A 5-year-old male child presented with multiple hyperpigmented macules over the trunk. When rubbed with a pen, he developed a urticarial wheal confined to the border of the lesions. The most likely diagnosis is urticaria pigmentosa, which is caused by an increase in dermal mast cells and presents in children as brownish papules and plaques over the body that become urticated upon rubbing.
This PowerPoint presentation demonstrate a useful review of Oral candidiosis, including its different types, clinical presentations, differential diagnosis, and treatment options.
Subspecialty of dermatology and pathology focused on performing and interpreting tests on human tissue samples to provide scientific data and consultative opinions to referring clinicians
Vesiculobullous Lesions - Pemphigus and Pemphigoid
Classification, Terminologies, Subsets of Pemphigus, Difference between pemphigus and pemphigoid, oral manifestations, differential diagnosis, Histopathology, Investigations and Management given in detail.
Erythema multiforme, Steven-Johnson syndrome and Toxic Epidermal NecrolysisBinaya Subedi
Erythema Multiforme is a common Vesiculobullous deramtological condition with mucosal manifestations trigged by Herpes virus infection and certain sulpha containing drugs.
This PowerPoint presentation demonstrate a useful review of Oral candidiosis, including its different types, clinical presentations, differential diagnosis, and treatment options.
Subspecialty of dermatology and pathology focused on performing and interpreting tests on human tissue samples to provide scientific data and consultative opinions to referring clinicians
Vesiculobullous Lesions - Pemphigus and Pemphigoid
Classification, Terminologies, Subsets of Pemphigus, Difference between pemphigus and pemphigoid, oral manifestations, differential diagnosis, Histopathology, Investigations and Management given in detail.
Erythema multiforme, Steven-Johnson syndrome and Toxic Epidermal NecrolysisBinaya Subedi
Erythema Multiforme is a common Vesiculobullous deramtological condition with mucosal manifestations trigged by Herpes virus infection and certain sulpha containing drugs.
1. Cutaneous T-cell pseudolymphomas
A) Primarily with stripe-like infiltration (the majority of cases)
Lymphomatoid drug eruption (most cases);
Lymphomatoid contact dermatitis;
Actinic reticuloid;
Nodular scabies (individual cases);
Idiopathic forms;
Clonal cutaneous T-cell pseudolymphomas.
B) Primarily with nodular infiltration (a small percentage
of the cases)
Drug-induced – mainly by anti-convulsive drugs
Persistent nodules after insect bites;
Nodular scabies (the majority of cases).
2. Cutaneous B-cell pseudolymphomas (with nodular infiltration)
Cutaneous lymphocytoma from Borrelia burgdorferi;
Cutaneous lymphocytoma after antigens injection;
Cutaneous lymphocytoma resulting from tattoo;
Cutaneous lymphocytoma after Herpes zoster;
Idiopathic forms;
Clonal cutaneous B-cell pseudolymphomas
Compilation of syndromes for last minute revision tips for neet pg, usmle , p...Abhishek Gupta
A compilation of most commonly asked syndromes in various exams like NEET PG , PLAB, USMLE, FMGE (MCI Screening Exams) for learning as well as last minute revision.
Previous year question on osteoporosis based on neet pg, usmle, plab and fmge...Abhishek Gupta
Revision with a Master Quiz of 38 questions based on NEET PG Sample Questions on Osteoporosis from Previous Year NEET PG Online Exams.
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
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Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
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Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
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ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Previous year question on lichen planus based on neet pg, usmle, plab and fmge or mci screening exams
1. A 5 year old male child has multiple hyperprigmented macules over the trunk. On rubbing
the lesion with the rounded end of a pen, he developed urticarial wheal, confined to the
border of the lesion. The most likely diagnosis is:
A: Lichen planus
B: Fixed drug eruption
C: Urticaria pigmentosa
D: Urticarial vasculitis
Correct Ans:C
Explanation
Patient is showing features of urticaria pigmentosa. It is a condition caused by an increase
in the number of dermal mast cells. Children presents with brownish dermal papules and
plaques distributed over the body. On rubbing, these plaques become urticated (Darier’s
sign). Symptoms are due to the release of histamines.
