Drug-drug interactions(DDI) are one of the commonest causes of medication error, particularly in the elderly due to poly-therapy, with a prevalence of 20-40%. Drug interactions represent factors of uncertainty in many therapeutic situations. Drug–drug interactions can cause profound clinical effects, either by reducing therapeutic efficacy or enhancing toxicity of drugs. With an increasing frequency in polypharmacy, DDIs are one of the major causes for drug withdrawal from the market. In particular, poly-therapy increases the complexity of therapeutic management and thereby the risk of clinically important DDIs, which can both induce the development of adverse drug reactions or reduce the clinical efficacy. Although DDIs can result in alterations of either drug pharmacokinetics (PK), pharmacodynamics(PD), or both, it is the pharmacokinetic drug interactions that is clinically significant. PK drug interactions, typically characterized by alterations of plasma concentration–time profiles, could be attributed to changes in processes of absorption, distribution, metabolism, and excretion of a drug substance mediated by another drug when they are given concomitantly. In this review we mainly focused on the pharmacokinetic drug interactions with various drug examples and their mechanism of drug interactions that are clinically significant.
This document describes the formulation and evaluation of a metformin HCl gastroretentive floating sustained release tablet. The tablet was formulated using the wet granulation technique and contained both effervescent and non-effervescent systems. HPMC K100 was used as the swellable polymer responsible for floating (non-effervescent system) and sodium bicarbonate was used as the effervescent agent. Various tests were conducted to authenticate the drug including melting point determination, log P value determination, and solubility studies. Tablets were evaluated for properties such as bulk density, tapped density, angle of repose, friability, weight variation, and in vitro drug release, which showed maximum release of 99
Preformulation studies characterize the physical and chemical properties of drug molecules to develop safe, effective, and stable dosage forms. The goals are to develop formulations that are stable, safe, and effective. Major areas of study include physical characterization of properties like crystallinity and polymorphism, hygroscopicity, particle size, and powder flow. Solubility is analyzed through measurements of ionization, partition coefficient, aqueous solubility, and pH-solubility profiles. Stability is analyzed through studies of photolytic stability, stability to oxidation, and drug-excipient compatibility.
This document discusses pulsatile drug delivery systems (PDDS). It defines PDDS as systems that provide rapid, transient release of drugs in a programmed pattern, such as at a specific time or site. The document outlines different types of PDDS, including time-controlled, internally stimulated, and externally regulated systems. It provides examples of diseases and drugs suited for PDDS. It also discusses various approaches to PDDS, advantages, and some example marketed products.
Transdermal drug delivery systems are formulations that deliver active drugs through the skin for systemic circulation. They provide advantages like avoiding first-pass hepatic metabolism and allowing extended therapy. The document discusses the definition, advantages, limitations and components of transdermal drug delivery systems. It describes the different routes of drug penetration through the skin, ideal drug properties, types of systems and factors affecting their design like skin permeation. Evaluation methods for transdermal patches including adhesion, release and permeation tests are also summarized.
Stability studies ensuring the maintenance of product quality, safety and efficacy throughout the shelf life are considered as pre-requisite for the acceptance and approval of any pharmaceutical product. Stability testing is a routine procedure performed on drug substances and products and is employed at various stages of the product development.
This document discusses various types of controlled drug delivery systems including diffusion controlled, dissolution controlled, and combined controlled systems. It describes the mechanisms of drug release for different types such as matrix systems, membrane controlled devices, and osmotic pressure devices. Key factors affecting drug release from these systems are also summarized such as polymer properties, drug solubility, and membrane thickness. The advantages of controlled drug delivery systems in improving bioavailability and patient compliance are highlighted.
The document discusses in situ gel drug delivery systems, which are liquid before administration but gel after contact with bodily fluids or tissues. It describes various polymers used to form in situ gels via temperature, pH, or ion triggers. It also categorizes in situ gel systems based on their gelation mechanism and administration route.
This document discusses the formulation and evaluation of calcium alginate beads loaded with diclofenac sodium. The objective is to develop an extended release dosage form of diclofenac sodium to reduce dosing frequency and improve patient compliance by maintaining therapeutic drug levels. Calcium alginate beads are prepared using an ionotropic gelation method by dropping sodium alginate solution containing diclofenac sodium into calcium chloride solution, resulting in crosslinking and formation of beads. The beads are evaluated for drug release using dissolution studies.
This document describes the formulation and evaluation of a metformin HCl gastroretentive floating sustained release tablet. The tablet was formulated using the wet granulation technique and contained both effervescent and non-effervescent systems. HPMC K100 was used as the swellable polymer responsible for floating (non-effervescent system) and sodium bicarbonate was used as the effervescent agent. Various tests were conducted to authenticate the drug including melting point determination, log P value determination, and solubility studies. Tablets were evaluated for properties such as bulk density, tapped density, angle of repose, friability, weight variation, and in vitro drug release, which showed maximum release of 99
Preformulation studies characterize the physical and chemical properties of drug molecules to develop safe, effective, and stable dosage forms. The goals are to develop formulations that are stable, safe, and effective. Major areas of study include physical characterization of properties like crystallinity and polymorphism, hygroscopicity, particle size, and powder flow. Solubility is analyzed through measurements of ionization, partition coefficient, aqueous solubility, and pH-solubility profiles. Stability is analyzed through studies of photolytic stability, stability to oxidation, and drug-excipient compatibility.
This document discusses pulsatile drug delivery systems (PDDS). It defines PDDS as systems that provide rapid, transient release of drugs in a programmed pattern, such as at a specific time or site. The document outlines different types of PDDS, including time-controlled, internally stimulated, and externally regulated systems. It provides examples of diseases and drugs suited for PDDS. It also discusses various approaches to PDDS, advantages, and some example marketed products.
Transdermal drug delivery systems are formulations that deliver active drugs through the skin for systemic circulation. They provide advantages like avoiding first-pass hepatic metabolism and allowing extended therapy. The document discusses the definition, advantages, limitations and components of transdermal drug delivery systems. It describes the different routes of drug penetration through the skin, ideal drug properties, types of systems and factors affecting their design like skin permeation. Evaluation methods for transdermal patches including adhesion, release and permeation tests are also summarized.
Stability studies ensuring the maintenance of product quality, safety and efficacy throughout the shelf life are considered as pre-requisite for the acceptance and approval of any pharmaceutical product. Stability testing is a routine procedure performed on drug substances and products and is employed at various stages of the product development.
This document discusses various types of controlled drug delivery systems including diffusion controlled, dissolution controlled, and combined controlled systems. It describes the mechanisms of drug release for different types such as matrix systems, membrane controlled devices, and osmotic pressure devices. Key factors affecting drug release from these systems are also summarized such as polymer properties, drug solubility, and membrane thickness. The advantages of controlled drug delivery systems in improving bioavailability and patient compliance are highlighted.
The document discusses in situ gel drug delivery systems, which are liquid before administration but gel after contact with bodily fluids or tissues. It describes various polymers used to form in situ gels via temperature, pH, or ion triggers. It also categorizes in situ gel systems based on their gelation mechanism and administration route.
This document discusses the formulation and evaluation of calcium alginate beads loaded with diclofenac sodium. The objective is to develop an extended release dosage form of diclofenac sodium to reduce dosing frequency and improve patient compliance by maintaining therapeutic drug levels. Calcium alginate beads are prepared using an ionotropic gelation method by dropping sodium alginate solution containing diclofenac sodium into calcium chloride solution, resulting in crosslinking and formation of beads. The beads are evaluated for drug release using dissolution studies.
This document provides information about tablets as a drug delivery system. It defines tablets and describes their key components and manufacturing process. Tablets consist of active pharmaceutical ingredients and excipients that control release and aid manufacturing. Excipients include fillers, disintegrants, binders, lubricants and others. Tableting involves powder compression in a die and punch press. Tablets offer benefits like precision dosing but some drugs are not suitable. Quality is ensured through testing dissolution and other properties.
Clinical pharmacokinetic studies are performed to examine the absorption, distribution, metabolism, and excretion of a drug under investigation in healthy volunteers and/or patients
This document discusses modified release drug products, including extended release and delayed release dosage forms. It defines modified release as altering the timing and/or rate of drug release. Extended release aims for twice daily dosing by providing continuous drug levels while delayed release releases the drug at a time other than promptly after administration. The document discusses various extended release drug delivery technologies like coated beads, multilayer tablets, microencapsulation, embedding in eroding matrices, plastic matrices, complexation, and osmotic pumps. It emphasizes the importance of in vitro-in vivo correlations and bioequivalence studies in evaluating these modified release products.
Introduction to CR/SR preparations, concept of controlled release formulation, challenges of CR drug delivery system, advantages and disadvantages, Factors influencing the design and performance of CR products (physiochemical properties: molecular size and diffusivity, aqueous solubility, ionization constant, partition coefficient, stability, pharmacokinetic and pharmacodynamic considerations: release rate and dose, Biological factors: Absorption, distribution, metabolism and elimination half life, therapeutic index, duration of action.
Kinetics of drug release from CRDS: Zero order, first order, Hixson-Crowell Release Model, Higuchi Release Model and Korsmeyer-Peppas Release Model
Oral controlled release systems: Dissolution controlled release (Matrix and encapsulated dissolution), diffusion controlled release (Reservoir and matrix system), dissolution and diffusion controlled release, Osmotically controlled release, pH independent formulations, Ion exchange resins.
Evaluation of CR formulations: Quality control methods( Identity, purity, strength, stability of the dosage form and drug in the dosage form, disintegration and dissolution, dosage form appearance, bioavailability of the drug from dosage form
This document provides an overview of oral disintegrating tablets (ODTs), including their development, technologies used in their production, and evaluation methods. ODTs are solid dosage forms that disintegrate rapidly in the mouth, typically within 3 minutes, without water. They offer advantages over conventional tablets for patients who have difficulty swallowing. The document reviews various ODT production technologies such as freeze drying, spray drying, mass extrusion, and direct compression. It also discusses ideal properties, advantages, and limitations of ODTs.
This document discusses strip packaging technology. Strip packaging involves enclosing individual articles between two webs of material sealed together in pockets by heated rollers. The process involves feeding articles and web materials between rollers with cavities to form sealed pockets around each article. Design considerations for the strips include pocket shape and size. Seal quality is inspected by heating sealed areas and checking for leaks underwater. Common materials used are foil laminates, PET, and aluminum foil for their barrier and sealing properties.
Dissolution: how to calculate dissolution calculation in excel sheetSagar Savale
The document describes how to calculate drug dissolution in an Excel sheet. It involves creating a standard calibration curve by measuring the absorbance of drug solutions with known concentrations. An equation is generated from the calibration curve graph that relates absorbance to concentration. This equation is then used to calculate the concentration of test solutions from their absorbance readings over time during a dissolution test. The concentrations are used to determine the percentage of drug dissolved at each time point.
Controlled Release Oral Drug Delivery System
Controlled drug delivery is one which delivers the drug at a predetermined rate, for locally or systemically, for a specified period of time.
This document discusses different types of solid drug forms including tablets, capsules, granules, powders, and pellets. Pellets are small, sterile tablets used for prolonged drug release and come in sizes between 0.5-1.5mm. Pellets can be manufactured using various methods including layering powders or liquids onto seed cores, spray drying, compaction processes like extrusion-spheronization, and globulation techniques. New production methods include hot melt extrusion and cryopelletization.
controlled drug delivery system classificationravipharmabwm
The document discusses different types of controlled drug delivery systems classified by physical or chemical means of activation. The key types are:
1. Osmotically activated systems where drug release is controlled by osmotic pressure gradients.
2. Mechanically activated systems like metered-dose inhalers that use manual activation to deliver precise drug doses.
3. Iontophoresis-activated systems where an electrical current enhances absorption of ionic drugs through the skin.
4. pH-activated systems that target drug delivery to specific pH ranges, like coatings protecting gastric drugs from stomach acid.
This document discusses osmotic controlled oral delivery systems. It provides advantages like continuous drug delivery at predictable rates independent of gastric conditions. Components include drugs, osmotic agents, and semipermeable membranes. Various osmotic pump types are described like elementary, push-pull, bursting. Applications include Glucotrol XL, Procardia XL, and other marketed products that use this technology to provide extended release of drugs.
