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Matrix microencapsulation through air extrusion systems
1. MICROINCAPSULAMENTO IN MATRICE ATTRAVERSO
SISTEMI DI ESTRUSIONE IN ARIA
Candidato
Marco Iasevoli
Matr. N06/125
Relatore
Ch.mo Prof.
Fabrizio Sarghini
ANNO ACCADEMICO 2012/2013
Matrix microencapsulation through air extrusion systems
2. Microencapsulation is the packaging of small particles of solid, liquid or
gas, also know as the core, within a secondary material, also know as the shell
or coating, to form small microparticles.
Spheres are usually classified in:
• Nanospheres (less than 100 nm)
• Microspheres (in the order of
microns)
3. Protection of the active ingredients
Controlled Release
Mask unpleasant taste of certain
ingredients
Convert liquids to solids
Increase Shelf-life
Increase Bioavailability
4. GRAS Biocompatible Good barrier properties Cheap
Alginate in molecular terms is considered as a family of unbranched binary
copolymer of (14 linked β-D-mannuronic acid (M) and α-L-guluronic acid
(G) residues.
Why Alginate?
5.
6. The droplet breaks off when the
gravitational force:
exceeds the surface tension induced counter
force:
leading to a droplet diameter:
MEMS 2007 - 20th IEEE International Conference on Micro Electro Mechanical Systems, 21-25 January 2007
11. Geometry 1 (Blue Line) Geometry 2 (Green Line)
D [4;3] 66,4 µm
D [4;3] 241 µm
12.
13. • Scaling-up of production is obtained by using multiple tip in parallel
14. Air is costless
There are only alginate
beads in hardening solution
Easy wash with water
No clog of device
Large quantity of oil means increased costs.
Oil presence in hardening solution can give
coalescence of alginate bead
Washing oil needs specific product
Device can clog
15. • Taste masking
• Color masking
• Flavour Stabilization
• Novel food
Technological
• Fortified foods
• Functional foods
• Drug delivery in food matrix
• Controlled release
Healty
• Studies on live cell (e.g. Probiotics)Analytical
16. Encapsulation in the food sector is becoming
even more important for its many applications.
Sodium alginate has been chosen as matrix
material because is regarded as:
•Biocompatible
•Non-toxic
•Biodegradable
•Cheap
Some issues related to the scale-up procedure
and polydispersity of the coaxial air flow
technology still need to be addressed.
Nonetheless, this technology provide to food
technologists a cheap, adaptable tool and a rapid
prototyping platform for studies on
microencapsulation through alginate.