Epidermolysis Bullosa
•Download as PPT, PDF•
18 likes•10,829 views
Epidermolysis bullosa (EB) is a genetic disorder that causes painful blistering of the skin and mucous membranes. There are three main types that vary in severity from very mild to life-threatening. The blisters are caused by minor friction or trauma to the skin. While there is no cure, treatment focuses on wound care, pain management, and preventing infections. EB affects about 1 in 50,000 births and support groups provide community for affected individuals and families.
Report
Share
Report
Share
![Description of EB ,[object Object],[object Object],[object Object]](data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7)
Recommended
Epidermolysis bullosa complete
Epidermolysis bullosa (EB) is a group of genetic skin disorders characterized by skin fragility and blistering from minor mechanical trauma. There are several types of EB including EB simplex, junctional EB, dystrophic EB, and Kindler syndrome. The diagnosis is based on the level within the skin that blistering occurs, as determined by immunofluorescence mapping and transmission electron microscopy of a skin biopsy. EB is managed by avoiding blistering through protective padding, preventing infection of wounds, and treating specific complications involving the eyes, esophagus, hands/feet, and risk of skin cancers in some severe types.
Epidermolysis bullosa
This document provides information on inherited epidermolysis bullosa (EB), a group of genetic disorders that result in fragile skin and blistering. It discusses the three major types of EB - simplex, junctional, and dystrophic - defined by the level at which blistering occurs. For each type, it describes the genetic mutations involved, characteristic clinical features, inheritance patterns, and differentiation from other conditions. Major components of the dermal-epidermal junction are also outlined, where blistering occurs in junctional EB.
Epidermolysis bullosa
Epidermolysis bullosa (EB) is a group of inherited connective tissue diseases that cause fragile, blistering skin. It results from a genetic defect causing a lack of protein anchors between the epidermis and dermis layers of the skin. This causes blistering from even minor friction or trauma. EB ranges in severity from mild to life-threatening. There are three main types - epidermolysis bullosa simplex, junctional epidermolysis bullosa, and dystrophic epidermolysis bullosa - classified based on the genetic mutations and level within the skin that blistering occurs. Treatment aims to improve wound healing and research is investigating therapies like bone marrow transplants and keratin
Ehlers-Danlos syndromes(EDS)
This document describes Ehlers-Danlos syndrome (EDS), a hereditary connective tissue disorder that affects the skin, joints, and blood vessel walls. It discusses the classification, signs and symptoms, and management of EDS. The patient case involves a 22-year-old female with vascular type EDS who presents with severe abdominal pain. Her treatment includes pain medications, antibiotics, gastric protection, and monitoring for complications related to her condition.
Lupus erythematosus. Slide Share
Lupus erythematosus (LE) is an autoimmune connective tissue disorder that can affect one or several organs. Circulating autoantibodies and immune complexes are due to loss of normal immune tolerance and are pathogenic. Clinical features of LE are highly variable. LE nearly always affects the skin to some degree.
Ectodermal dysplasia
Ectodermal dysplasia is a genetic condition characterized by abnormal development of structures derived from embryonic ectoderm such as hair, teeth, nails and sweat glands. The most common types are hypohidrotic (anhidrotic) and hydrotic ectodermal dysplasia. Symptoms include sparse hair, abnormal nails, missing or malformed teeth, lack of sweat glands and dry skin prone to infection. Treatment focuses on dental care, temperature regulation, artificial tears and infection prevention. The condition is caused by mutations in genes controlling ectodermal development and can be diagnosed through clinical features, imaging and genetic testing.
Behcet's disease
Behcet's disease is a chronic, relapsing inflammatory disease that causes blood vessel inflammation throughout the body. It is characterized by oral and genital ulcers, eye inflammation, skin lesions, and joint, gastrointestinal, and neurological symptoms. The cause is unknown but involves genetic and environmental factors. It is associated with genes related to immune function like HLA-B51. Symptoms typically begin in the 3rd or 4th decade of life and affect males more than females. Diagnosis is based on recurrent oral and genital ulcers along with other clinical features. Treatment focuses on reducing inflammation and symptoms.
Ichthyosis
Ichthyoses are a group of inherited skin disorders characterized by excessive scaling of the skin. The primary ichthyoses include ichthyosis vulgaris, X-linked ichthyosis, and lamellar ichthyosis. Ichthyosis vulgaris is the most common and mildest form, inherited in an autosomal dominant pattern. X-linked ichthyosis only affects males and is caused by steroid sulfatase deficiency. Lamellar ichthyosis is a severe form present at birth that involves the entire skin surface. Treatment focuses on moisturization and keratolytic agents with systemic retinoids for more severe forms.
Recommended
Epidermolysis bullosa complete
Epidermolysis bullosa (EB) is a group of genetic skin disorders characterized by skin fragility and blistering from minor mechanical trauma. There are several types of EB including EB simplex, junctional EB, dystrophic EB, and Kindler syndrome. The diagnosis is based on the level within the skin that blistering occurs, as determined by immunofluorescence mapping and transmission electron microscopy of a skin biopsy. EB is managed by avoiding blistering through protective padding, preventing infection of wounds, and treating specific complications involving the eyes, esophagus, hands/feet, and risk of skin cancers in some severe types.
Epidermolysis bullosa
This document provides information on inherited epidermolysis bullosa (EB), a group of genetic disorders that result in fragile skin and blistering. It discusses the three major types of EB - simplex, junctional, and dystrophic - defined by the level at which blistering occurs. For each type, it describes the genetic mutations involved, characteristic clinical features, inheritance patterns, and differentiation from other conditions. Major components of the dermal-epidermal junction are also outlined, where blistering occurs in junctional EB.
Epidermolysis bullosa
Epidermolysis bullosa (EB) is a group of inherited connective tissue diseases that cause fragile, blistering skin. It results from a genetic defect causing a lack of protein anchors between the epidermis and dermis layers of the skin. This causes blistering from even minor friction or trauma. EB ranges in severity from mild to life-threatening. There are three main types - epidermolysis bullosa simplex, junctional epidermolysis bullosa, and dystrophic epidermolysis bullosa - classified based on the genetic mutations and level within the skin that blistering occurs. Treatment aims to improve wound healing and research is investigating therapies like bone marrow transplants and keratin
Ehlers-Danlos syndromes(EDS)
This document describes Ehlers-Danlos syndrome (EDS), a hereditary connective tissue disorder that affects the skin, joints, and blood vessel walls. It discusses the classification, signs and symptoms, and management of EDS. The patient case involves a 22-year-old female with vascular type EDS who presents with severe abdominal pain. Her treatment includes pain medications, antibiotics, gastric protection, and monitoring for complications related to her condition.
Lupus erythematosus. Slide Share
Lupus erythematosus (LE) is an autoimmune connective tissue disorder that can affect one or several organs. Circulating autoantibodies and immune complexes are due to loss of normal immune tolerance and are pathogenic. Clinical features of LE are highly variable. LE nearly always affects the skin to some degree.
