1) The document describes several metabolic pathways involving cholesterol, bile acids, and steroid hormone synthesis.
2) It shows the neutral and acidic pathways for cholesterol catabolism into bile acids and the primary and secondary bile acid synthesis pathways.
3) Several figures are presented outlining the roles of nuclear receptors like FXR, LXR, PXR, and VDR in regulating bile acid, cholesterol, and triglyceride metabolism in the liver, intestine, and kidneys.
Complement refers, historically, to fresh serum capable of lysing antibody (Ab)-coated cells. This activity is destroyed (inactivated) by heating serum at 56EC for 30 minutes.
The lytic activity of complement is decreased in certain diseases, e.g. SLE, serum sickness, chronic infections, complement deficiencies, etc.
complement functions
Host benefit:
opsonization to enhance phagocytosis
phagocyte attraction and activation
lysis of bacteria and infected cells
regulation of antibody responses
clearance of immune complexes
clearance of apoptotic cells
Host detriment:
Inflammation, anaphylaxis
Complement refers, historically, to fresh serum capable of lysing antibody (Ab)-coated cells. This activity is destroyed (inactivated) by heating serum at 56EC for 30 minutes.
The lytic activity of complement is decreased in certain diseases, e.g. SLE, serum sickness, chronic infections, complement deficiencies, etc.
complement functions
Host benefit:
opsonization to enhance phagocytosis
phagocyte attraction and activation
lysis of bacteria and infected cells
regulation of antibody responses
clearance of immune complexes
clearance of apoptotic cells
Host detriment:
Inflammation, anaphylaxis
Riboflavin,flavoproteins and their clinical applicationsrohini sane
A presentation in lucid-style on Riboflavin (vitamin B2), Flavoproteins and their clinical applications for MBBS , BDS , B Pham and Biotechnology students to facilitate easy leaning.
RECÉM-LANÇADO, ESTA REVISTA MÉDICA É DE ALTO NÍVEL E ESTÁ COM OS PRIMEIROS NÚMEROS DE GRAÇA. APROVEITEM!! ESSE ARTIGO CAI MUITO BEM NO NOSSO BLOG SOBRE SULFONILURÉIAS. Journal of Diabetes Investigation Volume 1 Issue 1/2 February/April 2010
Il punto sul microbiota e le malattie umane- Covegno scientifico Attività scientifica
Il microbiota e le patologie umane- Perugia 20 aprile 2018- Convegno a Perugia-
Probiotici e trattamento delle patologie umane
Microbiota intestinale e malattie infiammatorie
Riboflavin,flavoproteins and their clinical applicationsrohini sane
A presentation in lucid-style on Riboflavin (vitamin B2), Flavoproteins and their clinical applications for MBBS , BDS , B Pham and Biotechnology students to facilitate easy leaning.
RECÉM-LANÇADO, ESTA REVISTA MÉDICA É DE ALTO NÍVEL E ESTÁ COM OS PRIMEIROS NÚMEROS DE GRAÇA. APROVEITEM!! ESSE ARTIGO CAI MUITO BEM NO NOSSO BLOG SOBRE SULFONILURÉIAS. Journal of Diabetes Investigation Volume 1 Issue 1/2 February/April 2010
Il punto sul microbiota e le malattie umane- Covegno scientifico Attività scientifica
Il microbiota e le patologie umane- Perugia 20 aprile 2018- Convegno a Perugia-
Probiotici e trattamento delle patologie umane
Microbiota intestinale e malattie infiammatorie
Giornata di studio sul microbiota e patologie umane- Esperti a confronto sul ruolo dl microbiota nelle patologie dell' apparato digerente Perugia 20 aprile 2018
Meeting sul microbiota umano 20 aprile 2018
Focus su microbiota intestinale e malattie infiammatorie ed epatiche- Probiotici: come valutare un probiotico?
These slides describe the pathophysiology and the management of patients with liver cirrhosis and portal hypertension. The slides are at the level of post-graduate students
GPBAR1 (TGR5) regulates il 10 production from intestinal macrophages Attività scientifica
Novel therapeutic approach to intestinal inflammation by targeting GPBAR1 (TGR5) stimulates release of anti-inflammatory cytokine IL-10.
Just published in J. Immunology June 2017
Nuovo website:
www.gastroenterologia.unipg.it
disponibile da oggi per aggiornamenti, didattica, blog ed informazioni sulla sezione di gastroenterologia di Perugia
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
Follow us on: Pinterest
Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
4. FAS Triglyceride
activity synthesis
CAR PXR
FXR PPARα
Srebp-1c
β-Oxidation PPARα CTP-1
ApoC III CD36
VLDL Fas
ApoA V Acc-1 β-Oxidation
receptor
ApoC II Scd-1
Syndecan-1 human
lipogenesis
Increase LPL mouse
activity
A
Increase VLDL and CM B
clearance
Figure 4
5. hyperglicaemia
FXR Insulin resistance
GS GLUT4
G6Pase PK
PEPCK glycogen synthesis Insulin
F1,6bPase glycolisis signaling
FAs synthesis Inflammatory
cytokines SKELETAL MUSCLE
gluconegenesis
Glucose
production
Glucose uptake
LIVER
appetite
Insulin secretion
FXR
Adipocytes β cells protection
GLUT4 differentiation
Lipid GLP-1 GLP-1
TGR5
Inflammatory
storage
cytokines AC
GDP
WAT αβ
γ
P
PANCREAS c-AM GTP
α
Figure 5 GUT
7. Skeletal muscle
TGR5 AC T4
TR
T3
D2 1α
C-AMP PGC
2
P α β γ UCP
FXR
GD
P CRE
GT
α
Rα PK
PPA
Uncoupling
n FFA /
atio TRIGLYCERIDES B-oxidation
xid
Β-o Oxidative phosphorylation
large
adipocyte
TNF-α
IR T4 TR
AC T3
TGR5 P
D2 C1
PG P1
α
c-AM UC
FXR adiponectin P2
/3
γ UC
αβ
DP
G CRE
adipocytes
differentiation
leptin
P
GT α
CAR
BAT
WAT
pre-adipocyte
Figure 7