This document is a thesis submitted by Federica Campana for a PhD in molecular dynamics investigations of drug-cell membrane interactions. It summarizes research on how drug molecules interact with and influence cell membranes. Key findings include that membrane cholesterol content influences the effects of membrane fluidizers and heat shock protein co-inducers. Hydroxylamine derivatives were found to modify membrane physical state and induce heat shock proteins. Hydroxy arachidonic acid was identified as a potential new non-steroidal anti-inflammatory drug that targets cyclooxygenase enzymes with less affinity than arachidonic acid.