Plaster of Paris has been used for centuries to immobilize fractures. It was first used by Arab physicians in the 9th century and became more widely used in the 19th century. While plaster of Paris remains effective, it can cause complications like skin injuries if not applied properly. Synthetic casting materials have advantages over plaster of Paris like being lighter and more radiotransparent, but plaster of Paris remains a common choice due to its lower cost. Both the application technique and materials used can affect the temperature under the cast and risk of burns.
Cast and immobilization techniques in orthopaedics by Dr O.O. AfuyeAlade Olubunmi
Cast, similar in function to splints are used to immobilize broken bones. The principles of its application and cast care most be followed for effectiveness.
VAC therapy also known as negative pressure wound therapy (NPWT) is a method of delayed wound closure, where in primary closure is not possible. this PPT details the make & model of the device, its modifications, principle , mechanism , advantages and disadvantages
it explain about introduction, definition, purpose of applying cast, indcation, type of cast, procedure of application and removal of plaster and management.
Cast and immobilization techniques in orthopaedics by Dr O.O. AfuyeAlade Olubunmi
Cast, similar in function to splints are used to immobilize broken bones. The principles of its application and cast care most be followed for effectiveness.
VAC therapy also known as negative pressure wound therapy (NPWT) is a method of delayed wound closure, where in primary closure is not possible. this PPT details the make & model of the device, its modifications, principle , mechanism , advantages and disadvantages
it explain about introduction, definition, purpose of applying cast, indcation, type of cast, procedure of application and removal of plaster and management.
Guidelines on the use of plaster of paris in fracture management. Quite useful for orthopedic residents, GPs, plaster techs, orthopedic care nurses, rehabilitation physicians, physiotherapists
This presentation will briefly touch on the basics of fabric expansion joints; however, is mainly focused on the various designs, material details, and applications. Learn how fabric expansion joints are engineered and fabricated for various applications and the many factors that influence those designs. View the abundance of materials used, including Fluoroplastic and Fluoroelastomer, and their respective capabilities. Take a journey through a Fossil Fired Power Plant and see exactly where fabric expansion joints are required.
HISTORY OF INSULATION
For as far back as history goes, the earth has experienced four distinct seasons. Some areas have always experienced more extremes in terms of temperatures and therefore had to find ways to maintain a comfortable living environment. Insulation has been used throughout the centuries to keep heat in and cold out or vice versa. It is interesting to note that some of the alternate environmentally friendly techniques that are being considered today, such as fabrics, were being used in ancient times as insulation.
Defining Insulation
Insulation refers to a substance that slows or retards the transfer of heat or sound. Most often, when talking about insulation in modern terms, it is in reference to the building and construction industry.
Ancient Forms of Insulation
Prehistoric people built shelters to protect themselves from the elements, originally using organic materials and later more durable substitutes.
Hot climates would construct homes with thick walls that would insulate against the heat and provide a cooler and more temperate indoor environment in which to live.
• Ancient Mayan ruins in Central America.
• Egyptians also used these construction methods to keep out the desert heat of the Sahara.
These homes had low roofs and small windows so the heat couldn’t easily enter and remain in the homes.
• Ancient Greeks probably made some of the more significant discoveries in terms of insulation - they used cavity walling to insulate the buildings. Cavity walling has a gap between two walls which traps air and moderates the temperatures. During the hot summer months, cavity walls kept the warm air out and in the cooler winter months, it would help keep the warmth inside the homes.
• The Romans also used cavity walls, though in addition, they used materials such as cork to insulate hot water pipes so the heat from the pipes would not transfer to the surrounding walls and floors, causing them to crack. Fabrics were also used as additional insulation. Scraps of cloth would be tucked into window frames to keep out the desert dusk or the icy European cold. Rugs made from animal furs were used as carpets and thick linen drapes were used as curtains. Elaborate tapestries were hung on walls and helped to manage some of the moisture buildup in the stone buildings. The tapestries also helped moderate the draughts that could sometimes cause an added chill.
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
2. Historical Perspective
• 9th century AD:
– Arab physicians used
strips of linen soaked in
a mixture of lime and
egg white which would
set “hard as stone” for
treatment of fractures.
3. Historical Perspective
• 1852: Classical plaster bandage.
– Antonius Mathysen, a Dutch army surgeon,
treated battle wounds in the Crimean War with
cotton bandages filled with dry plaster of Paris
(POP).
– POP was so called because it was first
prepared from the gypsum mined in Paris,
France.
4. Historical Perspective
• 1927: Binder ingredients (starches, gums,
and resins) were added to improve the
adherence of the plaster to the gauze.
• Later, other additives were incorporated to
change the physical properties pf POP,
such as setting time, which allowed
standardized production.
• 1970s: Synthetic materials.
5. Current Indications
• Immobilisation of
fractures
• Correction of deformities
• Splinting limbs
• Immobilisation of the
spine.
7. What Causes Complications?
Technical Error Resulting Complication
Improper and irregular application
of padding
Pressure sores beneath the cast
Inadequate padding material at the
ends of the cast
Sharp edges and skin irritation
Aggressive cast molding Pressure sores beneath the cast
Inadequate casting material Cast breakdown and loss of control
of the unstable fracture
Tight application of casting material or failure
to allow for underlying injury swelling
Compartment syndrome
Hot dip water Elevated setting temperatures / Skin
burns
8. Exothermic Reaction
• Occurs as the cast hardens.
• Causes the temperature within and
beneath the cast material to rise.
• Temperature may rise to dangerous
levels: Risk of thermal injury.
9.