Ectodermal dysplasia
Ectodermal dysplasia is a genetic condition characterized by abnormal development of structures derived from embryonic ectoderm such as hair, teeth, nails and sweat glands. The most common types are hypohidrotic (anhidrotic) and hydrotic ectodermal dysplasia. Symptoms include sparse hair, abnormal nails, missing or malformed teeth, lack of sweat glands and dry skin prone to infection. Treatment focuses on dental care, temperature regulation, artificial tears and infection prevention. The condition is caused by mutations in genes controlling ectodermal development and can be diagnosed through clinical features, imaging and genetic testing.
Behcet's disease
Behcet's disease is a chronic, relapsing inflammatory disease that causes blood vessel inflammation throughout the body. It is characterized by oral and genital ulcers, eye inflammation, skin lesions, and joint, gastrointestinal, and neurological symptoms. The cause is unknown but involves genetic and environmental factors. It is associated with genes related to immune function like HLA-B51. Symptoms typically begin in the 3rd or 4th decade of life and affect males more than females. Diagnosis is based on recurrent oral and genital ulcers along with other clinical features. Treatment focuses on reducing inflammation and symptoms.
Ichthyosis
Ichthyoses are a group of inherited skin disorders characterized by excessive scaling of the skin. The primary ichthyoses include ichthyosis vulgaris, X-linked ichthyosis, and lamellar ichthyosis. Ichthyosis vulgaris is the most common and mildest form, inherited in an autosomal dominant pattern. X-linked ichthyosis only affects males and is caused by steroid sulfatase deficiency. Lamellar ichthyosis is a severe form present at birth that involves the entire skin surface. Treatment focuses on moisturization and keratolytic agents with systemic retinoids for more severe forms.
vesiculobullous lesions, pempigus ppt
This document describes different types of vesiculobullous diseases classified according to the Fitzpatrick system based on the anatomical level of blister formation. It discusses conditions such as pemphigus vulgaris, pemphigus vegetans, pemphigus foliaceus, paraneoplastic pemphigus, bullous pemphigoid, cicatricial pemphigoid, and familial benign pemphigus. For each condition, it provides details on pathogenesis, clinical features, histopathology, immunopathology, and oral manifestations when present.
Genetic epidermolysis bullosa
This document provides an overview of genetic epidermolysis bullosa (EB), a group of inherited skin fragility disorders characterized by blistering of the skin from mild mechanical trauma. It defines the major types of EB - simplex, junctional, and dystrophic - based on the level in the skin where blistering occurs. For each type, it describes clinical features, molecular pathology, specific subtypes, management considerations, and prognosis. The document emphasizes EB is a genetically determined condition caused by mutations impacting proteins important for skin integrity.
Erythema multiforme, Steven-Johnson syndrome and Toxic Epidermal Necrolysis
Erythema Multiforme is a common Vesiculobullous deramtological condition with mucosal manifestations trigged by Herpes virus infection and certain sulpha containing drugs.
Ehlers danlos syndrome(eds)
Ehlers-Danlos syndrome (EDS) is a group of disorders associated with hyper-elasticity and fragility of the skin due to defects in collagen synthesis, secretion, or processing. There are over 10 types of EDS, with types I-IV, VII, and X associated with defects in collagen protein synthesis and types VI and IX associated with defects in collagen processing enzymes. EDS type IV can cause the most life-threatening complications such as spontaneous ruptures of arteries and organs. While there is no cure for EDS, treatment focuses on managing symptoms through physiotherapy, analgesics, and surgery.
Pemphigus and Pemphigoid
Vesiculobullous Lesions - Pemphigus and Pemphigoid
Classification, Terminologies, Subsets of Pemphigus, Difference between pemphigus and pemphigoid, oral manifestations, differential diagnosis, Histopathology, Investigations and Management given in detail.
Eb presentation final
Epidermolysis bullosa is a rare genetic disease characterized by extremely fragile skin that blisters easily from minor friction or trauma. There are several types that vary in severity from painful blistering of the hands and feet to widespread blistering that affects internal organs and is often lethal in early childhood. It is caused by genetic mutations that weaken the layers of the skin. While incurable, research aims to improve treatment and quality of life for patients.
Lichen planus
Lichen planus is a chronic inflammatory skin condition that causes itchy, purple-colored papules and plaques. It is thought to be an autoimmune reaction targeting skin cells. The lesions typically appear on the wrists, legs, and oral mucosa. On microscopy, distinctive saw-tooth shaped keratinocytes (Civatte bodies) and band-like inflammatory infiltrate are seen. Treatment involves topical corticosteroids and immunomodulators. While usually self-limiting, lichen planus can lead to scarring and has a small risk of malignant transformation, especially in oral lesions.
Nikolsky sign
Nikolsky's sign refers to the ability to induce peripheral extension of a blister by applying lateral pressure to the border of an intact blister. It is diagnostic of pemphigus and indicates disease activity, as it will be positive during active stages and negative once treatment begins. The sign is elicited by applying pressure with the thumb over a bony prominence, causing the upper epidermal layers to separate from the lower layers. Variants include marginal and direct Nikolsky's sign, as well as false-Nikolsky's sign seen in subepidermal blistering disorders where pressure pulls apart the blister roof rather than inducing new blistering.
behcets disease
Behcet's disease is a chronic, relapsing vasculitis affecting multiple organ systems. It is characterized by recurrent oral and genital ulcers, eye lesions, skin lesions, and arthritis. The cause is unknown but is believed to involve infectious agents triggering an autoimmune response in genetically susceptible individuals. Treatment involves managing symptoms with medications tailored to specific organ manifestations, with the goal of reducing exacerbations and preventing long term complications like blindness or vascular damage.
Apert Syndrome
Apert syndrome is a genetic condition characterized by premature fusion of skull bones resulting in an abnormal head shape. It is caused by mutations in the FGFR2 gene and is inherited in an autosomal recessive pattern. Symptoms include skull abnormalities, fusion of the fingers and toes, and sometimes intellectual disabilities. While there is no cure, treatments focus on corrective surgeries to separate skull bones and digits.
Erythema multiforme Dr Chithra P
This document provides an overview of erythema multiforme (EM), a self-limited inflammatory mucocutaneous disease that commonly affects the skin and oral mucosa. It discusses the etiology, pathogenesis, clinical features, classification variants, diagnosis and management of EM. Key points include: EM results from a hypersensitivity reaction, often to infections or drugs; it ranges from mild to severe based on extent of skin and mucosal involvement; diagnosis involves clinical exam, biopsy and ruling out other conditions; treatment depends on severity but may include antivirals, corticosteroids or immunosuppressants.
Clinicl aproch to blistering dissorder
Infection
Herpes simplex
Herpes zoster
Varicella
Bullous impetigo
SSSS
Genetic
Epidermolysis bullosa
Hailey-Hailey disease
Incontinentia pigmenti
Immunobullous
Pemphigus group of diseases
Paraneoplastic pemphigus
Bullous pemphigoid
Mucous membrane pemphigoid
Linear IgA disease
Dermatitis herpetiformis
Epidermolysis bullosa acquisita
Mechanical
Friction blister
Specific ulcers
This document summarizes several specific types of ulcers, including their causes, characteristic features, locations, investigations, and treatments. It discusses tuberculous ulcers, syphilitic ulcers, chancroid ulcers, actinomycosis ulcers, Meleney's ulcer, and Bairnsdale ulcer. For each type of ulcer, it provides details on etiology, appearance, distinguishing characteristics, affected body sites, diagnostic tests, and management approaches.