This document discusses chronopharmacokinetics and circadian rhythms. It begins by explaining that drug absorption, distribution, metabolism and elimination can vary based on the time of day due to physiological rhythms. It then defines chronopharmacokinetics as studying how drug plasma levels vary based on the time of administration. Key factors that can cause time-dependent variations, like changes in GI function, enzyme activity and organ blood flow, are summarized. Examples are given of disease symptoms and drug effects that vary over 24-hour periods. Finally, applications of chronotherapeutic drug delivery systems are briefly mentioned to maximize drug effects at specific times.
This document provides an overview of orally disintegrating tablets (ODTs), including:
1. The definition and ideal properties of ODTs according to regulatory agencies.
2. The large market potential and growth of ODTs globally, especially for drugs treating central nervous system and gastrointestinal conditions.
3. Important patented technologies for developing ODTs, such as Zydis® technology which uses a lyophilization process to create a porous structure for rapid disintegration.
4. Common excipients and formulation methods used in ODTs, including lyophilization, molding, and mass extrusion.
Superdisintegrants in Orally Administered Products of Pharmaceuticals A Reviewijtsrd
This document reviews superdisintegrants, which are added to pharmaceutical products to improve palatability and the performance of solid oral dosage forms. Superdisintegrants work by reducing the disintegration time of tablets, which improves drug dissolution rate. The review discusses various types of natural, synthetic, and semi-synthetic superdisintegrants. It also examines the mechanisms by which superdisintegrants cause rapid tablet disintegration, such as swelling, porosity, deformation, and particle repulsion. The ideal properties of superdisintegrants and their methods of incorporation into tablets are described. The document concludes that superdisintegrants can help advance the development of orally administered pharmaceutical products by improving acceptability and potency.
This document discusses floating drug delivery systems (FDDS). It defines FDDS as systems that have sufficient buoyancy to float over gastric contents and remain in the stomach for a prolonged period of time. This results in increased gastric retention and better control of drug concentrations. The document covers the importance of FDDS, factors affecting performance, classifications, suitable drugs, evaluation tests, and examples of marketed products. It provides details on the preparation and functioning of various FDDS types including non-effervescent, effervescent, raft forming, and hollow microspheres.
This document discusses parenteral products and water for injection (WFI). It provides details on:
1) What defines a parenteral product and reasons they are unique dosage forms.
2) The manufacturing process for parenteral products including procurement, processing, packaging, and quality control.
3) Key factors for WFI production including distillation units, storage and distribution, and validation to ensure quality standards.
Sustained and Controlled Release (SR/CR)Prachi Pandey
This document discusses sustained release (SR) and controlled release (CR) drug delivery systems. SR systems provide medication over an extended period, usually 8-12 hours, following first-order kinetics. CR systems maintain constant drug levels by releasing the drug at a predetermined rate following zero-order kinetics. SR systems do not necessarily localize drug to the active site, while CR systems often do. SR and CR delivery can reduce side effects and dosing frequency while improving bioavailability and patient compliance compared to conventional dosage forms. Factors like dosage form materials, drug properties, and environment affect drug release from these systems.
Compaction and compression, Forces involved in compression & Factors affectin...Dharmendra Chaudhary
This document summarizes key aspects of compaction and compression presented in a seminar. It discusses how compaction involves applying mechanical force to powdered solids, consolidating the material and increasing particle interaction. It also describes various forces involved in compression, including the applied force, force transmitted to the lower punch, and die wall friction. Factors affecting tablet hardness are compression force magnitude and distribution within the die, as well as material properties like plasticity and stress relaxation rate.
This document provides an overview of the factors that can affect drug absorption following oral administration. It discusses how a drug's solubility, permeability, and rate of dissolution can impact its bioavailability and classification in the Biopharmaceutics Classification System (BCS). The BCS categorizes drugs as Class I-IV based on their solubility and permeability properties, which can predict how variables like formulation, food, and disease may alter absorption. The document also reviews how patient characteristics like gastrointestinal physiology, age, and disease state can influence drug absorption by impacting solubility, permeability and transit time.
This document discusses food-drug interactions and their mechanisms. It notes that foods can interfere with drug absorption, action, and excretion, decreasing effectiveness. Common mechanisms are foods binding to or changing the pH of drugs, slowing gastric emptying, or altering transport. Some key interactions mentioned are vitamins affecting warfarin's anticoagulation; sodium negating antihypertensives; and calcium impairing fluoroquinolone absorption. The document emphasizes the importance of following doctors' instructions to maximize benefits and minimize interactions when taking medications with food.
This document provides information about tablets as a drug delivery system. It defines tablets and describes their key components and manufacturing process. Tablets consist of active pharmaceutical ingredients and excipients that control release and aid manufacturing. Excipients include fillers, disintegrants, binders, lubricants and others. Tableting involves powder compression in a die and punch press. Tablets offer benefits like precision dosing but some drugs are not suitable. Quality is ensured through testing dissolution and other properties.
Clinical pharmacokinetic studies are performed to examine the absorption, distribution, metabolism, and excretion of a drug under investigation in healthy volunteers and/or patients
This document discusses modified release drug products, including extended release and delayed release dosage forms. It defines modified release as altering the timing and/or rate of drug release. Extended release aims for twice daily dosing by providing continuous drug levels while delayed release releases the drug at a time other than promptly after administration. The document discusses various extended release drug delivery technologies like coated beads, multilayer tablets, microencapsulation, embedding in eroding matrices, plastic matrices, complexation, and osmotic pumps. It emphasizes the importance of in vitro-in vivo correlations and bioequivalence studies in evaluating these modified release products.
Introduction to CR/SR preparations, concept of controlled release formulation, challenges of CR drug delivery system, advantages and disadvantages, Factors influencing the design and performance of CR products (physiochemical properties: molecular size and diffusivity, aqueous solubility, ionization constant, partition coefficient, stability, pharmacokinetic and pharmacodynamic considerations: release rate and dose, Biological factors: Absorption, distribution, metabolism and elimination half life, therapeutic index, duration of action.
Kinetics of drug release from CRDS: Zero order, first order, Hixson-Crowell Release Model, Higuchi Release Model and Korsmeyer-Peppas Release Model
Oral controlled release systems: Dissolution controlled release (Matrix and encapsulated dissolution), diffusion controlled release (Reservoir and matrix system), dissolution and diffusion controlled release, Osmotically controlled release, pH independent formulations, Ion exchange resins.
Evaluation of CR formulations: Quality control methods( Identity, purity, strength, stability of the dosage form and drug in the dosage form, disintegration and dissolution, dosage form appearance, bioavailability of the drug from dosage form
This document provides an overview of oral disintegrating tablets (ODTs), including their development, technologies used in their production, and evaluation methods. ODTs are solid dosage forms that disintegrate rapidly in the mouth, typically within 3 minutes, without water. They offer advantages over conventional tablets for patients who have difficulty swallowing. The document reviews various ODT production technologies such as freeze drying, spray drying, mass extrusion, and direct compression. It also discusses ideal properties, advantages, and limitations of ODTs.
This document discusses strip packaging technology. Strip packaging involves enclosing individual articles between two webs of material sealed together in pockets by heated rollers. The process involves feeding articles and web materials between rollers with cavities to form sealed pockets around each article. Design considerations for the strips include pocket shape and size. Seal quality is inspected by heating sealed areas and checking for leaks underwater. Common materials used are foil laminates, PET, and aluminum foil for their barrier and sealing properties.
Dissolution: how to calculate dissolution calculation in excel sheetSagar Savale
The document describes how to calculate drug dissolution in an Excel sheet. It involves creating a standard calibration curve by measuring the absorbance of drug solutions with known concentrations. An equation is generated from the calibration curve graph that relates absorbance to concentration. This equation is then used to calculate the concentration of test solutions from their absorbance readings over time during a dissolution test. The concentrations are used to determine the percentage of drug dissolved at each time point.
Controlled Release Oral Drug Delivery System
Controlled drug delivery is one which delivers the drug at a predetermined rate, for locally or systemically, for a specified period of time.
This document discusses different types of solid drug forms including tablets, capsules, granules, powders, and pellets. Pellets are small, sterile tablets used for prolonged drug release and come in sizes between 0.5-1.5mm. Pellets can be manufactured using various methods including layering powders or liquids onto seed cores, spray drying, compaction processes like extrusion-spheronization, and globulation techniques. New production methods include hot melt extrusion and cryopelletization.
controlled drug delivery system classificationravipharmabwm
The document discusses different types of controlled drug delivery systems classified by physical or chemical means of activation. The key types are:
1. Osmotically activated systems where drug release is controlled by osmotic pressure gradients.
2. Mechanically activated systems like metered-dose inhalers that use manual activation to deliver precise drug doses.
3. Iontophoresis-activated systems where an electrical current enhances absorption of ionic drugs through the skin.
4. pH-activated systems that target drug delivery to specific pH ranges, like coatings protecting gastric drugs from stomach acid.
This document discusses osmotic controlled oral delivery systems. It provides advantages like continuous drug delivery at predictable rates independent of gastric conditions. Components include drugs, osmotic agents, and semipermeable membranes. Various osmotic pump types are described like elementary, push-pull, bursting. Applications include Glucotrol XL, Procardia XL, and other marketed products that use this technology to provide extended release of drugs.
This document discusses chronopharmacokinetics and circadian rhythms. It begins by explaining that drug absorption, distribution, metabolism and elimination can vary based on the time of day due to physiological rhythms. It then defines chronopharmacokinetics as studying how drug plasma levels vary based on the time of administration. Key factors that can cause time-dependent variations, like changes in GI function, enzyme activity and organ blood flow, are summarized. Examples are given of disease symptoms and drug effects that vary over 24-hour periods. Finally, applications of chronotherapeutic drug delivery systems are briefly mentioned to maximize drug effects at specific times.
This document provides an overview of orally disintegrating tablets (ODTs), including:
1. The definition and ideal properties of ODTs according to regulatory agencies.
2. The large market potential and growth of ODTs globally, especially for drugs treating central nervous system and gastrointestinal conditions.
3. Important patented technologies for developing ODTs, such as Zydis® technology which uses a lyophilization process to create a porous structure for rapid disintegration.
4. Common excipients and formulation methods used in ODTs, including lyophilization, molding, and mass extrusion.
Superdisintegrants in Orally Administered Products of Pharmaceuticals A Reviewijtsrd
This document reviews superdisintegrants, which are added to pharmaceutical products to improve palatability and the performance of solid oral dosage forms. Superdisintegrants work by reducing the disintegration time of tablets, which improves drug dissolution rate. The review discusses various types of natural, synthetic, and semi-synthetic superdisintegrants. It also examines the mechanisms by which superdisintegrants cause rapid tablet disintegration, such as swelling, porosity, deformation, and particle repulsion. The ideal properties of superdisintegrants and their methods of incorporation into tablets are described. The document concludes that superdisintegrants can help advance the development of orally administered pharmaceutical products by improving acceptability and potency.
This document discusses floating drug delivery systems (FDDS). It defines FDDS as systems that have sufficient buoyancy to float over gastric contents and remain in the stomach for a prolonged period of time. This results in increased gastric retention and better control of drug concentrations. The document covers the importance of FDDS, factors affecting performance, classifications, suitable drugs, evaluation tests, and examples of marketed products. It provides details on the preparation and functioning of various FDDS types including non-effervescent, effervescent, raft forming, and hollow microspheres.
This document discusses parenteral products and water for injection (WFI). It provides details on:
1) What defines a parenteral product and reasons they are unique dosage forms.
2) The manufacturing process for parenteral products including procurement, processing, packaging, and quality control.
3) Key factors for WFI production including distillation units, storage and distribution, and validation to ensure quality standards.
Sustained and Controlled Release (SR/CR)Prachi Pandey
This document discusses sustained release (SR) and controlled release (CR) drug delivery systems. SR systems provide medication over an extended period, usually 8-12 hours, following first-order kinetics. CR systems maintain constant drug levels by releasing the drug at a predetermined rate following zero-order kinetics. SR systems do not necessarily localize drug to the active site, while CR systems often do. SR and CR delivery can reduce side effects and dosing frequency while improving bioavailability and patient compliance compared to conventional dosage forms. Factors like dosage form materials, drug properties, and environment affect drug release from these systems.
Compaction and compression, Forces involved in compression & Factors affectin...Dharmendra Chaudhary
This document summarizes key aspects of compaction and compression presented in a seminar. It discusses how compaction involves applying mechanical force to powdered solids, consolidating the material and increasing particle interaction. It also describes various forces involved in compression, including the applied force, force transmitted to the lower punch, and die wall friction. Factors affecting tablet hardness are compression force magnitude and distribution within the die, as well as material properties like plasticity and stress relaxation rate.
