Platelets are a key component of hemostasis, the process of clotting blood after an injury. The document discusses platelets disorders including thrombocytopenia, where platelet counts are too low, and thrombocytosis, where they are too high. Some causes of low or high platelet counts include medications, diseases, infections, and pregnancy. Symptoms of low platelet counts can include bruising, bleeding, and heavy periods. Treatment depends on the underlying cause but may involve medications, transfusions, or lifestyle changes. Maintaining a healthy lifestyle can help sustain a normal platelet balance.

1. HAFIZ M WASEEM UNIVERSITY
OF EDUCATION LAHORE

3. Platelets
disorder
Prepared by:_ Hafsa wakeel

4. Introduction of platelets
Hemostasis
Causes of platelets
disorder
Thrombocytosis
Throbocytopania
Treatment
References
CONTENTS

5. Introduction

6.  It is an active process that clots the blood in
an area of blood vessel injury and limits the
bleeding.
 Over the time clot is lysed by fibrinolytic
system and normal blood flow is restored .
 The main components of hemostasis process
are.
 Vessel wall
 Platelets
 Coagulation proteins
 Anticoagulant proteins
 Fibrinolytic system
Hemostasis

7.  Autosomal recessive inheritance
 Autosomal dominant inheritance
 X linked inheritance
 Bleeding Time
 Peripheral blood smear and morphology
 Platelets aggregation test
 Bone marrow examination
Platelets disorder
diagnosed

9. Qualitative
disorder

10.  Deficient platelets production.
 Abnormal platelets distribution.
 Increased platelets destruction.
 causes. These include several medicines,
cancer, liver disease, pregnancy, infections,
and an abnormal immune system.
Thrombocytopania

11.  What are the signs of a low platelet counts.
 Small purple or red dots under your skin.
 Nosebleeds or bleeding gums.
 Black or bloody-looking bowel movements.
 Red or pink urine.
 Vomit with blood in it.
 An unusually heavy menstrual period.
 Severe headaches.
Signs and
symptoms

12.  Purpura:_hemorrhage larger then petechiae seen
in the skin.
 Petechiae:_tiny pin point hemorrhage in skin or
mucous membranes due to not enough platelets
to plug up the micro leaks small vessels each
day.
 Ecchymomosis purple black or blue area
resulting from bruise
Disease
s

14.  This is another condition caused by too many
platelets. Secondary thrombocytosis is more
common. It's not caused by a bone marrow
problem. Instead, another disease or condition
stimulates the bone marrow to make more platelets.
 Causes
 include infection, inflammation, some types of
cancer, and reactions to medicines. Symptoms are
usually not serious. The platelet count goes back to
normal when the other condition gets better.
Thrombocytosis

15.  Headache,Dizziness or lightheadedness ,Chest
pain,Weakness,Numbness or tingling of the
hands and feet.

16.  Specialized centers
 Desmopressin
 Platelets transfusion
 Should not use non steroid anti-inflammatory
drugs.
 Females may have to take additional measures to
make theoir monthly periods manageable.
Treatment

17. Platelets are important in case of any
injuries.
Therefore one should need to
maintain a healthy lifestyle sustain the
balance in the platelets numbers.

18.  Manthorpe R, Kofod B, et al.
Pseudothrombocytopenia, In vitro studies on the
underlying mechanisms. Scand J Haematol 1981;
26:385-92
 Nakashima MO, Kottke-Marchant K. Platelet
Testing: In: Kottke-Marhchant K, ed. An Algorithmic
Approach to Hemostasis Testing, 2nd ed. CAP
Press; 2016:101
 Schuff-Werner,Peter, et al. Effective estimation of
correct platelet counts in pseudothrombocytopenia
using an alternative anticoagulant based on
magnesium salt. Brit J of Haematol Vol 162, Issue
5. June 29, 2013

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