This document discusses the Rapaport-Leubering cycle, which is a supplementary pathway to glycolysis that operates in human and mammal red blood cells. The cycle is mainly concerned with synthesizing 2,3-bisphosphoglycerate from 1,3-bisphosphoglycerate produced in glycolysis using the enzyme 2,3-bisphosphoglycerate mutase. Approximately 15-25% of the glucose converted to lactate in red blood cells goes through this cycle of 2,3-bisphosphoglycerate synthesis.

1. RAPAPORT-LEUBERING CYCLE
Supplementary pathway to
Glycolysis

4. • This is supplementary pathway to glycolysis.
• These operative in the erytrocyte of man and
other mammals.
• Rapaport leubering cycle mainly concerned
with the synthesis of 2,3-bisphosphoglycerate
(2,3-BPG) in RBC.

5. 1,3-Bisphosphoglycerate(1,3-BPG) produced
In Glycolysis is converted to 2,3-BPG by the
Enzyme 2,3-bisphosphoglycerate mutase.
•2,3-BPG is hydrolysed to 3-phosphoglycerate
phosphatase

6. About 15-25% of the glucose
Converted to lactate in erythrocytes
Goes via 2,3-BPG synthesis.