This document provides an overview of the factors that can affect drug absorption following oral administration. It discusses how a drug's solubility, permeability, and rate of dissolution can impact its bioavailability and classification in the Biopharmaceutics Classification System (BCS). The BCS categorizes drugs as Class I-IV based on their solubility and permeability properties, which can predict how variables like formulation, food, and disease may alter absorption. The document also reviews how patient characteristics like gastrointestinal physiology, age, and disease state can influence drug absorption by impacting solubility, permeability and transit time.
This document discusses food-drug interactions and their mechanisms. It notes that foods can interfere with drug absorption, action, and excretion, decreasing effectiveness. Common mechanisms are foods binding to or changing the pH of drugs, slowing gastric emptying, or altering transport. Some key interactions mentioned are vitamins affecting warfarin's anticoagulation; sodium negating antihypertensives; and calcium impairing fluoroquinolone absorption. The document emphasizes the importance of following doctors' instructions to maximize benefits and minimize interactions when taking medications with food.
Drug food interactions in details - QAQussai Abbas
Drug interactions (DIs) represent an important and widely under recognized source of medication errors. Interactions between food and drugs may inadvertently reduce or increase the drug effect. Some commonly used herbs, fruits as well as alcohol may cause failure of the therapy up a point of to serious alterations of the patient’s health. The majority of clinically relevant food-drug interactions are caused by food induced changes in the bioavailability of the drug. Major side-effects of some diet (food) on drugs include alteration in absorption by fatty, high protein and fiber diets.
Underlying factors:
Classification of drug-food interactions:
Pharmacodynamic interactions
Pharmacokinetic interactions
I. Absorption interactions
II. Transport and distribution interactions
III. Metabolism interactions
IV. Excretion interactions
Grapefruit juice
Alcohol and Medication Interactions
Common Alcohol-Medication Interactions
Specific Alcohol-Medication Interactions
Pharmacokinetic interactions my assignment to be submited to sir ismail shahZeeshan Habib
This document discusses pharmacokinetic interactions and their mechanisms. It defines pharmacokinetics as how the body affects a drug and interactions as how two substances affect each other. Pharmacokinetic interactions occur via changes in drug absorption, distribution, metabolism, or excretion. Absorption can be affected by changes in gastric pH or emptying. Distribution can be altered through protein binding displacement. Metabolism involves cytochrome P450 enzymes and interactions can occur through inhibition or induction of these enzymes. Elimination involves the kidneys and interactions can happen through tubular secretion or reabsorption. Strategies to prevent interactions include consulting interaction reports and conducting therapeutic drug monitoring.
This document summarizes drug-drug interactions and their mechanisms. It discusses how interactions can affect the pharmacokinetics and pharmacodynamics of drugs. Pharmacokinetic interactions alter absorption, distribution, metabolism, or excretion of a drug. They are common and can change a drug's plasma concentration. Pharmacodynamic interactions involve drugs with similar or opposing effects. The document focuses on the ways pharmacokinetics and pharmacodynamics are altered in different conditions and the mechanisms involved in enzyme induction and inhibition during drug interactions.
Bioavailability refers to the amount of drug that enters systemic circulation and is available at the site of action. It depends on the rate and extent of drug absorption from its dosage form. Many physiological and drug-specific factors can affect bioavailability such as pH, enzymes, blood flow, and food interactions. Careful evaluation and standardization of bioavailability is important for drug development and quality control to ensure accurate and safe dosing.
The document discusses drug interactions, defining it as when the pharmacological activity of one drug is altered by the concomitant use of another drug. It describes the main types of interactions as pharmacokinetic, involving effects on absorption, distribution, metabolism and excretion, and pharmacodynamic, involving effects on pharmacological activity. The key mechanisms of pharmacokinetic interactions are induction or inhibition of drug-metabolizing enzymes and displacement from plasma protein binding. Food and herbs can also cause interactions.
This document discusses the individualization of drug dosage regimens to account for variability between patients. It notes that while humans are alike as a species, there are differences between individuals that impact their responsiveness to drugs. Failing to tailor drug administration to each patient can lead to ineffective therapy in some or toxicity in others. The document outlines the main sources of variability in pharmacokinetics as biological factors like age, weight, gender and genetics, environmental factors like drug interactions and disease states, and cultural factors. It discusses approaches to designing individualized dosage regimens based on estimating pharmacokinetic parameters in individual patients or using population averages with adjustments. The key parameters that can be adjusted are dose size and dosing frequency.
pharmacokinetic drug interactions,factors affecting drug interaction ,mecahan...SUJITHA MARY
This document discusses pharmacokinetic drug interactions, including factors that influence them, mechanisms, and classifications. It describes several important interaction types like absorption interactions caused by complexation/adsorption or changes in GI pH. Distribution interactions can involve protein binding alterations, while metabolism interactions may be due to enzyme induction/inhibition. Excretion interactions can change active tubular secretion or urine pH. The effect of protein binding is explained using equations for volume of distribution and hepatic clearance. Cytochrome P450 inhibitors can increase drug bioavailability by inhibiting hepatic metabolism. In conclusion, recognizing interaction principles and vigilance when changing drugs can help identify harmful interactions.
This document discusses food-drug interactions, providing definitions and discussing underlying factors. It covers how foods can impact drug absorption, metabolism, and excretion pharmacokinetically. Foods can also impact drugs pharmacodynamically. The document also notes drugs can impact nutrient status. Common food-drug interactions are discussed, including those involving grapefruit juice and St. John's wort. The summary provides high-level information about the topic and scope of the document in under 3 sentences.
This document discusses adverse drug interactions that may occur in dentistry. It begins with an introduction to drug interactions and their mechanisms. It then covers various types of interactions like pharmacokinetic interactions involving absorption, distribution, metabolism and excretion. It also discusses pharmacodynamic interactions. The document focuses on clinically important interactions that may occur with local anesthetics, analgesics/NSAIDs and antibiotics commonly used in dentistry. It provides examples of interactions with CNS depressants, drugs that share metabolic pathways, general anesthetics, antidepressants and others for local anesthetics. It also discusses interactions between NSAIDs, anticoagulants, corticosteroids, alcohol and antihypertensives. The document emphasizes the importance of
Factors Affecting Sustain Realease Drug delivery SystemAnam Sami
This document provides an overview of sustain release drug delivery systems and formulations. It discusses the advantages and disadvantages of SRDD systems as well as key factors that affect their formulation, including physiological factors like dose size, partition coefficient, aqueous solubility, drug stability, and protein binding. Biological factors like absorption, distribution, metabolism, and biological half-life are also reviewed. Different approaches for SRDD systems are mentioned, along with examples of specific approaches.
This document provides information on drug interactions in a pocket guide reference format. It begins with an introduction and overview of types of drug interactions. The bulk of the document is a table that lists specific drug classes and examples of drugs, potential interacting drugs, the effect of the interaction, and recommendations for management. It concludes with references for additional information. The document is intended as a concise reference for health professionals on important drug interactions involving medications commonly used in patients with renal conditions.
This document provides information on drug interactions in a pocket guide reference format. It begins with an introduction and overview of types of drug interactions. The bulk of the document is a table that lists specific drug classes and examples of drugs, potential interacting drugs, the effect of the interaction, and recommendations for management. It concludes with references for additional information. The document is intended as a concise reference for health professionals on important drug interactions involving medications commonly used in patients with renal conditions.
This document discusses drug interactions, defining them as when the effects of one drug are altered by another drug, food, drink, or other agent. It provides examples of different types of interactions, including drug-drug, drug-food, drug-lab, drug-herbal, and drug-disease. The main mechanisms of interactions are also summarized, including pharmacokinetic interactions which affect absorption, distribution, metabolism, or excretion, and pharmacodynamic interactions which affect the drug's site of action. Risk factors and approaches for managing interactions are briefly covered.
Introduction of Veterinary pharmacologyQaline Giigii
This document provides an introduction to veterinary pharmacology. It discusses how pharmacology can be defined as the study of substances that interact with living systems, and how veterinary pharmacology specifically focuses on preventing, diagnosing and treating disease in animals. The document then summarizes that veterinary pharmacology has two main subdivisions: pharmacokinetics, which is what the body does to a drug, and pharmacodynamics, which is what the drug does to the body. Several key pharmacokinetic and pharmacodynamic concepts are then defined, including absorption, distribution, metabolism, excretion, drug receptors, and drug effects.
Introduction of Veterinary pharmacology Somaliland Dr.Osman Abdulahi FarahQaline Giigii
This course was prepared by Dr.Osman Abdulahi Farah
Cismaan shiine Lecturer of Gollis University Faculty of Agriculture and Veterinary Medicine 2014
The main content of this course including introduction of Veterinary Pharmacology, division of pharmacology and list of terms of terminology about veterinay pharmacology
Malnutrition is a condition that develops from an imbalance between the nutrients the body needs and the nutrients supplied through diet. The main types of protein-energy malnutrition are marasmus and kwashiorkor. Marasmus is characterized by severe wasting and loss of muscle and fat tissue due to low energy intake. Kwashiorkor is caused by low protein intake and presents with edema, skin changes, and hair discoloration. Prevention strategies include promoting breastfeeding, education on proper nutrition, immunization, and early diagnosis and treatment.
Major depressive disorder, also known as clinical depression, is characterized by a persistent low mood and loss of interest over at least two weeks. The exact causes are unknown but may involve genetic, biological, environmental, and psychological factors like stress, childhood trauma, and substance abuse. The pathophysiology of depression involves deficiencies in neurotransmitters like serotonin, norepinephrine, and dopamine according to the monoamine hypothesis. The neurotrophic hypothesis also links low levels of brain-derived neurotrophic factor to loss of neurons and brain atrophy.
Cancer is caused by genetic mutations that lead to uncontrolled cell growth. Molecular changes in genes that control cell division, DNA repair, apoptosis, and angiogenesis can result in cancer development. Environmental factors like chemicals and viruses can also damage DNA and induce mutations that cause cancer by altering gene expression and cell signaling pathways.
A document provides information about an individual named Spurthi B.S who holds a Doctor of pharmacy (Pharm D) degree from Mallige college of pharmacy. The document lists an individual's name, their professional degree which is a Pharm D, and the educational institution from which they obtained their degree, Mallige college of pharmacy.
This document discusses Acquired Immunodeficiency Syndrome (AIDS), which is caused by the Human Immunodeficiency Virus (HIV). It destroys and impairs the function of immune cells called CD4+ T cells, leading to immunosuppression and increased susceptibility to opportunistic infections. The document outlines the structure of HIV, signs and symptoms of AIDS, stages of HIV infection from acute to chronic to final crisis phase, diagnostic methods including antibody tests, viral load tests, and CD4+ T cell counts.
This document discusses countercurrent extraction, a multiple liquid-liquid extraction technique used to separate components with varying solubility in two immiscible liquids. In countercurrent extraction, the two liquids flow in opposite directions through multiple stages, allowing the components to reach equilibrium and become purified in separate streams. A diagram shows how component A concentrates in one liquid while B concentrates in the other over several stages. Factors like solvent selection, operating conditions, extractor design, and number of stages influence the process. Countercurrent extraction has applications in separating synthetic mixtures, plant extracts, and purifying compounds.
Majocchi Granuloma, Masquerading As Psoriasis: A ReviewSpurthiPunam
Majocchi’s granuloma (MG) is a rare, atypical yet well recognized deep infection of dermal and subcutaneous tissue caused by dermatophytes such as anthropophilic Trichophyton rubrum; however, other dermatophytes including T. mentagrophytes T. epilans, T. violaceum, M. audouinii, M. gypseum, M. ferrugineum, and M. canis may be the causative agent usually limited to the superficial epidermis. In both healthy individuals and immunocompromised hosts MG is characterized clinically by papular, pustular or nodular inflammatory lesions occurring typically on the limbs or face, immunocompromised patients are at increased risk for infection. A favorable factor for the infection is an injury caused by epilation, which together with an existing fungal infection. The aim of this article is to provide a detailed review on clinical manifestations, diagnosis, risk factors, pathophysiology and pharmacological treatment options.
