This document discusses breast cancer prevention and awareness. It covers several key points:
1) Breast cancer awareness campaigns aim to educate the public about symptoms and treatment to raise awareness and reduce stigma. National Breast Cancer Awareness Month is held in October in many countries.
2) Common risk factors for breast cancer include family history and genetic factors, while factors like antiperspirant and bras have not been linked. Screening methods include breast self-exams, clinical exams by doctors, and mammograms.
3) Angelina Jolie's decision to undergo preventative double mastectomy was informed by her family history and genetic testing showing an 87% risk of breast cancer. She hopes sharing
Check a showcase of our Breast Cancer PowerPoint Presentation. Download Breast Cancer PowerPoint presentation now for great and creative presentation ideas on Breast Cancer Prevention & Control. This is our general marketing powerpoint presentation on breast cancer prevention & control. We invite you to download TheTemplateWizard's Breast Cancer PPT presentation for great ideas on healthcare presentations. We have created Breast Cancer sample powerpoint presentations that demonstrates how to use visuals and illustrations in your PowerPoint presentations.
Breast cancer awareness - Causes, Diagnosis, Treatment and PreventionMafia Rashid
Breast cancer
Causes of breast cancer
Sympotms of breast cancer
Diagnosis of breast cancer
Treatment of Breast cancer
Prevention of Breast cancer
<i"https://www.youtube.com/embed/6N2QDjzamzA" >
https://youtu.be/m2M713R9Bh8
Raising Awareness And Understanding of Breast CancerBanupriyaMBBSMD
October month is the Breast Cancer Awareness Month.
Breast cancer is cancer that occurs in the breast tissue. Signs of breast cancer may include a change in breast shape, fluid coming from the nipple, a lump in the breast,a newly-inverted nipple, or a red or scaly patch of skin. The most common types of breast cancer are Invasive lobular carcinoma and invasive ductal carcinoma.
Check a showcase of our Breast Cancer PowerPoint Presentation. Download Breast Cancer PowerPoint presentation now for great and creative presentation ideas on Breast Cancer Prevention & Control. This is our general marketing powerpoint presentation on breast cancer prevention & control. We invite you to download TheTemplateWizard's Breast Cancer PPT presentation for great ideas on healthcare presentations. We have created Breast Cancer sample powerpoint presentations that demonstrates how to use visuals and illustrations in your PowerPoint presentations.
Breast cancer awareness - Causes, Diagnosis, Treatment and PreventionMafia Rashid
Breast cancer
Causes of breast cancer
Sympotms of breast cancer
Diagnosis of breast cancer
Treatment of Breast cancer
Prevention of Breast cancer
<i"https://www.youtube.com/embed/6N2QDjzamzA" >
https://youtu.be/m2M713R9Bh8
Raising Awareness And Understanding of Breast CancerBanupriyaMBBSMD
October month is the Breast Cancer Awareness Month.
Breast cancer is cancer that occurs in the breast tissue. Signs of breast cancer may include a change in breast shape, fluid coming from the nipple, a lump in the breast,a newly-inverted nipple, or a red or scaly patch of skin. The most common types of breast cancer are Invasive lobular carcinoma and invasive ductal carcinoma.
Breast Cancer Awareness Conversation Starters Series by iStudentNurseiStudentNurse.com
The 'Conversation Starters' is a series by iStudentNurse designed to promote discussions about life-saving awareness topics. Composed by a team of RNs, it draws upon the latest evidence-based research to provide a summary of the most crucial breast cancer awareness concepts. While designed as a lecture outline for nursing students, the Breast Cancer Awareness presentation is also of value to patients, survivors, and healthcare professionals. Topics addressed include: pathophysiology, etiology, epidemiology, risk factors, genetic testing/counseling, the 3 Tiers of Early Detection, screening and diagnostic methods, and treatment modalities (surgery, chemo, radiation, and endocrine therapy). The self-breast exam (SBE) is described step-by-step. Additionally, an example nursing care plan for a post-operative mastectomy is provided, which describes nursing diagnoses, interventions, and outcomes. Happy Student Nursing!