Ref: Color Handbook of Dermatology By R. Rycrof, Pages 33, 34; Field guide to clinical
dermatology By David H. Frankel, 2nd Edition, Page 59
3. A Practical Guide to Pediatric Emergency Medicine: Caring for Children By N. Ewen
Amieva-Wang, Page 135
Sample Previous Year Question on Lichen Planus based on previous Year
Questions of NEET PG, USMLE,PLAB,FMGE (MCI Screening). Please visit
www.medicoapps.org for more such Quizzes
Pseudo-isomorphic phenomenon is seen in:
A: Psoriasis
B: Lichen planus
C: Vitiligo
D: Plane warts
Correct Ans:D
Explanation
Pseudo-isomorphic phenomenon is seen in infections like plane warts, molluscum contagiosum and
eczematous lesions. Whereas, psoriasis, lichen planus and vitiligo are all associated with Isomorphic
phenomenon instead, and not with pseudoisomorphic phenomenon.
Ref: Pocket atlas of dermatology, By Gerd Klaus Steigleder, Howard I. Maibach, Page 171.
2. Sample Previous Year Question on Lichen Planus based on previous Year
Questions of NEET PG, USMLE,PLAB,FMGE (MCI Screening). Please visit
www.medicoapps.org for more such Quizzes
Which of the following is a secondary cutaneous diseases?
A: Ichthyosis
B:
Psoriasi
s
C: Lichen planus
D: Reiter's disease
Correct Ans:D
Explanation
The skin involvement is secondary in Reiter’s disease which is primarily characterised by
arthritis, urethritis and uveitis. While psoriasis, lichen planus and icthyosis exhibit
dermatological manifestations as their primary clinical features.
Ref: Harrison’s Textbook of Internal Medicine, 17th Edition, Page 2174; Inherited Metabolic
Diseases: A Clinical Approach By Georg F. Hoffmann, Johannes Zschocke, William L. Nyhan,
Pages 204-205; Psoriasis and Psoriatic Arthritis: An Integrated Approach By Kenneth B.
Gordon, Eric M. Ruderman, Pages 23-26, 67-72
Sample Previous Year Question on Lichen Planus based on previous Year
Questions of NEET PG, USMLE,PLAB,FMGE (MCI Screening). Please visit
www.medicoapps.org for more such Quizzes
Physical examination on a 65-year-old man with mild congestive heart failure reveals
varicose veins, ankle edema, and inflammation of much of the skin near the ankles of both
legs. The affected skin exhibits edema, erythema, mild scaling, and brown discoloration.
The edges of skin involvement are poorly defined. On one ankle, a one centimeter diameter
ulcerated area is seen within the erythematous area. The patient says that his leg lesions
look much worse than they feel. Which of the following is the most likely diagnosis?
A: Atopic dermatitis
B: Lichen simplex chronicus
C: Stasis dermatitis
D: Seborrheic dermatitis
Correct Ans:C
Explanation
3. This is stasis dermatitis, which is a common complication of chronic lower leg edema,
typically due to either congestive heart failure, venous incompetence, or both. The
condition may be neglected by both the patient and the physician because of its relative
lack of symptoms. However, it should be taken seriously because once skin breakdown
occurs, the resulting ulcer may be very difficult to treat successfully. Helpful measures in
the treatment of stasis dermatitis include elevating the ankles above the heart, properly
fitted support hose, and tap water compresses. Ulcers are treated with compresses and
bland dressings. Oral antibiotics are used when an ulcer becomes infected.
Atopic dermatitis is an itchy inflammation of the skin that appears to have an allergic basis.
Lichen simplex chronicus can also involve the ankles, but the lesion is very itchy, tends to
be relatively localized, and is not typically accompanied by ankle edema.
Seborrheic dermatitis causes diffuse scaling (dandruff) of the scalp.
Ref: Suurmond D. (2009). Section 16. Skin Signs of Vascular Insufficiency. In D. Suurmond
(Ed), Fitzpatrick's Color Atlas & Synopsis of Clinical Dermatology , 6e.
Sample Previous Year Question on Lichen Planus based on previous Year
Questions of NEET PG, USMLE,PLAB,FMGE (MCI Screening). Please visit
www.medicoapps.org for more such Quizzes
Koebner's phenomenon is seen in all of the following conditions, EXCEPT:
A: Lichen planus
B:
Ichthyosi
s
C: Psoriasis
D: Pemphigus
Correct Ans:B
Explanation
Koebner’s phenomenon refers to development of morphologically identical lesions in the
traumatized uninvolved skin of the patients who have cutaneous diseases. It is also known
as isomorphic phenomenon.