Cyclosporine is an immunosuppressant used to prevent organ rejection after transplantation. It works by inhibiting calcineurin and blocking IL-2 production. It is dosed orally at 15 mg/kg before transplantation and 1.25 mg/kg twice daily for rheumatoid arthritis and psoriasis. Cyclosporine is metabolized by CYP3A4 and has variable absorption and a half-life of 8.4-27 hours. Therapeutic drug monitoring is important to prevent toxicity and rejection. FDA approved uses include transplantation and rheumatoid arthritis and psoriasis. Major side effects include hirsutism, hypertriglyceridemia and gum hyperplasia. It
Sirolimus is an immunosuppressant that inhibits T-cell activation and proliferation, preventing rejection of transplanted organs. It is used to prevent renal transplant rejection when taken with cyclosporine and corticosteroids, targeting a blood concentration of 16-24 ng/mL for the first year and 12-20 ng/mL thereafter. Sirolimus has low oral bioavailability and a long half-life of 2.5 days, is highly protein bound, metabolized by CYP3A4 and primarily eliminated in the feces. Monitoring of liver enzymes, cholesterol, triglycerides and other parameters is required during treatment. Side effects include edema, hyperlipidemia, constipation and joint pain.
The premature ageing disorder Hutchinson - Gilford Progeria syndrome (HGPS) is one of the orphan (rarest) human diseases The Classic type of Progeria is HGPS. In humans hundreds of mutations in LMNA gene have been identified which causes several diseases termed as laminopathies. Products of LMNA gene primarily lamin A and C are key components of the nuclear lamina, a proteinaceous mesh work of inner nuclear membrane. Classic HGPS is caused by a de novo point mutation in exon 11(Residue 1824 C to T) of the LMNA gene which results in the production of mutant lamin A protein termed as 'Progerin'. In particular, progerin accumulation elicits nuclear
morphological abnormalities. HGPS is characterized by the presence of aging associated symptoms, including loss of subcutaneous fat, alopecia, cardiovascular Pathology and death due to myocardial infarction and stroke in childhood. Laboratory findings are unremarkable, with the exception of an increased urinary excretion of hyaluronic acid. Without progerin - specific treatment death occurs at an average age of 14.6 years from accelerated atherosclerosis. Supportive therapy like vitamin supplementation, Nutrini, pro-cal are recommended. Treatment usually includes low dose aspirin, lonafarnib, zoledronic acid, pravastatin, gene therapy and RNA therapy.
The document discusses some positive environmental impacts and economic challenges that have emerged from the COVID-19 pandemic. Pollution levels over cities like Delhi and China have reduced by 40% with fewer vehicles on the roads. The water quality of the Ganga River has also improved to the point some experts say it is now fit for drinking. However, the International Labour Organization claims that about 400 million Indian workers are at risk of falling deeper into poverty due to unemployment. There have also been benefits to flora and fauna as less human presence has allowed wildlife to thrive more freely in forests.
This document discusses wound healing. It defines wounds and classifies them based on origin, contamination, and depth. The two main processes of healing are regeneration, which results in complete tissue restoration, and repair through granulation tissue formation and wound contraction. Wound healing can occur through primary intention, with wound edges approximated, or secondary intention, with the wound left open. Secondary healing involves granulation tissue filling the wound space and wound contraction. Factors like infection, nutrition, and immobilization can affect healing. Complications include infection, keloids, hypertrophic scars, and pigmentary changes.
Chronic obstructive pulmonary disease (COPD) refers to two commonly co-existing lung diseases: chronic bronchitis and emphysema. In COPD, less air flows in and out of the airways due to narrowing of the airways. The primary risk factor for COPD is smoking, as the irritants in cigarette smoke damage the lungs over time. Other risk factors include air pollution, occupational exposures, infections, and genetic conditions like alpha-1 antitrypsin deficiency. The main clinical features of COPD are chronic cough, sputum production, wheezing, chest tightness, dyspnea on exertion, weight loss, and respiratory insufficiency.
This document discusses stroke, specifically focusing on ischemic and hemorrhagic stroke. It defines stroke as an abrupt onset of focal neurologic deficit lasting at least 24 hours presumed to be of vascular origin. Ischemic stroke, which accounts for 87% of cases, occurs from local thrombus formation or emboli blocking a cerebral artery. Hemorrhagic stroke can be subarachnoid, intracranial, or subdural depending on where the bleeding occurs in the brain. The document then examines the pathogenesis of ischemic stroke, outlining how arterial occlusion leads to decreased blood flow and nutrients, cell damage, and ultimately cell death within 2-3 hours. For hemorrhagic stroke, the presence
Spurthi BS completed her Doctor of Pharmacy degree from Mallige College of Pharmacy. Her document discusses various classes of antiarrhythmic drugs, their mechanisms of action, examples, and side effects. It covers sodium channel blockers, beta blockers, potassium channel blockers, calcium channel blockers, digoxin, and adenosine. The classes are compared in terms of their effects on cardiac action potential phases and conduction. Specific drugs are also described in terms of their uses, dosages, and contraindications.
The document provides information about various vitamins, including their sources, daily requirements, and functions. It discusses both water-soluble vitamins (B vitamins and vitamin C) and fat-soluble vitamins (A, D, E, K). For each vitamin, there is a section on dietary sources, daily intake recommendations, and the key roles the vitamin plays in the body.
This document discusses diabetes mellitus (DM), providing information on the classification, pathophysiology, risk factors, clinical presentation, and treatment of the two main types of DM - Type 1 and Type 2. It defines DM as a chronic condition characterized by hyperglycemia. Type 1 DM is due to insulin deficiency caused by an autoimmune destruction of beta cells, usually developing before age 30. Type 2 DM involves both insulin resistance and relative insulin deficiency, usually developing after age 40 in obese individuals. The clinical presentation of Type 1 DM includes symptoms of polyuria, polydipsia, and ketoacidosis, while Type 2 DM symptoms may be more mild or asymptomatic.
1) Gene knockout of CCR5 chemokine co-receptor prevents HIV entry into target cells by knocking out the CCR5 gene which codes for the CCR5 receptor.
2) Gene knockin alters the CCR5 genomic sequence to produce an altered CCR5 that prevents viral entry while maintaining normal CCR5 function.
3) Genetic mutations open the door to new possibilities, as evidenced by the ability to alter CCR5 and prevent HIV infection while preserving CCR5's role in cell communication.
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Histololgy of Female Reproductive System.pptxAyeshaZaid1
Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
Does Over-Masturbation Contribute to Chronic Prostatitis.pptxwalterHu5
In some case, your chronic prostatitis may be related to over-masturbation. Generally, natural medicine Diuretic and Anti-inflammatory Pill can help mee get a cure.
ABDOMINAL TRAUMA in pediatrics part one.drhasanrajab
Abdominal trauma in pediatrics refers to injuries or damage to the abdominal organs in children. It can occur due to various causes such as falls, motor vehicle accidents, sports-related injuries, and physical abuse. Children are more vulnerable to abdominal trauma due to their unique anatomical and physiological characteristics. Signs and symptoms include abdominal pain, tenderness, distension, vomiting, and signs of shock. Diagnosis involves physical examination, imaging studies, and laboratory tests. Management depends on the severity and may involve conservative treatment or surgical intervention. Prevention is crucial in reducing the incidence of abdominal trauma in children.
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
1. IOSR Journal Of Pharmacy
(e)-ISSN: 2250-3013, (p)-ISSN: 2319-4219
Volume 10, Issue 8 Series. I (August 2020), PP. 27-44 www.iosrphr.org
27
A Review: Pharmacokinetic Drug Interactions, A Primer For
Clinical Pharmacist.
Chaithanya K.J.*1
, Spurthi B.S.2
, K.U. Janmita3
1
(4th
PharmD, Dept. of Pharmacy Practice, Mallige College of Pharmacy, Bangalore, Karnataka, India
2
(3rd
PharmD, Dept. of Pharmacy Practice, Mallige College of Pharmacy, Bangalore, Karnataka, India
3
(3rd
PharmD,Dept. of Pharmacy Practice, Mallige College of Pharmacy, Bangalore, Karnataka, India
Corresponding Author: Chaithanya .K.J
4th
year Pharm D Dept. of Pharmacy Practice Mallige College of Pharmacy,
Bangalore, Karnataka, India
Received 30 July 2020; Accepted 15 August 2020
ABSTRACT
Drug-drug interactions(DDI) are one of the commonest causes of medication error, particularly in the elderly
due to poly-therapy, with a prevalence of 20-40%. Drug interactions represent factors of uncertainty in many
therapeutic situations. Drug–drug interactions can cause profound clinical effects, either by reducing therapeutic
efficacy or enhancing toxicity of drugs. With an increasing frequency in polypharmacy, DDIs are one of the
major causes for drug withdrawal from the market. In particular, poly-therapy increases the complexity of
therapeutic management and thereby the risk of clinically important DDIs, which can both induce the
development of adverse drug reactions or reduce the clinical efficacy. Although DDIs can result in alterations of
either drug pharmacokinetics (PK), pharmacodynamics(PD), or both, it is the pharmacokinetic drug interactions
that is clinically significant. PK drug interactions, typically characterized by alterations of plasma
concentration–time profiles, could be attributed to changes in processes of absorption, distribution, metabolism,
and excretion of a drug substance mediated by another drug when they are given concomitantly. In this review
we mainly focused on the pharmacokinetic drug interactions with various drug examples and their mechanism
of drug interactions that are clinically significant.
KEYWORDS - Drug-drug interaction, Pharmacodynamics, Pharmacokinetics, Polypharmacy.
I. INTRODUCTION
As drug use rises worldwide, pharmacists should be increasingly concerned about adverse
consequences arising from drug interactions. Pharmacists are often the health professionals who represent the
last line of defense between patients and the harmful effects of medications. Interactions between drugs often
are predictable and avoidable. Thus, pharmacists who monitor patients and carefully check for rational
prescribing can minimize adverse drug interactions. Prescription and nonprescription drugs can interact when
given concurrently. Drugs can also interact with environmental chemicals and dietary substances. Some
interactions are clinically valuable. However, many are undesirable and have potentially serious consequences
for patients.[1] Medicines are often used concomitantly with other drugs, and some degree of drug-drug
interaction occurs with concomitant use. drug interactions,especially for the drugs having a very narrow
therapeutic index, may have severe adverse reactions. Therefore, within the evaluation and clinical application
of medicine, appropriate efforts should be made to predict the character and degree of drug interactions in order
that patients won‘t be adversely affected.[2] The clinical response depends on many factors,including individual
patient characteristics such as age, co-morbidities and pharmacogenetics. [3] Most drug interactions are drug-
drug interactions that occur when one drug alters the magnitude or duration of the pharmacologic response of
another. Drug-drug interactions occur in patients by two mechanisms. Pharmacokinetic interactions occur when
one drug changes the disposition of another by affecting the latter's absorption, distribution, biotransformation,
or excretion; that is, it alters the concentration of the second drug at the site of action, altering the drug's effect
The second type,pharmacodynamic interactions, involves additive, synergistic, or antagonistic effects of drugs
acting on the same receptors or physiologic systems, with the result that the drugscombined effect is lesser or
greater than either would elicit alone.[1] drug interactions might readily cause clinically significant changes in
blood drug levels concentration in whole blood, plasma, or serum in patients having pharmacokinetic
parameters markedly deviating from those of the standard population. The former interaction is the phenomenon
that is induced by changes in blood levels and tissue distribution of a drug or its active metabolites by the
interaction of the drugs, nutritional and environmental by the processes of absorption, distribution, metabolism,
and excretion.[2,4]
