitive strain injury (RSI) refers to musculoskeletal disorders caused by repetitive movements over time. Common RSIs include carpal tunnel syndrome and tendinitis. RSIs develop due to ergonomic and psychosocial stressors and cause pain, numbness, and functional limitations. Occupations involving repetitive computer use or manual labor pose the highest risk. Diagnosis is based on symptoms and physical exam. Treatment focuses on rest, stretching, splinting, and therapies to address underlying muscle imbalances and stresses.