Conditions associated with Koebner’s phenomenon are:
Warts
Molluscum contagiosum
Autoimmune (vitiligo)
Psoriasis
Pemphigus
Lichen planus
Ref: An Aid to the MRCP: Essential Lists, Facts and Mnemonics By Nicholas Boeckx, page
184.
4. Sample Previous Year Question on Lichen Planus based on previous Year
Questions of NEET PG, USMLE,PLAB,FMGE (MCI Screening). Please visit
www.medicoapps.org for more such Quizzes
Which of the following condition is associated with the development of photosensitive rash?
A: Acute intermittent porphyria
B: Erythropoietic protoporphyria
C: Leprosy
D: Lichen planus
Correct Ans:B
Explanation
Erythropoietic porphyria is the most common childhood porphyria. Children with this
condition after brief sun exposure presents with acute discomfort, burning sensation, and
red painful photosensitive rash. This is an autosomal dominant condition resulting in
reduced ferrochelatase activity in peripheral blood, liver, bone marrow and skin.
Acute intermittent porphyria is an autosomal dominant disorder caused by deficiency
of porphobilinogen deaminase. Patients often presents with abdominal pain, anorexia,
vomiting and constipation 70% of patients develops polyneuropathy and is more often
motor than sensory.
Ref: Medicine and Surgery: An integrated textbook With STUDENT CONSULT online access
By Eric KS Lim
Sample Previous Year Question on Lichen Planus based on previous Year
Questions of NEET PG, USMLE,PLAB,FMGE (MCI Screening). Please visit
www.medicoapps.org for more such Quizzes
A 36-year-old factory worker developed itchy, annular scaly plaques in both groins.
Application of a corticosteroid ointment led to temporary relief but the plaques continued to
extend at the periphery. The most likely diagnosis is:
A: Erythema annulare centrifugum
B:
Granuloma
annulare
C: Annular lichen planus
D: Tinea cruris
Correct Ans:D
Explanation
Tinea cruris is dermatophytic infection of groin. Presence of bilateral annular scaly plaques
in the groin, itching and unresponsiveness to steroids and peripheral extension leads to
5. diagnosis of Tinea cruris.
Ref: Anthony Du Vivier, Phillip H. McKee, Chapter 15, “Superficial Fungal Infections”, In the
book, “Atlas of Clinical Dermatology”, Elsivier Publication, 2002, 3rd Edition, Spain, Page
320
Sample Previous Year Question on Lichen Planus based on previous Year
Questions of NEET PG, USMLE,PLAB,FMGE (MCI Screening). Please visit
www.medicoapps.org for more such Quizzes
A 30 year old male presents with a creamy white patch on the tongue. The most probable
diagnosis is:
A: Candidiasis
B: Histoplasmosis
C: Lichen Planus
D: Aspergillosis
Correct Ans:A
Explanation
Candidal stomatitis or oral thrush is the presence of a curdy white pseudomembrane on the
buccal, labial, tongue, gingival or palatal mucosa in otherwise healthy individuals.
Ref: Skin Diseases and Sexually Transmitted Infection, Uday Khopkar, 6th Eidition, Page 61;
Harrison’s Principles of Internal Medicine, 16th Edition, Page 183, 188.
Sample Previous Year Question on Lichen Planus based on previous Year
Questions of NEET PG, USMLE,PLAB,FMGE (MCI Screening). Please visit
www.medicoapps.org for more such Quizzes
Which of the following is a Tuberculid infection that is characterized by involvement of the
sweat glands and hair follicles by causing non caseating epitheloid granulomas?
A: Lupus Vulgaris
B: Papulonecrotic Type
C: Miliary Tuberculosis
D: Lichen Scrofulosorum
Correct Ans:D
Explanation
6. In the above given condition, the presence of non-caseating epethelioid granulomas which
are localized around the hair follicles and sweat ducts, definitely points the diagnosis
towards “Lichen Scrofulosorum”. Lichen Scrofulosorum is the most common form of
tuberculid infection. Papulonecrotic tuberculid infection often presents with central necrosis
but are not typically localized to the hair follicles and sweat ducts.