2. A Review: Pharmacokinetic Drug Interactions, A Primer For Clinical Pharmacist.
28
II. DRUG ABSORPTION INTERACTIONS
The absorption of drugs from the human gastrointestinal tract has received relatively little attention
from clinical pharmacologists. Yet the great majority of drugs are given orally, and it has been known for years
that there may be enormous intra- and inter-individual variations in the rate and completeness of absorption of
drugs. [5] To reach the bloodstream form the alimentary tract,a drug must cross the intestinal
epithelium,basement membrane and capillary endothelium. For drugs, the most important process of absorption
is passive diffusion, no energy is needed and it is a non-saturable process and the transfer is directly proportional
to the concentration gradient and to the lipid – water partition coefficient of the drug. [6]
The extent of absorption is determined by drug solubility, the rate of drug permeation across the
intestinal membrane, and the time of exposure (i.e., transit time through the intestine). These variables
can be influenced by drug-induced changes in physiological or biochemical activities, and consequently,
are potential factors in DDIs. Intestinal absorption is a kinetic process considered to occur under sink
conditions wherein soluble drug concentrations in the intestinal lumen unidirectionally diffuse across
the intestinal epithelium into a relatively large systemic volume. [7] The complexity of the gastro-intestinal
tract, and the effects of several drugs with functional activity on the digestive system, represent favorable
conditions for the emergence of DDI that may alter the drug bioavailability. [8] Interactions between drugs that
influence absorptionfrom the gastrointestinal tract into thesystemic circulation represent a major problem indrug
therapy. While many types of interactionshave been identified, many others probably have not been recognized
due to the difficulty of establishing cause-effect relationships for symptomaticchanges in patients receiving
multiple drugtherapy. [9] However, there are a number of interrelated factors that can complicate efficient drug
absorption like altered gastric pH, complexation and adsorption of compounds, altered gastric motility,
modulation of p-glycoprotein and alteration GI microflora.[6,8,9,10,11]
2.1 Interactions altering gastric pH
Several factors may influence the absorption of a drug through the gastrointestinal mucosa. The
prerequisite factor is the change in gastric pH. The majority of drugs orally administered requires, to be
dissolved and absorbed, gastric pH between 2.5 and 3.[5,8] Because most drugs are administered as solid
preparations (such as tablets and capsules), they have to be dissolved in gastric or intestinal fluids to be
absorbed. Many factors influence the dissolution. Among them, gastric pH has a crucial influence on the
absorption of weakly acidic or basic drugs, because their solubility may be critically dependent on pH. It is well
known that the dissolution rate of a formula in the gastric fluid is a rate-limiting step for absorption for some
drugs.[12]DDIs can occur as a result of changes in drug solubility and dissolution as a consequence of altered
gastric pH, or through changes to GI transit impacting the time of exposure of a drug to the absorptive intestinal
epithelium. For the former, the acidic environment of the stomach facilitates dissolution of solid dosage forms
and impacts solubility of some drugs. Acid-reducing agents (antacids, H2 antagonists, and proton pump
inhibitors) can increase gastric pH from normal values of 1.5–3 to values as high as 5–6.11 Many weak basic
drugs show dramatic changes in solubility over this pH range resulting in reduced dissolution and bioavailability
at elevated pH. Clinical DDIs associated with increased GI pH resulting from acid-reducing drugs have been
observed with many basic drugs, especially those with pH-dependent solubility.[5,8,13]
We consider that changes in the extent of drug absorption (quantified by area under the concentration-
time curves [AUC] are more important than changes in the rate of absorption, quantified by maximum drug
concentration [Cmax] and time to Cmax [tmax]), because the former is more directly associated with the
cumulative systemic exposure to the drug and hence with therapeutic responses.[12]
2.1.1 Antacids,H2 blockers and PPIs associated interactions.
Antacids may interact with drugs or their dosage forms in various ways. By raising the pH in the
gastrointestinal tract they may increase the solubility of acids and decrease the solubility of bases. Conversely,
they may increase the proportion of solubilized basic molecules that are in the un-ionized state, thus facilitating
their absorption, while having the opposite effect on acidic molecules. [9] H2 antagonists (e.g., ranitidine),
antacids (e.g., aluminum hydroxide and sodium bicarbonate) and PPI (e.g., omeprazole, esomeprazole,
pantoprazole) that increase the gastric pH lead to a decrease in cefpodoxime bioavailability, but on the other
hand, facilitate the absorption of beta-blockers and tolbutamide.[8]
Cimetidine increased blood salicylate level when co-administered with aspirin, by inhibiting gastric
acid secretion cimetidine increases absorption of aspirin by increasing the dissolution rate of the aspirin
tablet.[6] The absorption of most compounds is significantly reduced by coadministration of antacid mixtures.
Compounds thus affected include chlorpromazine,chlortetracycline,digoxin,isoniazid,penicillamine,tetracycline
and vitamin A. Increased gastric pH due to antacids has been shown to increase the absorption rate of aspirin
from an enteric-coated formulation and also of the sulphanomides, sulphadiazine and sulphathiazole. More
rapid absorption of the sulphonamides is consistent with faster dissolution of the free acid form of these
3. A Review: Pharmacokinetic Drug Interactions, A Primer For Clinical Pharmacist.
29
compounds with increasing pH. The availability of pseudoephedrine is increased by concurrent aluminum
hydroxide, and this is probably because of raised gastrointestinal pH increasing the proportion of
pseudoephedrine present in the un ionized, and therefore more readily absorbed, form. [9,14,15]
2.1.2 Antifungal agents association interactions
Antifungal agents (e.g., ketoconazole or itraconazole), requires an acidic environment for being
properly dissolved, therefore, their co-administration with drugs able to increase gastric pH, may cause a
decrease in both dissolution andabsorption of antifungal drugs. Therefore, antacid or anticholinergics, or PPI
might be administered at least 2 h after the administration of antifungal agents.[8]these drugs are weak bases
with an acid dissociation constant (pKa) of approximately 3.0, they are nearly insoluble at pH >4.0. If
coadministration of an antacid elevates the gastric pH to >4.0 for a period longer than the gastric emptying time
(for liquid: 10–20 minutes), the drug may reach the small intestine before dissolution takes place and hence
absorption is decreased.[12]
2.1.3 Iron salts and tetracycline associated interactions
The binding of drugs to iron is pH dependent, hence drugs and foodwhich effect gastrointestinal pH
will alter iron-drug binding. [16]The decreased absorption of a solid dosage form, but not a solution, of
tetracyclinein the presence of bicarbonate indicates that the dissolution step must be involved and can be
explained by the importance of a low gastric pH to effect dissolution of solid tetracycline prior to absorption.
The aqueous solubility of tetracycline at pH 1 to 3 is 100 times greater than that at 5 to 6. The rate of dissolution
is markedly reduced at the higher pH values.Any substance which significantly increase the intragastric pH may
result in a decreased fraction of tetracycline in solution available for absorption by a mechanism which is
independent of the ability of the substance to chelate with tetracycline. Physiologic or pathologic conditions
which increase gastric pH, such as achlorhydria might also result in a decreased absorption of
tetracycline.[17,18]
2.2 Complexation and adsorption of compounds
The mechanism of DDIs is explained by chelation rather than elevation of gastric pH It may appear
rather simple to alleviate DDIs based on the chelation mechanism. In order to interfere with the absorption of a
concomitantly administered drug, a large amount of polyvalent cations must coexist with the susceptible drug in
the upper gastrointestinal lumen for long enough to form substantial amounts of chelate complexes before
absorption of the susceptible drug is completed.[10,12]
Fig. 1 When a soluble drug reacts with a metal ion it forms a insoluble drug -metal ion complex which interfere
with the absorption of drug.
2.2.1 Antacids and tetracycline
Subsequent studies have reported that antacids containing aluminum and magnesium hydroxides
interfered with the intestinal absorption of tetracycline, doxycycline and demeclocycline by approximately 90%
compared with the respective control values Chelation would therefore appear to be the primary mechanism of
the antacid-tetracycline interaction. This is the formation of a compound between a metal ion and an organic
molecule having two groups spatially arranged so as to form a ring structure with the metal. Although this
complex is undoubtedly important in the interaction of tetracyclines with di and trivalent metal ions (e.g.,
calcium and aluminum in antacid formulations),The rank order of stability of tetracycline-metal complexes is
Fe3+ > Al3+ > Cu2+ > Ni2+ > Fe2+ > Co2+ > Zn2+ > Mn2+.Some of these complexes are insoluble and thus
cannot be absorbed into the mucosa.[10,12]
4. A Review: Pharmacokinetic Drug Interactions, A Primer For Clinical Pharmacist.
30
2.2.2 cholestyramine associated interactions
Cholestyramine, an anionic exchange resin, binds cholesterol metabolites and bile acids in the intestinal
lumen and prevents their reabsorption, thus depleting body cholesterol, Such binding is not limited to bile acids,
however, and cholestyramine may markedly reduce the availability of co-administered drugs. especially acidic
drugs (e.g., warfarin, acetyl salicylic acid, sulfonamides, phenytoin, and furosemide). Cephalexin
,sulphamethoxazole, thyroxine and also to reduce the absorption rate, but not the overall availability, of
trimethoprim.[8,9,15,16]
2.2.3 Adsorption of rifampicin by bentonite
An interaction between two anti-tuberculous drugs, rifampicin and para-amino salicylic acid (PAS),
leading to a clinically important decrease in the serum levels of the former, the excipients in the granules,
especially the bentonite, which was found in vitro rapidly and strongly to adsorb RMP.[9,20]
2.2.4 Iron salts associated interactions
Iron compounds have been shown to cause marked reduction in the absorption of tetracycline, the
tetracycline derivatives doxycycline, methacycline and oxytetracycline as well as penicillamine, methyldopa,
levodopa, carbidopa and ciprofloxacin. The mechanism by which iron interacts with these drugs is the formation
of iron-drug complexes. The formation of the iron-drug complexes reduces the extent of drug absorption and
does not appear to reduce the rate of drug absorption. The ferric form of iron binds strongly to methyldopa with
a log Ks of 18 Methyldopa has been shown to increase the rate of oxidation of ferrous iron to its ferric form.
Iron-drug complexes may have increased iron-drug interactions hence there will low amount of free drug to be
absorbed.[16]
2.2.5 Charcoal and adsorption
Recent reviews have described the effect of activated charcoal on the systemic availability of various
drugs including salicylates, paracetamol, phenylpropanolamine, digoxin, dextropropoxyphene, nortriptyline and
propantheline. The inhibitory effect of charcoal on the absorption of other drugs is dependent upon the amount
of the adsorbent administered. This was demonstrated in two studies in which the availability of oral digoxin,
phenytoin, phenobarbitone, carbamazepine and phenylbutazone was reduced by greater than 95% and aspirin
by 70%.[9]
2.3 Altered gastric motility
The rate and extent of drug absorption can also be influenced by GI motility. Although GI motility is
typically associated with food effects, some drugs (e.g. Metoclopramide, cisapride, and erythromycin) increase
gastric emptying and intestinal motility, whereas others (anticholinergic drug, opioids, and anesthetics) can slow
these processes. [7,12] On the other hand, the absorption of drugs or formulations with slow dissolution
characteristics and compounds actively absorbed from a limited area of the small intestine may actually be
enhanced if the gastrointestinal transit time is reduced by propantheline because they remain longer at the sites
of maximum absorptionand metoclopramide increases stomach emptying rate. [5,9] For example propantheline
delays the gastrointestinal uptake of hydrochlorothiazide.[21] Oral absorption of desmopressin (a poorly
permeable nine amino acid peptide) was increased threefold in healthy subjects treated with loperamide relative
to untreated controls consistent with enhanced absorption as a consequence of increased intestinal transit time.
[7] metoclopramide, may accelerate gastric emptying, hence decreasing the absorption of digoxin and
theophylline whereas it can accelerate the absorption of alcohol, acetylsalicylic acid, acetaminophen,
tetracycline and levodopa.[8,22,23]Gastric acidity inhibits emptying, whereas slight alkalinity enhances it.
