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DR RANDY CHANCE BMSC BDS
Outline
INTRO
(Lipschutz
ulcers)
OTHER NAMES
The term “aphthous” is derived from a Greek word “aphtha” which
means ulceration
It is commoner in:
Predisposing factors
Pathogenesis
Viral associations
• Characteristics of aphthous ulcers which are indicative of
infectious etiology include recurrent ulceration,
lymphocytic infiltration, perivascular cuffing, presence of
auto-antibodies, inclusion bodies in case of herpetiform
ulcers and similarity of RAS to viral ulcerative diseases in
animals.
Presentation
Minor
Major
Herpetiform
Minor aphthae (Mikulicz ulcers)
Major aphthae (Sutton’s ulcers)
Herpetiform aphthae (Cooke’s ulcers)
They recur so frequently that ulceration may be virtually
continuous.
• There could be more than one type in a patient but that would
herald an underlying systemic problem
• The usual combinations seen would be major + herpetiform and
may be the first sign of the disease in up to 75% of cases
• Sometimes the ulcerations can be the only sign of celiac disease
•Mikulicz>Cooke>Sutton
Pre-ulcerative stage is predominantly lymphocytic infiltrates with initial CD4
preponderance. Later CD8+ outnumbers CD4+. Mainly in a perivascular distribution
Diagnosis
Major criteria for diagnosis of RAU minor (Natah et al.[12] 2004)
Minor criteria for diagnosis of RAU minor
4 major and 1 minor
By Jan Polák - Own work, CC BY-SA 3.0, https://commons.wikimedia.org/w/index.php?curid=16627492
Local differentials
Systemic disorders associated with aphthous-
like ulceration
Treatment

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