Recurrent aphthous stomatitis
Recurrent aphthous stomatitis (RAS) is the most common oral ulcerative condition, affecting 1 in 5 individuals. It is classified into minor, major, and herpetiform ulcers, with minor ulcers being the most common. The pathogenesis involves an abnormal T-cell mediated immune reaction, though the exact cause is unknown. Certain factors like nutritional deficiencies, infections, genetics, and trauma may contribute to disease development or severity. RAS is diagnosed based on clinical examination and history. Treatment involves managing pain and preventing infections, with some evidence that vitamin B12 supplementation may help resolve ulcers.
Genodermatosis
Genodermatosis refers to inherited skin conditions caused by genetic mutations. This document summarizes information on three types: neurofibromatosis type 1 (NF1), tuberous sclerosis, and xeroderma pigmentosum. NF1 is caused by mutations in the NF1 gene and is characterized by café au lait spots, freckling, neurofibromas, and Lisch nodules. Tuberous sclerosis results from mutations in TSC1 or TSC2 and presents with ash leaf macules, angiofibromas, and connective tissue nevi. Xeroderma pigmentosum involves defective DNA repair causing photosensitivity and early development of skin cancers upon
18.gardner's syndrome
Gardner's syndrome is a hereditary condition caused by a gene on chromosome 5 that results in multiple intestinal polyps and bone growths. Patients commonly experience colonic polyps that have a high risk of becoming cancerous, as well as benign bone tumors (osteomas) in the jaw, face and skull that can cause facial deformities and restricted mouth opening. Diagnosis involves detecting unerupted teeth and jaw osteomas on radiological exams. Treatment requires preventative removal of the colon due to the high cancer risk and surgery to remove jaw osteomas for cosmetic purposes.
Aphthous ulcers
This document summarizes recurrent aphthous stomatitis (canker sores). It defines the condition as recurring ulcers confined to the oral mucosa with no signs of systemic disease. It describes the three main types (minor, major, herpetiform), their clinical features, histopathology, associated syndromes, differential diagnosis, and treatments which include topical steroids, antimicrobial mouthwashes, analgesics, and intralesional steroid injections. The conclusion emphasizes that recurrent aphthous ulcers are the most common oral ulcers with three subtypes, unknown etiology, and palliative treatment of lesions.
Lichen planus
Lichen planus is a chronic autoimmune disease that affects the skin and mucous membranes. It is characterized by pruritic polygonal papules and plaques that are flat topped and violaceous. The disease commonly affects middle aged women more than men. Oral lichen planus presents as white lacy lesions inside the mouth, while skin lesions typically occur on the wrists and legs. Treatment focuses on reducing symptoms through topical corticosteroids and immunosuppressants. While usually self-limiting, oral lichen planus poses a small risk of malignant transformation over the long term.
Peutz jeghers syndrome
Peutz-Jeghers syndrome is a rare, autosomal dominant genetic disorder characterized by hamartomatous polyps in the gastrointestinal tract and pigmented lesions on the skin. It is caused by a mutation in the STK11 gene. People with PJS are at increased risk of cancers of the gastrointestinal tract as well as other organs. Management involves endoscopic screening and removal of polyps to prevent cancer complications.
Lichen planus
This document provides an overview of lichen planus, specifically oral lichen planus (OLP). It discusses the history, epidemiology, definition, etiology, predisposing factors, clinical features, clinical variants (reticular, erosive, atrophic, plaque-like, papular, bullous), and histopathology of OLP. OLP is a chronic immunological mucocutaneous disorder that commonly presents as white striations or plaques on the oral mucosa. It is believed to be mediated by T-cells that trigger apoptosis of epithelial cells, though the exact cause is still unknown.
EPIDERMOLISIS BULLOSA
epidermólisis bullosa, una enfermedad genética que, en sus formas más severas, afecta a toda la piel del cuerpo, incluyendo el esófago y los ojos. En los casos más graves, la piel se ampolla o se rasga de la carne ante la más mínima fricción, por ejemplo, cuando un enfermo gira la cabeza mientras duerme puede sufrir el desprendimiento de la piel de las orejas, despertando en la mañana con más de treinta ampollas.
Epidermólisis bullosa
La epidermólisis bullosa (EB) es un grupo de desórdenes genéticos que causan ampollas en la piel y mucosas ante traumas mínimos. Existen tres tipos principales dependiendo de la capa de la piel donde se forman las ampollas: EB simple (epidermis), EB juntural (entre epidermis y dermis), y EB distrófica (dermis). Los síntomas varían según el tipo pero incluyen ampollas, dificultad para alimentarse, infecciones, contracturas y cáncer de piel. El
More Related Content
What's hot
vesiculobullous lesions, pempigus ppt
This document describes different types of vesiculobullous diseases classified according to the Fitzpatrick system based on the anatomical level of blister formation. It discusses conditions such as pemphigus vulgaris, pemphigus vegetans, pemphigus foliaceus, paraneoplastic pemphigus, bullous pemphigoid, cicatricial pemphigoid, and familial benign pemphigus. For each condition, it provides details on pathogenesis, clinical features, histopathology, immunopathology, and oral manifestations when present.
Genetic epidermolysis bullosa
This document provides an overview of genetic epidermolysis bullosa (EB), a group of inherited skin fragility disorders characterized by blistering of the skin from mild mechanical trauma. It defines the major types of EB - simplex, junctional, and dystrophic - based on the level in the skin where blistering occurs. For each type, it describes clinical features, molecular pathology, specific subtypes, management considerations, and prognosis. The document emphasizes EB is a genetically determined condition caused by mutations impacting proteins important for skin integrity.
Erythema multiforme, Steven-Johnson syndrome and Toxic Epidermal Necrolysis
Erythema Multiforme is a common Vesiculobullous deramtological condition with mucosal manifestations trigged by Herpes virus infection and certain sulpha containing drugs.
Ehlers danlos syndrome(eds)
Ehlers-Danlos syndrome (EDS) is a group of disorders associated with hyper-elasticity and fragility of the skin due to defects in collagen synthesis, secretion, or processing. There are over 10 types of EDS, with types I-IV, VII, and X associated with defects in collagen protein synthesis and types VI and IX associated with defects in collagen processing enzymes. EDS type IV can cause the most life-threatening complications such as spontaneous ruptures of arteries and organs. While there is no cure for EDS, treatment focuses on managing symptoms through physiotherapy, analgesics, and surgery.
Pemphigus and Pemphigoid
Vesiculobullous Lesions - Pemphigus and Pemphigoid
Classification, Terminologies, Subsets of Pemphigus, Difference between pemphigus and pemphigoid, oral manifestations, differential diagnosis, Histopathology, Investigations and Management given in detail.
