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Rapaport leubering cycle
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Rapaport leubering cycle
1.
RAPAPORT-LEUBERING CYCLE Supplementary pathway
to Glycolysis
2.
3.
4.
• This is
supplementary pathway to glycolysis. • These operative in the erytrocyte of man and other mammals. • Rapaport leubering cycle mainly concerned with the synthesis of 2,3-bisphosphoglycerate (2,3-BPG) in RBC.
5.
1,3-Bisphosphoglycerate(1,3-BPG) produced In Glycolysis
is converted to 2,3-BPG by the Enzyme 2,3-bisphosphoglycerate mutase. •2,3-BPG is hydrolysed to 3-phosphoglycerate phosphatase
6.
About 15-25% of
the glucose Converted to lactate in erythrocytes Goes via 2,3-BPG synthesis.
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