[8]the decreased rate of absorption of diazepam following the administration of morphine was a result of
delayed gastric emptying. It is well known that morphine slows gastric emptying, and it may delay the passage
of gastric contents through the duodenum for as long as 12 h. [11] The administration of glycopyrrolate
produced considerable decreases in the plasma paracetamol concentration and the area under the paracetamol
concentration curve (total amount of paracetamol absorbed). Since the area under the curve 1 h after
administration of paracetamol closely relates to gastric emptying. [24] Oral metoclopramide has also been
shownto increase the rate of absorption of other drugs given concurrently by the oral route. Drugs for which this
has been demonstrated include tetracycline, levodopa and paracetamol.[25,26]
5. A Review: Pharmacokinetic Drug Interactions, A Primer For Clinical Pharmacist.
31
2.4 Modulation of P-glycoprotein.
P-gp or gp-120 for its molecular weight, is a transmembrane protein. [8]P-glycoprotein (PGP), a
member of the superfamily of ATA-binding cassette transporters. Has been increasingly recognized because of
the discovery of multidrug resistance (MDR) in chemotherapy. This multidrug transporter prevents the
intracellular accumulation and cytotoxic effects of anticancer drugs by actively removing them from the cell
membrane before they reach their intracellular targets.[27,28] Among the interactions studied, it is worth
mentioning the effects of terfenadine on the transport of doxorubicin as well as the effects chlorpromazine and
progesterone on the transport of cyclosporine.[4] The DDIs on P-gp might induce a clinical effect in presence of
drugs with a low therapeutic index (e.g., digoxin, theophylline, anticancer drugs) when co-administered with
macrolides (e.g., erythromycin, roxithromycin, clarithromycin), PPIs (e.g., omeprazole or esomeprazole) or anti-
arrhythmic drugs (e.g., dronedarone, amiodarone, verapamil or diltiazem).[8] cyclosporin A is a substrateof
PGP, which is responsible for controlling the rate and extent of cyclosporin absorption.[27]
2.5 Gut microbiome interactions.
The fate and activity of drugs are frequently decided not only by the host per se but also by the
collection of microorganisms present in the gastrointestinal (GI) tract Drug-induced changes in the gut
microbiome may alter the pharmacokinetics of concomitantly taken medication. An increased plasma level of
the antiplatelet drug, aspirin, was observed in rats who were treated with a β-lactam antibiotic, ampicillin, 3 days
previously. This enhanced bioavailability was attributed to the antibiotic- induced suppression of the metabolic
activity of the gut microbiome. Moreover, ampicillin treatment significantly prolonged bleeding time in aspirin
treated rats, suggesting antibiotic treatment may potentiate its anti-thrombotic effect.[29] Digoxin, the most
widely used cardiac glycoside,it undergoes metabolic conversion in many patients to cardioinactive metabolites
during which the lactone ring is reduced. This appears to occur within the gastrointestinal tract
Eubacteriumlentum, a common anaerobe of the human colonic flora, converted digoxin to reduced
derivatives.[30]
III. DRUG DISTRIBUTION INTERACTIONS
After absorption, drugs are rapidly distributed around the body by the circulation. [31] Distribution is
the delivery of drug from the systemic circulation to tissues. [32] Some drugs are totally dissolved in the plasma
water, but many others are transported with some proportion of their molecules in solution and the rest bound to
plasma proteins. [31,32,33]
Common plasma proteins that bind drugs are human serum albumins, lipoproteins, glycoproteins, and
globulins. Albumin is the most abundant contributor in the blood plasma. [31,32,33,34] Many medications
extensively bind to the albumins. [33,34] Protein binding plays an important role in the distribution of drugs
and can have multiple effects on the pharmacokinetics (PK) of a drug. [32,33] The degree of drug-protein
binding might affect a drug‘s efficiency. [33] The binding of drug to plasma proteins is a major determinant of
drug disposition. [33] When a drug is bound to the plasma proteins, it is not actively distributed to the site of
action to interact with the target tissues and bound drug may act as a reservoir. There can be delay in therapeutic
effect (because no drug is available to react). The free drug distributes from the vasculature into the organs and
tissues or may be metabolized and eliminated. [31,32,33,34] Moreover, the bound drug is kept in the blood,
while the unbound (free) fraction may be metabolized or excreted. Only the unbound (free) drug interacts with
receptors, therefore only the free drug can produce therapeutic effect. [31,32,33,34] The binding has a very
important effect also on drug pharmacodynamics (PD). [33]
Despite, the ubiquity and severity of drug-drug interactions, the concept that plasma protein binding
displacement is a common cause of clinically significant interaction which is poorly recognized and poorly
understood issues within clinical medicine. [35,36] Protein binding interactions are displacement reactions,
which has been suspected as the causative appliance in many drug-drug interactions, which are predominant
among protein binding reactions. [33]
Competitive displacement interactions are predominant one among protein binding reactions which
results in the increased free plasma concentration of the displaced medication. Clinically, displacement reactions
acquire importance when the displaced drug is highly bound to plasma proteins. In this case the displacer drug
produces a significant rise in the plasma concentration of the displaced medication. [33,37] The result of this
interaction can be dramatic, if the second drug (displaced drug) is a drug with narrow therapeutic index, then
such type of interaction can lead to enhanced toxicity and pharmacological effects of displaced drug. [33]
6. A Review: Pharmacokinetic Drug Interactions, A Primer For Clinical Pharmacist.
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Fig. 2 When Drug A and Drug B is Co-administered, Competitive displacement reaction occurs as result, Drug
B (displacing drug) which is highly bound to plasma protein (Albumin) displaces Drug A from Albumin
thereby, the plasma concentration of Drug A (unbound or displaced drug ) increases resulting in the toxicity of
Drug A.
For e.g.a) Warfarin is a widely used anticoagulant which is used for the treatment of venous
thromboembolism, atrial fibrillation, mechanical and bio-prosthetic heart valves, post-myocardial infarction, and
recurrent systemic embolism. Warfarin is a narrow therapeutic range drug and more clinically the important
property of warfarin is warfarin‘s propensity to bind to protein; about 99% is bound to albumin in the plasma.
Many NSAIDs affect warfarin protein binding, but the clinical significance of this interaction has been
overstated. The traditional view has been that, NSAIDs are also highly protein-bound, they displace warfarin
from albumin thereby enhancing the anti-coagulant effect such as marked increase in the concentration of free
coumarin, severe hypothrombinemia by decreasing vitamin-k dependent clotting factors, prolongs bleeding time
and it also affects platelet function. [33,36,38]
Free drug plasma concentration must be carefully monitored during warfarin therapy. [33]
b)Phenylbutazone, fibrate antihyperlipidemicand some beta blockers can cause severe hypoglycemia
when it is co-administered with oral sulfonylureas due to the displacement of these agents from plasma protein
binding sites and inhibition of their metabolic clearance. Tolbutamide is affected the most. [39]
c)Valproic acid displaces diazepam from plasma protein binding sites and inhibits its metabolism.
Valproic acid increases the serum levels of diazepam approximately two fold. It also induces a significant
increase in apparent volume of distribution and plasma clearance of diazepam. [40]
7. A Review: Pharmacokinetic Drug Interactions, A Primer For Clinical Pharmacist.
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Table 1 Drug-Drug Interactions Mediated by Plasma Protein Binding displacement
Drug of Interest
(Displaced drug)
Displacing Drug
(Highly bound
drug)
Mechanism of Drug-Drug interaction
Warfarin NSAIDs, Tizoxanide Enhancing the anti-coagulant effect such as marked
increase in the concentration of free coumarin , severe
hypothrombinaemia by decreasing vitamin-k dependent
clotting factors, prolongs bleeding time and it also affects
platelet function.
Tolbutamide Phenylbutazone,
Salicylates,
Sulphonamides,
Fibrates
Beta blockers
Can cause severe hypoglycaemia due to inhibition of their
metabolic clearance.
Diazepam Valproic acid Increases the serum levels of diazepam approximately two
folds causing CNS, respiratory depression and cardiac
arrest.
IV. DRUG METABOLISM INTERACTIONS
Drug metabolism is a process which is very important for the living organisms and thus provides
various metabolic sites at various levels. [41] The major site for the metabolism of drug is liver, whereas the
first pass metabolism occurs. [31,37,41,42]
Although a few drugs are cleared from the body simply by being excreted unchanged in the urine,
most are chemically altered within the body to less lipid-soluble compounds, which are more easily excreted by
the kidneys. If this were not so, many drugs would persist in the body and continue to exert their effects for a
long time. This chemical change is called ‗metabolism‘, ‗biotransformation‘, or sometimes ‗detoxification‘.
Some drug metabolism goes on in the serum, the kidneys, the skin and the intestines, but the greatest
proportion is carried out by enzymes that are found in the membranes of the endoplasmic reticulum of the liver
cells. [56]
Metabolism is one of the major determinants of the fate of drugs in the body, as it determines their
pharmacokinetic properties, their efficacy and toxicity. [43]
Metabolism is a biological process of drugs by the body, normally done with specific catalyst systems.
[41] Drug metabolism (biotransformation) involves an outsized sort of chemical reactions, mainly mediated by
enzymes, which converts drug into inactive form. [42,43] The metabolism rate of a drug describes the time
period and potency of a drug pharmacologic action. [41]
Factors that affect the metabolism of foreign substances (collectively called xenobiotics or drugs)
include age, sex, hereditary and genetic factors, disease states, dietary and nutritional status, hormonal changes
in the body and the activity of liver enzymes. [42]
Drug-drug interactions are often explained by alterations in the metabolic enzymes that are present
within the liver and one of the major pharmacokinetic interactions between drugs are due to hepatic cytochrome
P450 (P450 or CYP) enzymes being affected by previous administration of other drugs. [44,45]
Cytochromes P450 (CYP450) are a major source of variability in drug pharmacokinetics and response.
[32,46] Cytochrome P450 (CYP450) system is a superfamily of heme-containing mono-oxygenase enzymes
embedded primarily in the lipid bilayer of the endoplasmic reticulum of hepatocytes which plays an important
role in the metabolism of xenobiotics and endogenous compounds. [31,42,43,44,46,47,48]
Cytochrome P450(CYP450) was firstly named in 1961 to identify the cellular chromophore/pigment
(P) that derives the name from the spectrophotometric absorption peak at 450 nm when reduced and bound to
carbon monoxide; the P signifies pigment. [41,42,43] The present system of nomenclature for the various CYP
isozymes employs a three-tiered classification based on the conventions of molecular biology: numeral and a
capital letter designate the amino-acid sequence, with a final number indicating the individual enzyme, e.g.
CYP3A4. [42,44]
CYP450 enzymes are ubiquitous in nature and are found in almost all mammalian tissues such as brain,
kidney, heart, intestine, lung, nasal and tracheal mucosa, adrenal gland, gonads, skin, and many other tissues.
However, the highest abundance and largest number of individual CYP450s is found in the liver. [41,42,43,44]
8. A Review: Pharmacokinetic Drug Interactions, A Primer For Clinical Pharmacist.
34
In humans, 57 putatively functional genes and 58 pseudo-genes divided among 18 families of CYP450
genes and 43 sub-families. [42,43,46]
Specially, the CYP450 isoenzymes primarily responsible for the metabolism of therapeutic drugs in the
human liver mostly includes ; CYP1A1, 1A2, 1B1, 2A6, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1, 3A4, 3A5, 3A7 and
4A11. [41,42,43,44,45,46, 48]
Of all CYP450 enzymes, the CYP3A4 is the most abundant isoform and is the main metabolizing
system of therapeutic drugs, and other xenobiotic, where it may serve as a primary defense mechanism.
[37,42,43,44,45,47,48]
Fig.3 Proportion of drugs metabolized by CPY450 enzymes
Drug interactions involving the CYPP450 isoforms generally are of two types:
Enzyme induction or Enzyme inhibition.[44]
3.1 Enzyme induction:
Hepatic enzyme induction is the result of an increase in the amount of hepatic enzyme. In most cases, enzyme
induction leads to an increase in the rate of metabolism of the affected drug (Substrate), with a consequent
decrease in the serum concentration of the parent drug and possibly a loss of clinical efficacy. [44,45,49]
Induction of drug-metabolizing activity can be due to,
3.1.1 Increased Enzyme expression
Inducer drug binds a cytoplasmic/nuclear receptor resulting in translocation of inducer-receptor complex to
nucleus. Thereby, which give rise to an increased enzyme levels. [42,48]
3.1.2 Enzyme Stabilization or decreased degradation
Inducer binds to active site of enzyme which stabilizes the enzymes or decreases the proteolytic enzyme
degradation. [38,45,48] Enzyme induction is most commonly associated with therapeutic failure due to inability
to achieve required drug concentrations. [32]
For e.g.
a) In women, co-administration of Oral contraceptives (OCs) with the enzyme-inducing Anti-epileptic drugs
(AEDs) such as phenobarbitone, primidone, phenytoin and carbamazepine can cause significant alterations of
sex hormones, higher incidence of break through bleeding, can decrease the efficacy of oral contraceptives and
pose potential risk of un-intended pregnancy. [49,50,51,52,53]
b) Rifampicin, a very strong inducer of hepatic enzymes, was shown to increase the metabolism and clearance
of warfarin, leading to decreased activity of the anticoagulant. [54] Rifampicin can also leads to reduced plasma
levels of the anti-diabetic drug pioglitazone. [47]
9. A Review: Pharmacokinetic Drug Interactions, A Primer For Clinical Pharmacist.
35
3.2 Enzyme inhibition:
Hepatic enzyme inhibition usually occurs because of competition at the active site and leads to a decrease in the
rate of metabolism of the affected drug (substrate). Clinically, this is associated with an increased plasma
concentration of the affected drug and the potential for an increased pharmacologic response. [41,44,45,49]
For e.g.