Eb presentation final
Epidermolysis bullosa is a rare genetic disease characterized by extremely fragile skin that blisters easily from minor friction or trauma. There are several types that vary in severity from painful blistering of the hands and feet to widespread blistering that affects internal organs and is often lethal in early childhood. It is caused by genetic mutations that weaken the layers of the skin. While incurable, research aims to improve treatment and quality of life for patients.
Lichen planus
Lichen planus is a chronic inflammatory skin condition that causes itchy, purple-colored papules and plaques. It is thought to be an autoimmune reaction targeting skin cells. The lesions typically appear on the wrists, legs, and oral mucosa. On microscopy, distinctive saw-tooth shaped keratinocytes (Civatte bodies) and band-like inflammatory infiltrate are seen. Treatment involves topical corticosteroids and immunomodulators. While usually self-limiting, lichen planus can lead to scarring and has a small risk of malignant transformation, especially in oral lesions.
Nikolsky sign
Nikolsky's sign refers to the ability to induce peripheral extension of a blister by applying lateral pressure to the border of an intact blister. It is diagnostic of pemphigus and indicates disease activity, as it will be positive during active stages and negative once treatment begins. The sign is elicited by applying pressure with the thumb over a bony prominence, causing the upper epidermal layers to separate from the lower layers. Variants include marginal and direct Nikolsky's sign, as well as false-Nikolsky's sign seen in subepidermal blistering disorders where pressure pulls apart the blister roof rather than inducing new blistering.
behcets disease
Behcet's disease is a chronic, relapsing vasculitis affecting multiple organ systems. It is characterized by recurrent oral and genital ulcers, eye lesions, skin lesions, and arthritis. The cause is unknown but is believed to involve infectious agents triggering an autoimmune response in genetically susceptible individuals. Treatment involves managing symptoms with medications tailored to specific organ manifestations, with the goal of reducing exacerbations and preventing long term complications like blindness or vascular damage.
Apert Syndrome
Apert syndrome is a genetic condition characterized by premature fusion of skull bones resulting in an abnormal head shape. It is caused by mutations in the FGFR2 gene and is inherited in an autosomal recessive pattern. Symptoms include skull abnormalities, fusion of the fingers and toes, and sometimes intellectual disabilities. While there is no cure, treatments focus on corrective surgeries to separate skull bones and digits.
Erythema multiforme Dr Chithra P
This document provides an overview of erythema multiforme (EM), a self-limited inflammatory mucocutaneous disease that commonly affects the skin and oral mucosa. It discusses the etiology, pathogenesis, clinical features, classification variants, diagnosis and management of EM. Key points include: EM results from a hypersensitivity reaction, often to infections or drugs; it ranges from mild to severe based on extent of skin and mucosal involvement; diagnosis involves clinical exam, biopsy and ruling out other conditions; treatment depends on severity but may include antivirals, corticosteroids or immunosuppressants.
Clinicl aproch to blistering dissorder
Infection
Herpes simplex
Herpes zoster
Varicella
Bullous impetigo
SSSS
Genetic
Epidermolysis bullosa
Hailey-Hailey disease
Incontinentia pigmenti
Immunobullous
Pemphigus group of diseases
Paraneoplastic pemphigus
Bullous pemphigoid
Mucous membrane pemphigoid
Linear IgA disease
Dermatitis herpetiformis
Epidermolysis bullosa acquisita
Mechanical
Friction blister
Specific ulcers
This document summarizes several specific types of ulcers, including their causes, characteristic features, locations, investigations, and treatments. It discusses tuberculous ulcers, syphilitic ulcers, chancroid ulcers, actinomycosis ulcers, Meleney's ulcer, and Bairnsdale ulcer. For each type of ulcer, it provides details on etiology, appearance, distinguishing characteristics, affected body sites, diagnostic tests, and management approaches.
Recurrent aphthous stomatitis
Recurrent aphthous stomatitis (RAS) is the most common oral ulcerative condition, affecting 1 in 5 individuals. It is classified into minor, major, and herpetiform ulcers, with minor ulcers being the most common. The pathogenesis involves an abnormal T-cell mediated immune reaction, though the exact cause is unknown. Certain factors like nutritional deficiencies, infections, genetics, and trauma may contribute to disease development or severity. RAS is diagnosed based on clinical examination and history. Treatment involves managing pain and preventing infections, with some evidence that vitamin B12 supplementation may help resolve ulcers.
Genodermatosis
Genodermatosis refers to inherited skin conditions caused by genetic mutations. This document summarizes information on three types: neurofibromatosis type 1 (NF1), tuberous sclerosis, and xeroderma pigmentosum. NF1 is caused by mutations in the NF1 gene and is characterized by café au lait spots, freckling, neurofibromas, and Lisch nodules. Tuberous sclerosis results from mutations in TSC1 or TSC2 and presents with ash leaf macules, angiofibromas, and connective tissue nevi. Xeroderma pigmentosum involves defective DNA repair causing photosensitivity and early development of skin cancers upon
18.gardner's syndrome
Gardner's syndrome is a hereditary condition caused by a gene on chromosome 5 that results in multiple intestinal polyps and bone growths. Patients commonly experience colonic polyps that have a high risk of becoming cancerous, as well as benign bone tumors (osteomas) in the jaw, face and skull that can cause facial deformities and restricted mouth opening. Diagnosis involves detecting unerupted teeth and jaw osteomas on radiological exams. Treatment requires preventative removal of the colon due to the high cancer risk and surgery to remove jaw osteomas for cosmetic purposes.
Aphthous ulcers
This document summarizes recurrent aphthous stomatitis (canker sores). It defines the condition as recurring ulcers confined to the oral mucosa with no signs of systemic disease. It describes the three main types (minor, major, herpetiform), their clinical features, histopathology, associated syndromes, differential diagnosis, and treatments which include topical steroids, antimicrobial mouthwashes, analgesics, and intralesional steroid injections. The conclusion emphasizes that recurrent aphthous ulcers are the most common oral ulcers with three subtypes, unknown etiology, and palliative treatment of lesions.
Lichen planus
Lichen planus is a chronic autoimmune disease that affects the skin and mucous membranes. It is characterized by pruritic polygonal papules and plaques that are flat topped and violaceous. The disease commonly affects middle aged women more than men. Oral lichen planus presents as white lacy lesions inside the mouth, while skin lesions typically occur on the wrists and legs. Treatment focuses on reducing symptoms through topical corticosteroids and immunosuppressants. While usually self-limiting, oral lichen planus poses a small risk of malignant transformation over the long term.
Peutz jeghers syndrome
Peutz-Jeghers syndrome is a rare, autosomal dominant genetic disorder characterized by hamartomatous polyps in the gastrointestinal tract and pigmented lesions on the skin. It is caused by a mutation in the STK11 gene. People with PJS are at increased risk of cancers of the gastrointestinal tract as well as other organs. Management involves endoscopic screening and removal of polyps to prevent cancer complications.
