This document discusses stem cells, their types and uses. It covers:
- Stem cells are unspecialized cells that can differentiate into specialized cells. There are two main types - embryonic stem cells isolated from blastocysts and adult stem cells found in tissues.
- Stem cells act as a repair system and can differentiate into specialized cells like blood, skin or intestinal tissues. In developing embryos they can become any cell type.
- Applications of stem cells include treatment of diseases, drug development/testing, and regenerative medicine to treat conditions like Parkinson's, Alzheimer's, spinal cord injuries and heart disease.
- Studies show mesenchymal stem cell transplantation may safely improve outcomes for strokes
There are a lot of orthopedic conditions and injuries that presently have limited treatment options available.
Here regenerative technologies comes up as a ray of hope among surgeons for the treatment by functionally repairing the tissues and organs using growth factors, stem cells and products developed by genetic engineering with the advancement in the stem cells research field .
The purpose of this presentation is to first provide idea about the orthopedic conditions along with the therapeutic potential of stem cells to treat these diseases.
Autologous Mesenchymal Stem Cells in OrthopaedicsVladimir Bobic
Nuffield Health, The Grosvenor Hospital Chester, UK
27 June 2013. GP and Physiotherapy Seminar: Autologous Stem Cell Therapies in Orthopaedics. Moderator and Presenter: Vladimir Bobic, Chester Knee Clinic
There are a lot of orthopedic conditions and injuries that presently have limited treatment options available.
Here regenerative technologies comes up as a ray of hope among surgeons for the treatment by functionally repairing the tissues and organs using growth factors, stem cells and products developed by genetic engineering with the advancement in the stem cells research field .
The purpose of this presentation is to first provide idea about the orthopedic conditions along with the therapeutic potential of stem cells to treat these diseases.
Autologous Mesenchymal Stem Cells in OrthopaedicsVladimir Bobic
Nuffield Health, The Grosvenor Hospital Chester, UK
27 June 2013. GP and Physiotherapy Seminar: Autologous Stem Cell Therapies in Orthopaedics. Moderator and Presenter: Vladimir Bobic, Chester Knee Clinic
What to know before getting stem cells - short versionMegan Hughes
Dr. Hughes discusses stem cell types including embryonic vs. adult stem cells, multipotent vs. pluripotent stem cells, mesenchymal vs peripheral blood-based stem cells, and how to make a stem cell decision. Learn more at http://aspenintegrativemedicine.com/adult-stem-cells/
Get the bone marrow transplant treatment in Delhi by best doctor / surgeon in world class hospital. We ensure you get the best medical care and even stay in touch for more assistance. website :- http://www.transplantsurgeryindia.com/bone-marrow-transplants/
Cartilage Repair using Stem cell & OrthobiologicsVaibhav Bagaria
Regenerating Cartilage is a challenge. What's new in this field of cartilage regeneration and the current status of the stem cell use in this field is described.
Ortho: to make straight or right. The use of biologic substances to prompt, stimulate or support a “healing event” within the body.The use of biologic substances to promote healing or reduce pain.The use of platelets and stem cells in treatment and management of musculoskeletal conditions
The Blood-Brain Barrier in Neurological DiseaseEvan Wehr
A power point I will present on Friday (8/5/2011) to everyone in my internship program, about 150 people. It should be easy counting that I've spoken in front of the entire high school before.
POWERPOINT PRESENTATION ON MENSTRUAL BLOOD BANKING. It will give information regarding menstrual cycle, and process of collection, storage and preservation of Menstrual blood. It provides information of its cost and benefits of Menstrual Blood Baking. Mostly explains about futuristic scops and researches going on...
This is my short presentation in one of my university classes. It's obvious that the future of the stem cell biology is tightly engaged with organoids and they will absolutely change the way science is going to.
Kind regards
Shahin Ahmadian
Dr. Kenneth Dickie from Royal Centre of Plastic Surgery in Barrie, Ontario explained the use of stem cells technology in plastic surgery.