Breast cancer is known as the cancer that grow up in the cells of breasts. Breast cancer is the most typical cancer detected in the women. We are celebrating October month as the breast cancer awareness month. It helps the women to get more information about the breast cancer. DDRC SRL diagnostics center in Kerala provides free mammography campaigns for the women in Kerala in this breast cancer awareness month.
Breast cancer is increasing year by year in India and we are moving towards western statistics in prevalence of disease.
I was invited by air force gandhinagar to deliver the breast cancer awareness talk to their staff.
This presentation is all about breast cancer, early signs, symptoms, prevention, diagnosis and treatment.
Awareness session on breast cancer awareness on 21st oct 2021 at Mehran university, Jamshoro organized by American institute of Chemical engineering society AIChE MUET chapter
A Topic Where Every Woman Must Know. Early warning signs of breast cancer.knip xin
PLEASE LIKE AND COMMENT FOR ANY CONSTRUCTIVE CRITICISM. This power point presentation was made to raise awareness about breast cancer. Slides include definition of breast cancer, signs and symptoms, diagnostic exam, stages of breast cancer and treatment.
October is 'Breast Cancer Awareness' month. Cancer is scary but we can fight it. With a little bit of proactive action and awareness, you and I may be able to save lives. Do spread the word and help make the world a better place.
Cancer Awareness By Ms. Susmita Mitra
This is part of the HELP Talk series at HELP,Health Education Library for People, the worlds largest free patient education library www.healthlibrary.com.
For info log on to www.healthlibrary.com.
Breast Cancer Awareness Conversation Starters Series by iStudentNurseiStudentNurse.com
The 'Conversation Starters' is a series by iStudentNurse designed to promote discussions about life-saving awareness topics. Composed by a team of RNs, it draws upon the latest evidence-based research to provide a summary of the most crucial breast cancer awareness concepts. While designed as a lecture outline for nursing students, the Breast Cancer Awareness presentation is also of value to patients, survivors, and healthcare professionals. Topics addressed include: pathophysiology, etiology, epidemiology, risk factors, genetic testing/counseling, the 3 Tiers of Early Detection, screening and diagnostic methods, and treatment modalities (surgery, chemo, radiation, and endocrine therapy). The self-breast exam (SBE) is described step-by-step. Additionally, an example nursing care plan for a post-operative mastectomy is provided, which describes nursing diagnoses, interventions, and outcomes. Happy Student Nursing!
Breast cancer is known as the cancer that grow up in the cells of breasts. Breast cancer is the most typical cancer detected in the women. We are celebrating October month as the breast cancer awareness month. It helps the women to get more information about the breast cancer. DDRC SRL diagnostics center in Kerala provides free mammography campaigns for the women in Kerala in this breast cancer awareness month.
Breast cancer is increasing year by year in India and we are moving towards western statistics in prevalence of disease.
I was invited by air force gandhinagar to deliver the breast cancer awareness talk to their staff.
This presentation is all about breast cancer, early signs, symptoms, prevention, diagnosis and treatment.
Awareness session on breast cancer awareness on 21st oct 2021 at Mehran university, Jamshoro organized by American institute of Chemical engineering society AIChE MUET chapter
A Topic Where Every Woman Must Know. Early warning signs of breast cancer.knip xin
PLEASE LIKE AND COMMENT FOR ANY CONSTRUCTIVE CRITICISM. This power point presentation was made to raise awareness about breast cancer. Slides include definition of breast cancer, signs and symptoms, diagnostic exam, stages of breast cancer and treatment.
October is 'Breast Cancer Awareness' month. Cancer is scary but we can fight it. With a little bit of proactive action and awareness, you and I may be able to save lives. Do spread the word and help make the world a better place.
Cancer Awareness By Ms. Susmita Mitra
This is part of the HELP Talk series at HELP,Health Education Library for People, the worlds largest free patient education library www.healthlibrary.com.
For info log on to www.healthlibrary.com.
High Blood Pressure or Hypertension is known as the silent killer. It is a condition that occurs without symptoms for many years and in most cases the cause is unknown. Genetic or environmental are the most explained reasons.
Breast cancer pathology ( Ref: bailey & love 26th edition ) - Abdullah Taskeen
pathology of breast cancer
ductal carcinoma , lobular carcinoma
In situ , Invasiv , vannusclassification
paget disease
inflammatory cancer
local , lymphatic , blood spreading & metastasis
A blood pressure measurement is always expressed in two numbers. The higher (systolic) number represents the pressure while the heart is beating, and the lower (diastolic) number represents the pressure when the heart is resting between beats.