Lichen planus
This document provides an overview of lichen planus, specifically oral lichen planus (OLP). It discusses the history, epidemiology, definition, etiology, predisposing factors, clinical features, clinical variants (reticular, erosive, atrophic, plaque-like, papular, bullous), and histopathology of OLP. OLP is a chronic immunological mucocutaneous disorder that commonly presents as white striations or plaques on the oral mucosa. It is believed to be mediated by T-cells that trigger apoptosis of epithelial cells, though the exact cause is still unknown.
What's hot (20)
Erythema multiforme, Steven-Johnson syndrome and Toxic Epidermal Necrolysis
Erythema multiforme, Steven-Johnson syndrome and Toxic Epidermal Necrolysis
Viewers also liked
EPIDERMOLISIS BULLOSA
epidermólisis bullosa, una enfermedad genética que, en sus formas más severas, afecta a toda la piel del cuerpo, incluyendo el esófago y los ojos. En los casos más graves, la piel se ampolla o se rasga de la carne ante la más mínima fricción, por ejemplo, cuando un enfermo gira la cabeza mientras duerme puede sufrir el desprendimiento de la piel de las orejas, despertando en la mañana con más de treinta ampollas.
Epidermólisis bullosa
La epidermólisis bullosa (EB) es un grupo de desórdenes genéticos que causan ampollas en la piel y mucosas ante traumas mínimos. Existen tres tipos principales dependiendo de la capa de la piel donde se forman las ampollas: EB simple (epidermis), EB juntural (entre epidermis y dermis), y EB distrófica (dermis). Los síntomas varían según el tipo pero incluyen ampollas, dificultad para alimentarse, infecciones, contracturas y cáncer de piel. El
Epidermolisis bullosa
La epidermolisis bullosa es un grupo de enfermedades hereditarias de la piel caracterizadas por la fragilidad de la piel y las mucosas que causan ampollas con mínimos traumatismos. Se debe a mutaciones genéticas que afectan a las proteínas de la membrana basal como las queratinas, la laminina y el colágeno, lo que debilita la unión entre la epidermis y la dermis. Existen diferentes tipos según la capa afectada como la epidermólisis bullosa simple, de unión
Epidermolysis bullosa
Epidermolysis bullosa is a group of genetic diseases that cause blistering of the skin and mucous membranes. It results in fragile skin that blisters easily from minor friction or trauma. Some internal injuries can also occur, causing esophageal closure that leads to weight loss from inability to digest food, though these issues mainly appear in recessive dystrophic epidermolysis bullosa. It has no cure and causes severe, chronic wounds that easily become infected and cause malnutrition and anemia.
Epidermólisis ampollosa
La epidermólisis ampollosa simple es una enfermedad hereditaria dominante que causa ampollas en la piel ante mínimos traumatismos. Se presenta desde el nacimiento o durante los primeros días de vida, y puede afectar principalmente las manos y pies, o ser generalizada. Está causada por mutaciones en genes de queratinas que debilitan la integridad de las células basales de la piel.
Vesiculobullous diseases
This document discusses several vesiculobullous diseases including pemphigus vulgaris, pemphigoid, erythema multiforme, and epidermolysis bullosa. Pemphigus vulgaris is an autoimmune disease causing fluid-filled blisters and ulcers in the mouth and skin. Pemphigoid includes bullous pemphigoid and cicatricial pemphigoid, which are autoimmune diseases affecting the elderly that cause subepithelial blistering. Erythema multiforme is often triggered by infection and causes red macules and mouth sores. Epidermolysis bullosa is a group of genetic disorders that results in easy blist
Vesiculobullous diseases
This document discusses the classification and features of vesiculobullous diseases. It focuses on Pemphigus vulgaris, describing it as an autoimmune disease characterized by the formation of painful fluid-filled blisters or bullae in the mouth and other areas. Histopathology shows acantholysis in the stratum spinosum layer. Diagnosis involves skin biopsy, immunofluorescence and ELISA tests. Treatment involves systemic corticosteroids and other immunosuppressants.
Epidermólisis ampollosa
La epidermólisis ampollosa es una enfermedad genética que causa ampollas en la piel luego de una leve lesión. Existen 5 tipos y sus síntomas incluyen ampollas, pérdida de cabello y uñas, y dificultades respiratorias y para alimentarse. El tratamiento se enfoca en prevenir ampollas y complicaciones a través de cuidados de la piel, apósitos, esteroides y cirugía. Además, se requiere un seguimiento multidisciplinario e información para
Epidermolisis ampollosa
La epidermólisis ampollosa es un grupo de trastornos hereditarios que causan ampollas en la piel debido a roces o traumatismos menores. Existen cuatro tipos principales que afectan diferentes partes de la piel y membranas mucosas. El diagnóstico requiere biopsias de piel y exámenes genéticos. El tratamiento se enfoca en prevenir infecciones, mejorar la nutrición y realizar injertos de piel cuando sea necesario.
Lluvia de ideas fase 1_francy_olmos
Este documento presenta las respuestas de Luis Pigaboza a 10 interrogantes sobre herramientas telemáticas. Proporciona definiciones de red informática, proveedores de internet en Quibdó, y recomienda una red WLAN inalámbrica para conectar 4 oficinas. También describe formas de conectarse a internet, riesgos como virus y spyware, buscadores médicos, navegadores web, correo electrónico y medios de transmisión alámbricos e inalámbricos.
Dermatology 5th year, 2nd lecture (Dr. Kazhan)
These disorders are due to abnormalities in keratinization and keratin metabolism. Different syndromes related to abnormal keratinization include various forms of ichthyosis, which are characterized by persistent non-inflammatory scaling of the skin surface. Icthyosis vulgaris is the most common type and appears in the first months of life as abnormal desquamation of the entire skin surface. Treatment focuses on using emollients to relieve dryness and scaling.
Tooth
The document discusses tooth development and the genes involved. It begins by describing the stages of tooth development from the bud stage to the bell stage. It then discusses the cells and components that make up the developing tooth germ during the cap and bell stages. The role of the Hertwig's epithelial root sheath in root formation is explained. The document concludes by discussing some of the key genes involved in each stage of tooth development, such as BMP, FGF, SHH, Wnt, and others, and how they regulate signaling pathways between the dental epithelium and mesenchyme to control the morphogenesis of the tooth.
11 immunobullous diseases
This document discusses several immunobullous diseases:
1) Cicatricial pemphigoid is a chronic, progressive disease typically affecting elderly women with oral mucosal lesions and less common skin lesions. It can lead to complications affecting the eyes including ankyloblepharon.
2) Stevens-Johnson syndrome is an acute, self-limiting disease typically affecting young men with oral and eye lesions that are often hemorrhagic and necrotic. Eye complications can include symblepharon.
3) Other diseases discussed include toxic epidermal necrolysis, epidermolysis bullosa, pemphigus vulgaris, and linear IgA bullous dermatosis
Sur mucosal lesions
This Presentation will help ou to compare the spectrum of pathologies in ulcerated versus non-ulcerated exophytic oral mucosal lesions and explore the significance of surface ulceration as an indication of various oral diseases
The Biology of the Basement Membrane Zone
It is a critical interface between the epidermis and dermis and is a highly specialized structure that allows for communication between different cell types.