If you have any questions, please contact Dr. Kenneth Dickie at http://royalcentreofplasticsurgery.com/
What to know before getting stem cells - short versionMegan Hughes
Dr. Hughes discusses stem cell types including embryonic vs. adult stem cells, multipotent vs. pluripotent stem cells, mesenchymal vs peripheral blood-based stem cells, and how to make a stem cell decision. Learn more at http://aspenintegrativemedicine.com/adult-stem-cells/
Get the bone marrow transplant treatment in Delhi by best doctor / surgeon in world class hospital. We ensure you get the best medical care and even stay in touch for more assistance. website :- http://www.transplantsurgeryindia.com/bone-marrow-transplants/
Cartilage Repair using Stem cell & OrthobiologicsVaibhav Bagaria
Regenerating Cartilage is a challenge. What's new in this field of cartilage regeneration and the current status of the stem cell use in this field is described.
Ortho: to make straight or right. The use of biologic substances to prompt, stimulate or support a “healing event” within the body.The use of biologic substances to promote healing or reduce pain.The use of platelets and stem cells in treatment and management of musculoskeletal conditions
The Blood-Brain Barrier in Neurological DiseaseEvan Wehr
A power point I will present on Friday (8/5/2011) to everyone in my internship program, about 150 people. It should be easy counting that I've spoken in front of the entire high school before.
POWERPOINT PRESENTATION ON MENSTRUAL BLOOD BANKING. It will give information regarding menstrual cycle, and process of collection, storage and preservation of Menstrual blood. It provides information of its cost and benefits of Menstrual Blood Baking. Mostly explains about futuristic scops and researches going on...
This is my short presentation in one of my university classes. It's obvious that the future of the stem cell biology is tightly engaged with organoids and they will absolutely change the way science is going to.
Kind regards
Shahin Ahmadian
Dr. Kenneth Dickie from Royal Centre of Plastic Surgery in Barrie, Ontario explained the use of stem cells technology in plastic surgery.
If you have any questions, please contact Dr. Kenneth Dickie at http://royalcentreofplasticsurgery.com/
For better view, press F5.
As we go through our lives each of us will have very different needs for our own healthcare.
Scientist's are constantly researching to make medical care treatment more personalized.
One way they are doing this is by-
Stem Cells therapy
Stem-cell therapy is the use of stem cells to treat or prevent a disease or condition.
It is also known as regenerative medicine, promotes the reparative response of diseased, dysfunctional or injured tissue using stem cells or their derivatives.
It is the next chapter of organ transplantation and uses cells instead of donor organs, which are limited in supply.
What are Stem cells?
Stem cells are called “master cells”
Stem cells are cells that are undifferentiated.
What are Stem cells?
Steam cells have the potential to become all other kinds of cells in our body.
What are Stem cells?
Types of Stem cells
How stem cell therapy works?
Disease cured by stem cell therapy.
Spinal Cord Injuries
Stem cell treatment of Diabetes mellitus type 1 & 2
Stem cell treatment of Stroke
Cancer treatment
Heart damage
Baldness
Tooth implanting
Deafness and blindness
Have stem cells already been used to treat diseases?
Ethical Consideration of Stem Cell Therapy
As the research method mainly focused on Embryonic Stem Cells, which involves taking tissue from an aborted embryo to get proper material to study. This is typically done just days after conception or between the 5th and 9th week.
Since then, researchers have moved on to more ethical study methods, such as Induced Pluripotent Stem Cells (iPS). iPS is artificially derived from a non-pluripotent cell, such as adult somatic cells.
Nowadays stem cell treatment has been spreaded throughout the world. It has also been grown commercially in developed countries.
It is thought that one day it may be the major key to treat various diseases.
Using stem cells to conduct medical research and treat disease is acceptable?
