Mental attitude: A study found that eye contact between dogs and their owners releases oxytocin in both, indicating the bond is similar to a parent-child relationship.
Health alert: Electronic cigarette use among adolescents has tripled from 2013 to 2014, exceeding the use of all other tobacco products including conventional cigarettes. Health officials are concerned about addiction and effects on the developing brain.
Diet: The availability of fresh seasonal foods increases in spring, so nutrition experts recommend incorporating more spinach, strawberries, asparagus into meals and snacks.
This daily health update email provides concise summaries of recent studies on various health topics in 3 sentences or less per study:
1) A study found that male brain volume related to memory declines faster starting at age 40 compared to females.
2) A meta-analysis linked higher body mass index to greater risks of colorectal cancer mortality and premature death.
3) A study suggests folic acid may help reduce stroke risk in people with high blood pressure when taken with blood pressure medication.
The document provides a daily health update with summaries of recent studies on various health topics. It includes the following summaries:
1) A study found that mild cognitive impairment affects men and women differently, with females experiencing greater impairment in verbal learning and recall.
2) Salmonella can survive for at least six months in dry foods like cookies and crackers, posing a risk of foodborne illness.
3) A study linked low vitamin D levels with irritable bowel syndrome in many patients.
4) A study on older elite runners found their muscle fibers experienced similar age-related reductions as non-athletes, despite maintaining superior performance.
5) A review found that chiropractic services have been
This document provides summaries of several recent health-related studies and articles, including: 1) Loneliness and depression are associated with TV binge-watching; 2) Combining certain antibiotics and heart medications can double the risk of sudden death in seniors; 3) Many prepackaged toddler meals and snacks contain high levels of salt and added sugar.
This document provides summaries of several recent health-related studies:
1) A study found that well-spoken pitches were more effective at motivating action than well-written submissions.
2) A survey of college students found high rates of e-cigarette use, often combined with other tobacco products, and lower grades among users.
3) Excessive salt intake was linked to damage to blood vessels and organs even without high blood pressure.
4) A study associated greater aerobic fitness in elementary students with 8-11% higher math scores.
5) Sitting for long periods, both at home and work, increased risk of back injuries in blue-collar workers.
Daily health update for 11/09/2015 from Poway Chiropractor Dr. Rode of Rode Chiropractic in Poway, CA 92064.
The latest health and chiropractic information
Mental attitude: A study found that eye contact between dogs and their owners releases oxytocin in both, indicating the bond is similar to a parent-child relationship.
Health alert: Electronic cigarette use among adolescents has tripled from 2013 to 2014, exceeding the use of all other tobacco products including conventional cigarettes. Health officials are concerned about addiction and effects on the developing brain.
Diet: The availability of fresh seasonal foods increases in spring, so nutrition experts recommend incorporating more spinach, strawberries, asparagus into meals and snacks.
This daily health update email provides concise summaries of recent studies on various health topics in 3 sentences or less per study:
1) A study found that male brain volume related to memory declines faster starting at age 40 compared to females.
2) A meta-analysis linked higher body mass index to greater risks of colorectal cancer mortality and premature death.
3) A study suggests folic acid may help reduce stroke risk in people with high blood pressure when taken with blood pressure medication.
The document provides a daily health update with summaries of recent studies on various health topics. It includes the following summaries:
1) A study found that mild cognitive impairment affects men and women differently, with females experiencing greater impairment in verbal learning and recall.
2) Salmonella can survive for at least six months in dry foods like cookies and crackers, posing a risk of foodborne illness.
3) A study linked low vitamin D levels with irritable bowel syndrome in many patients.
4) A study on older elite runners found their muscle fibers experienced similar age-related reductions as non-athletes, despite maintaining superior performance.
5) A review found that chiropractic services have been
This document provides summaries of several recent health-related studies and articles, including: 1) Loneliness and depression are associated with TV binge-watching; 2) Combining certain antibiotics and heart medications can double the risk of sudden death in seniors; 3) Many prepackaged toddler meals and snacks contain high levels of salt and added sugar.