10. Exothermic Reaction
• Recommendations for safe casting:
– Use luke-warm water with plaster casts
– Use cool water with fiberglass casts
– Pad appropriately to avoid sharp edges or
cast pressure points
11. Exothermic Reaction
• Lavallette et al:
– Risk of burns is directly related to:
• dip water temperature
• length of time the plaster is kept in the dip water
– Dip water temperature can play a key role in
the ultimate temperature beneath the cast.
12. Exothermic Reaction
• Kaplan:
– Temperature elevations can be related to the
plaster being dipped too briefly and the water
being squeezed too aggressively out of the
plaster.
– The water itself helps to release the heat, and
if there is not enough, the plaster gets hotter.
13. Exothermic Reaction
• Selesnick & Griffiths
– With fiberglass cast materials, use only cool
dip water to reduce the chance of burns.
14. Exothermic Reaction
• Hutchinson and Hutchinson (2008):
– There is a direct relationship with increasing
dip water temperature from 32 to 39º C and
the ultimate peak temperature beneath both
plaster and fiberglass casts.
15. Exothermic Reaction
• Dirty dip water and ambient humidity have
also been implicated as contributing to
temperatures beneath maturing casts.
• Lavalette and Ganaway:
– Plaster residue in the dip water might play a
role in elevating cast temperature and
broadening the time-temperature curve; i.e.,
maintaining the peak temperature for a longer
period.
16. Exothermic Reaction
• Ganaway:
– Cast padding plays little role in effecting the
temperature beneath a cast.
• Hutchinson & Hutchinson:
– Increased cast padding:
• little effect on the fiberglass casts.
• significant effect of elevated temperatures with additional
layers of Webril applied beneath 20 layers of extra-fast setting
plaster.
– Explanation: increased insulation traps the heat beneath.
• Cast padding likely plays a greater role to protect the
skin against pressure points than its effect on
temperature.
17. Exothermic Reaction
Conclusion:
• Extra fast setting plaster achieves peak temperatures quicker and
higher than slower setting plasters.
• Increased thickness of casting materials (both plaster and
fiberglass) are related to increased temperatures beneath the cast.
• Dip water temperature is directly related to the peak temperature
beneath the cast.
• Prefabricated splints do not achieve the same temperature levels
when compared to circumferential casts and, therefore, from a
thermal perspective, may be safer.
• Thickness and type of cast padding did not play a significant role
regarding ultimate temperatures beneath the cast in this study.
• At the thicker levels of padding, it may actually serve as an insulator
entrapping additional heat.
• The greatest risk of thermal injury occurs when a thick cast using
warm dip water is allowed to mature while resting on a pillow.
18. Cast Wedging
• When fracture reduction is
incompletely obtained in a cast,
wedging may be a viable
technique to correct deformity
and avoid surgical intervention.
19. Cast Wedging
• Types of wedging:
–Open wedging
–Closed wedging
–Combination of opening and closed
wedging.
20. Cast Wedging
• Open wedging:
– More commonly used
– Avoids the risks that accompany closing
wedges
21. Cast Wedging
• Closed wedging:
– Possible complications:
• Pinching of the skin (may cause skin breakdown)
• Accumulation of cast padding at the wedge site
(may also cause skin breakdown)
• Fracture shortening
• Reduction of the volume of the cast (may result in
compartment syndrome).
22. Cast Wedging
• Predicting the wedge size:
– Bebbington, Lewis, and Savage:
• Trace the angle of displacement onto the cast itself using a
marking pen.
• The line is meant to represent the fracture fragments.
• Wedges are then inserted until the bent line becomes
straight.
– Guastavino and Husted:
• Both introduced formulae that could be used to predict the
amount of wedging.
• Husted’s method even accounted for radiographic
magnification.
23. Synthetic Cast Materials
• Introduced on the market place in the
seventies, but have not superseded
traditional POP.
24. Synthetic Cast Materials
• Advantages:
– Better physical and mechanical properties
than traditional POP
– Lighter
– More resistant to humidity
– More radiotransparent
– Generate less dust when removed
25. Synthetic Cast Materials
• Disadvantages:
– Less malleable
– Cause higher pressure in case of limb edema
26. Synthetic Cast Materials
• POP therefore remains indicated in the
acute posttraumatic or postoperative
period.
• This material is also cheaper, but the
pecuniary benefit is limited for several
reasons, particularly because POP is
associated with a higher rate of cast
replacement.
27. Synthetic Cast Materials
• Thermoplastic Materials:
– More recent
– Used to make splints and orthoses,
particularly at the wrist and hand.
28. References
• Colditz JC: Plaster of Paris: The Forgotten Hand
Splinting Material. J Hand Ther 2002; 15:144-157
• Hutchinson MJ, Hutchinson MR: Factors contributing
to the temperature beneath plaster or fiberglass cast
material. Journal of Orthopaedic Surgery and Research
2008, 3:10
• Schuind F, Moulart F, Liegeois JM, Dejaie Strens LC,
Burny F: La contention orthopédique. Acta Orthopædica
Belgica 2002; 68(5):439-461
• Wells L, Avery AL, Hosalkar HH, Friedman JE,
Davidson RS: Cast Wedging: A “Forgotten” Yet
Predictable Method for Correcting Fracture Deformity.
UPOJ 2010; 20:113-116
Editor's Notes
Based on data from Williamson C, Scholtz JR. (1949) Time-Temperature relationships in thermal blister formation. J Invest. Dermatol. 12: 41–47; this figure represents the time-temperature relationship to create burns on skin.
Bebbington A, Lewis P, Savage R. Cast wedging for orthopaedic surgeons! Injury. 2005 Jan;36(1):71-2.
Husted CM. Technique of cast wedging in long bone fractures. Orthop Rev. 1986 Jun;15(6):373-8.
Guastavino TD. Technique of cast wedging in long bone fractures. Orthop Rev. 1987
Sep;16(9):691.