Don’t know
No
Yes
Do you approve of the extraction of stem cells from human embryos for medical research?
Don’t know
No
Yes
Neurodegenerative diseases are a group of disorders characterized by the gradual loss of structure or function of neurons in the brain or spinal cord. Some common neurodegenerative diseases include Alzheimer's disease, Parkinson's disease, and Huntington's disease.
This presentation deals with stem cell therapy & new avenues in stem cell therapy. It also discusses latest advances such as treatment against baldness, multiple sclerosis, type 1 diabetes, spinal cord injury, demyelinating diseases, deafness, eye, Parkinson's disease. Also discusses about umbilical cord stem cells and finally clinical trials without patients (organs on chips).
Stem cell Therapy in Neurological diseases Ibad khan
Stem cell Therapy in Neurological diseases
difinition
mechanism
types
history
advantages or disadvantages
in this presentation all theses information include ,
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
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Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Are There Any Natural Remedies To Treat Syphilis.pdf
Power 2
1.
2.
3. Stem cells
are undifferentiated biological cells that can differentiate into
specialized cells and can divide (through mitosis ) to produce
more stem cells. They are found in multicellular organisms .In
mammals there are two broad types of stem cells: Embryonic ;
which are isolated from the inner cell mass of blastocysts and
Adult , which are found in various tissues In adult organisms,
stem cells and progenitor cells act as a repair system for the
body, replenishing adult tissues. In a developing embryo stem
cells can differentiate into all the specialized cells—ectoderm,
endoderm and mesoderm (see induced pluripotent ste cells )—
but also maintain the normal turnover of regenerative organs,
such as blood, skin, or intestinal tissues.
4. • SCs are unspecialized cells in the human body that
are capable of becoming specialized cells with
specialized functions.
• For example: HSCs are unspecialized stem cells and
able to into blood cells; RBC, platelet &
WBC with specific function each.
• Stem cell remains uncommitted until it receives a
signal to develop. Each new cell, either become a
stem cell or another cell type with a specific
function, i.e. blood cells.
5. stem cell biology:
It is an attracted field, has a role in treatment of
incurable diseases, major classes and option
of work.
word of “ ” has been loosely used by
some scientists without the demonstration of
SC markers or confirmation of stemness via
transcriptone profiling. The correct definition
through the proper and accepted tests be
addressed before a particular cell type is
classified as stem cell
12. Origin of adult stem cells
• Some believe that adult stem cells and
fetal SC are evolved from embryonic SC
. Therefore the few SCs in adult are
from the remnants of original
embryonic SCs. These either develop
into an organs or remained in the cell
niches in the organs ready for repair in
the future.
• https://prezi.com/3yht9req9fs7/what-are-
stem-cells/
13. First: protocol of embryonic SC (
ESC)
Fertilized ova, zygote, 2-cells, 4-cells, 8-cells and
morula resulting from cleavage of the early
embryo are example of totipotent cells ( has
the ability to form a complete organism)
Three layers are developed : endoderm ,
mesoderm and ectoderm
Embryo should be lack of genetic & infectious
diseases
14.
15.
16.
17. Fetal Stem Cells
• They are primitive cell types found in the
organ of fetuses.
• Neural crest cells, pancreatic, HSCs have been
isolated from abortuses
• Fetal neural SCs derived from fetal brain
• Fetal blood, placenta and cord are rich in HSCs
19. Characteristics of cord BSCs
-contains stem cells which are quite distinct from
bone marrow SCs
-stem cells are equal or exceeds that of bone marrow
and produce large colonies in vitro, have different
growth factors, long telomere and can be expanded
in long term culture
-shows decreased graft versus host reaction
-multipotent ( liver and neuron cells)
-can be storage for later use
-matrix of Wharton`s jelly source of MSCs which have
high c-kit marker useful for neurons
27. Principles of stem cell
plasticity
There are four mechanism of differentiation of HSC:
1- differentiation: cells develop from a less
differentiated to a more differentiated states and
maintain the ability to diff into multiple cell lines
2- indirect trans-differentiation: gene expression of
HSC changes to an alternative cell type through
de re-diff.