This document provides summaries of several recent health-related studies:
1) A study found that well-spoken pitches were more effective at motivating action than well-written submissions.
2) A survey of college students found high rates of e-cigarette use, often combined with other tobacco products, and lower grades among users.
3) Excessive salt intake was linked to damage to blood vessels and organs even without high blood pressure.
4) A study associated greater aerobic fitness in elementary students with 8-11% higher math scores.
5) Sitting for long periods, both at home and work, increased risk of back injuries in blue-collar workers.
Daily health update for 11/09/2015 from Poway Chiropractor Dr. Rode of Rode Chiropractic in Poway, CA 92064.
The latest health and chiropractic information
Daily Health Update from Poway Chiropractor Dr. Kip Rode of Rode Chiropractic in Poway, CA 92064. The latest daily health and chiropractic information.
This daily health update email summarizes recent studies on various health topics. A study found that differences in brain structure may help explain increased risk of hallucinations for schizophrenia patients. Rates of sexually transmitted diseases like chlamydia, syphilis and gonorrhea increased for the first time in years, possibly due to less access to clinics. Research links eating breakfast, especially nutritious breakfasts, to better academic performance in students. Exercise can benefit patients with chronic kidney disease by improving quality of life and increasing fitness. Chronic neck pain patients are more likely to develop insomnia, with high pain levels and depression as predictors. Sleeping more on non-work days may increase risks for diabetes and heart disease.
The document discusses issues with the current US healthcare system including multiple emergency room visits and misdiagnoses leading to a loss of faith in the system. It notes the focus on treatment over prevention, lack of effective communication between professionals, rising costs but decreasing coverage, and doctors prioritizing procedures for profit over primary care. Between 44,000 to 98,000 people die each year from preventable medical errors. The presentation calls for changes like improving insurance, implementing coordinated patient plans, and focusing more on preventative care rather than overprescribing medications.
This document summarizes an article about Dr. Theodore Schreiber being named one of the top 1% of cardiologists in the US according to a U.S. News & World Report list. It notes that he performs over 1,500 heart procedures annually and created a 24/7 heart attack treatment program at Detroit Medical Center that exceeds national treatment goals. The CEO of DMC praised Dr. Schreiber for his leadership and the rising reputation of their cardiology program.
This document contains summaries of several recent health-related studies and articles:
1) A study found that men score higher in narcissism than women, which may explain some gender disparities in leadership outcomes.
2) A new study linked statin drugs to an increased risk of developing type 2 diabetes, with higher doses associated with higher risk.
3) Research showed that consuming fried foods more than once a week is linked to an increased risk of heart failure.
4) A study found that exercising after dinner was more effective at reducing blood sugar, cholesterol, and triglyceride levels in type 2 diabetics compared to exercising before dinner or not at all.
This document discusses conveying trusted health information to employees. It notes that a study found eating tomatoes and tomato-based foods is associated with a lower risk of stroke. Specifically, people with the highest levels of the antioxidant lycopene in their blood had a 55% lower risk of stroke than those with the lowest levels. The document provides tips and resources for evaluating the reliability of health information online and delivering it to employees, including asking employees their preferred methods of receiving such information and considering barriers to generating trusted information.
Scientists have identified an enzyme that may play a role in age-related muscle wasting and other problems. Inhibiting this enzyme, 11beta-HSD1, could potentially prevent or reverse the effects of aging. Researchers found that women over 60 have higher levels of this enzyme in their muscles compared to younger women. An anti-aging drug targeting this enzyme could be available within 5 years.
An aging heart with reduced pumping ability may decrease blood flow to the brain's memory center, potentially leading to mild cognitive impairment or reduced memory function. The preterm birth rate in the US continues to rise, increasing health risks for mothers and babies. A diet high in fish and vegetables may lower the risk of depression by 14-18%. Moderate exercise was found to reduce side effects of breast cancer treatment like pain and fatigue while improving cardiovascular fitness.
