This document discusses podoplanin, a protein that can help detect tumor invasion. Podoplanin is expressed in tumors and promotes collective cell migration and invasion at tumor edges. It can help detect microinvasion in squamous cell carcinoma of the skin and oral cavity when histological examination alone is equivocal. Immunohistochemistry for podoplanin shows expression at the advancing edge of tumors exhibiting collective cell migration, but not in tumors using single cell invasion. Podoplanin is a promising new approach to better identify tumor invasion.