This document discusses radiation-induced heart disease (RIHD) from radiotherapy for cancers near the heart. It covers:
1) Types of cancer treatment that can expose the heart to radiation like breast and lung cancer.
2) Manifestations of RIHD like coronary artery disease and arrhythmias.
3) Studies like one by Sarah Darby that showed increased heart risks proportional to mean heart dose.
4) Techniques to reduce heart exposure like deep inspiration breath hold, prone positioning, and proton beam therapy.
CVD in cancer survivors.Screening of cancer survivors.Chest Radiotherapy .JACC Scientific Expert Panel
( J Am Coll Cardiol 2019;74:905–27 )manifestations of chest and mediastinal radiotherapy .
Hypofractionation in early breast cancer is no more a research scholars topic. Multiple studies with robust data have proven its utility. It may hold an important role in many countries with constrained resources. This is a short presentation incorporating important completed and ongoing trials. Feel free to use this.
Evolution of Hypofractionated Radiotherapy in Breast Cancerkoustavmajumder1986
Hypofractionated radiotherapy in breast cancer is one of the major evolution. It started few decades back. We have to know its history and radiobiological perspective. In this presentation I have tried to cover as much as possible. It would be helpful for all Radiation Oncologist specially the trainees.
CVD in cancer survivors.Screening of cancer survivors.Chest Radiotherapy .JACC Scientific Expert Panel
( J Am Coll Cardiol 2019;74:905–27 )manifestations of chest and mediastinal radiotherapy .
Hypofractionation in early breast cancer is no more a research scholars topic. Multiple studies with robust data have proven its utility. It may hold an important role in many countries with constrained resources. This is a short presentation incorporating important completed and ongoing trials. Feel free to use this.
Evolution of Hypofractionated Radiotherapy in Breast Cancerkoustavmajumder1986
Hypofractionated radiotherapy in breast cancer is one of the major evolution. It started few decades back. We have to know its history and radiobiological perspective. In this presentation I have tried to cover as much as possible. It would be helpful for all Radiation Oncologist specially the trainees.
Tried to summarise all landmark trials in carcinoma breast in radiation oncology,medical oncology as well in surgical oncology.
References taken from Devita Book,Breast Disease book from Springer,journals like NEJM,JAMA,LANCET,ANNL ONCOLOGY etc,internet,Perez book,Practical Clinical Oncology by Hanna etc textbooks.
Thanks.
External beam radiotherapy (EBRT) for differentiated thyroid cancer (DTC) is debated due to lack of prospective studies. Surgery and radioactive iodine usually effective for locoregional control. Recent retrospective studies report benefit in select patients. Goal of EBRT is to improve locoregional control while limiting treatment toxicity
Tried to summarise all landmark trials in carcinoma breast in radiation oncology,medical oncology as well in surgical oncology.
References taken from Devita Book,Breast Disease book from Springer,journals like NEJM,JAMA,LANCET,ANNL ONCOLOGY etc,internet,Perez book,Practical Clinical Oncology by Hanna etc textbooks.
Thanks.
External beam radiotherapy (EBRT) for differentiated thyroid cancer (DTC) is debated due to lack of prospective studies. Surgery and radioactive iodine usually effective for locoregional control. Recent retrospective studies report benefit in select patients. Goal of EBRT is to improve locoregional control while limiting treatment toxicity
Drs. Angela Pikus, Alex Blackwell, Mark Baumgarten, Rosa Malloy-Post are Emergency Medicine Residents and interested in medical education. With the guidance of Dr. Michael Gibbs, a notable Professor of Emergency Medicine, they aim to help augment our understanding of emergent imaging. Follow along with the EMGuideWire.com team as they post these educational, self-guided radiology slides. This set will cover:
• Abnormalities of the Thoracic Aorta
o Traumatic aortic disruption
o Thoracic aortic aneurysm with acute dissection
Breast conserving surgery followed by adjuvant radiotherapy is adopted in the early detected cases and mastectomy followed by radiotherapy or chemotherapy in the advanced cases are the general practices.