Gen-X adults who experienced socioeconomic disadvantages as children are more likely to have lower wellbeing later in life according to a new study. Staying active with 30 minutes of exercise per day in one's 60s and 70s reduces the risk of falls in the 90s by 35% according to another study. A third study found that colorectal cancer patients who ate more fiber after their diagnosis had an 18% lower risk of cancer-related death over the following eight years.
The newsletter discusses various topics related to the IMA Kozhikode branch including:
- An interview with the IMA State President
- A cover story on whether quality is a priority in the healthcare sector, arguing that practicing quality reduces risks and ensures safety and satisfaction of patients.
- Other articles include a journal scan summarizing recent research, obituaries, and news and events from the IMA Kozhikode branch.
The newsletter serves to keep IMA members updated on activities of the vibrant IMA Kozhikode branch and features different content in an attractive presentation style, covering the initial three months of the branch's activity year.
This document outlines primary and secondary research plans for a documentary on dieting and eating disorders. Primary research will include interviews with professionals like psychologists and people with different experiences of dieting and eating disorders. Locations for filming include gyms, hospitals, support group meetings, homes, stores, and restaurants. Secondary research covers physical health statistics on obesity rates, health costs, and risks in the UK as well as facts about eating disorders, their causes, and common types. Bibliographic sources are also listed.
Cuáles son las sanciones por crear falsas empresas en colombiaMiguel Ramírez
La Ley 1429 de 2010 recoge una serie de beneficios para las pequeñas empresas que se constituyeran tras entrar la Ley en vigor. Se procuraba bonificar la generación de empleo en Colombia, pero junto con los efectos positivos de la Ley se ha detectado el intento de muchas empresas ya existentes de adscribirse ilícitamente al régimen previsto.
El documento describe las 7 etapas de un proceso de pensamiento para realizar una tarea: 1) leer y comprender el texto, 2) identificar qué se pide, 3) planear cómo realizarlo, 4) revisar el plan, 5) ejecutar cada paso del plan, 6) revisar el punto 2 si hay dudas, y 7) reflexionar sobre cómo te sientes al terminar.
Daily Health Update from Poway Chiropractor Dr. Kip Rode of Rode Chiropractic in Poway, CA 92064. The latest daily health and chiropractic information.
This daily health update email summarizes recent studies on various health topics. A study found that differences in brain structure may help explain increased risk of hallucinations for schizophrenia patients. Rates of sexually transmitted diseases like chlamydia, syphilis and gonorrhea increased for the first time in years, possibly due to less access to clinics. Research links eating breakfast, especially nutritious breakfasts, to better academic performance in students. Exercise can benefit patients with chronic kidney disease by improving quality of life and increasing fitness. Chronic neck pain patients are more likely to develop insomnia, with high pain levels and depression as predictors. Sleeping more on non-work days may increase risks for diabetes and heart disease.
The document discusses issues with the current US healthcare system including multiple emergency room visits and misdiagnoses leading to a loss of faith in the system. It notes the focus on treatment over prevention, lack of effective communication between professionals, rising costs but decreasing coverage, and doctors prioritizing procedures for profit over primary care. Between 44,000 to 98,000 people die each year from preventable medical errors. The presentation calls for changes like improving insurance, implementing coordinated patient plans, and focusing more on preventative care rather than overprescribing medications.
This document summarizes an article about Dr. Theodore Schreiber being named one of the top 1% of cardiologists in the US according to a U.S. News & World Report list. It notes that he performs over 1,500 heart procedures annually and created a 24/7 heart attack treatment program at Detroit Medical Center that exceeds national treatment goals. The CEO of DMC praised Dr. Schreiber for his leadership and the rising reputation of their cardiology program.
This document contains summaries of several recent health-related studies and articles:
1) A study found that men score higher in narcissism than women, which may explain some gender disparities in leadership outcomes.
