Current treatment approach is based on sign and symptoms but near future it will be based on genetic structure/ genome. Genomics Data have great reasearch opportunities in near future.

1. ASHISH KUMAR

2. .. ..About making
the treatment
as
individualized
as the disease
…The ability of
predict an
individuals'
susceptibility to
disease
…A young but
rapidly
advancing
field.
..the use of new
method of
molecular
analysis
..is..

3. .. People vary from one other in many ways:
All are these factor play important role in
health and disease
The person
What they
eat
Their lifestyle
Exposure of the
environmental
factor
Their DNA

4. • The term “personalized medicine” is often
described as providing “the right patient with
the right drug and the right dose at the right
time”.
• More broadly “personalized medicine” may
be thought of as the tailoring of medical
treatment to the individual characteristics,
needs and preferences of the patient during
the all stages of care, including prevention,
diagnosis, treatment and follow up.

5.  Personalized medicine is also defined as of
medical treatment to individual
characteristics of each patient that not only
improves our ability to diagnose and to treat
disease, but offers the potential to detect
disease at an earlier stage and to treat it
effectively.

7. 1. The Right Drug
2. To The Right Patient
3. For The Right Disease
4. At The Right Time
5. With The Right Dose and
Right Route

9. Same diagnosis
same prescription
but different
people
Drug toxic but
beneficial
Drug Not toxic
and not
beneficial
Drug toxic
but not
beneficial
Drug not toxic
but beneficial
Personalized medicine

10. Based on
Large cohort studies
One size fits all
models
Increased cost and low
safety concern
Response rate of drug
still unsatisfactory
Blockbuster medicine
Do not account individual
difference
Without proven efficacy
Result varying 20% to 75%

11. Pharmacogenetics
The study how to gene affects a person’s response to
drug
Pharmacology
(Science of Drugs)
Genomics
Study of gene and
their function
Pharmacogenetics

12. 1. Treat the patient not just a disease
2. Individual approach
3. Predict susceptibility and risk factor
pre-empt disease progression
treatment intervention
avoid ineffective treatment
prevent adverse reactions
4. Reduce cost in long term
5. No drug resistance

13. 1. Similar symptom but different illness.
2. Medical interventions may work in some
people but note all.
3. 40% Of drug are taken are not effective.
4. Advance in genomics help to treat a patients
precisely and effectively.
5. To avoid any allergic and adverse effect.

14. 1. To study of variations of DNA and RNA characteristics and
related to the drug responsive in critically important area of
personalized medicine.
2. Convergence of advance in pharmacology and genomics.
3. Seeks to understand how difference in gene and their
expression affects the body’s response to medications.
4. Uses of genetics information for purposes of explaining
interindividual difference in drug metabolism
[pharmacokinetics] and physiological drug response
[phamacodynamics]

15. 1. Depend on identification of biomarkers.
2. Study of the variation of DNA.
3. Based on patients unique genetics profile.
4. It is participatory, engaging, patient in
lifestyle
5. Choices and health maintenance to
compensate for genetics susceptibilities.

16.  To predict a patient's response to drugs.
 To develop “customized” prescriptions.
 To minimize or eliminate adverse events.
 To improve efficacy and patients
compliance.
 To improve rational drug development.
 To develop more powerful, safer vaccine.
 Pharmacogenetics test need only be
conducted once in lie time.

20. Thanks you