Polymers have played an integral role in the advancement of drug delivery technology by providing controlled release of therapeutic agents in constant doses over long periods, cyclic dosage, and tunable release of both hydrophilic and hydrophobic drugs.
1. Presented By,
Mast:- Dhiraj Dilip Malunjkar
M Pharmacy -First Year
Department :- Pharmaceutics
Loknete .Dr. J. D. Pawar College Of Pharmacy ,Manur
POLYMERS
2. Introduction
Definition
Polymerization
Term Used
Classification
Types of polymer used in Drug delivery
Protein Based polymers
Applications
Advantages
Disadvantages.
CONTENTS
3. Polymers are the large molecules consisting of repeating structural unit called
as “Monomer”.
World ‘Polymer’ Derived Form Greek Greek Word
Poly :- Many
Mer:- Unit Part
They are also referred as macromolecules.
Ex:-
DEFINITION
5. Monomer:-
Small Molecule Which is repeated called as Monomer.
Polymerization:-
It is an chemical reaction in Which Two or more than two molecules
are joined together called polymerization.
Degree Of Polymerization:-
Number of repeating unit (n) in the polymer chain called as Degree
of Polymerization.
it is used to calculate Average molecular weight of polymer.
Average Weight = DP * Weight of repeating unit.
TERM USED
7. 1)Natural Polymer:- Isolated form Natural Materials
Ex. Cotton, Silk , wool, rubber
2)Synthetic Polymer:- Synthesize Form low molecular
weight compound.
Ex . Polyethylene, nylon
3)Semisynthetic Polymer:-Mostly Derived form naturally
Occurring polymer.
Ex .Reyon
BASED ON SOURCE
8. 1)Linear Polymer:-Monomer join form long chain.
Ex . Polyethylene, Nylon.
2)Branched Chain:-Straight long chain with different long chain.
Ex .Polypropylene, amylopectin.
3)Cross Linked:- Two linear chain are joined by covalent bond and having 3D
structure.
Ex .Bakelite , Formaldehyde resins.
BASED ON STRUCTURE
9. 1)Addition Polymerization:-Formed by repeated addition of monomer.
Ex . Polythene.
2)Condensation Polymer:-combination of two monomer by removal of water.
Ex . Nylon 6,6.
BASED ON MODE OF
POLYMERIZATION
Water molecule
removed.
10. 1)Elastomer:-these are rubber – like solid with elastic properties.
Ex .Neoprene.
2) Fibres:-high tensile strength and high modulus.
Ex .Nylon 6,6.
BASED ON MOLECULAR
FORCESES.
11. 1)Crystalline Polymers:-
They not perfectly crystalline structure.
2) Amorphous Polymer:-
they are hard or rubbery state.
BASED ON MORPHOLOGY
12. • Rubber:-
dimensionally unstable
Tensile range 300-1000psi.
• Plastic:-
Stronger than rubber
Tensile range 4000-13000psi.
• Fibres:-
Strongest in different types.
Tensile range20000-150000psi.
BASED ON END USE
13. Protein Based Polymers:-
• Collagen
• Albumin
• Gelatine
Polysaccrides:_
• Alginate cychlodextrines
• Chitosan's
• Dextran
Biodegradable polymers:-
• Polyesters
• Polyunhydried
• Polyamines
• Phosphorous based polymers
Non- Biodegradable Polymer:-
• Cellulose derivative
• Silicones
• others
Natural polymer Synthetic Polymers
TYPES OF POLYMER USED IN
DRUG DELIVERY
14. 1)Collagen:-
• Major natural protein component in mammals .
• Good Compatible.
• Used in implantation.
2)Gelatine:-
• Water soluble.
• Bio compatible.
• Low antigenicity.
3)Albumin:-
• Cross linked.
• Hydrogels used in materials.
PROTEIN BASED POLYMERS
15. Alginate:-
• Extracted from seaweed, algae, bacteria.
• Biocompatible
• Biodegradable
• Water soluble
Dextran:-
• Synthesized form Sucrose.
• Used in protein, vaccine and drugs.
Starch:-
• Plant origin
• Mostly used.
POLYSACCHARIDES
