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RABIES VIRUS
• Rabies; is a fatal but preventable viral disease.
• Affects the central nervous system.
• most common reservoirs; In Canada and USA:
bats, foxes, skunks and raccoons.
• most common reservoirs; In worldwide, mostly
dogs
• Negri bodies; is abnormalities in the neurons.
CHARACTERISTICS OF RABIES VIRUS
• It is Family Rhabdoviridae
• Linear
• Single-stranded RNA
• Negative sense RNA
• Genome Replicate in cytoplasm
• Non segmented
TRANSMISSION
• The bite and virus-containing saliva of an
infected host
• Contamination of mucous membranes (i.e.,
eyes, nose, mouth)
• Aerosol transmission
• Corneal transplantations
DIAGNOSIS
• 1. Detection of antigen by taking skin biopsy using
immunofluorescence
• 2. virus isolation from saliva & other secretions.
• 3. CSF analysis and CT scan
• 4. ELISA
• 5. RT-PCR; (for rabies RNA in CNS (most sensitive method to detect rabies)
• 6. DFA testing ( for corneal epithelial cells)
• 7. microscopic examination of the CNS reveals Negri bodies
TREATMENT
• No established treatment for rabies.
• Recent treatment failures of antiviral therapy,ketamine, and therapeutic coma-milwaukee
protocol
• Expert opinion to be sought before any experimental therapy
• A palliative approach may be appropriate for some patients.
REFERENCES
• HTTPS://WWW.RESEARCHGATE.NET/FIGURE/TYPICAL-REPRESENTATION-OF-
THE-PATHOGENESIS-OF-RABIES-VIRUS-WHERE-THE-VIRUS-INFECTS-
THE_FIG3_321874302
• HTTPS://WWW.WHO-RABIES-BULLETIN.ORG/SITE-PAGE/DIAGNOSIS-RABIES
• HTTPS://WWW.MOUNTSINAI.ORG/HEALTH-LIBRARY/DISEASES-
CONDITIONS/RABIES
• HTTPS://QUIZLET.COM/20816985/THE-RABIES-VIRUS-FLASH-CARDS/
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