Anti aging drug may be just 5 years away

1. Anti-aging drug may be just 5
years away
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2. Contd..
A new anti-aging drug may be just five years away , say scientists who
have identified the role of an enzyme in muscle wasting and associated
age-related problems.
Researchers at the University of Birmingham believe that inhibiting the
enzyme could hold the key to developing ways of preventing, or
reversing, the adverse effects of aging.
The research is a significant step in understanding the role played by
the enzyme 11beta-HSD1 in the degenerative effects of aging -including
sarcopenia (age related muscle wasting).
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3. Contd..
Researchers claim the anti-aging drug could be available to the general
public within the next five years. The expression of 11beta-HSD1,
responsible for activating the steroid hormone cortisol, was increased
in the muscles of older females.
About 134 healthy volunteers, aged between 20-80, underwent
physical and biochemical tests at a clinical research facility. The findings
show that expression of 11beta-HSD1 in skeletal muscles is increased
2.72-fold in women over 60 years of age, compared to those aged
between 20 and 40. In male participants, no difference was seen.
“As yet, we don't know why it appears to only occur in women, it is
obviously an interesting area for further research.
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4. Contd..
We are planning to look at whether hormones such as estrogens could
be involved,“ Dr Zaki HassanSmith, from the University of Birmingham,
said. The researchers wanted to investigate novel ways of increasing
healthy life span -the years in which people can maintain active
lifestyles without the debilitating impact of muscle wasting.
“Looking at this particular enzyme seemed like an intriguing way
forward. We knew how it works in relation to Cushing's Syndrome,
which is characterised by similar symptoms, and thought it would be
worthwhile applying what we knew to the aging population,“ said
Hassan-Smith.
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