Renaissance art developed in 15th century Italy and spread across Europe in the 15th-16th centuries. It was inspired by antiquity, rejecting Gothic styles, and focused on naturalism, ideal beauty, and humanism. Major art centers included Florence under the Medicis and Rome under the popes. Famous Renaissance artists like Michelangelo, Leonardo da Vinci, Raphael, and Titian produced influential works in sculpture, painting, and architecture that emphasized harmony, proportion, and perspective.