Concept of Bioelectronic Medicines A new era of novel drug delivery system made possible to control chronic diseases using bioelectronic signal manipulation, added a new insight in the treatment of chronic diseases like rheumatoid arthritis, crohn's disease, inflammatory bowel disease, asthma, cancer etc.. This might be a big hope now and in the future

1. BIOELECTRONIC
MEDICINES
PRESENTED BY- ABHISHEK G. HARNE
M.PHARM 1ST YEAR
(PHARMACEUTICS)
AISSMS COLLEGE OF PHARMACY, PUNE

2. CONTENTS
❏ Introduction
❏ Definition
❏ How It Works
❏ Example Of Diseases
❏ Recent Advancement
❏ Next Generation Neuromodulation
❏ Advantages
❏ Disadvantages

3. INTRODUCTION
1.The nervous system uses electrical signals to communicate information
throughout the body. Virtually every cell and organ of the body is directly or
indirectly controlled by these neural signals.
2.Bioelectronic Medicine focuses on electrical signaling in the nervous system.
Insights into the regulatory functions of the nervous system and technologies
that record, stimulate, or block neural signaling to affect specific molecular
mechanisms.
3.This field brings together material science, biochemistry, biophysics, molecular
medicine, neuroscience, immunology, bioengineering, electrical engineering,
mechanical engineering, computer science, mathematics, artificial intelligence, and
other basic and clinical disciplines
4.This medicine system brought a new insight in treatment of chronic diseases
like rheumatoid arthritis, inflammatory bowel disease, Asthma, Diabetes,
Blindness, Cancer, Cardiovascular diseases etc

4. DEFINITION
● A branch of science that deals with the role of electron transfer in biological
processes.
● Also called as electroceuticals.
● Aimed at interfacing electronics with nerves to specifically target the biological
processes underlying disease.

5. HOW IT WORKS!
● The idea of electrically stimulating the body to alleviate illness is not new.
Doctors have implanted patients with pacemakers, deep-brain stimulators,
and other electrical devices for decades.
● Bioelectronic medicines are basically devices that may be pre programmed
type like pacemakers that is to be fixed on the atrium for pulse generation
BUT now the advancement in this type of medicines involves the smaller
chips, circuits or optical devices that is to be fixed on the neuronal bundles.
● That tiny devices either blocks or stimulate or record neuronal signal to
affect specific molecular mechanism

7. Examples of diseases
Rheumatoid Arthritis : Asthma :
Device attached to Pulmonary
nerve potentially blocks the
signals that cause lungs to
constrict

8. RECENT ADVANCEMENT
● Researchers at Northwestern University developed the first example of a
bioelectronic medicine: an implantable, biodegradable wireless device that
speeds nerve regeneration and improves the healing of a damaged nerve.
● materials scientists and engineers at Northwestern and neurosurgeons at
Washington University -- developed a device that delivers regular pulses of
electricity to damaged peripheral nerves in rats after a surgical repair process,
accelerating the regrowth of nerves in their legs and enhancing the ultimate
recovery of muscle strength and control. The size of a dime and the thickness
of a sheet of paper, the wireless device operates for about two weeks before
naturally absorbing into the body.

9. Progression of autodegradation

12. .
.
NEXT GENERATION
NEUROMODULATION
1
4
3
2
SENSITIVITY
i.e. able to sense signals from
neurons in the cortex and nerve
fascicles and fibers in the periphery,
in a highly sensitive manner against
other background interference..
RESPONSIVENESS
i.e. form closed-loop around
recording of neural signatures
and detection of biomarkers
SELECTIVITY
i.e. able to precisely target
nerves near visceral organs
central in chronic diseases
with clear endpoints.
ACCEPTANCE
i.e. miniaturized low power devices that
can be delivered with minimally invasive
implantation thereby reducing patient
burden and improving aces

13. .
ADVANTAGES
1)The introduction of various revolutionary technique in medicine field makes less pain
in approach to cure diseases.
2)These implants provide targeted treatment;by controlling the neural signals going to
specific organ.
3)Device would minimal or even zero side effects.
4)It will avoid or overcome the problems faced by conventional dosage forms. With
merging with nanotechnology, aimed at increasing selectivity and specificity of cellular
control.
5)It could be customeized for each patient to account for severity of a disease for better
patient compliance. These better results lead people more faith in modern medical
sciences.

14. DISADVANTAGE
S
1. Costly process..if a single part of chip is damaged the total
technique will be meaningless.
2. High compact state of nerve and cardiac
systems,indiscriminate stimulator can lead to undesirable
effects.
3. Chances to get electrical shock.
4. Installation of an implant may cause harm to our body.

15. References
1. Bioelectronic medicine: technology targeting molecular mechanisms
for therapy P. S. Olofsson and K.J.Tracey source-
(https://www.ncbi.nlm.nih.gov)
2. Bioelectronic medicine: an unexpected path to new therapies by
P.S.Olofsson (source- Internet, www.onlinelibrary.Wiley.com)
3. International Journal of Pharmaceutical science and research(Article
by Dhwanibahen Patel and Sunita Chaudhary
4. PNAS-Core Concept: The rise of bioelectric medicine sparks interest
among researchers, patients, and industry by Lynne Peeples
(www.pnas.org)
5. Bioelectronic Medicines (Wikipedia)

16. THANK YOU