it is short summary of production of hyaluronic acid by using microbes

1. Hyaluronic acid

2. Introduction
• Hyaluronic acid is composed of disaccharide
repeats of D-glucuronic acid and N-acetyl
glucosamine joined alternately by β-1,3 and β-
1,4 glycosidic bond.
• The molecular weight of hyaluronic acid
ranging from 10k-1000k Dalton.
• Hyaluronic acid present in capsule of certain
microbial strain.

4. In human……
• In human body hyaluronic acid occurs in salt
hyaluronate form .
• It Is found in high concentration in the
1. Skin
2. Umbilical cord
3. Viterous humor

5. Strain used for production
• Streptococcus zooepidemicas
• Recombined Bacillus subtillis
• Recombined Escherichia coli
• Recombined Agronbacterium sp.
And so on…..

6. Applications
• Due to high moisture retention and
viscoelasticity properties numerous
application in
1. medical,
2. pharmaceutical and
3. cosmatic

7. Contionued….
• It involved in many signaling pathway
including those involved in embryonic
development, wound healing, inflammation
and cancer.
• HA with high molecular weight (10k Da
) is desirable for product used in
opthalmology, orthopaedic and cosmatic

8. Biosynthesis of hyaluronic acid

10. Thank you