This document discusses the medications pirfenidone and nintedanib for treating pulmonary fibrosis. It provides details on their mechanisms of action, dosing protocols, adverse effects, monitoring recommendations, and dosage adjustments. Pirfenidone is thought to inhibit TGF-beta and TNF-alpha to reduce inflammation. Its most common side effects include nausea, rash, and diarrhea. Nintedanib targets tyrosine kinases involved in fibrosis, and its frequent adverse effects are diarrhea, nausea, and liver enzyme elevations. Both drugs require careful titration and monitoring of liver function due to potential for toxicity.
COPD exacerbation case presentation and disease overview farah al souheil
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New technology called Electromagnetic Navigation Bronchoscopy® (ENB) that uses virtual bronchoscopy and real time 3-dimensional CT images that enable me to localize these peripheral lung nodules for diagnosis and treatment. This outpatient procedure is minimally invasive and therefore has a small risk of pneumothorax (2-3%) and its published diagnostic yield rates range from 67% - 86%
ACUTE RESPIRATORY DISTRESS SYNDROME AND HOW TO MANAGEmataharitimoer MT
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Division of Interventional Pulmonology & Respiratory Critical Care
Department of Pulmonology & Respiratory Medicine
Faculty of Medicine University of Indonesia – Persahabatan Hospital
Disampaikan pada acara PIT VI IDI Kota Bogor | 9 Nopember 2013
Ranitidine is a gastro-intestinal agent that inhibits histamine H2 receptors.
The histamine H2 receptor antagonist ranitidine is used to treat erosive esophagitis, Zollinger-Ellison syndrome, gastric ulcers, GERD, and duodenal ulcers.
COPD exacerbation case presentation and disease overview farah al souheil
management of a simulated case scenario: patient presenting with COPD exacerbation: what's the best next step? summary of the guideline is then described
New technology called Electromagnetic Navigation Bronchoscopy® (ENB) that uses virtual bronchoscopy and real time 3-dimensional CT images that enable me to localize these peripheral lung nodules for diagnosis and treatment. This outpatient procedure is minimally invasive and therefore has a small risk of pneumothorax (2-3%) and its published diagnostic yield rates range from 67% - 86%
ACUTE RESPIRATORY DISTRESS SYNDROME AND HOW TO MANAGEmataharitimoer MT
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Wahju Aniwidyaningsih
Division of Interventional Pulmonology & Respiratory Critical Care
Department of Pulmonology & Respiratory Medicine
Faculty of Medicine University of Indonesia – Persahabatan Hospital
Disampaikan pada acara PIT VI IDI Kota Bogor | 9 Nopember 2013
Ranitidine is a gastro-intestinal agent that inhibits histamine H2 receptors.
The histamine H2 receptor antagonist ranitidine is used to treat erosive esophagitis, Zollinger-Ellison syndrome, gastric ulcers, GERD, and duodenal ulcers.
Intrahepatic Cholestasis of Pregnancy : Dr Sharda Jain & Dr Jyoti Agarwal Lifecare Centre
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NAFLD is a vast topic and recently gaining a lot of importance. Fatty liver, NASH, are other topics discussed here. sleissenger, sheila sherlock and Harrisons are used for reference
Pulmonology Histoplasmosis is a fungal infection which is caused by endemic fungas histoplasma capsulatum. May present with acute or chronic pulmonary histoplasmosis and disseminated histoplasmosis.
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
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These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
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Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
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Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
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Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
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Pirfenidone and Nintedanib.pptx
1. Pirfenidone and Nintedanib
DR. MD. SHAFIQUL ISLAM DEWAN
RESIDENT (PULMONOLOGY)
RESPIRATORY MEDICINE DEPARTMENT
DHAKA MEDICAL COLLEGE HOSPITAL
4/27/2023
2. 4/27/2023 DR. MD. SHAFIQUL ISLAM DEWAN, RESIDENT (PULMONOLOGY), DMCH
Pirfenidone
3. Mechanism of Action
Precise mechanism by which pirfenidone may work in pulmonary fibrosis has not been
established.
Inhibits transforming growth factor (TGF)-beta, a chemical mediator that controls many cell
functions including proliferation and differentiation.
Also inhibits the synthesis of TNF-alpha, a cytokine that is known to have an active role in
inflammation.
Metabolized by Liver and Excreted by Kidney.
4/27/2023 DR. MD. SHAFIQUL ISLAM DEWAN, RESIDENT (PULMONOLOGY), DMCH
4. Initial dose titration
Take with food
Doses should be taken at the same time each day.
