Personalized medicine uses a patient's genetic profile to determine the best medication, therapy, and dose for treating and preventing disease. It allows targeting of treatment based on an individual's genetic makeup, which can influence drug metabolism and efficacy. Pharmacogenetics studies how genetic variations affect individual responses to drugs by influencing protein functions like metabolism and transport. Genetic testing can predict treatment responses before starting therapy to optimize treatment selection and reduce adverse reactions.
The growing field of Personalized therapy and newer approaches for dosage forms related to Personalization for the safe and effective treatment of patients. The field of personalized medicine aims at converting the term of "one drug fits all " approach to Personalized therapy. Thus, shifting emphasis in medicine from reaction to prevention.
hi.friends this is my first slide presentation which contain the information about the PERSONALIZED MEDICINES.this is the future medicinal treatment so,I hope you people like my presentation.
Personalized medicine also known as individualized medicine, it is the ability to offer right drug to the right patient, at right time, with right dosage form
Personalised Medicine is a young but rapidly advancing field.
The term 'Personalised Medicine' is described as providing "the right patient with the right drug at the right dose at the right time".
Personalised medicines -pharmacogentics and pharmacogenomicsAlakesh Bharali
This seminar basically introduces and explains the learner about what is personalised medicines, what is the need for it, how personalised medicines work. For this, the concept of pharmacogenetics and pharmacogenomics are considered. After going through the presentation, the learner will be able to understand about the concept of pharmacogentics and pharmacogenomics. Certain examples of personalised medicines are included in this seminar.Although personalised medicines are specific and helpful, ins spite of having lots of advantages , it also have some disadvantages which are also specified in this seminar.Although , we speak about personalised medicines, we never saw personalised medicines in our local market. So here is an approach given that , when will we see personalised medicines at the local pharmacy. Again, certain marketed products are also listed in the seminar.Also, the future of personalised medicines is depeicted in the seminar. How medicines will be in a an around 2050 is shown in the seminar. After going through the seminar, the learner would be able to understand about personalised medicines and all its aspects in detail.
Personalized medicine involves the prescription of specific therapeutics best suited for an individual based on their genetic or proteomic profile. This talk discusses current approaches in drug discovery/development, the role of genetics in drug metabolism, and lawful/ethical issues surrounding the deployment of new health technology. I highlight some bioinformatic roles in the drug discovery process, and discuss the use of semantic web technologies for data integration and knowledge discovery..
The growing field of Personalized therapy and newer approaches for dosage forms related to Personalization for the safe and effective treatment of patients. The field of personalized medicine aims at converting the term of "one drug fits all " approach to Personalized therapy. Thus, shifting emphasis in medicine from reaction to prevention.
hi.friends this is my first slide presentation which contain the information about the PERSONALIZED MEDICINES.this is the future medicinal treatment so,I hope you people like my presentation.
Personalized medicine also known as individualized medicine, it is the ability to offer right drug to the right patient, at right time, with right dosage form
Personalised Medicine is a young but rapidly advancing field.
The term 'Personalised Medicine' is described as providing "the right patient with the right drug at the right dose at the right time".
Personalised medicines -pharmacogentics and pharmacogenomicsAlakesh Bharali
This seminar basically introduces and explains the learner about what is personalised medicines, what is the need for it, how personalised medicines work. For this, the concept of pharmacogenetics and pharmacogenomics are considered. After going through the presentation, the learner will be able to understand about the concept of pharmacogentics and pharmacogenomics. Certain examples of personalised medicines are included in this seminar.Although personalised medicines are specific and helpful, ins spite of having lots of advantages , it also have some disadvantages which are also specified in this seminar.Although , we speak about personalised medicines, we never saw personalised medicines in our local market. So here is an approach given that , when will we see personalised medicines at the local pharmacy. Again, certain marketed products are also listed in the seminar.Also, the future of personalised medicines is depeicted in the seminar. How medicines will be in a an around 2050 is shown in the seminar. After going through the seminar, the learner would be able to understand about personalised medicines and all its aspects in detail.
Personalized medicine involves the prescription of specific therapeutics best suited for an individual based on their genetic or proteomic profile. This talk discusses current approaches in drug discovery/development, the role of genetics in drug metabolism, and lawful/ethical issues surrounding the deployment of new health technology. I highlight some bioinformatic roles in the drug discovery process, and discuss the use of semantic web technologies for data integration and knowledge discovery..
Pharmacogenomics is new science about how the systematic identification of all the human genes, their products, interindividual variation, intraindividual variation in expression and function over time affects drug response/metabolism, etc.
Improve drug safety and reduce ADRs. The presentation explained the advantages of pharmacogenomics. Explained Goals of Pharmacogen(etics)omics.
Pharmacogenomics deals with the influence of genetic variation on drug response by co-relating gene expression or polymorphism with a drug’s efficacy or toxicity.
genetic polymorphism new Presentation.pptxRumaMandal5
Genetic polymorphism was formerly applied to variants occurring at a frequency greater than 1%.
