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BT-202 Netaji Subhas Institute of Technology, Dwarka, New Delhi. Dr. Amita Pandey Sept 9, 2011
Types of Lipids ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
STORAGE LIPIDS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
FATTY ACIDS ,[object Object],[object Object]
FATTY ACIDS -high melting point -poor solubility in water
FATTY ACIDS -Low melting points -Occur in  cis  form
-poor solubility is due to long non-polar HC chains -melting point is due to the degree of packing of FAs -FAs are present in blood in two forms -serum albumin -esters or amides
PUFAs ,[object Object],[object Object],[object Object],[object Object],[object Object]
PUFAs and cardiovascular disease ,[object Object],[object Object],[object Object]
Properties of Saturated Fatty Acids ,[object Object],[object Object],[object Object],[object Object],[object Object]
Properties of Unsaturated Fatty Acids Contain one or more double C =C bonds Nonlinear chains do not allow molecules to pack closely Few interactions between chains Low melting points Liquids at room temperature
Triacylglycerols / Triglycerides -three FA molecules linked to  one glycerol molecule -two types of triacylglycerols -simple (eg. tripalmitin) -mixed -hydrophobic molecules
Triacylglycerols ,[object Object],[object Object],[object Object],[object Object]
Trans Fatty Acids
Trans Fatty Acids - Hydrogenation converts double bonds in oils to single bonds.  -helps improve stability of oils during frying  -increase shelf life
Trans Fatty Acids ,[object Object],[object Object]
Waxes ,[object Object],[object Object]
LIPIDS
Structural LIpids ,[object Object],[object Object],[object Object],[object Object],[object Object]
Glycerophospholipids/Phosphoglycerides ,[object Object],[object Object],[object Object],[object Object],[object Object]
Glycerophospholipids/Phosphoglycerides ,[object Object],[object Object]
Glycerophospholipids/Phosphoglycerides
Glycerophospholipids/Phosphoglycerides Phosphatidylinositol , with inositol as polar head group,  -a membrane lipid  -has roles in cell signaling.
Glycerophospholipids/Phosphoglycerides Phosphatidylcholine, with choline as polar head group is a common membrane lipid.
Glycerophospholipids/Phosphoglycerides Ether lipids -plasmalogen -platelet-activating factor
Galactolipids/Sulfolipid ,[object Object],[object Object],[object Object],[object Object]
Archaeal ether lipids
Sphingolipids ,[object Object],[object Object],[object Object]
Sphingolipids
Sphingolipids
Sphingomyelin ,[object Object],[object Object],[object Object],[object Object]
Glycosphingolipid ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Gangliosides ,[object Object],[object Object],[object Object],[object Object]
Function of Sphingolipids ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object]
Sterols ,[object Object],[object Object],[object Object],[object Object]
LIPIDS IN THE CELL ,[object Object],[object Object],[object Object]
LIPOPROTEINS ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],Lipoprotein lipases
LIPIDS AND BIOLOGICAL MEMBRANES ,[object Object],[object Object],[object Object],[object Object]
Lipid composition of  plasma membrane and organelle membrane of rat hepatocytes
[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
[object Object],-Determination of protein conformation -sequence of 20 hydrophobic residues
Lipid-linked membrane proteins ,[object Object],[object Object],inside outside
Movement of lipids in the bilayer ,[object Object],[object Object],[object Object],[object Object],[object Object]
Transport across membrane
[object Object],[object Object],Simple diffusion
Facilitated diffusion ,[object Object],[object Object]
Classification of transporters
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
SERCA pump Na+ K+ ATPase
[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],Lactose permease
AQUAPORINS (AQPs) ,[object Object],[object Object]
Ion-selective channels ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
 

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Sept 9 bt202