Introduction • Macro scale difficulties • How Nanotechnology able give solution & Working mechanism • Specific Advantages • Method of preparation • Polymers used for preparation of nanoparticles & nano capsules • Nanomaterials of Health Antibacterial effect & Drug delivery system • Drug delivery real world examples

1. Nanotechnology Drug
delivery systems for
antibacterial treatments
TG/2016/006
TG/2016/023
TG/2016/034
TG/2016/046
TG/2016/058
TG/2016/078
Group Members

2. Contents
• Introduction
• Macro scale difficulties
• How Nanotechnology able give solution &
Working mechanism
• Specific Advantages
• Method of preparation
• Polymers used for preparation of
nanoparticles & nano capsules
• Nanomaterials of Health Antibacterial
effect & Drug delivery system
• Drug delivery real world examples

3. What is Nanotechnology?
“Manipulation of matter with at least one dimension in the size range from
1nm to 100nm, to build microscopic devices in all the other science fields
such as chemistry, biology, physics, Engineering, material science, etc.
(National Nanotechnology Institute, USA)

4. Nanotechnology Drug delivery systems
• Nanotechnology Drug delivery applications occur through the use of
designed nanomaterials as well as forming drug delivery systems
from nanoscale molecules.

5. Common routes of Antibiotic Drug Delivery
• Oral
• Rectal
• Sublingual
• Topical
• Inhalation
• Intravenous
• Intramuscular
• subcutaneous

6. Why Nanotechnology drug delivery systems for antibiotics
“Antimicrobial resistance” is the main reason
for applying the nanotechnology to improve
antibacterial drug delivery systems.
Nanotechnology drug delivery systems help
with more effective treatments for bacterial
infections when compared to the available
conventional and standard treatments.

7. Macro scale difficulties
• The properties of nanoparticles are not governed by the same
physical laws as larger particles, but by quantum mechanics
• Color, strength, chemical reactivity, solubility and toxicity can be
quite different from those of larger particles of the same
substance
• Means to achieve monodispersity of particles.
• Size and shape control
• Building complex nanostructures
• Scale up
• Reproducibility

8. • Cardiovascular diseases (CVDS) have become a serious worldwide public
health problem, and the morbidity and mortality rank first above other diseases
in the world . therefor developing drugs for the treatment of CVDS has
become a top priority.
• Use the nanotechnology has become a new solution to overcome the bottleneck
of cardiovascular disease treatment.
• Nano-drug delivery systems (NDDSS) are a class of nanomaterials that have
abilities to increase the stability and water solubility of drugs, prolong the cycle
time, increase the uptake rate of target cells or tissues, and reduce enzyme
degradation, thereby improve the safety and effectiveness of drugs.
How Nanotechnology able give solution & Working mechanism

9. Types of the NDDSs
• Liposomes
• Polymer Micellar Co-delivery System
• Dendritic Macromolecules
• Metal Nanomaterials
• Inorganic Non-metallic Nanomaterials
• Composite Nanomaterials
• An ideal drug delivery system should have effective targeting and controlled release.
The two main targeting strategies,
➢ Passive targeting
➢ Active targeting

10. Specific Advantages
• Nanoparticles can act as controlled release system depending on their polymeric composition.
• Less amount of dose required.
• They enhance aqueous solubility of poorly soluble drug therefore increase its bioavailability
• Reduce side effect
• Nano particles can be administered by various routes including oral,nasal,parenteral,intra-ocular
etc.
• As a target drug carrier nanoparticles reduce drug toxicity.

11. Method of preparation
1. Amphiphilic macromolecule cross-linking
• Heat cross-linking
• Chemical cross-linking
2. Polymerization based method
• Emulsion polymerization
• Dispersion polymerization

12. Polymers used for preparation of nanoparticles & nano capsules
Polymer use Technique Candidate drug
Hydrophilic
Albumin, gelatin
Heat denaturation & cross linking
in w/o emulsion desolation &
cross linking in aqueous medium
Hydrophilic
Hydrophilic & protein affinity
Alginate, chitosan Cross linking in aq. Medium Hydrophilic & protein affinity
Dextran
Polymer precipitation in an
organic solvent
Hydrophilic
Hydrophobic
Emulsion polymerization
Interfacial/ polymerization
Hydrophilic
Hydrophobic
Polyesters
Solvent extraction- evaporation
Solvent displacement
Salting out
Hydrophilic, Hydrophobic
Soluble in polar solvent
Soluble in polar solvent

13. Nanomaterials of Health Antibacterial effect & Drug delivery system
Nanomaterials of health antibacterial effect
Metals and metal oxides have been widely studied for
their antimicrobial activities. Metal oxide nanoparticles,
well known for their highly potent antibacterial effect.
nanoparticles are including in this.
• Silver (Ag)
• Titanium dioxide (TiO2)
• Zinc Oxide
Figure : Titanium dioxide
Figure : Silver Nano Particles

14. Nanomaterials of drug delivery system
• Chitosan
• Alginate
• Xanthan gum (XG)
• Cellulose
• Liposomes
• Dendrimers
Nanomaterials of Health Antibacterial effect & Drug delivery system
Structure : Chitosan
Structure : Alginate

15. Drug delivery real world examples
Nanotechnology in drug delivery mostly use for cancer treatment. Particles are engineered so that
they are attracted to diseased cells, which allows direct treatment of those cells. This technique
reduces damage to healthy cells in the body.
• Chemotherapy
• Cancer radiation therapy
• Cancer heat therapy
• Heart disease

16. Any Questions?
Thank you for you Attention !