a) Hepatic enzyme inhibitors such Cyclosporine,macrolide antibiotics, azole antifungal agents, protease
inhibitors, and calcium channel blockers can inhibit the metabolism of statins such as atorvastatin, simvastatin,
and lovastatin. [55,56]
As a result of this interaction, it is recognized that plasma levels of statins may increase with concomitant
administration of CYP3A4 inhibitors. This may in turn increase the risk of significant statin toxicity such as
myopathy (muscle pain, weakness and tenderness) which may occur with or without raised concentrations of
creatine kinase and rhabdomyolysis, a more severe form of skeletal muscle damage, is the occurrence of muscle
related symptoms with creatine kinase greater than 10 times the upper limit of normal. [55,56,57]
b) When single oral dose of metoprolol, a beta-adrenoceptor blocking agent and propafenone (hepatic enzyme
inhibitor) were administered, or when the two drugs were given in combination, an approximately two fold
reduction in the oral clearance of metoprolol was observed when propafenone was included and increased risk
of cardiovascular toxicity has been shown due to increased plasma concentration of metoprolol. [44]
3.2.1 Enzyme inhibitors as therapeutic agents:
In present, many health care professionals use hepatic enzyme inhibitors to the improve the pharmacokinetics of
co-administered drug and finally, utilization of inhibitors helps the patient to reduce the economic burden of
high cost medications. [41,45,58]
a)Ritonavir boosted HIV regimens
Ritonavir have played an instrumental role in decreasing mortality and morbidity among people with HIV
infection. Ritonavir‘s inhibition of the cytochrome P450 (CYP3A4) enzyme reduces the metabolism of
concomitantly administered protease inhibitors and changes their pharmacokinetic parameters.The primary role
of ritonavir in boosted Protease inhibitors (PI) regimen is to improve the pharmacokinetics, bioavailability and
efficacy of the second Protease inhibitors (PI) such as saquinavir, lopinavir, amprenavir, nelfinavir and
indinavir. [45,58,59,60]
b)Prodrugs are not efficacious till they metabolize and regenerated to a active form. Few inhibitors can interact
by the in vivo transformation of prodrugs if given at the same time. For example, tamoxifen, the anticancer
prodrug, needs cytochrome P450 (CYP2D6) to transform to an active drug. [41]
c) The co-administration of hepatic enzyme inhibitors and proton-pump inhibitor (omeprazole) as part of
therapy against Helicobacter pylori infection may have significantly better clinical outcomes. [42,44]
Table 2 Some Common Substrates, Inducers and Inhibitors of CYP450 isoenzymes
Cytochrome
P450 Gene
Family/subfamily
Substrate
(Drug affected by
inhibitors or inducers)
Hepatic enzyme
Inducers
Hepatic enzyme
Inhibitors
CYP1A1 Caffeine, warfarin Omeprazole Amiodarone, fluvoxamine
CYP1A2 Acetaminophen,
amitriptyline
cyclobenzaprine,
desipramine, diazepam,
Barbiturates, omeprazole,
phenobarbital, phenytoin
Rifampin.
Cimetidine, Ciprofloxacin
Enoxacin
CYP2A6 Warfarin Dexamethasone,
phenobarbital
pilocarpine, selegiline
CYP2B6 Artemisinin, methadone, Carbamazepine, phenytoin Clopidogrel, imidazoles
10. A Review: Pharmacokinetic Drug Interactions, A Primer For Clinical Pharmacist.
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V. DRUG EXCRETION INTERACTIONS
Excretion is a process whereby drugs are transferred from the internal to the external environment, and
the principle organs involved in this activity are the kidneys, lungs, biliary system, and intestine. Despite the
reduction in activity that happens as a drug leaves its site of action, it's going to remain within the body for a
substantial period, especially if it's strongly bound to tissue components. Thus, reduction in pharmacological
activity and drug elimination are to be seen as related but separate phenomena.[32] Most of the drugs are
excreted either in the bile or in the urine except inhalational anesthetics.[31] The kidney is principle excretory
organ for drugs and their metabolites and has developed high capacity transport systems to rapidly eliminate the
large quantities of foreign compounds delivered to it which helps in determining both the duration of drug action
and the rate of drug elimination. [32,61,62] Renal elimination is the result of three concurrent processes
occurring in the nephron which is glomerular filtration, tubular secretion and tubular reabsorption involving a
variety of transporters located on the basolateral, contra-luminal and luminal membranes of the tubular
epithelium. [61,63] These selective transporters for organic cations (OC) and organic anions (OA) transporters
are predominantly expressed in the proximal tubule and work in diligence to eliminate drugs from the blood
circulation to the urine. [61,62,63] Transporter-mediated drug–drug interactions (DDIs) are growingly
recognized as an important modifier of the pharmacokinetics and pharmacodynamics of drugs. Drugs inhibiting
renal drug transporters may cause marked changes in the pharmacokinetics of the affected drug, resulting in
clinically significant DDIs end up in abnormal drug accumulation in renal tubular cells, leading to drug-induced
nephrotoxicity.[61]
CYP2C8 Amiodarone Nelfinavir, rifampin Gemfibrozil, montelukast
CYP2C9 Celecoxib, diclofenac,
losartan, piroxicam,
torsemide, warfarin.
Rifampin, secobarbital Amiodarone,
chloramphenicol,
cimetidine, fluvoxamine,
isoniazid
CYP2C19 Amitriptyline, citalopram,
diazepam, omeprazole,
phenobarbital,
propranolol,
warfarin.
Carbamazepine,
phenobarbital
Azole antifungals,
chloramphenicol,
cimetidine fluvoxamine,
omeprazole, topiramate.
CYP2D6 Amphetamine,
ondansetron
Rifampin Fluoxetine,methadone
CYP2E1 Acetaminophen, alcohols,
dapsone, halogenated
alkanes, isoflurane,
theophylline
Isoniazid Acute ethanol ingestion,
Disulfiram
CYP3A4/5/7 Acetaminophen,
alprazolam, amiodarone,
amitriptyline, amlodipine,
busiprone, budesonide,
calcineurin inhibitors,
carbamazepine, celecoxib,
codeine, cortisol,
dapsone, diazepam,
digoxin, diltiazem,
donepezil,
ethinylestradiol, statins,
warfarin.
Carbamazepine,
dexamethasone,
ethosuximide,
phenobarbital, phenytoin
rifampin/rifabutin,
St. John‘s wort
Amiodarone,
azole antifungals,
cimetidine, cyclosporine,
fluoxetine,
macrolide antibiotics,
metronidazole,
nicardipine, propofol,
protease inhibitors,
quinine, sertraline,
verapamil.
11. A Review: Pharmacokinetic Drug Interactions, A Primer For Clinical Pharmacist.
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5.1 Drug interactions biasing active tubular secretion
The clinical importance of the renal transporters resides predominantly in the domain of drug-drug
interactions. The pharmacokinetic variable that describes renal excretion is renal clearance of drug in plasma.
[62] Various transporters are (as depicted in fig. 4)
5.1.1 Cationic drug transporters
Transporters for organic cations is located predominantly in the S1 (the early convoluted tubule)
segment, whereas in juxtamedullary nephron they are equally located in S1 and S2 segments. [62] In humans,
hOCT2 is the major OCT isoform expressed in the kidney, hOCT1 on the other hand, is incredibly expressed in
the liver and hOCT3 is broadly expressed in many tissues including the skeletal muscle, heart, placenta, and
salivary glands. [61] At the luminal or brush border membrane, the transport of cations given by an
electroneutral H+/ organic cation antiport system is present, in which the organic cation is exchanged for a
hydrogen ion and facilitated by the inside negative membrane potential existing in the kidney tubular cells.
[61,62] Common substrates for hOCT2 includes (cations) endogenous monoamines, [the antidiabetic drug]
metformin, [the anti- hypertensive drug] atenolol, [the antiviral drug] lamivudine, and [the cytostatic drug]
oxaliplatin. Most hOCT2 inhibitors are larger, more hydrophobic cations that may or may not be transported by
the transporter that includes cimetidine, quinidine and dolutegravir. [61,62,63] hOCT2 –mediated active
secretion plays important role in metformin renal elimination. However dolutegravir, a newly approved anti-
HIV drug is also an inhibitor of hOCT2 that interferes with metformin elimination through an intracellular
binding site. Thus, hOCT2-mediated uptake into kidney cells could have an impact on dolutegravir's inhibitory
effect towards hOCT2-mediated metformin up take, was thought to be the mechanism underlying the observed
interaction with [area under curve] AUC of 2.5 fold increase for metformin. So it‘s recommended that dose
adjustments of metformin be considered when patients are starting or stopping dolutegravir while on metformin
therapy. [61]
5.1.2 Anionic drug transporters
These transporters are located equally in the S2 segments (which comprise the latter part of the
convolution and the first part of the straight section) of superficial and juxtamedullary nephrons. [62] OATs
belongs to SLC22 family that also encodes the OCTs. In human, 10 OAT isoforms have been identified, which
includes hOAT1– 8, hOAT10, and the urate transporter1(hURAT1). Most hOATs have been expressed at the
renal proximal tubule, except hOAT7,which is limited only to liver. In the kidney, hOAT1–3 are located at the
basolateral membrane of renal tubule cells whereas hOAT4, hOAT10 and hURAT1are expressed on the luminal
membrane. Basally-expressed hOAT1–3 operates as organic anion/ dicarboxylate exchangers which mediate the
first step of OA renal excretion by transporting OAs in to renal tubule cells utilizing the outward dicarboxylate
(e.g., α-ketoglutarate for hOAT1/3, succinate for hOAT2)gradient established by the Na+
–dicarboxylate
cotransporter. [61,62] Substrate for this transporter have a hydrophobic domain with decreased pKa that
increases the affinity for the transporter and may have electron-attracting side groups (chloride/ bromide atoms),
which increase the interaction with the transporter. [65] Numerous drugs have been shown to be substrates of
hOAT1/3, that includes antibiotics, antivirals, antihypertensive drugs, diuretics, cytostatic, H2-antagonists, non-
steroidal anti-inflammatory drugs(NSAIDs), statins and uricosurics. The recorded substrates of hOAT2 includes
some endogenous compounds, such as glutamate, nucleobases, nucleosides and nucleotides and some drug
molecules, such as salicylate, bumetanide and erythromycin.hURAT1is known to play an important role in urate
homeostasis. It reabsorbs urate from lumen of renal tubule by exchanging extracellular urate with intracellular
OAs such as lactate and nicotinate. [62] Therapeutically, inhibition of renal anion secretion by inhibitors as such
probenecid, a uricosuric and penicillin-sparing agent has also been employed to produce beneficial drug
interactions to either enhance activity of antibiotics or reduce renal accumulation and nephrotoxicity of certain
antiviral drugs. Probenecid exhibits similar inhibition potencies towards hOAT1 and hOAT3. [61] Probenecid
could potentially alter the pharmacokinetics of certain cephalosporins, primarily through a reduction in renal
clearance through competition between probenecid and the other acids for secretion by a common tubular
mechanism. [64,65,66] Cephalosporins are potentially nephrotoxic besides being broadly used antibiotics. [67]
The addition of probenecid to cephalosporin therapy results in sustained systemic concentrations adequate for
indication of N. gonorrhoeae. [64,62] Fexofenadine, a non- sedative histamine H1 receptor antagonist which is
efficiently transported only by hOAT3 inhibition of basolateral uptake can be one of the sites of interaction
between fexofenadine and probenecid. The non-renal clearance of fexofenadine is explained by biliary
excretion, showing a minimal inhibitory effect on the hepatic uptake of fexofenadine via hOATP1B3 in liver.
Adefovir and cidofovir, a novel antivirals have been suggested to be readmitted by the kidney viaOAT1 leading
to luminal accumulation at proximal tubule cells resulting nephrotoxicity. Clinically the combination with
probenecid will have a beneficial effect in suppressing the nephrotoxicity on top of prolonging their plasma
12. A Review: Pharmacokinetic Drug Interactions, A Primer For Clinical Pharmacist.
38
retention time, leading to an increase in the concentration in the liver, the target organ for the treatment of
hepatitis B. [63,61] Thus rationalizing the antiviral agents.
Fig. 4 drug interactions affecting tubular secretion and renal blood flow.