Dr. Sachin Verma is a young, diligent and dynamic physician. He did his graduation from IGMC Shimla and MD in Internal Medicine from GSVM Medical College Kanpur. Then he did his Fellowship in Intensive Care Medicine (FICM) from Apollo Hospital Delhi. He has done fellowship in infectious diseases by Infectious Disease Society of America (IDSA). He has also done FCCS course and is certified Advance Cardiac Life support (ACLS) and Basic Life Support (BLS) provider by American Heart Association. He has also done a course in Cardiology by American College of Cardiology and a course in Diabetology by International Diabetes Centre. He specializes in the management of Infections, Multiorgan Dysfunctions and Critically ill patients and has many publications and presentations in various national conferences under his belt. He is currently working in NABH Approved Ivy super-specialty Hospital Mohali as Consultant Intensivists and Physician.
What Black Women Need to Know About Endometrial Cancerbkling
Dr. Kemi Doll, gynecologic oncologist at the University of Washington Medical Center, shares her passion for improving the lives of black women affected by this disease through her extensive research and knowledge about endometrial cancer.
This webinar is being put on in partnership with ECANA.
Breast Cancer – Types, Causes, Symptoms and PreventionHashmi Healthcares
It is the fact that, due to the breast cancer thousands of women die around the world. To be specific, The American Cancer Society estimates, 40,920 women will die, 266,120 new cases of invasive breast cancer and 63,960 Non-invasive will be diagnosed alone in America in 2018. Now, you can know how dangerous breast cancer is and how important to diagnose and prevent it before it overcomes you.
Wendy Noe, education coordinator for the Central Indiana Affiliate of Susan G. Komen for the Cure® presents an overview of breast cancer information, facts and advances in treatment.
The human being is fighting against several types of cancer for decades. Breast cancer is something that is spreading its claw day by day. Not only women but men also have this deadly cancer. Nusuki always has worked for the social cause, and this time it is no different too. In this October, as known as the month of International Breast Cancer Month, Nusuki is taking a step forward to support the person with breast cancer.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
Follow us on: Pinterest
Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Factory Supply Best Quality Pmk Oil CAS 28578–16–7 PMK Powder in Stockrebeccabio
Factory Supply Best Quality Pmk Oil CAS 28578–16–7 PMK Powder in Stock
Telegram: bmksupplier
signal: +85264872720
threema: TUD4A6YC
You can contact me on Telegram or Threema
Communicate promptly and reply
Free of customs clearance, Double Clearance 100% pass delivery to USA, Canada, Spain, Germany, Netherland, Poland, Italy, Sweden, UK, Czech Republic, Australia, Mexico, Russia, Ukraine, Kazakhstan.Door to door service
Hot Selling Organic intermediates
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
2. Breast cancer awareness is an effort to raise
awareness and reduce the stigma of breast cancer
through education on symptoms and treatment.
The goal of this campaign is to raise the public's “brand
awareness" for breast cancer, its detection, its treatment, and the
need for a reliable, permanent cure.
In many countries the month of October is National Breast Cancer
Awareness Month (NBCAM) and was begun in 1985 by the
American cancer society and pharmaceutical company.
As a result of awareness, breast cancers are being detected at an
earlier, more treatable stage.
3. The PINK RIBBON is the most prominent
symbol of breast cancer awareness.
It is associated with individual generosity, faith in scientific progress,
and an optimistic "can-do" attitude.
It encourages individuals to focus on the emotionally appealing
ultimate vision of a cure for breast cancer, rather than the reality that
there is no certain cure for breast cancer.
The practice of blindly wearing or displaying a pink ribbon without
making efforts to cure breast cancer has been described as a kind of
slacktivism.
4. Breast cancer is the most common cancer in
Pakistan. Approximately one in every nine Pakistani
women is likely to suffer from breast cancer. This is
one of the highest incidence rates in Asia.
According to World Health Organization, breast cancer rates are
getting worse and it is not sparing even younger age group.
“Women in the developing countries, like Pakistan tend to die at
greater rates than in more developed countries because the
disease is generally detected when it is in its advance stages”.
