The pterygopalatine fossa is a small pyramidal space located below the apex of the orbit on the lateral side of the skull. It functions as a neurovascular conduit, containing the maxillary nerve, terminal part of the maxillary artery, pterygopalatine ganglion and their branches. The fossa has boundaries of the posterior maxilla anteriorly, pterygoid process posteriorly, perpendicular plate of palatine bone medially, and pterygomaxillary fissure laterally. It communicates with surrounding areas through various foramina and fissures. Due to its anatomic location and contents, the pterygopalatine fossa is clinically significant in spread of