Days 1-7: 267 mg PO TID (801 mg/day)
Days 8-14: 534 mg PO TID (1602 mg/day)
Day 15 and thereafter (maintenance): 801 mg PO TID; not to exceed 2403
mg/day.
4/27/2023 DR. MD. SHAFIQUL ISLAM DEWAN, RESIDENT (PULMONOLOGY), DMCH
5. Treatment interruption
Following treatment interruption of ≥14 days: Titrate dosage upward using the
initial 2-week dosage titration regimen.
Following treatment interruption of <14 days: Therapy can be resumed at
dosage received prior to treatment interruption.
4/27/2023 DR. MD. SHAFIQUL ISLAM DEWAN, RESIDENT (PULMONOLOGY), DMCH
6. Dosage Modifications
If patients experience significant adverse reactions (ie, gastrointestinal,
photosensitivity reaction, rash);
Consider temporary dosage reductions or therapy interruptions of pirfenidone
to allow for resolution of symptoms;
Discontinue if symptoms persist despite these interventions.
4/27/2023 DR. MD. SHAFIQUL ISLAM DEWAN, RESIDENT (PULMONOLOGY), DMCH
7. CYP1A2 inhibitors
Strong inhibitors (eg, fluvoxamine, enoxacin): Reduce maintenance
dose to 267 mg (1 capsule) TID
Moderate inhibitors (eg, ciprofloxacin): Reduce maintenance dose
to 534 mg (2 capsules) TID (with ciprofloxacin 750 mg BID)
4/27/2023 DR. MD. SHAFIQUL ISLAM DEWAN, RESIDENT (PULMONOLOGY), DMCH
8. Hepatic impairment
Mild-to-moderate (Child Pugh A or B): Use caution; monitor and consider
dosage modification or discontinuation as needed
Severe (Child Pugh C): Not recommended (not studied)
4/27/2023 DR. MD. SHAFIQUL ISLAM DEWAN, RESIDENT (PULMONOLOGY), DMCH
9. Renal impairment
Mild, moderate, or severe: Use caution; monitor and consider dosage
modification or discontinuation as needed.
ESRD requiring dialysis: No recommended (not studied)
4/27/2023 DR. MD. SHAFIQUL ISLAM DEWAN, RESIDENT (PULMONOLOGY), DMCH
12. Post marketing Reports
Blood and lymphatic system disorders: Agranulocytosis
Immune system disorders: Angioedema
Hepatobiliary disorders: Drug-induced liver injury
4/27/2023 DR. MD. SHAFIQUL ISLAM DEWAN, RESIDENT (PULMONOLOGY), DMCH
13. Recommended liver monitoring
Perform liver function tests (ALT, AST, and bilirubin) before initiating treatment
with pirfenidone.
Monthly intervals for the first 6 months.
Then every 3 months thereafter.
4/27/2023 DR. MD. SHAFIQUL ISLAM DEWAN, RESIDENT (PULMONOLOGY), DMCH
14. Dose adjustments due to liver enzyme abnormalities
3–5-times ULN without bilirubin elevation
◦ Exclude other causes
◦ Monitor the patient closely
◦ Consider discontinuing other medicines associated with liver toxicity
◦ Consider possible drug interactions if the patient is taking inhibitors of CYP isoenzymes
involved in the metabolism of pirfenidone.
◦ Reduce or interrupt the dose of pirfenidone if clinically appropriate
◦ Re-escalate pirfenidone to the recommended daily dose if tolerated once liver function
tests are within normal limits.
4/27/2023 DR. MD. SHAFIQUL ISLAM DEWAN, RESIDENT (PULMONOLOGY), DMCH
15. Dose adjustments due to liver enzyme abnormalities
3–5-times ULN accompanied by hyperbilirubinaemia or clinical signs or symptoms indicative
of liver injury
◦ Permanently discontinue pirfenidone therapy; do not reinitiate
treatment
Higher than 5-times ULN
◦ Permanently discontinue pirfenidone therapy; do not reinitiate
treatment
4/27/2023 DR. MD. SHAFIQUL ISLAM DEWAN, RESIDENT (PULMONOLOGY), DMCH
16. Pregnancy & Lactation
Pregnancy: Data in pregnant women are insufficient to inform on drug
associated risks for major birth defects and miscarriage.
Lactation: No information is available on presence of pirfenidone in human
milk, effects of drug on breastfed infant, or effects of drug on milk production.