7. FACTORS NOT LINKED TO
BREAST CANCER
Antiperspirant
Bras
Induced abortion
Breast implants
8. SCREENING FOR BREAST
CANCER
A GOOD BREAST HEALTH
PLAN:
Breast Self Examination
(BSE)
Clinical Breast Examination
(CBE)
Mammograms
Genetic screening
9. BREAST SELF EXAMINATION
(BSE)
It is an opportunity for woman to
become familiar with her
breasts.
BSE is a useful and essential
screening strategy.
About 20% of the time, breast
cancers are found by physical
examination rather than by
mammography.
It aids in early detection of
changes in breast tissue.
10. WHEN TO DO BSE
First BSE is recommended after
you have had your first menstrual
cycle.
Monthly examination of the
breasts and underarm area one
week after the periods.
In postmenopausal women same
date of each month.
In pregnant women same date
each month.
11. WHY DON’T MORE WOMEN
PRACTICE BSE
Fear
Embarrassment
Youth
Lack of knowledge
Too busy, forgetfulness
12. CLINICAL BREAST
EXAMINATION (CBE)
Performed by doctor or trained
nurse practitioner.
Annually for women over 40 yrs.
At least every 3 years for women
between 20 and 40 years.
More frequent examination for
high risk patients.
13. MAMMOGRAPHY
It is a low-energy X-rays technique to
examine the human breast, which is
used as a diagnostic and screening
tool.
The goal is early detection of breast
cancer, typically through detection of
masses and/or microcalcifications.
Normal mammogram does not rule out
possibility of cancer completely.
14. GENETIC SCREENING
The BRCA gene test is a blood test that uses DNA analysis to
identify mutations in either one of the two breast cancer
susceptibility genes — BRCA1 and BRCA2.
Women who have inherited mutations in these genes are at
an increased risk of developing breast cancer and ovarian
cancer compared with the general population.
The BRCA gene test is offered only to people who are likely
to have an inherited mutation based on personal or family
history, or who have a specific type of breast cancer.
15. The BRCA gene test isn't routinely performed on women
at average risk of breast and ovarian cancers.
A BRCA gene test determines whether you carry an
inherited BRCA mutation.
If you do, your result is positive and your doctor can help
you understand your cancer risk.
If you don't have a mutation, this is considered a
negative result.
However, you may learn you have a gene variant that
doctors aren't sure about. It may or may not be
associated with an increased risk of breast and ovarian
cancer. This result is known as a variant of uncertain
significance.
16. SUCCESSFUL STORY
Angelina Jolie is an American
actress, filmmaker, humanitarian
and mother of six children.
In The New York Times she
shared her personal experience.
Her mother had breast cancer
and she died of ovarian cancer at
56.
She said my children will never
have the chance to know their
grandmother and to experience
how loving and gracious she was.
Her grandmother and aunt also
died of cancers.
17. Since she had strong maternal family history of cancers, she had her
own genetic testing and discovered that she carries a mutation of
BRCA1 gene.
She said my doctor estimated that I had 87% risk of breast cancer and
50% risk of ovarian cancer.
So she made a decision to be proactive and to minimize the risk to
develop cancer for sake of six children.
18. On Feb 2013, at age 37 she underwent preventive
double mastectomy followed by reconstruction surgery
and two years later she had bilateral oophorectomy.
She said I can tell my children that they don’t need to fear that
they will lose their mother of breast cancer.
It is reassuring that they see nothing that makes them
uncomfortable. They can see my small scars and that’s it.
Everything else is just Mommy, the same as she always was.
On a personal note, I do not feel any less of a woman. I feel
empowered that I made a strong choice that in no way
diminishes my femininity.
19. In a piece she wrote for New York Times, Jolie said:
“I went through what I imagine thousands of other women
have felt”. She added that I am writing this because I choose
not to keep my story private as there are many women who
do not know that they might be living under the shadow of
cancer. It is my hope that other women can benefit from my
experience. Cancer is still a word that strikes fear into
people’s hearts, producing a deep sense of powerlessness.
But today it is possible to find out through a blood test
whether you are at highly risk to develop breast and ovarian
cancer, and then you will know that you have strong options."
“I CHOOSE TO LIVE DIFFERENTLY”