Miliary tuberculosis and Lupus vulgaris are not Tuberculid infections.
Ref: Skin Pathology By Weedon and Strutton, 2nd Edition, Page 627; Mycobacterial Skin
Diseases By Harahap, 1989, Pages 26-27; Atlas of Dermatology in Internal Medicine By
Néstor P. Sánchez, 1st Edition, Pages 23-26
Sample Previous Year Question on Lichen Planus based on previous Year
Questions of NEET PG, USMLE,PLAB,FMGE (MCI Screening). Please visit
www.medicoapps.org for more such Quizzes
The lichenoid eruption known as 'Tuberculids' are seen in which of the skin conditions?
A: Lupus vulgaris
B:
Scrofuloderm
a
C: Lichen scrofulosorum
D: Tuberculosis Cutis Orificialis
Correct Ans:C
Explanation
Lichen scrofulosorum (also known as "Tuberculosis cutis lichenoides") is a rare tuberculid
that presents as a lichenoid eruption of minute skin-colored to reddish-brown papules,
often perifollicular and are mainly found on the abdomen, chest, back, and proximal parts of
the limbs. The eruption is usually associated with a strongly positive tuberculin reaction.
Ref: Lee's Dermatology 12th Edition, Page 592; Mycobacterial Skin Diseases By Marwali
Harahap, 1989, Page 27
Sample Previous Year Question on Lichen Planus based on previous Year
Questions of NEET PG, USMLE,PLAB,FMGE (MCI Screening). Please visit
www.medicoapps.org for more such Quizzes
Which of the following drugs is used in generalised lichen planus?
A: Systemic steroids
B:
Dapson
e
C: Both Dapsone & Systemic steroids
7. D: Methotrexate
Correct Ans:C
Explanation
A combination therapy with steroids and Dapsone gives a better result than 1 drug used alone.
Sample Previous Year Question on Lichen Planus based on previous Year
Questions of NEET PG, USMLE,PLAB,FMGE (MCI Screening). Please visit
www.medicoapps.org for more such Quizzes
A 5 year old male child has multiple hyperprigmented macules over the trunk. On rubbing
the lesion with the rounded end of a pen, he developed urticarial wheal, confined to the
border of the lesion. The most likely diagnosis is:
A: Lichen planus
B: Fixed drug eruption
C: Urticaria pigmentosa
D: Urticarial vasculitis
Correct Ans:C
Explanation
Patient is showing features of urticaria pigmentosa. It is a condition caused by an increase
in the number of dermal mast cells. Children presents with brownish dermal papules and
plaques distributed over the body. On rubbing, these plaques become urticated (Darier’s
sign). Symptoms are due to the release of histamines.
Ref: Color Handbook of Dermatology By R. Rycrof, Pages 33, 34; Field guide to clinical
dermatology By David H. Frankel, 2nd Edition, Page 59
3. A Practical Guide to Pediatric Emergency Medicine: Caring for Children By N. Ewen
Amieva-Wang, Page 135
Sample Previous Year Question on Lichen Planus based on previous Year
Questions of NEET PG, USMLE,PLAB,FMGE (MCI Screening). Please visit
www.medicoapps.org for more such Quizzes
A 25 year old male presents with multiple erythematous annular plaques with peripheral
collarette of scales arranged predominantly over trunk. What is the most probable
diagnosis?
A: Pityriasis versicolor
B: Pityriasis rubra pilaris
8. C: Pityriasis rosea
D: Pityriasis lichenoides chonica
Correct Ans:C
Explanation
Pityriasis Rosea is a self limiting papulosquamous dermatoses of unknown aetiology characterised by
Herald patch, annular plaque with peripheral collarette of scales on the trunk and secondary lesions
arranged in Christmas tree/fir tree appearance. Treatment is usually symptomatic. It resolves in about
8-10 weeks.
