This document summarizes lipid transport and storage. It discusses the structure of the small intestine and how triglycerides are packed and transported via chylomicrons through the lymphatic system and blood circulation to tissues like liver, muscle and adipose tissue. It also outlines the roles of various apolipoproteins involved in lipid transport, including ApoA, ApoB, ApoC, ApoD and ApoE. Finally, it briefly mentions disorders related to lipid transport and recommended textbooks for further reading on the topic.

1. Lipid Transport and Storage Dr. Bibi Kulsoom Assistant Professor Department of Biochemistry

2. Countrywide Transport

3. Structure of Small Intestine

4. Structure of Small Intestine

5. Triglyceride Packing & Transport

6. Chylomicron A-II A-II

7. Lymphatic system

8. Blood Circulation

9. Chylomicron Apo C II, E B 48 E C II A II HDL

10. Deloading of Chylomicrons http://www.richmond.edu

11. Triacylgycerol Storage

12. Triacylgycerol Storage http://www.trudicanavan.com http://www.vivo.colostate.edu Brown Adipose Tissue

13. Chylomicron Transport to Liver

14. Countrywide Transport

15. Hepatic uptake of Chylomicron Remnants

16. Fate of Chylomicron Remnants Chol TG FFA PhoL

17. Secretion of VLDL

18. Lipoproteins

19. Lipoprotein Structure

21. Composition of Lipoproteins

22. Free Fatty acid Adipose tissue Free fatty acids with Albumin A-I, A-II, A-IV, C-I,C-II, C-III, D, E Phospholipids, Cholesterol Liver, Intestine HDL B-100 Cholesterol IDL LDL B-100, E Triacylgycerol VLDL IDL B-100, C-I, C-II, C-III Triacylgycerol, Cholesterol Liver VLDL B-48, E Triacylgycerol, Phospholipids, Cholesterol Chylomicron Chylomicron remnants A-I, A-II, A-IV, B-48, C-I, C-II, C-III, E Triacylgycerol Intestine Chylomicron Apolipoproteins Main Lipid Sources Lipoprotein

23. Apolipoproteins

24. Closely associated with LCAT. ApoD Inhibits LPL. ApoC-III Activates LPL. ApoC-II Probably activates LCAT. ApoC-I Binds to LDL receptors. ApoE Binds LDL receptor. ApoB-100 Contributes to structure. ApoB-48 Contributes to structure. ApoA-IV Enhanced hepatic lipase activity. ApoA-II Activates LCAT. ApoA-I Function Apoprotein

25. Triacylglycerol Transport

26. Bood circulation Harper’s Illustrated Biochemistry

27. Triacylglycerol & Cholesterol Transport

28. Harper’s Illustrated Biochemistry

29. Reverse Cholesterol Transport

30. Harper’s Illustrated Biochemistry

32. Dislioproteinemias Hypoliproteinemias abetalipoproteinemia Hyperliproteinemias Deficiency of LPL Hepatic lipase LCAT LDL receptor Apo E etc

33. THANK YOU Suggested Reading: Harper’s Illustrated Biochemistry, 28 Ed. McGraw-Hill. Lehninger Principles of Biochemistry, 5 Ed. WHFreeman & Co. Lipid Transport and Storage