2) A new study linked statin drugs to an increased risk of developing type 2 diabetes, with higher doses associated with higher risk.
3) Research showed that consuming fried foods more than once a week is linked to an increased risk of heart failure.
4) A study found that exercising after dinner was more effective at reducing blood sugar, cholesterol, and triglyceride levels in type 2 diabetics compared to exercising before dinner or not at all.
This document discusses conveying trusted health information to employees. It notes that a study found eating tomatoes and tomato-based foods is associated with a lower risk of stroke. Specifically, people with the highest levels of the antioxidant lycopene in their blood had a 55% lower risk of stroke than those with the lowest levels. The document provides tips and resources for evaluating the reliability of health information online and delivering it to employees, including asking employees their preferred methods of receiving such information and considering barriers to generating trusted information.
Scientists have identified an enzyme that may play a role in age-related muscle wasting and other problems. Inhibiting this enzyme, 11beta-HSD1, could potentially prevent or reverse the effects of aging. Researchers found that women over 60 have higher levels of this enzyme in their muscles compared to younger women. An anti-aging drug targeting this enzyme could be available within 5 years.
An aging heart with reduced pumping ability may decrease blood flow to the brain's memory center, potentially leading to mild cognitive impairment or reduced memory function. The preterm birth rate in the US continues to rise, increasing health risks for mothers and babies. A diet high in fish and vegetables may lower the risk of depression by 14-18%. Moderate exercise was found to reduce side effects of breast cancer treatment like pain and fatigue while improving cardiovascular fitness.
Gen-X adults who experienced socioeconomic disadvantages as children are more likely to have lower wellbeing later in life according to a new study. Staying active with 30 minutes of exercise per day in one's 60s and 70s reduces the risk of falls in the 90s by 35% according to another study. A third study found that colorectal cancer patients who ate more fiber after their diagnosis had an 18% lower risk of cancer-related death over the following eight years.
The newsletter discusses various topics related to the IMA Kozhikode branch including:
- An interview with the IMA State President
- A cover story on whether quality is a priority in the healthcare sector, arguing that practicing quality reduces risks and ensures safety and satisfaction of patients.
- Other articles include a journal scan summarizing recent research, obituaries, and news and events from the IMA Kozhikode branch.
The newsletter serves to keep IMA members updated on activities of the vibrant IMA Kozhikode branch and features different content in an attractive presentation style, covering the initial three months of the branch's activity year.
This document outlines primary and secondary research plans for a documentary on dieting and eating disorders. Primary research will include interviews with professionals like psychologists and people with different experiences of dieting and eating disorders. Locations for filming include gyms, hospitals, support group meetings, homes, stores, and restaurants. Secondary research covers physical health statistics on obesity rates, health costs, and risks in the UK as well as facts about eating disorders, their causes, and common types. Bibliographic sources are also listed.
Cuáles son las sanciones por crear falsas empresas en colombiaMiguel Ramírez
La Ley 1429 de 2010 recoge una serie de beneficios para las pequeñas empresas que se constituyeran tras entrar la Ley en vigor. Se procuraba bonificar la generación de empleo en Colombia, pero junto con los efectos positivos de la Ley se ha detectado el intento de muchas empresas ya existentes de adscribirse ilícitamente al régimen previsto.
El documento describe las 7 etapas de un proceso de pensamiento para realizar una tarea: 1) leer y comprender el texto, 2) identificar qué se pide, 3) planear cómo realizarlo, 4) revisar el plan, 5) ejecutar cada paso del plan, 6) revisar el punto 2 si hay dudas, y 7) reflexionar sobre cómo te sientes al terminar.
