Occupational exposure refers to potential exposure to bloodborne infections like HIV, HBV, and HCV that can occur in healthcare settings. Post exposure prophylaxis (PEP) involves comprehensive medical management to minimize infection risk after potential exposure. The most common diseases from needlestick injuries are HBV, HCV, and HIV. PEP for hepatitis exposure involves HBIG and/or vaccination depending on the source's status and the exposed person's vaccination history. For HIV exposure, PEP involves a three-drug antiretroviral regimen for 28 days. Proper sharps handling and immediate reporting of injuries can help prevent exposure and ensure appropriate follow up care.