Examination of BMZ/Structure of BMZ/Origin of BMZ/Function of BMZ/Examples of Some diseases affecting BMZ
Epidermólisis bullosa
El documento describe la epidermólisis bullosa distrófica (EBD), un trastorno genético que causa fragilidad de la piel y mucosas. Los pacientes con EBD tienen una alteración en la unión dermoepidérmica que provoca ampollas y úlceras cutáneas. Además de afectar la piel, puede comprometer mucosas y causar complicaciones como estenosis esofágica. El diagnóstico se basa en el hallazgo histológico de ampollas subepidérmicas sin inflam
Enfermedades cutaneas
Este documento trata sobre varias enfermedades de la piel como la psoriasis, rosácea, epidermólisis bullosa, osteogénesis imperfecta, carcinoma basocelular y sudoración excesiva. Describe los síntomas, causas, diagnóstico y tratamiento de cada una. También incluye información sobre la dishidrosis, una afección que causa pequeñas ampollas en las manos y pies.
Immunologically mediated skin diseases
This document discusses immunologically mediated skin diseases. It begins by outlining different components of the epidermis and dermal-epidermal junction that are targeted by autoantibodies in various blistering skin diseases. It then provides details on specific diseases like pemphigus vulgaris, pemphigus foliaceus, and bullous pemphigoid. For pemphigus vulgaris, it describes the epidemiology, etiology, clinical presentation, histopathology, immunopathology, treatment and prognosis. It also provides similar details for pemphigus foliaceus and bullous pemphigoid.
Krishan Mehra
A 32-year-old serving soldier from Maharashtra presented with a 5-month history of non-healing mouth ulcers and fluid-filled skin lesions over the upper body. Examination revealed multiple raw areas over the scalp, face, neck, chest and back. Investigations including Tzanck smear, skin biopsy and immunofluorescence studies were consistent with a diagnosis of Pemphigus vulgaris.
Viewers also liked (20)
Similar to Epidermolysis Bullosa
Child abuse and neglect
This document discusses child abuse and neglect. It defines various types of child abuse like physical abuse, sexual abuse, emotional abuse, and neglect. It describes characteristics of abused children and abusers. Specific injuries from different types of abuse are outlined like bruises in physical abuse and indicators of sexual abuse. Factors contributing to abuse are noted. The roles of medical professionals like dentists in identifying, documenting, and managing abuse cases are discussed. Prevention, intervention, legal aspects, and management of child abuse are also covered.
Incontinentia Pigmenti
Incontinentia Pigmenti is a rare genetic disorder that affects the skin, nails, teeth, and hair. It is caused by an abnormal gene on the X chromosome inherited from the mother. Symptoms include skin redness, fluid-filled blisters, warty growths, discolorations, hair loss, and discolored nails. The most serious complication is destruction of the retina, so early diagnosis and treatment can help slow its progress. The disorder affects approximately 1 in 388,571 people in the USA.
Incontinentia Pigmenti
Incontinentia Pigmenti is a rare genetic disorder that affects the skin, nails, teeth, and hair. It is caused by an abnormal gene on the X chromosome inherited from the mother. Symptoms include skin redness, fluid-filled blisters, warty growths, discolorations, hair loss, and discolored nails. The most serious complication is destruction of the retina, so early diagnosis and treatment can help slow its progress. The disorder affects approximately 1 in 388,571 people in the USA.
Hereditary Diseases
Hereditary diseases can be passed down from parent to child through genes or chromosomes. Cystic fibrosis is caused by a defective gene that causes thick, sticky mucus to build up in the lungs and digestive system. There is no cure, but treatments help manage symptoms. Down syndrome occurs when there is extra genetic material from chromosome 21, causing lifelong intellectual disabilities and delays. It varies in severity and can be caused by trisomy 21, mosaicism, or translocation. Therapies help promote development, independence, and skills for those with Down syndrome.
Chediak higashi syndrome, Phenylketonuria, Dentinogenesis Imperfecta
Chédiak-Higashi syndrome is a rare autosomal recessive disorder caused by mutations in the LYST gene. This results in abnormal granules in skin and immune cells, leading to partial albinism, infections, and neuropathy. Without treatment, an accelerated phase can develop with fever, bleeding, infections and organ failure. Diagnosis involves observing giant granules in leukocytes. There is no cure, but bone marrow transplants have been successful in some cases.
EWMA 2013 - Ep573 - INCIDENCE OF EPIDERMOLYIS BULLOSA AMONG COUPLES WITH CONS...
Vania Declair Cohen
RN, MS, PhD - Clinical Pharmacologist, Dermatology Specialist - São Paulo - SP – Brazil
EWMA 2013 - Ep573 - INCIDENCE OF EPIDERMOLYIS BULLOSA AMONG COUPLES WITH CONS...
Author: Vania Declair Cohen
RN, MS, PhD - Clinical Pharmacologist, Dermatology Specialist - São Paulo - SP – Brazil
Cornelia de Lange DSW 208 presentation
Cornelia De Lange Syndrome (CdLS) is a rare genetic disorder affecting cognitive, physical and medical functioning from birth until adulthood. It causes facial abnormalities like thin eyebrows and cleft lip and/or palate. Children with CdLS often have developmental delays, feeding difficulties, and medical issues like GERD. While the causes are genetic, involving several genes, the exact cause is unknown. Families of children with CdLS require support services to help with developmental, medical and behavioral needs. Support organizations provide information, clinics, and opportunities for families to connect.
Personal Health Issues and Concerns
This document discusses personal health issues and concerns experienced during puberty. It begins by explaining that puberty is when adolescents reach maturity and become capable of reproduction, and their bodies experience many changes. Some common issues teenagers face include problems related to height and weight, eyes, ears, skin, hair and nails, posture and spine, and oral health. Specific conditions discussed include astigmatism, myopia, hyperopia, conjunctivitis, cerumen impaction, swimmer's ear, otitis media, sunburn, calluses, blisters, dandruff, lordosis, kyphosis, scoliosis, cavities, gingivitis, halitosis, and periodontitis. The document
Natural remedies for_eczema
Fortunately, the incredibly delicious desserts that I’m about to share with you have no processed sugars or preservatives.
Oral manifestation of Systemic Diseases
This document discusses the oral manifestations of various systemic diseases. It begins by outlining the topics to be covered, which include endocrine disorders, blood disorders, immunodeficiency, oral cancer therapy effects, drug effects on the oral cavity, and oral manifestations of systemic diseases. It then states that the oral cavity can reflect internal body secrets and diseases through certain manifestations. The document proceeds to discuss specific diseases in more detail, including cardiovascular diseases and their oral effects such as periodontal disease, lichenoid stomatitis, xerostomia, gingival hyperplasia, and hemorrhagic complications. It also covers diabetes mellitus, thyroid disorders, parathyroid disorders, Addison's disease, HIV infection
Ectodermal dysplasia
Ectodermal dysplasia is a large group of inherited disorders characterised by a primary defect in hair, teeth, nails or sweat gland function, in addition to another abnormality in any tissue of ectodermal origin. These are ears, eyes, lips, mucous membranes of the mouth or nose, and the central nervous system. Despite some of the syndromes having different genetic causes, the symptoms are sometimes very similar. Diagnosis is usually by clinical observation, often with the assistance of family medical histories so that it can be determined whether transmission is autosomal dominant or recessive.