3- direct diff : HSC ability to change gene expression
directly into other cell type
4- fusion: usually MSC fuses with other non
haematopoietic cells and gene expression of
marrow cell takes on nucleus of the latter.
However, nucleoli have not to fuse
28.
29. Adult stem cell plasticity
examples
- Blood cells becoming neurons
- Liver cells stimulating to produce
insulin
- Haematopoietic ( blood cell
producing ) stem cells that become
heart cells
30. Clinical applications
• Stem cells, which are undifferentiated, have
many clinical and scientific uses:
- Cell based therapy ( regenerative therapy )
- Therapeutic cloning
- Gene therapy
- Cancer research
31. Potential uses of SCs in Vitro
• Biotechnology ( drug development and
discovery ) stem cells provide cell to test
new drugs
• Safety testing of new drugs on
differentiated cell lines
• screening of potential drugs to test anti
tumor cells and reduce animal testing
32. Potential uses continue..
Cell based therapies:
• Regenerative therapy to treat Alzhiemer`s,
Parkinson`s, spinal cord injury, stroke, sever burn,
heart disease, diabetes. Osteoarthritis and
rheumatoid arthritis.
• Stem cells in gene therapy as vehicles
• Stem cells in therapeutic cloning
• Stem cells in cancer
33. Stem cells for the treatment of
neurological disorders
Human neurological disorders such as Parkinson's disease,
Huntington's disease, Alzheimer's disease, multiple
sclerosis (MS), stroke, and spinal cord injury are caused by
a loss of neurons and glial cells in the brain or spinal cord.
Cell replacement therapy and gene transfer to the diseased
or injured brain have provided the basis for the
development of potentially powerful new therapeutic
strategies for a broad spectrum of human neurological
diseases.
In recent years, neurons and glial cells have successfully
been generated from stem cells such as embryonic stem
34. ability to heal after injury due to the inability of the
brain to make new cells. Researchers observed
that there are two special regions of the brain that
actually do produce new cells, even in adults. The
cells from these two special regions are called
neural stem cells and now scientists are working
hard to determine how their special properties can
be used to treat different types of damage in the
brain.
35.
36. Autologous mesenchymal stem cells for the treatment of
secondary progressive multiple sclerosis: an open-label
phase 2a proof-of-concept study, 2012
This study applied on Patients with secondary
progressive multiple sclerosis involving the visual
pathways who were recruited from the East Anglia
and north London regions of the UK in 2012.
The study aims: the safety & feasibility of the MSCs
infusion, adverse effect of infusion 20 months before
and 10 after infusion and finally to assess the
anterior visual pathway.
Isolated, expanded, characterize and administered in
ten patients. There were no adverse effects
identifiable and there were improvement in visual
acuity, visual evoked response latency and an
increase in optic nerve area. However there were no
37. Changes in visual function, visual evoked
response amplitude and optic nerve area after
SC treatment respectivly
38.
39. There was a study has tested a Long-Term Follow-Up of Intravenous
Autologous
Mesenchymal Stem Cell Transplantation in Patients With Ischemic Stroke
in neurology department, school of medicine in South Korea in 2010
• The study has evaluated the safety and efficacy
of i.v. MSCs transplantation in 85 patients with
sever middle cerebral artery territory infarct.
• Patients were randomly allocated to one of two
groups, those who received i.v. autologous ex
vivo cultured MSCc (MSC group) or those who
did not (control group), and followed for up to 5
years.
• Mortality of any cause, long term side effects,
41. Results of that study were depended
on clinical, biomarkers and neuro-
images
• 25% of MSCs group and 58% of control group
died during the follow up period.
• Significant side effects were not observed
following MSC treatment.