Este documento describe el uso de la tecnología educativa para mejorar la enseñanza y el aprendizaje. Señala que las nuevas tecnologías permiten crear entornos comunicativos que facilitan nuevas experiencias educativas para los estudiantes. También explica que es necesario capacitar a los maestros en estas herramientas y cambiar su rol del transmisor de conocimiento al facilitador del aprendizaje. Resalta la importancia de aplicar estas tecnologías de manera adecuada considerando factores como la metodología, recursos,
El documento describe la evolución de la educación a distancia a través de las generaciones. Inicialmente surgió en Europa a finales del siglo XIX y se basaba en el libro de texto y el correo postal. Posteriormente, se incorporaron medios como la radio, la televisión y los videos educativos. Más tarde, la educación a distancia comenzó a utilizar tecnologías como el teléfono, el fax y la videoconferencia. En la generación actual, la distancia física ya no es un aspecto funcional y las nuevas tecnologías permit
Clojure is considered pretty cool because it provides immutable and persistent data structures, handles concurrency well through software transactional memory, and runs on the Java Virtual Machine while also having a simple homoiconic syntax like LISP and functional programming concepts such as laziness.
Sólidos de revolución con wolfram mathematica 7chavaortiz
El documento describe cómo girar una función matemática en un intervalo específico para generar un sólido de revolución tridimensional. Se instruye al usuario a seleccionar una función, el intervalo de giro y una etiqueta para los ejes antes de graficar la función en 2D para visualizar la superficie a rotar y generar el sólido final.
La UNIDAD EDUCATIVA CALASANZ ofrece un beneficio educativo de alta calidad para sus estudiantes. Brinda una educación integral enfocada en el desarrollo de valores y habilidades para la vida. El beneficio principal es formar personas con pensamiento crítico, consciencia social y preparadas para continuar su educación superior.
A reciclagem envolve o reaproveitamento de materiais já utilizados como matéria-prima para novos produtos. O papel reciclado, por exemplo, é transformado e utilizado de maneira diferente do original. O lixo é levado para usinas de reciclagem onde é separado o que pode ser reutilizado e vendido, preferencialmente em locais afastados das cidades devido aos riscos à saúde.
Wondering how you can increase productivity and employee satisfaction at the same time? Check out how Mobile Information Access can keep both IT and users smiling.
Total de medios_comunitarios_habilitadoshinterlaces
Este documento presenta un resumen de los medios de comunicación comunitarios habilitados en Venezuela por estado, incluyendo el número de radios y canales de televisión en cada uno. En total hay 244 radios y 36 canales de televisión comunitarios a través del país, para un total de 280 medios comunitarios. La información fue provista por la Gerencia de Acompañamiento Técnico.
This daily health update email provides summaries of recent studies on various health topics. A Swedish study found that men with lower IQ scores were more likely to engage in heavy or binge drinking. Another study suggests that a family history of prostate cancer may increase a woman's risk of breast cancer. Additional articles discuss research on an olive oil compound that may help fight cancer, benefits of exercise for brain health and mobility in older adults, neck and shoulder pain relief from stretching, and overall health benefits from diet and exercise.
Daily Health Update from Poway Chiropractor Dr. Kip Rode of Rode Chiropractic in Poway, CA 92064. The latest daily health and chiropractic information.
Traffic noise exposure may exacerbate Parkinson's disease symptoms, leading to more hospital visits. Drugs, not alcohol, are now the leading cause of fatal car crashes in the US due to legalized marijuana and opioids. Energy drinks have a greater effect on heart activity and blood pressure than other caffeinated drinks. Increasing children's physical activity by 25 minutes three times a week could save $62.3 billion in future medical costs and lost wages. Lumbar disk degeneration is common in young women and progresses rapidly with age.
This daily health update email contains summaries of recent studies on various health topics in 3 sentences or less per study:
1) A study found that individuals who have undergone weight-loss surgery are about 50% more likely to attempt suicide after losing weight, and more than 90% of suicide attempts involved a history of mental health problems.
2) Researchers found that teenagers who are overweight or obese are more than twice as likely to have high blood pressure, which can lead to artery problems later in life.