Ref: Illustrated Synopsis of Dermatology and STD’s By Neena Khanna, Pages 50-51
Sample Previous Year Question on Lichen Planus based on previous Year
Questions of NEET PG, USMLE,PLAB,FMGE (MCI Screening). Please visit
www.medicoapps.org for more such Quizzes
Wickham's striae are seen in:
A: Lichen nitidus
B: Lichenoid eruption
C: Lichen striatus
D:
Lichen
planus
Correct Ans:D
Explanation
Lichen planus is a self limiting condition in which flat topped violaceous papules are seen
on the flexor aspect of the body. Wickham's striae are white streaks seen on the lesions
especially when viewed with magnifying lens.
Ref: Illustrated Synopsis of Dermatology and STD’s By Neena Khanna, Page 55
Sample Previous Year Question on Lichen Planus based on previous Year
Questions of NEET PG, USMLE,PLAB,FMGE (MCI Screening). Please visit
www.medicoapps.org for more such Quizzes
Which of the following disorders is associated with pterygium of nails?
A: Psoriasis
9. B: Lichen planus
C: Tinea unguium
D: Alopecia areata
Correct Ans:B
Explanation
When Lichen planus affects the nails, it causes scarring of the nail bed with early nail
ridging and splitting later leading to pterygium formation. Pterygium of nail is scarring from
the base of the nail outward in a V formation, which leads to loss of nail.
Nail changes in psoriasis includes presence of irregular pits, oil spots, separation of nail
plate from its bed, thickening and crumbling of nail plate. People with alopecia areata
people have regular nail pits that form a pattern.
Ref: Harrison’s Principles of Internal Medicine, 18th Edition, Chapter 52; The Merck Manual
Home Health Handbook By Merck; The Landscape Makeover Book By Sara Jane Von Trapp,
Page 122.
Sample Previous Year Question on Lichen Planus based on previous Year
Questions of NEET PG, USMLE,PLAB,FMGE (MCI Screening). Please visit
www.medicoapps.org for more such Quizzes
A young lady presents with white lacy lesions in oral cavity and her proximal nail fold has
extended onto the nail bed. What is the likely diagnosis?
A: Candidiasis
B:
Psoriasi
s
C: Geographic tongue
D: Lichen planus
Correct Ans:D
Explanation
Presence of lacy lesions in the oral cavity and nails with pterygium suggests a diagnosis of
Lichen Planus in this patient.
It commonly affects young adults. The characteristic skin lesion is pruritic,plane topped,
polygonal, purplish papule covered with scanty scales. Buccal mucosa, lips and genitalia are
commonly involved. Treatment includes antihistaminics for pruritus and topical steroids for
localised lesions. Systemic steroids may be given for widespread disease after ruling out
contraindications.
Ref: Skin Diseases and Sexually Transmitted Infection, Uday Khopkar, 6th Edition, Pages
124, 119, 58; Clinical Outline of Oral Pathology : Diagnosis and Treatment By Lewis R.
Eversole, Page 56
10. Sample Previous Year Question on Lichen Planus based on previous Year
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All of the following have non-scarring alopcia, EXCEPT:
A: T. capitis
B: Androgenic alopecia
C: Alopecia areata
D: Lichen planus
Correct Ans:D
Explanation
Lichen planus - Lichen Planus is a muco-cutaneous disease of immunological origin. It leads
to a characteristic pruritic, papular, violaceous eruption of polygonal shape and is often
covered with fine scales. Lichen planus most commonly leads to thick patchy rough, scaly
skinthat develops on the flexor surfaces of the upper extremities, around the ankles, in the
genital region genitalia, and on the mucous membranes and is itchy in nature. It causes
scarring alopecia leading permanent hair damage.
Taenia capitis - It is a fungal dermatophyte infection of the scalp and hair caused especially
by the Trichophyton and Microsporum. It causes contagious non-scarring alopecia. It
causes inflammatory lesions such as pustules, scaling and itching. The hallmark of
diagnosis is patches of hair loss with a “black-dot” pattern on examination. The clinical
diagnosis is confirmed by mycological examination.
Androgenic alopecia - It is an autosomal dominant disorder which is the most common
cause of alopecia in both men and women. It causes miniaturisation of the hair follicles
which is androgen dependent and caused by scalp dihydrotestosterone. There is a typical
shortening of the hair cycle leading to increased numbers of anagen hairs entering the
telogen phase and thus leading to premature hair fall. It leads to scarring alopecia.