(a) Proximal tubular cell with various basolateral transporters and apical efflux transporters i.e. OAT-Organic
Anion Transporter which is inhibited by drugs:- indomethacin and probenecid (OAT1), probenecid and
furosemide (OAT3); OCT- Organic Cation Transporters which is inhibited by drugs:- quinidine, dolutegravir,
trimethoprim, ranitidine; PepT1-Peptide Transporters, its substrates are cefadroxil, bestatin; NHE – Sodium
Hydrogen Exchanger. (b) depicting vasoconstrictor action of NSAIDs on afferent and efferent arterioles of
nephron resulting a reduced GFR
5.2 Drug interactions altering renal blood flow
Acute renal failure [ARF] is a frequent complication in postsurgical procedures and in critically ill
patients. [62] As during surgery, renal blood flow is reduced by almost 30%. Prostaglandin has vasodilatory
effects on renal vascular bed and enhances blood flow from renal cortex to nephrons, that helps to keep up the
glomerular filtration rate (GFR). [69] Prostaglandins predominantly doesn‘t have major role in normal subject
but, its inhibition may have profound adverse renal effects. [68] And dopamine too produced an increase in
renal blood flow, this increase could be prevented by indomethacin or ibuprofen(cyclo-oxygenase inhibitors).
[70] NSAIDs are notable renal toxins that alter renal function by inhibiting protective renal prostaglandins that
leads to reversible renal ischemia. [68] Due to the decreased GFR because of NSAIDs administration, there is
decreased elimination of ceftriaxone that may lead to the increase of ceftriaxone in plasma and might precipitate
toxic effects on kidney resulting in progression of ARF. A way out of this DDI is ceftriaxone can be replaced by
other antibiotic which may not depended on renal clearance or can be continued by dose adjustment according
to creatinine clearance with other less toxic analgesics. [68] Similar effect was seen with indomethacin that
attenuates the vasodilator action of hydralazine causing increase renal blood flow long with the ability to
suppress prostaglandins, which is agonized by potassium sparing diuretic triamterene which increases the
urinary excretion of prostaglandins. [71,72]
5.3 Drug interactions revamp tubular reabsorption
The renal tubular cells additionally possess active and passive transport systems for the reabsorption of
drugs. Intrusion by drugs with these transport systems can alter the excretion of other drugs. [31] Peptide
transporter 2[PEPT2]-primarily needed for renal reabsorption of drugs belongs to the class of proton-coupled
oligopeptide transporters (POTs) that deliver peptide-bound amino nitrogen to cells. PEPT2 is particularly
expressed on the apical (luminal) membrane of epithelial cells of the proximal tubule in the kidney that
transports a broad range of peptide-like compounds such as- cefadroxil, enalapril, bestatin [ubenimex] and
valacyclovir,`5-amino-levulinic acid. [66] Further there are some other receptors known as g-protein coupled
13. A Review: Pharmacokinetic Drug Interactions, A Primer For Clinical Pharmacist.
39
receptors [gPCR] with adenosine as endogenous ligand. The adenosine receptor subtypes are A1, A2a, A2b, or
A3. Adenosine A1 receptors are present in mesangial cells, juxtaglomerular cells and vasa recta and adenosine
A2a receptor are present in whole kidney, glomeruli, outer medullary and at descending vasa recta. Whereas
A2b receptor are seen at the cortical, in the distal convoluted tubule, the outer medullary descending vasa recta
and A3 receptors are present at the brush-border membranes. [73] Methylxanthines- an adenosine receptor
antagonist in proximal tubule that reduces collecting duct water reabsorption via inhibition of adenosine
receptors. Methylxanthine-induced natriuresis is primarily a consequence of inhibition of salt transport
alongside the proximal convoluted tubule which increases in the clearance of lithium. [74,73] Lithium is a drug
with many adverse effects and drug interactions. [75] Lithium and sodium have similar properties and both are
found in group I A of the Modern Periodic Table. When there is inadequate sodium in the body and lithium is
available, reabsorption of lithium is increased end up to lithium toxicity and a negative sodium balance. Lithium
is reabsorbed more readily in the proximal tubule where methylxanthine shows its inhibitory effect on adenosine
receptors. [74] Adenosine A1 receptor activation stimulates Na+
dependent phosphate transport that mediate
increase inproximal tubular reabsorption include increasing intracellular Ca+2
accompanied by reduction of
intracellular cAMP levels. The low concentrations of the adenosine stimulate NHE3 and high concentrations
inactivated NHE3 which proves it to be pharmacologically significant. [74,73]
5.4 Drug interactions that tackle alteration of urine pH
The effect of urine pH on renal excretion and systemic disposition has been observed for many drugs
and metabolites. When urine pH is altered, tubular ionization, passive reabsorption, renal clearance, and
systemic exposure of drugs and metabolites may all change dramatically, raising clinically significant concerns.
[76] Complex interactions occurs between drugs resulting an altered pH leading to reordering of excretion of
other drugs at renal tubules. [77] The mechanism behind this phenomenon is believed to be the altered
ionization status of weak acids and bases with changes in renal tubular filtrate pH with consequent alterations in
renal passive reabsorption of unionized drugs. For example, when urine pH decreased from alkaline (pH - 7.5–
8.5) to acidic (pH _4.5–5.5), the weak bases drug excreted unchanged in urine such as pethidine,
methamphetamine and mexiletine is increased, whereas the renal clearance of weak acids, such as
chlorpropamide and salicylic acid decreased. Also, after dosing of imipramine, methamphetamine, and
amitriptyline, their respective metabolites, desipramine, amphetamine, and nortriptyline, have shown increases
in urinary excretion, respectively, in acidic urine condition in comparison with alkaline urine condition. [76]
5.4.1 Acidic urine
Drugs that decrease urine pH are- cholestyramine, an insoluble quaternary ammonium anion exchange
resin. When given orally increases fecal excretion of bile acids, blocking their enteral reabsorption. The same
may be assumed for MTX as it is a weak organic anion [indicated for hypercholesterolemia]. [78]
Cholestyramine was shown to induce metabolic acidosis and therefore can decrease urinary pH to as low as 4.8.
Furthermore, urine acidification is observed with diabetes, obesity, and chronic kidney disease. [76]
5.4.2 Basic urine
Drugs that increase urine pH are- acetazolamide, which was indicated for glaucoma and edema, has
been shown to increase urinary pH in humans from 5.5 to 7.6. In contrast, and urine alkalinisation is observed
with vomiting and urinary tract infection.[76]
Quinidine remains a very useful anti-arrhythmic drug in spite of its well-known toxic potential. With
urine alkalinisation there is a decreased excretion of quinidine, an increasing its serum concentration
accompanied by decrease in glomerular filtration rate. As the urine pH increases, the net charge on the quinidine
molecule decreases to 0.79 at pH 8.0. The decrease in the net charge of the molecule makes passive back
diffusion of the non-ionic component more probable, and hence the excretion is decreased with increased
resorption. [79]
Aspirin [a salicylate], a potent anti-inflammatory and analgesic produces steady plasma concentrations
at normal urinary pH of 5.6 to 6.1, whereas in presence of urine alkalizers such as sodium bicarbonate the urine
pH alkalizes to 6.2- 6.9 causing decrease in serum concentration of aspirin. [80] Similar example deals with
methotrexate [MTX] is poorly soluble in water at low pH and tends to precipitate in kidney tubules with
subsequent nephrotoxicity and decreased elimination. [81] Acetazolamide is a carbonic anhydrase inhibitor that
alkalizes urine by the inhibition of tubular-cell carbonic anhydrase, leading to a lack of reabsorption of tubular
bicarbonate through the prevention of hydrogen ion synthesis in tubular cells resulting alkaline urine aids in
MTX increased renal clearance. [82] A small increase in urine pH increases MTX solubility sharply - from
2.2mM at urine pH 5.7 to 22 mM at pH 6.9. [81] Thus methotrexate – acetazolamide proves to be clinically
significant interaction DDIs avoiding crystalluria due to methotrexate renal toxicity.
14. A Review: Pharmacokinetic Drug Interactions, A Primer For Clinical Pharmacist.
40
5.5 Effect of forced diuresis on renal clearance of corresponding drugs
Forced diuresis is induced by administering a fluid overload [usually via furosemide] and a diuretic
[usually via mannitol]concurrently. Intoxicants that are most likely to respond to forced diuresis are those with a
high level of renal excretion of the primary toxicant (e.g., bromide, lithium, amphetamine, phenobarbital, and
salicylate). [83] Mannitol-induced diuresis reduce the duration of tubular necroses, accounting for the
protection of renal function. [84] The chemotherapeutic agent cisplatin proposed for a broad spectrum of
malignancies. Cisplatin accumulates in proximal tubular epithelial cells occurs via passive diffusion, and then
exerts several cytotoxic effects, such as generation of reactive oxygen species bind covalently to
macromolecules, activation of apoptosis signaling pathways, and stimulation of inflammation, resulting in
nephrotoxicity. [85,84]
However this nephrotoxicity via hydration that decreases the proximal reabsorption rate or proximal
tubule transit time of cisplatin. The nephroprotective effect of hydration, in a broad sense, can be regarded as a
drug–drug interactions. The forced diuresis treatments increased the cumulative amount of unbound cisplatin
excreted in urine. [85]
5.6 Drug interactions biasing protein drug binding
Diuretics concurrently with the antibiotic, an observation that raised the possibility of an interaction
between these drugs, leading to the development of acute renal damage. [86] Aminoglycoside antibiotics are
widely used in the treatment and prevention of Gram-negative bacterial infections. [87,88] The widespread
therapeutic use of the aminoglycoside antibiotic gentamicin (GM) is limited by its nephrotoxic side effect,
which can lead to acute renal failure. [87] The glomerular basement membrane [GBM] is composed of two
membranes: the lamina rarainterna (LRI; formed from the endothelial cells) and the lamina rara externa (LRE;
formed from the pedicels of the epithelial cells), which fuse and generate a common lamina densa (LD) in the
central part of membrane. The urine is formed in mature glomeruli by filtration through the GBM, which
prevents filtration of the large molecules [proteins]. This selectivity permeability of the GBM is considered to be
mainly due to an electrostatic shield made of highly negatively charged heparan sulphate proteoglycans
constituting the anionic sites situated in the LRI and LRE. The exposure to gentamycin found that the
developing GBM was abnormal morphologically and functionally abnormal. LRI and LRE were thinner while
the LD was enlarged. The counting of anionic sites showed an increase of their number per square micrometer
of the LRE or LRI and thus an increased density. [87] Furosemide is a potent diuretic which acts by inhibition of
active chloride transport in the thick ascending limb of the loop of Henle. Diuresis will reduce reabsorption by
reducing the tubular fluid: plasma concentration gradient and by reducing any solvent drag. [89] Furosemide has
been reported to increase total renal medullary blood flow by increasing renal prostaglandin production and
therefore may cause increased removal of drugs from plasma which are secreted. [90,89] The fall in GFR by
furosemide could largely explain the fall in gentamicin clearance. [89,91,92] Accurate correction of fluid deficit
during furosemide treatment ensures complete normalization of urinary output of gentamicin by restoration of
GFR. Reduced medullary concentration when urine flow is inordinately high seems to demonstrated decreased
passive diffusion of the drug in the distal nephron. Since gentamicin is highly hydrophilic, passive movement in
the medullary region must be limited using furosemide diuretics. [91] Thus this drug interaction between
diuretics and gentamycin approved to be of therapeutically significance in preventing renal toxicity. Similar
effect has been seen with nitric oxide that has been proposed to modulate renal response to proteins as well as
basal renal hemodynamic.[93]
VI. CONCLUSION
DDIs represent a common clinical problem during the management of patients treated with several
drugs. Attention to drug interactions is crucial in order to prevent toxicities and side effects and to avoid
decreased efficacy due to subtherapeutic drug levels. Therapeutic drug monitoring of narrow–therapeutic index
medications, a long half-life and a higher bound with plasma proteins is crucial when drug interactions cannot
be avoided. Often, clinicians must make empiric therapeutic adjustments or perform more intensive clinical
monitoring to either prevent or manage drug-drug interactions. Ultimately, due to the clinical variability of drug-
drug interactions for various agents, it is important to approach
medication management with a multidisciplinary team, including physicians, nurses, and pharmacists.
Pharmacokinetic interactions are the major clinically significant interaction most commonly encountered by a
clinical pharmacist and a prescriber,hence it is the responsibility of the prescriber and the clinical pharmacist to
closely check for interaction and monitor them and prevent the possible adverse reactions.
15. A Review: Pharmacokinetic Drug Interactions, A Primer For Clinical Pharmacist.
41
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