• Co morbidities occurrence did not differ between
groups.
• Modified Ranken Scale score was increased in
MSCs group whereas decreased in control
• i.v. MSC transplantation was safe.
• Clinical improvement may improve recovery after
stroke
42.
43. The results conducted functional outcome at day 7 of
admission and last evaluation median 3.5 years
according to mRS score
44. • Patients with stroke who received MSC
infusion and the subventricular zone status
(SVZ)
46. Stem cells therapy in joints
• Experts are researching ways to use stem cells to treat arthritis
in the knee and other joints. Many doctors already use stem
cell therapy to treat arthritis, but it is not considered standard
practice.
• Stem cells can be applied during a surgery (such as the
surgical repair of a torn knee meniscus) or delivered through
injections directly into the arthritis joint.
• When administering stem cell injections, many physicians use
medical imaging, such as ultrasound, in order to deliver cells
precisely to the site of cartilage damage.
• There is some evidence that people with severe arthritis can
benefit from stem cell therapy.1 Most research indicates that
younger patients who have relatively mild osteoarthritis or
cartilage damage see the most benefit
47. Stem cell therapy safety
• Most stem cell therapy using adult stem cells is
considered safe because the stem cells are collected
from the patient, minimizing the risk of an unwanted
reaction. The most common side effects are temporary
swelling and pain.
• Some research suggests stem cell therapy engaging in
these kinds of practices may elevate the risk of tumors.
• when applied to an arthritic joint, stem cells might:
- Develop into needed cartilage cells
- Suppress inflammation that can make arthritis worse
- Release proteins (cytokines) that slow down
cartilage degeneration and/or decrease pain
48. Candidate!!??Stem cell implantation may be
recommended for patients with osteoarthritis of the
knee. Typically these patients have failed other
treatment options including rest, medications,
other injections and physical therapy and are not
anxious for total knee replacement.
• Who is not candidate??!! Patient with a blood
borne Cancer (such as lymphoma or leukemia),
not in remission for at least 5 year
• Certain other malignancies or blood borne
diseases that you are being treated for
• Patient with any current infection
• Patient who uses a high dose of Coumadin
• Patients with multiple medical issues may not be
good candidates
49.
50.
51. There was a study about the role of PRP
and stem cells injection in O A patients of
knee J in 2015
• The study supplied the affected knee joint
with MSC in combination with PRP. As
they have treated 65 of cases of moderate
to sever OA of knee joint (56 to 87 years
age) and 50 other cases for control.
• the study conducted from 2012 to 2014,
control group received local steroid and
both groups were undergoing medical
52. Procedure was as below:
• Treated group were injected 7cc of PRP
mixed with 3cc of stem cell preparation in to
the select joint along with 5cc of 0.5%
preservative free bupivacaine, under strict
aseptic precautions. Sterile bandages were
applied after the injection followed by
mobilization immediately after the procedure.
• Whereas control group similar procedure is
performed in the control group with 10cc of
0.5%bupivacaine, with 60mg of
53.
54.
55. RESULTS: Both the groups were observed from time to
time and analyzed based on the pain scores at 3 days, 1
week, 4 weeks, 3 months and 6 months intervals.
0
10
20
30
40
50
60
70
3 days 1st week 4 weeks 3 months 6 months
tested group
control group
Column1
56. Final Results were 86%of test group had improvement in
pain and function of knee joint and 52%of control group
had improvement and pain and function of the knee
joint at the end of the 6 months.
57. So it can be concluded that:
• PRP and stem cells injections in to the
osteoarthritic knees, produces good
results and safe. If the patient is not opting
for surgical procedures and this is the only
better treatment modality for controlling
the pain and improvement of joint function.
Hence use of PRP and stem cells
injections in osteoarthritic patients is great
value in preventing the further damage of
the cartilage. By repairing the damaged
cartilage with the PRP and stem cells, pain
is greatly reduced, increase in the function