Alopecia areata - It is a inflammatory non-scarring alopecia of auto-immune origin. There is
a inappropriate immune response due to the hair follicle associated antigens. The patient
presents with well - demarcated patches of reversible hair loss. Histologically there is a
typical peribulbar lymphocyte infiltration. The disturbance of hair shaft growth leads to
characteristic exclamation point hairs which is the hallmark for diagnosis.
Ref: Textbook of Cosmetic Dermatology By Robert Baran, 3rd Edition, Page 561; The Manual
of Dermatology By Jennifer A. Cafardi, Page 15-64; Aging Hair By Ralph M. Trüeb, Desmond
J. Tobin, Pages 201-202; Evidence-Based Dermatology By Hywel Williams, Pages 386-387
Sample Previous Year Question on Lichen Planus based on previous Year
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11. Peripheral 'Collarette of scales' is a feature of:
A: P. rosea
B: P.veriscolor
C: Lichen planus
D: Pityriasis rubra pilaris
Correct Ans:A
Explanation
Clinical features of Pityriasis rosea is the rash which consists of circular or oval pink macules with a
‘collarette of scale’ and is more prominent on the trunk than on the limbs.
Ref: Kumar and Clark's Clinical Medicine by Parveen June Kumar, Michael L. Clark, Elsevier Saunders,
2005, Page 1335; Thieme Clinical Companions Dermatology By Wolfram Sterry, Walter Burgdorf, Ralf
Paus, 2006, Pages 279-280
Sample Previous Year Question on Lichen Planus based on previous Year
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Itching associated with linear IgA deposition in dermal papillae is a feature of:
A: Bullous disease of childhood
B:
Lichenoid bullous
disease
C: Dermatitis herpetiformis
D: Pemphigus vulgaris
Correct Ans:C
Explanation
The cutaneous lesions of Dermatitis herpetiformis (DH) in childhood resemble those in adult and are
severely pruritic papulovesicles. DH is associated with granular deposition of IgA antibody within the
dermal papillae.
Ref: Cambridge Textbook of Accident and Emergency Medicine edited by David V. Skinner, Andrew
Swain, Colin Robertson, J. W. Rodney Peyton, 1997, Page 1051
Sample Previous Year Question on Lichen Planus based on previous Year
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12. A young male presented with scaly truncal lesions. O/E genital lesions along with oral 'lace-
like' lesions are seen. The most likely diagnosis is:
A: Lichen planus
B:
Psoriasi
s
C: Secondary syphilis
D: Behcet's disease
Correct Ans:A
Explanation
In oral lichen planus, the characteristic lesions are white striae or papules forming a reticular lace like
pattern on the buccal mucosa or lateral margins of the tongue, often with a bilaterally symmetrical
distribution.
Ref: Principles and Practice of Geriatric Medicine edited by M.S. John Pathy, Alan J. Sinclair, John E.
Morley, 2006, Page 265
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Scenario: Maliya was diagnosed with Lichen Planus after suffering with flat topped
polygonal papules which retains the skin lines.
Assertion: Wickham’s striae are white lines which traverse the surface of the papules.
Reason: A focal decrease in thickness of the granular layer and infiltrate corresponds to the presence
of Wickham’s striae.
A: Both Assertion and Reason are true, and Reason is the correct explanation for Assertion
B:
Both Assertion and Reason are true, and Reason is not the
correct explanation for Assertion
C: Assertion is true, but Reason is false
D: Assertion is false, but Reason is true
Correct Ans:C
Explanation
LP is characterized by shiny, violaceous, flat-topped polygonal papules which retain the
skin lines. Wickham’s striae are white lines which traverse the surface of the papules. A
focal increase in thickness of the granular layer and infiltrate corresponds to the presence
of Wickham’s striae.
13. Reference:
Rook’s Textbook of Dermatology, 8th Edition
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All of the following conditions are a differential diagnosis for Koebner Phenomenon,
EXCEPT:
A: Lichen planus
B:
Vitilig
o
C: Pyoderma gangrenosum
D: Leukocytoclastic vasculitis
Correct Ans:C
Explanation
Heinrich Koebner in the late nineteenth century, first described the Koebner phenomenon in
patients with Psoiriasis. It refers to the development of skin lesions after minor traumatic
insult. Koebnerization involves the development of lesions characteristic to an underlying
disorder.