Down syndrome
Down syndrome is a genetic condition caused by the presence of an extra chromosome 21. It causes delays in physical and intellectual development. The majority of cases are caused by nondisjunction during meiosis resulting in three copies of chromosome 21 rather than the typical two. Clinical features include a flat face, almond shaped eyes, poor muscle tone, and intellectual disability. Treatment is symptomatic and involves supportive care, early intervention, physical/occupational therapy, and addressing any associated health issues. Nursing care focuses on monitoring development, providing support to develop self-care skills, managing infections risks, and supporting the family.
Respond to this forum reflection- Do you agree and-or disagree with th.pdf
Respond to this forum reflection. Do you agree and/or disagree with their reflection? Be sure to respond to specific
points in reflection. Do you have anything to add to supplement their response? 250 word minimum.
"I dentifying common disorders of the integumentary system and describing the common diagnostics
used to determine the type and cause of integumentary disorders was a learning objecting
discussed in this week's reading. Since there are so many types of skin diseases, it can be a
complex process to accurately diagnose. Some skin disorders have hallmark signs that lead to an
easy diagnosis. However, many present the same or similarly and can make diagnosis difficult.
Culture and sensitivity are useful in determining the presence of bacterial infections. Blood tests can
help indicate whether there is a systemic infection or metabolic disorder. Cultures and microscopic
smear examinations can identify and diagnosis fungal and parasitic infections. Common disorders of
the integumentary system can be classified as infections, metabolic, hypersensitivity, idiopathic
disorders, and tumors. Skin infections are common and usually contagious. Viruses, bacteria, fungi,
and parasites can all cause infections of the skin. As a future healthcare provider, it is important to
recognize the signs and symptoms of these diseases. Early detection and treatment can help to
prevent the spread of one are of the body to another and from one person to another. Hyperactive
sebaceous glands also play a role in several skin diseases. Inflammation and infection can impact
these diseases, but the primary cause is metabolic. Hypersensitivity diseases are caused by an
immune reaction within the body. The cause is frequently unknown and treatment is based on
symptoms. Eczema is an example of a hypersensitivity or immune disease. I used to struggle with
eczema as a child, but flare-ups occur less often as I have gotten older and started identifying and
avoiding the factors that would exacerbate my symptoms. Idiopathic diseases of the skin have
unknown causes and tend to be chronic, with periods of remission and exacerbation of the disease
process. Benign tumors are common and tend to be familial while premalignant and malignant
tumors are normally associated with overexposure to the sun. Being knowledgeable on disorders of
the integumentary system is crucial when working in the healthcare field because the skin is the
largest organ of the body and is the first line of defense against disease. It is important to be able to
educate patients on how to properly protect their skin and prevent disease."
Respond to this forum reflection. Do you agree and/or disagree with their reflection? Be sure to respond to specific
points in reflection. Do you have anything to add to supplement their response? 250 word minimum..
Café
The document summarizes several common ear, nose, and throat conditions. It describes conditions such as otitis media (ear infections), glue ear (buildup of fluid behind the eardrum), ear wax buildup, swimmer's ear (infection from water in the ear canal), Meniere's disease (inner ear disorder causing dizziness), sinus issues, nasal polyps, deviated septum, empty nose syndrome, nosebleeds, acne, eczema, seborrheic dermatitis, skin cancer, psoriasis, tooth decay, gum disease, mouth sores, bad breath, and tooth erosion. It provides brief descriptions of the symptoms and causes for each condition.
Oral manifestations
This document discusses oral manifestations of systemic diseases in older patients. It provides background on oral structures and functions. It then examines relationships between oral symptoms and conditions like drug reactions, fungal/viral infections, leukemia, Behcet's disease, Sjogren's syndrome, diabetes mellitus, nutritional deficiencies, and amyloidosis. For each condition, it describes common oral presentations and recommendations for treatment and differential diagnosis. The document concludes that the mouth can provide insights into a patient's immune function and that differential diagnosis is important.
Waardenburg Syndrome
Waardenburg Syndrome is an inherited disorder characterized by hearing loss and changes in hair and skin pigmentation. There are four types, with types I and II being most common. It is caused by a dominant gene mutation and symptoms may include deafness, pale eye color, and patchy hair loss. While symptoms are present at birth, diagnosis is usually made in infancy through tests like audiometry and genetic testing. Treatment focuses on managing hearing loss and other symptoms, as there is no cure for the underlying condition.
Diseases of skin
This document discusses ectodermal dysplasia syndrome (EDS), a heterogeneous group of inherited disorders that affect ectodermal tissues like skin, hair, nails, sweat glands, and teeth. It describes two main types - hypohidrotic EDS and hidrotic EDS. Hypohidrotic EDS is characterized by hypohidrosis, anomalous dentition, onychodysplasia, and hypotrichosis. It can cause facial abnormalities, dry skin, intellectual disability, and other issues. Hidrotic EDS causes nail dystrophy, sparse hair, and palmoplantar changes. The document outlines clinical features and manifestations of both conditions, including oral findings like hypodontia and
Deafness and hearing impairement
this topic is all about deafness and hearing impairment, this is all about the classification of deafness and hearing impairment and the cause language disorder.
Down syndrome
Down syndrome is a genetic disorder caused by the presence of an extra chromosome 21. It can be caused by trisomy 21, translocation, or mosaicism. Common symptoms include distinctive facial features, poor muscle tone, cognitive delays, and heart defects. While there is no cure, early intervention including speech, physical, and occupational therapy can help children with Down syndrome reach their full potential. Lifespan and quality of life have improved significantly in recent decades for those living with Down syndrome.
Similar to Epidermolysis Bullosa (20)
Chediak higashi syndrome, Phenylketonuria, Dentinogenesis Imperfecta
Chediak higashi syndrome, Phenylketonuria, Dentinogenesis Imperfecta
EWMA 2013 - Ep573 - INCIDENCE OF EPIDERMOLYIS BULLOSA AMONG COUPLES WITH CONS...
EWMA 2013 - Ep573 - INCIDENCE OF EPIDERMOLYIS BULLOSA AMONG COUPLES WITH CONS...
EWMA 2013 - Ep573 - INCIDENCE OF EPIDERMOLYIS BULLOSA AMONG COUPLES WITH CONS...
EWMA 2013 - Ep573 - INCIDENCE OF EPIDERMOLYIS BULLOSA AMONG COUPLES WITH CONS...
Respond to this forum reflection- Do you agree and-or disagree with th.pdf
Respond to this forum reflection- Do you agree and-or disagree with th.pdf
Recently uploaded
Computer in pharmaceutical research and development-Mpharm(Pharmaceutics)
Statistics- Statistics is the science of collecting, organizing, presenting, analyzing and interpreting numerical data to assist in making more effective decisions.
A statistics is a measure which is used to estimate the population parameter
Parameters-It is used to describe the properties of an entire population.