Abstract—Colorectal cancer is leading cancer-related public health problem. This study was conducted to determine the effect of High-Dose-Rate intraluminal brachytherapy (HDR-BT) with or without interstitial brachytherapy during neoadjuvant chemoradiation for locally advanced rectal cancer. This randomized contrial was conducted on 28 patients attended with locally advanced rectal cancer (T3, T4 or N+) treated initially with concurrent capecitabine (800 mg/m2 twice daily for 5 days per week) and pelvic external beam radiation therapy (45Gy in 25 Fractions) after one week MRI for all patients; received intraluminal HDR-BT with 4Gy x 2 Fractions with one week interval for those had gross residual disease within 1cm of rectal wall and receiveed intraluminal and interstitial brachytherapy with 4Gy x 2 Fractions with one week interval for those had gross residual disease far from 1cm of rectal wall. All patients underwent surgery within 4-8 week after completion of neoadjuvant therapy. In the control group which were not randomized, twenty-eight patients underwent neoadjuvant chemoradiation (45Gy in 25 Fraction with concurrent capecitabine 800mg/m2 twice daily for 5 days per week) followed by surgery. It was found that in HDR-BT group pathologic complete response (pCR), pathologic partial response (pPR) and pathologic response rates (pCR+pPR) based on AJCC TNM staging for colorectal cancer were %35.7, %35.7, and %71.4 respectively. The pCR, pPR, and pRR were %25, %17, and %42 in the control group respectively. pCR, pPR, and pRR were improved with HDR-BT. However, only response rate improvement was statistically significant (p=0.031). There was no a statistically significant difference in the complications between the two groups (p > 0.05). So it can be concluded that HDR intraluminal with or without interstitial brachytherapy may be an effective method of dose escalation technique in neoadjuvant chemoradiation therapy of locally advanced rectal cancer with higher response rate and manageable side effects.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdf
RADIATION INDUCED CARDIAC DISEASES
1. WH-WORDS ABOUT RIHD
DR KANHU CHARAN PATRO
MD,DNB(RADIATION ONCOLOGY),MBA,FICRO,FAROI,PDCR,CEPC
HOD,RADIATION ONCOLOGY
Mahatma Gandhi Cancer Hospital And Research Institute, Visakhapatnam
drkcpatro@gmail.com /M+91-9160470564
2. Slow my flow
• Introduction
• Sarah Darby article
• Burden
• Etiopathogenesis
• Parts
• Prevention
• Screening
• Conclusion
13. Conclusion
• The overall average of the mean doses to the whole heart was 4.9 Gy (range, 0.03 to
27.72).
• Rates of major coronary events increased linearly with the mean dose to the heart by
7.4% per Gray (95% confidence interval, 2.9 to 14.5; P.0001
• With no apparent threshold. The increase started within the first 5 years after
radiotherapy and continued into the third decade after radiotherapy.
• The proportional increase in the rate of major coronary events per gray was similar in
women with and women without cardiac risk factors at the time of radiotherapy
• Exposure of the heart to ionizing radiation during radiotherapy for breast cancer increases
the subsequent rate of ischemic heart disease.
• The increase is proportional to the mean dose to the heart, begins within a few years after
exposure, and continues for at least 20 years.
• Women with preexisting cardiac risk factors have greater absolute increases in risk from
radiotherapy than other women
18. Post hoc analysis
• The original article revealed that the volume of heart receiving greater
than or equal to 5 Gy (V5) or greater than or equal to 30 Gy (V30)
was associated with worse overall survival.
• A secondary analysis of RTOG 0617 published 2 years later reported
that heart volume of heart receiving greater than or equal to 40 Gy
was the dose parameter most strongly associated with survival
• Zhang et al.performed a systematic review of studies published
before January 2018. They included 18 studies of patients with
NSCLC
• Heart V30 was associated with decreased overall survival in two
studies and MHD was associated with post radiotherapy cardiac
events in two studies
19.
20. Hallmarks of RIHD
Fibrosis and calcification of the
aortic root and the aortomitral
curtain that can lead to
progressive stenosis of the aortic
and mitral valves;
Ostial coronary stenosis;
myocardial atrophy and
widespread pericardial
adhesions and thickening
ultimately leading to intractable
and inoperable pericardial
constriction
28. QUANTEC DATA
• Qualitative Analyses of Normal Tissue Effects in the Clinic
• QUANTEC recommended that the volume of heart receiving greater than
or equal to 30 Gy (V30) should be kept below 46%
• MHD less than 15 Gy
• First time that the risk of MACE (defined as MI, coronary
revascularization, or death from IHD) in breast cancer survivors increases
in a linear relationship to cardiac radiation dose, even at low-dose levels.
• The rate of MACE increased by 7.4% per one gray increase in MHD in
this cohort of patients
50. Planning technique
• 10 left-sided postmastectomy patients with very challenging anatomy were
selected for this dosimetry study.
• The enface electron fields were designed from a single isocenter and gantry
angle with different energy beams using different cutouts that matched on
the skin.
• Smaller energy was used in the central thin chest wall part and higher
energy in the medial internal mammary nodes (IMN) area, superior part of
the thick chest wall, and/or Axilla area.
• The electron fields were matched to the photon supra-clavicular field in the
superior region.
• Daily field junctions were used to feather the match lines between all the
fields.
• Electron field dose calculations were done with Monte Carlo
51.
52. The electron chest wall
irradiation technique using
electron Monte Carlo dose
algorithm can provide
adequate dose coverage to
the chest wall, IMNs and/or
Axilla nodes while achieving
heart sparing with acceptable
ipsilateral lung dose, minimal
contralateral lung and breast
dose.
61. APBI
1. MC-APBI for left-sided BC
demonstrate that MC-APBI delivers a
low dose to both the heart and LAD.
2. Especially in women with favorable
anatomic and pathologic features,
MC-APBI is a safe, convenient, and
effective mode of radiation delivery
62. Conclusion
Thoracic radiotherapy is known to cause a variety of cardiac damage through the
inflammatory pathways.
Who typically have multiple comorbidities, are at higher risk of cardiac events and
early mortality after thoracic radiotherapy
Evaluation with echocardiography, electrophysiological, or cardiac perfusion
studies are currently not part of the routine assessment of patients with beast and
lung cancer
There is a need for high-quality prospective research to investigate advanced
radiotherapy technologies such as MR-guided radiotherapy and PBT