Koebner phenomenon occurs in 25% of patients with psoriasis, often resulting from mild
trauma such as a sunburn or scratch.
Lichen planus, vitiligo, and leukocytoclastic vasculitis also demonstrate the Koebner
phenomenon.
Note: The lesions that appear after a trauma in Pyoderma gangrenosum are Pathergy, not
Koebner.
Ref: Tan J.K., Vleugels R.A. (2012). Chapter 147. Dermatologic Findings in Systemic
Disease. In S.C. McKean, J.J. Ross, D.D. Dressler, D.J. Brotman, J.S. Ginsberg (Eds),
Principles and Practice of Hospital Medicine.
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14. Which of the following skin conditions is treated with PUVA therapy?
A: Psoriasis
B: Tinea versicolor
C: Lichen planus
D: Porphyria cutanea tarda
Correct Ans:A
Explanation
PUVA is used to treat extensive psoriasis and psoriasis that has not responded to other
therapies. PUVA stands for psoralens plus UVA. Psoralens are used orally followed by
exposure of lesions to measured amount of a type of ultraviolet light-UVA.
Short term side effects of PUVA therapy include tanning, pruritus, nausea, headache and
dizziness. Long term side effects include cataracts, lentigines, photoaging, squamous cell
carcinoma and melanoma.
Ref: Step by Step® Psoriasis Management By Khanna Neena, page 283. Manual of
Dermatologic Therapeutics By Kenneth A. Arndt page 262.
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A woman presents to a dermatologist because she has lost almost all the hair on her body,
including scalp hair, eyebrows, eyelashes, armpit and groin hair, and the fine hairs on her
body and extremities. She most likely has a variant of which of the following?
A: Alopecia areata
B: Androgenic alopecia
C: Chronic cutaneous lupus erythematosus
D: Lichen planopilaris
Correct Ans:A
Explanation
Alopecia areata is caused by an autoimmune attack on hair follicles. It has a wide range of
clinical severity, with most cases involving a localized patch of hair (which regrows within 1
year in half of the patients). The hair that does regrow may be gray or depigmented. More
severe cases can involve the entire scalp (alopecia totalis) or, as in this patient, the entire
body surface (alopecia universalis). These more severe cases are less likely to resolve
adequately. Treatment of alopecia areata is often unsuccessful, but topical steroids are
typically tried.
Androgenic alopecia is common male pattern baldness.
15. Chronic cutaneous lupus erythematosus can produce localized baldness. Lichen
planopilaris can produce localized baldness.
Ref: Landthaler M., Bäumler W., Hohenleutner U. (2012). Chapter 239. Lasers and
Flashlamps in Dermatology. In K. Wolff (Ed), Fitzpatrick's Dermatology in General Medicine,
8e.
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A patient presents with scarring Alopecia, thinned nails, hypopigmented macular lesions
over trunk and oral mucosa. The diagnosis is :
A: Psoriasis
B:
Lepros
y
C: Lichen planus
D: Pemphigus
Correct Ans:C
Explanation
Lichen planus (LP) is a papulosquamous disorder that may affect the skin, scalp, nails, and
mucous membranes. The primary cutaneous lesions are pruritic, polygonal, flat-topped,
violaceous papules. Close examination of the surface of these papules often reveals a
network of gray lines (Wickham's striae). The skin lesions may occur anywhere but have a
predilection for the wrists, shins, lower back, and genitalia. Involvement of the scalp, lichen
planopilaris, may lead to scarring alopecia, and nail involvement may lead to permanent
deformity or loss of fingernails and toenails. LP commonly involves mucous membranes,
particularly the buccal mucosa, where it can present a spectrum of disease from a mild,
white, reticulate eruption of the mucosa, to a severe, erosive stomatitis. Erosive stomatitis
may persist for years and may be linked to an increased risk of oral squamous cell
carcinoma.