3) An animal study showed that a diet high in processed fructose slows recovery from brain injuries, with rats on a fructose diet taking 30% longer to exit a maze after a head trauma
This document discusses gender differences in cardiac care. It summarizes findings from a study that used MRI scans to analyze how male and female hearts change with age. The study found significant differences: the male heart muscle grows thicker with age while the female heart retains its size or gets slightly smaller. This has implications for the types of heart failure seen in each gender and indicates a need for gender-specific treatments. Currently, diagnostics and treatments are often developed based on the male heart model. The study suggests men and women may develop heart disease for different reasons.
Daily Health Update for 10/22/2015 from Poway Chiropractor Dr. Rode of Rode Chiropractic in Poway CA 92064 specializing in Chiropractic care for patients
This document contains summaries of several recent health-related studies and articles:
1) A study found that mental health disorders increase mortality risk by over 2 times, and account for 8 million deaths worldwide annually. Efforts are needed to reduce risks from severe mental illnesses and common disorders.
2) Research suggests smoking may cause over 540,000 US deaths per year when including other conditions like kidney disease and cancer. This challenges the current estimate of 480,000 smoking deaths.
3) A study links following the Mediterranean diet to a lower risk of ischemic stroke due to the diet's emphasis on plants, fish and limits on meat and dairy.
1) The document discusses strategies for managing allergies, addressing common myths and misconceptions about allergies. It notes that growing up around allergens may actually help build immunity. The protein in dried animal secretions, not the fur itself, causes pet allergies. Natural fibers are better than synthetic for staying allergy-free. New drugs that target IgE antibodies may cure allergies.
2) To diagnose allergies, consider family history and see a doctor. Treatments include nasal sprays, antihistamines, decongestants, and immunotherapy injections.
This daily health update email contains summaries of recent research on potential alternative treatments for depression, rising deaths due to high blood pressure, reducing liver cancer risk through limiting alcohol and maintaining a healthy weight, midlife fitness reducing cancer risk in men, unstable shoes possibly helping back pain patients, and planning for children in emergencies. The email concludes with a quote about not pretending second rate is first rate.
This daily health update email provides summaries of recent studies on various health topics. It includes summaries of studies finding that happiness can spread through the smell of sweat, that chemicals in e-cigarettes may exceed safe limits, that fruit intake is associated with lower obesity risk, that muscle strength in childhood is important for bone development, and that breastfeeding could help reduce smoking relapse after pregnancy. It also provides information on migraine prevalence and treatments. The email concludes by providing contact information for the chiropractor who authored the update.
Brain-to-brain communication may be possible by linking individuals' brains to allow one person to understand another's thoughts through digitized nerve signals over the internet. Dizziness upon standing could indicate neurological issues and increased risk of early death. Eating more fruits and vegetables may help prevent weight gain and obesity over time. Daily aerobic exercise for at least 45 minutes can reduce dementia risk in seniors by 19%.
Daily Health Update from Poway Chiropractor Dr. Kip Rode of Rode Chiropractic in Poway, CA 92064. The latest daily health and chiropractic information.
This daily health update email contains summaries of recent studies on various health topics. A study found that individuals with heart disease reported higher rates of anxiety and negative emotions than those without heart issues. Another study found that a child's risk of a fatal drug overdose increases if a parent is prescribed opioids. A review of studies found that higher doses of B vitamins were effective at reducing symptoms of schizophrenia. Another study found that employees who averaged over 10,000 steps per day were less likely to bring home work frustrations than those averaging under 7,000 steps. A study showed that mobilization of the neck can cause a small, short-lived drop in blood pressure. The update concludes with a reminder that insufficient sleep can negatively impact cognitive function
This daily health update email contains summaries of recent studies on various health topics:
1) A study found that about 15% of adults diagnosed with coronary artery disease suffered from depression, which is higher than the general population, and those with depression were more likely to die in the following decade.
2) Researchers discovered that patients with osteoarthritis have an elevated risk of stroke, with the risk being nearly four times greater for those with severe osteoarthritis.