4/27/2023 DR. MD. SHAFIQUL ISLAM DEWAN, RESIDENT (PULMONOLOGY), DMCH
17. 4/27/2023 DR. MD. SHAFIQUL ISLAM DEWAN, RESIDENT (PULMONOLOGY), DMCH
Nintedanib
18. Indication
Idiopathic pulmonary fibrosis
Chronic fibrosing interstitial lung disease with A progressive phenotype
Systemic sclerosis-associated interstitial lung disease
4/27/2023 DR. MD. SHAFIQUL ISLAM DEWAN, RESIDENT (PULMONOLOGY), DMCH
19. Mechanism of Action
Tyrosine kinase inhibitor; targets growth factors, which have been shown to be
potentially involved in pulmonary fibrosis (eg, vascular endothelial growth
factor receptor [VEGFR], fibroblast growth factor receptor [FGFR], platelet-
derived growth factor receptor [PDGF])
Binds competitively to the adenosine triphosphate (ATP)-binding pocket of
these receptors and blocks the intracellular signaling, which is crucial for the
proliferation, migration, and transformation of fibroblasts, representing
essential mechanisms of the IPF pathology.
4/27/2023 DR. MD. SHAFIQUL ISLAM DEWAN, RESIDENT (PULMONOLOGY), DMCH
20. Metabolism and Elimination
Metabolized by Liver
Excretion: 93.4% feces/biliary; 0.65% urine
4/27/2023 DR. MD. SHAFIQUL ISLAM DEWAN, RESIDENT (PULMONOLOGY), DMCH
21. Doses
Administer 150mg tab orally twice daily (approximately 12 hours apart) with
food.
Swallow capsules whole with liquid; do not chew or crush.
If a dose is missed, take the next dose at the regularly scheduled time. Do not
double the dose or take extra doses.
4/27/2023 DR. MD. SHAFIQUL ISLAM DEWAN, RESIDENT (PULMONOLOGY), DMCH
22. Dosage Modification for Toxicity
Hepatic Toxicity
◦ ALT or AST elevations >3 times but <5 times the ULN without signs or
symptoms of severe liver damage: Temporarily interrupt therapy or reduce
dosage to 100 mg twice daily. When liver function tests return to baseline
values, may resume nintedanib at 100 mg twice daily and may subsequently
increase dosage to 150 mg twice daily.
◦ ALT or AST elevations >5 times the ULN, or >3 times the ULN with signs or
symptoms of severe liver damage: Discontinue therapy.
4/27/2023 DR. MD. SHAFIQUL ISLAM DEWAN, RESIDENT (PULMONOLOGY), DMCH
23. Dosage Modification for Toxicity
Other Adverse Effects
◦ If adverse reactions occur and are intolerable, despite symptomatic
treatment, temporarily interrupt therapy or reduce dosage to 100 mg
twice daily until the adverse reaction improves or resolves.
◦ May resume nintedanib 150 mg twice daily; alternatively, initially
reduce dosage to 100 mg twice daily and may subsequently increase
dosage to 150 mg twice daily.
◦ Discontinue therapy if intolerable adverse reactions occur or persist at
a dosage of 100 mg twice daily.
4/27/2023 DR. MD. SHAFIQUL ISLAM DEWAN, RESIDENT (PULMONOLOGY), DMCH
24. Hepatic Impairment
No initial dosage adjustment required in patients with mild hepatic impairment
(Child-Pugh class A); monitor closely and reduce dosage or temporarily interrupt
therapy if not tolerated.
Not studied in patients with moderate or severe hepatic impairment (Child-
Pugh class B or C).
4/27/2023 DR. MD. SHAFIQUL ISLAM DEWAN, RESIDENT (PULMONOLOGY), DMCH
25. Renal Impairment
No initial dosage adjustment required in patients with mild to moderate renal
impairment (Clcr 30–90 mL/minute).
Not studied in patients with severe renal impairment (Clcr <30 mL/minute) or
end-stage renal disease.
4/27/2023 DR. MD. SHAFIQUL ISLAM DEWAN, RESIDENT (PULMONOLOGY), DMCH
29. Monitoring
Monitor liver function tests prior to initiation,
Monthly for the first 3 months,
Then every 3 months, and as clinically indicated.
4/27/2023 DR. MD. SHAFIQUL ISLAM DEWAN, RESIDENT (PULMONOLOGY), DMCH
30. 4/27/2023 DR. MD. SHAFIQUL ISLAM DEWAN, RESIDENT (PULMONOLOGY), DMCH
Thank You