Examples-Measures of central tendency Dispersion, Variance, Standard Deviation (SD), Absolute Error, Mean Absolute Error (MAE), Eigen Value
How to choose the best dermatologists in Indore.
The skin is the largest organ and its health plays a vital role among the other sense organs. The skin concerns like acne breakout, psoriasis, or anything similar along the lines, finding a qualified and experienced dermatologist becomes paramount.
Medical Quiz ( Online Quiz for API Meet 2024 ).pdf
This quiz was conducted as a promotional event for the 2024 Annual Meet of Kerala Chapter of API.
More than 20 participants took part everyday !
Hemodialysis: Chapter 5, Dialyzers Overview - Dr.Gawad
- Video recording of this lecture in English language: https://youtu.be/Pt1nA32sdHQ
- Video recording of this lecture in Arabic language: https://youtu.be/uFdc9F0rlP0
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Nano-gold for Cancer Therapy chemistry investigatory project
chemistry investigatory project
The development of nanogold-based cancer therapy could revolutionize oncology by providing a more targeted, less invasive treatment option. This project contributes to the growing body of research aimed at harnessing nanotechnology for medical applications, paving the way for future clinical trials and potential commercial applications.
Cancer remains one of the leading causes of death worldwide, prompting the need for innovative treatment methods. Nanotechnology offers promising new approaches, including the use of gold nanoparticles (nanogold) for targeted cancer therapy. Nanogold particles possess unique physical and chemical properties that make them suitable for drug delivery, imaging, and photothermal therapy.
Acute Gout Care & Urate Lowering Therapy .pdf
In this document , the management of acute gout attacks and a description of urate lowering therapy is mentioned.
biomechanics of running. Dr.dhwani.pptx
The biomechanics of running involves the study of the mechanical principles underlying running movements. It includes the analysis of the running gait cycle, which consists of the stance phase (foot contact to push-off) and the swing phase (foot lift-off to next contact). Key aspects include kinematics (joint angles and movements, stride length and frequency) and kinetics (forces involved in running, including ground reaction and muscle forces). Understanding these factors helps in improving running performance, optimizing technique, and preventing injuries.
Giloy in Ayurveda - Classical Categorization and Synonyms
Giloy, also known as Guduchi or Amrita in classical Ayurvedic texts, is a revered herb renowned for its myriad health benefits. It is categorized as a Rasayana, meaning it has rejuvenating properties that enhance vitality and longevity. Giloy is celebrated for its ability to boost the immune system, detoxify the body, and promote overall wellness. Its anti-inflammatory, antipyretic, and antioxidant properties make it a staple in managing conditions like fever, diabetes, and stress. The versatility and efficacy of Giloy in supporting health naturally highlight its importance in Ayurveda. At Planet Ayurveda, we provide a comprehensive range of health services and 100% herbal supplements that harness the power of natural ingredients like Giloy. Our products are globally available and affordable, ensuring that everyone can benefit from the ancient wisdom of Ayurveda. If you or your loved ones are dealing with health issues, contact Planet Ayurveda at 01725214040 to book an online video consultation with our professional doctors. Let us help you achieve optimal health and wellness naturally.
Breast cancer: Post menopausal endocrine therapy
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
Call Girls In Mumbai +91-7426014248 High Profile Call Girl Mumbai
Call Girls In Mumbai +91-7426014248 High Profile Call Girl Mumbai
Travel Clinic Cardiff: Health Advice for International Travelers
Travel Clinic Cardiff offers comprehensive travel health services, including vaccinations, travel advice, and preventive care for international travelers. Our expert team ensures you are well-prepared and protected for your journey, providing personalized consultations tailored to your destination. Conveniently located in Cardiff, we help you travel with confidence and peace of mind. Visit us: www.nxhealthcare.co.uk
Pollen and Fungal allergy: aeroallergy.pdf
Pollen and Fungal allergy: aeroallergy.pdfChulalongkorn Allergy and Clinical Immunology Research Group
Pollen and Fungal allergy
Presented by Chaloemchai Chumsaengchotsakul, MD.
June 14, 2024SENSORY NEEDS B.SC. NURSING SEMESTER II.
Sensation is the neurological process by which we become aware of surrounding environment.
How to Control Your Asthma Tips by gokuldas hospital.
Respiratory issues like asthma are the most sensitive issue that is affecting millions worldwide. It hampers the daily activities leaving the body tired and breathless.
The key to a good grip on asthma is proper knowledge and management strategies. Understanding the patient-specific symptoms and carving out an effective treatment likewise is the best way to keep asthma under control.
STUDIES IN SUPPORT OF SPECIAL POPULATIONS: GERIATRICS E7
Unit 4: MRA 103T Regulatory affairs
This guideline is directed principally toward new Molecular Entities that are
likely to have significant use in the elderly, either because the disease intended
to be treated is characteristically a disease of aging ( e.g., Alzheimer's disease) or
because the population to be treated is known to include substantial numbers of
geriatric patients (e.g., hypertension).
Pharmacology of 5-hydroxytryptamine and Antagonist
5-hydroxytryptamine or 5-HT or Serotonin is a neurotransmitter that serves a range of roles in the human body. It is sometimes referred to as the happy chemical since it promotes overall well-being and happiness.
It is mostly found in the brain, intestines, and blood platelets.
5-HT is utilised to transport messages between nerve cells, is known to be involved in smooth muscle contraction, and adds to overall well-being and pleasure, among other benefits. 5-HT regulates the body's sleep-wake cycles and internal clock by acting as a precursor to melatonin.
It is hypothesised to regulate hunger, emotions, motor, cognitive, and autonomic processes.
Recently uploaded (20)
Computer in pharmaceutical research and development-Mpharm(Pharmaceutics)
Computer in pharmaceutical research and development-Mpharm(Pharmaceutics)
Medical Quiz ( Online Quiz for API Meet 2024 ).pdf
Medical Quiz ( Online Quiz for API Meet 2024 ).pdf
Hemodialysis: Chapter 5, Dialyzers Overview - Dr.Gawad
Hemodialysis: Chapter 5, Dialyzers Overview - Dr.Gawad
Nano-gold for Cancer Therapy chemistry investigatory project
Nano-gold for Cancer Therapy chemistry investigatory project
Giloy in Ayurveda - Classical Categorization and Synonyms
Giloy in Ayurveda - Classical Categorization and Synonyms
Call Girls In Mumbai +91-7426014248 High Profile Call Girl Mumbai
Call Girls In Mumbai +91-7426014248 High Profile Call Girl Mumbai
Travel Clinic Cardiff: Health Advice for International Travelers
Travel Clinic Cardiff: Health Advice for International Travelers
How to Control Your Asthma Tips by gokuldas hospital.
How to Control Your Asthma Tips by gokuldas hospital.
STUDIES IN SUPPORT OF SPECIAL POPULATIONS: GERIATRICS E7
STUDIES IN SUPPORT OF SPECIAL POPULATIONS: GERIATRICS E7
Pharmacology of 5-hydroxytryptamine and Antagonist
Pharmacology of 5-hydroxytryptamine and Antagonist