3) A USDA report notes that vegetarian meals can be satisfying if they include lean proteins like beans as well as veggie-based foods like pizza, pasta, and stir fries.
Vitamin B-12 may boost brain function by elevating levels of the inhibitory neurotransmitter GABA. Nearly 600,000 albuterol inhalers are being recalled due to possible issues with the delivery system. Fruits and vegetables like sweet corn, avocados, and grapefruit tend to have lower pesticide levels. Providing pedometers to rheumatoid arthritis patients can increase activity and reduce fatigue. Cigarette smoking is associated with increased musculoskeletal pain for female veterans. Asthma sufferers should minimize air pollution exposure to reduce inflammation.
This daily health update provides 3 health-related news items in under 3 sentences each:
1) A study found that women with moderate to severe hot flashes have a higher risk of depression.
2) Research suggests Parkinson's disease may start in the gut and spread to the brain via the vagus nerve.
3) A study linked drinking one artificially sweetened beverage per day to an increased risk of stroke.
low birth weight presentation. Low birth weight (LBW) infant is defined as the one whose birth weight is less than 2500g irrespective of their gestational age. Premature birth and low birth weight(LBW) is still a serious problem in newborn. Causing high morbidity and mortality rate worldwide. The nursing care provide to low birth weight babies is crucial in promoting their overall health and development. Through careful assessment, diagnosis,, planning, and evaluation plays a vital role in ensuring these vulnerable infants receive the specialize care they need. In India every third of the infant weight less than 2500g.
Birth period, socioeconomical status, nutritional and intrauterine environment are the factors influencing low birth weight
Summer is a time for fun in the sun, but the heat and humidity can also wreak havoc on your skin. From itchy rashes to unwanted pigmentation, several skin conditions become more prevalent during these warmer months.
Lecture 6 -- Memory 2015.pptlearning occurs when a stimulus (unconditioned st...AyushGadhvi1
learning occurs when a stimulus (unconditioned stimulus) eliciting a response (unconditioned response) • is paired with another stimulus (conditioned stimulus)
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
- Video recording of this lecture in English language: https://youtu.be/Pt1nA32sdHQ
- Video recording of this lecture in Arabic language: https://youtu.be/uFdc9F0rlP0
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
10 Benefits an EPCR Software should Bring to EMS Organizations Traumasoft LLC
The benefits of an ePCR solution should extend to the whole EMS organization, not just certain groups of people or certain departments. It should provide more than just a form for entering and a database for storing information. It should also include a workflow of how information is communicated, used and stored across the entire organization.
Breast cancer: Post menopausal endocrine therapyDr. Sumit KUMAR
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
NAVIGATING THE HORIZONS OF TIME LAPSE EMBRYO MONITORING.pdfRahul Sen
Time-lapse embryo monitoring is an advanced imaging technique used in IVF to continuously observe embryo development. It captures high-resolution images at regular intervals, allowing embryologists to select the most viable embryos for transfer based on detailed growth patterns. This technology enhances embryo selection, potentially increasing pregnancy success rates.
Are you looking for a long-lasting solution to your missing tooth?
Dental implants are the most common type of method for replacing the missing tooth. Unlike dentures or bridges, implants are surgically placed in the jawbone. In layman’s terms, a dental implant is similar to the natural root of the tooth. It offers a stable foundation for the artificial tooth giving it the look, feel, and function similar to the natural tooth.