Types: SNPs,Insertions or deletions
Pharmacokinetic variations and pharmacodynamics variations
Application on G6PD deficiency
Introduction to adverse drug reactions
Definitions and classification of ADRs
Detection and reporting
Methods in Causality assessment
Severity and seriousness assessment
Predictability and preventability assessment
Management of adverse drug reactions
Pharmacological implications of genetic polymorphism and PharmacogeneticsRumaMandal4
Genetic polymorphism is applied to variants occuring at frequency >1%
Pharmacogenetics is study of genetic variation on drug response.
Pharmacogenetic traits may be Pharmacogenetics and pharmacodynamic types
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2. PERSONALIZED MEDICINES
• All patients do not respond to the same medicine in the same way.
• Some patients may experience adverse drug reactions that do not occur in
other patients taking the same drug at the same dose.
• A drug may also display varied efficacy in different patients.
• In the past, the differences in the risk-benefit ratio between patients taking
the same drug was attributed to non-genetic factors such as age, gender,
nutritional state, general medical condition (e.g. hepatic and renal dys-
function), lifestyle (diet, alcohol abuse, smoking), concomitant therapy or
the presence of comorbidity.
• Today, in addition to these factors the differences in patient genetic make-
up have been recognized to play an important role in the individual response
to drugs.
3.
4. • Personalized medicine also called individualized or precision medicine is a
medicinal model that uses patient’s genetic profile to choose the proper
medication, therapy and dose in regards to the prevention, diagnosis and
treatment of the disease.
• Personalized medicine introduces the ability to use molecular markers that
signal disease risk or presence before clinical signs and symptoms appear.
• It offers the opportunity to focus on prevention and early intervention rather
than on reaction at advanced stages of disease.
• There are more than 15,000 tests for more than 2,800 genes.
• For example 1, women with certain BRCA1 or BRCA2 gene variations
have up to an 85 percent lifetime chance of developing breast cancer,
compared with a 13 percent chance among the general female population.
These women also have up to a 60 percent chance of developing ovarian
cancer, compared with a 1.7 percent chance among the general female
population. The BRCA1 and BRCA2 genetic test can guide preventive
measures, such as prophylactic surgery, and chemoprevention.
5. • Example 2- Some people are fast metabolizers, and hence they utilize
the drug quickly. Others are slow metabolizers with difficulties in
degrading down some drugs, leading to high risk of intoxication and
ADRs. Several tests are available to detect variations in CYP450
genes.
• Example 3- Azathioprine (AZA) is frequently used in treatment of
Crohn’s disease. Absence or low levels of thiopurine methyl
transferase (TPMT), an enzyme that is required to metabolize
azathioprine could lead to dose dependent side effects or even toxic
reactions. It is now required to check the TPMT level and genotype
before starting these medicines.
6. BENEFITS OF PERSONALISED
TREATMENT
• Direct the selection of optimal therapy and reduce trial-and-error
prescribing
• Help avoid adverse drug reactions
• Increase patient adherence to treatment
• Improve quality of life
• Help control the overall cost of health care
7. PHARMACOGENETICS
• Pharmacogenetics involves the study of single gene mutations and
their effect on drug response.
• Polymorphic variation in the genes that encode the functions of
transporters, metabolizing enzymes, receptors, and other proteins can
result in individual differences in the dose-plasma concentration
response relationships for many important therapeutic agents.
• the term Pharmacogenetics is used to refer to the study of inter-
individual variations in the DNA sequence that are related to drug
response and efficacy.
• Measuring the DNA differences can thus predict the variation in
response to the medicine.
8.
9. • An advantage to using genetic testing as opposed to other types of
laboratory testing, such as measuring the concentration of the drug in
the blood during treatment, is that genetic tests can predict the
response to treatment before the treatment is started.
• In the past, systematic research into the basis of adverse drug
reactions has been hampered by the fact that these events are rare and
individuals are difficult to trace and study while suffering a reaction.
The ability to conduct genetic research retrospectively, at the end of a
clinical trial or after a medicine has been launched, using stored
samples of DNA, gives researchers a powerful new tool to explore
how medicines work.
10. • Such research will result in tests for responses to drugs that clinicians can
use to identify patients with a greater chance of effective response and
reduced risk of adverse reactions.
• Genetic markers to select appropriate treatment have, of course, been used
for decades. Whenever a patient needs a blood transfusion, the ABO blood
types—classic genetic markers—are used to identify the best match of
blood.
• Tissue typing before transplantation and Rhesus factor testing are other
examples.
• Trastuzumab (Herceptin; Genentech) has recently been licensed for treating
some types of breast cancer. It is a humanized monoclonal antibody against
the HER2 receptor and has been licensed together with a specific test
(Herceptest) to identify the appropriate subgroup of patients who
overexpress the HER2 receptor in the tumour tissue. This is the direction
that pharmacogenetics is likely to take drug treatment.
11.
12. • Pharmacogenetics in cardiovascular medicine - These include genetic
tests to predict the maintenance dose and risk of bleeding with
warfarin, the possibility of myopathy and myositis with simvastatin,
and the risk of recurrent thrombotic events with clopidogrel .
• The cost of a pharmacogenetic test can be as low as $100 using low-
cost nanotechnology.