Skin is the largest organ that protects the body from microbes and maintains homeostasis. Streptococci and staphylococci commonly cause skin infections, producing lesions ranging from minor to severe. The skin has a normal flora that colonizes it after birth and helps prevent infections by competing with pathogens and producing toxic fatty acids. Common pyodermas like folliculitis, furuncles, and carbuncles are often caused by Staphylococcus aureus infections of hair follicles when the skin barrier is broken by injury, disruption, or immunosuppression.