Travel Clinic Cardiff: Health Advice for International TravelersNX Healthcare
Travel Clinic Cardiff offers comprehensive travel health services, including vaccinations, travel advice, and preventive care for international travelers. Our expert team ensures you are well-prepared and protected for your journey, providing personalized consultations tailored to your destination. Conveniently located in Cardiff, we help you travel with confidence and peace of mind. Visit us: www.nxhealthcare.co.uk
Daily Health Update for 06/24/2015 for Rode Chiropractic of Poway CA 92064
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This information should not be substituted for medical or chiropractic advice. Any and all health care concerns, decisions, and actions
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DAILY HEALTH UPDATE
Wednesday, June 24th
, 2015
Courtesy of:
Mental Attitude: Delaying Umbilical Cord Clamping Could Improve a Child's Development. Experts suggest that simply
waiting just a few minutes before severing the umbilical cord can increase a baby's blood volume up to 33%. Dr. Heike Rabe, a
neonatologist at the Brighton and Sussex Medical School in the United Kingdom adds, "The extra blood at birth helps the baby to
cope better with the transition from life in the womb, where everything is provided for them by the placenta and the mother, to the
outside world. Their lungs get more blood so that the exchange of oxygen into the blood can take place smoothly."
JAMA Pediatrics, May 2015
Health Alert: Moderate Drinking May Result in Heart Damage in Elderly. Older men who drink at least two alcoholic beverages
daily may be damaging their cardiovascular system. Investigators analyzed data concerning 4,466 older men and women and found an
association between alcohol consumption and the enlarging of the left ventricle of the heart, a condition linked to an increased risk for
heart attack and stroke. While left ventricular hypertrophy was observed in both men and women, it was most prominent among men
who consumed more than 14 drinks per week. The researchers write, "In summary, we found that increasing alcohol intake among the
elderly is associated with mild alterations in cardiac structure and function. In women, moderate alcohol consumption was associated
with modest reduction in systolic function, potentially contributing to a higher risk of alcoholic cardiomyopathy [diseases of the heart
muscle], for any given level of alcohol intake." American Heart Association, May 2015
Diet: Fish Oil Consumption Could Mean Better Brain Function in Older Adults. Research involving 40 mentally healthy older
adults who possessed a gene placing them at risk for late-onset Alzheimer's disease found that consuming higher amounts of omegs-3
fatty acids helped participants perform better on mental tasks that assessed mental flexibility. Study author Dr. Aron Barbey writes,
"Our findings add to the evidence that optimal nutrition helps preserve cognitive function, slow the progression of aging, and reduce
the incidence of debilitating diseases in healthy aging populations." Frontiers in Aging Neuroscience, May 2015
Exercise: Fitness Improves Survival Odds for Patients Undergoing Allogeneic Stem Cell Transplant. For lymphoma and
leukemia patients considering an allogeneic stem cell transplant, engaging in regular exercise may improve their odds for a successful
recovery. A study including 103 patients found that those who participated in an exercise intervention before, during, and after
treatment were more than twice as likely to survive the two years following their allogeneic stem cell transplant than those who did
not exercise. International Journal of Cancer, June 2015
Chiropractic: Pregnant Nurse Helped By Chiropractic. A 30-year-old nurse-midwife sought help from a doctor of chiropractic for
hip pain and right-sided sciatica during the third trimester of her pregnancy. After receiving six weeks of chiropractic treatment, her
symptoms resolved and she successfully gave birth without further issues. This case provides support for the role of chiropractic in the
treatment of pregnant women. Journal of Pediatric, Maternal & Family Health - Chiropractic, April 2015
Wellness/Prevention: Smoking Legislation Prevents Hospital Admissions Among Children. Experts claim that smoke-free
legislation in the United Kingdom has resulted in over 11,000 fewer pediatric hospital admissions per year for respiratory infections.
Dr. Carlos Jimenez-Ruiz, the chair of the European Respiratory Society's Tobacco Control Committee adds, "We know that more than
600,000 non-smokers die from exposure to passive smoke each year. The findings of this new study add more weight to the argument
that smoke-free legislation is a valuable tool in reducing the health harms of smoking, particularly in children. We must use this
evidence to increase awareness and knowledge among policymakers of the harm caused by tobacco and the value of legislation
designed to reduce this harm." European Respiratory Journal, May 2015
Quote: “Just because you can doesn't mean you should.” ~ Sherrilyn Kenyon
Kip Rode, D.C.
(858) 391-1372
92064RODE