Ref: Harrison's Internal Medicine;Part 2. Cardinal Manifestations and Presentation of
Diseases ;Section 9. Alterations in the Skin ;Chapter 53. Eczema, Psoriasis, Cutaneous
Infections, Acne, and Other Common Skin Disorders-Eczema and Dermatitis
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A patient presents with scarring Alopecia, thinned nails, hypopigmented macular lesions
over trunk and oral mucosa. The diagnosis is:
16. A: Psoriasis
B:
Lepros
y
C: Lichen planus
D: Pemphigus
Correct Ans:C
Explanation
Lichen planus (LP) is a papulosquamous disorder that may affect the skin, scalp, nails, and
mucous membranes. The primary cutaneous lesions are pruritic, polygonal, flat-topped,
violaceous papules. Close examination of the surface of these papules often reveals a
network of gray lines (Wickham's striae). The skin lesions may occur anywhere but have a
predilection for the wrists, shins, lower back, and genitalia. Involvement of the scalp, lichen
planopilaris, may lead to scarring alopecia, and nail involvement may lead to permanent
deformity or loss of fingernails and toenails. LP commonly involves mucous membranes,
particularly the buccal mucosa, where it can present a spectrum of disease from a mild,
white, reticulate eruption of the mucosa, to a severe, erosive stomatitis. Erosive stomatitis
may persist for years and may be linked to an increased risk of oral squamous cell
carcinoma.
Ref: Harrison's Internal Medicine;Part 2. Cardinal Manifestations and Presentation of
Diseases ;Section 9. Alterations in the Skin ;Chapter 53. Eczema, Psoriasis, Cutaneous
Infections, Acne, and Other Common Skin Disorders-Eczema and Dermatitis.
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Photochemotherapy is useful in :
A: Pityriasis rosea
B:
Psoriasi
s
C: Lichen planus
D: Ichthyosis vulgaris
Correct Ans:B
Explanation
Photochemotherapy is useful in Psoriasis.Phototherapy and photochemotherapy are
treatment methods in which UV or visible radiation is used to induce a therapeutic response
either alone or in the presence of a photosensitizing drug. Orally administered 8-
methoxypsoralen followed by UVA (PUVA) is FDA approved for the treatment of vitiligo and
psoriasis.
17. Ref :Burkhart C., Morrell D., Goldsmith L. (2011). Chapter 65. Dermatological
Pharmacology. In B.C. Knollmann (Ed), Goodman & Gilman's The Pharmacological Basis of
Therapeutics, 12e.
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All are SLE associated rashes, EXCEPT:
A: Recurring urticaria
B: Lichen planus–like dermatitis
C: Llupus profundus
D: Lichen plannus pigmentosus
Correct Ans:D
Explanation
Lupus dermatitis can be classified as
1. Discoid lupus erythematosus (DLE),
2. Systemic rash
3. Subacutecutaneous lupus erythematosus (SCLE)
Discoid skin lesions
Circular with slightly raised, scaly hyperpigmented erythematous rims and depigmented
with atrophic centers.
Disfiguring, particularly on the face and scalp.
Treatment -topical or locally injected glucocorticoids and systemic antimalarials.
The most common SLE rash is a photosensitive, slightly raised erythema, scaly, on the face,
ears, chin, V region of the neck and chest, upper back, and extensor surfaces of the arms.
Other SLE rashes are:
Recurring urticaria,
Lichen planus–like dermatitis
Bullae
Llupus profundus
Ref: Harrison, E-18, P-2734.
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All are causes which predisposes to S.aureus infection, EXCEPT:
18. A: Eczema
B: Insect bite
C: Lichen planus
D: Injections especially insulin
Correct Ans:C
Explanation
S. aureus Skin infections:
Factors predisposing to S. aureus cutaneous infection include chronic skin conditions
Eczema
Skin damage e.g., insect bites, minor trauma
Injections (e.g., in diabetes, injection drug use)
Poor personal hygiene.
MUST KNOW:
Folliculitis is a superficial infection involving the hair follicle, with a central area of
purulence surrounded by induration and erythema.
Furuncles are extensive, painful lesions that tend to occur in hairy, moist regions of the
body to become a true abscess with an area of central purulence.
Carbuncles are often located in the lower neck and are more severe and painful, resulting
from the coalescence of other lesions that extend to a deeper layer of the subcutaneous
tissue.
Mastitis develops in 1–3% of nursing mothers. It generally presents within 2–3 weeks after
delivery, It range from cellulitis to abscess formation.
ALSO KNOW:
Other cutaneous S. aureus infections are impetigo, cellulitis, and hidradenitis suppurativa .
Ref: Harrison, Edition-18, Page-1163.
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