PIMS Feb. 2016 Packaging Innovation

16 February 2016 © iDi Pac Ltd 2016
Confidential
Innovation in Pharma Packaging to
Drive Business Growth
Prepared for: PIMS Berlin 2016

Ideas | Development | Implementation
© iDi Pac Ltd 2016
Confidential
16 February 2016
Client Logo (change me
in master slide)
Max 5cm x 2cmiDi Pac - Who we are and what we do?
iDi Pac is a Packaging and Supply Chain
Consultancy.

Working at the interface of Packaging
Technology and the Supply Chain we provide
innovative thinking required to implement a
truly End to End service; ideas through to
Development and implementation.

We excel in understanding the challenges of our
clients and their stakeholders with the
technical expertise, experience & imagination
to develop optimised Packaging Technology &
Supply Chain solutions.

© iDi Pac Ltd 2016
Confidential
16 February 2016
in master slide)
Max 5cm x 2cmiDi Pac - Expertise and Proposition
…our
philosophy
…delivering value
at this STRATEGIC
overlap

© iDi Pac Ltd 2016
Confidential
16 February 2016
in master slide)
Max 5cm x 2cm
Patient Adherence
•  Better communications
•  DigiLeaflet Technologies
•  Discreet and travel packs
•  Personalised medicines
Smaller Batches; how to manage effectively
•  Late stage customisation
•  Manufacturing flexibility
•  Portfolio management
•  Rapid changeovers
•  3D printing of components
Trends we will be reviewing and how Packaging
Innovation can support in addressing these issues
Traceability
•  Unit doses in hospitals
•  Component tech example
Future Concepts
•  Printed electronics
•  Printed drugs
•  Augmented reality
•  Holographics
•  Flexible screens

© iDi Pac Ltd 2016
Confidential
16 February 2016
in master slide)
Max 5cm x 2cm
50% of patients do not take medicines as prescribed & miss doses
Wasted medicines cost NHS in England around £300 million per year.
Academy of Medical Sciences 2014
$188 billion lost annually to US pharma industry due to medication non-
adherence.
Capgemini 2012
125000 deaths annually due to non-adherence
How can communications be improved for greater adherence? What
innovations can drive adherence?
Patient non-adherence: The costs

© iDi Pac Ltd 2016
Confidential
16 February 2016
in master slide)
Max 5cm x 2cmExisting packaging communications
Seniors (and others!) already have issues
with current packaging systems:
Readability of text – small font sizes
Overwhelming presentation of
information
Oversized PILs
Black & White presentation

© iDi Pac Ltd 2016
Confidential
16 February 2016
in master slide)
Max 5cm x 2cmMacro trend … short lead time, smaller batches, more data!

© iDi Pac Ltd 2016
Confidential
16 February 2016
in master slide)
Max 5cm x 2cmDelivering for today’s market demands - DigiLeaflets
Conventional
Sheet
Trim
Bind
Cut
Fold
Collate
Print
Booklet
Roll
Complex
Pre-Print
OR
DigiLeaflet
Print
Fold-Cut-Form-Seal-Trim
BookletMaterial Load
In-line Print-Fold-Cut-Form-Seal-Trim
BookletMaterial Load
Simple

© iDi Pac Ltd 2016
Confidential
16 February 2016
in master slide)
Max 5cm x 2cmPerformance data Vs existing technology
Reduce processes, reduce labour, reduce
capital…….cost effective booklet formats
Effect of Changeover Time vs Absolute Output
Change-over times become ever more
critical as batch sizes fall

© iDi Pac Ltd 2016
Confidential
16 February 2016
in master slide)
Max 5cm x 2cmDiscreet use & transit packaging
Why broadcast that you or your loved ones are taking
medication? Do wish that others know?
Opportunities for pocket-friendly, travel-friendly
disguised, discreet packaging and medical device
designs to encourage adherence in ‘real-life’ situations
Encourages use in situations where privacy is limited.
Reduces stress for the user & discomfort for others

© iDi Pac Ltd 2016
Confidential
16 February 2016
in master slide)
Max 5cm x 2cmEngagement: Brand adoption
Use design to remove stigma & mask underlying
functionality of delivery system
Penetrate markets/increase sales by leveraging
goodwill generated by user-friendly packs

© iDi Pac Ltd 2016
Confidential
16 February 2016
in master slide)
Max 5cm x 2cmMade ‘just for you’ - Personalisation!
Creates emotional connection to encourage repeat
use & generates goodwill for product/brand
Requires manufacturing agility to deliver..!
..and new technologies e.g. Print on Demand

© iDi Pac Ltd 2016
Confidential
16 February 2016
in master slide)
Max 5cm x 2cm
Portfolio management
Standardisation
Flexible, agile manufacture
Novel application of technologies
‘New eyes’ to review pack systems
Core activities to be addressed
Segmentation & use in the market
Understanding of market place/user
practices

© iDi Pac Ltd 2016
Confidential
16 February 2016
in master slide)
Max 5cm x 2cm
Existing manufacturing strategies typically aligned to
mass manufacture of key SKUs/few change-overs.
Pressure to adapt to changing demands…
For example: Breast Cancer treatment, identified as
10 x strains, ergo there are 10 x treatments, now ten
times number of batches at smaller sizes
Supply chain has to deliver more SKU’s at lower
volumes, more frequently – cost effectively
…on lines that are designed for quite the opposite
Small Batches: The trends

© iDi Pac Ltd 2016
Confidential
16 February 2016
in master slide)
Max 5cm x 2cmLate Stage Customisation: Print on line
Market specific text
on label (digital)
Common Core pack
Market specific
leaflet
Sequentially numbered
label (digital)
Datamatrix code
for core pack,
label and leaflet
Tamper evident
feature

© iDi Pac Ltd 2016
Confidential
16 February 2016
in master slide)
Max 5cm x 2cmManufacturing flexibility
Challenge: Reduce complexity and increase
manufacturing agility.
Identify all components and their interconnected
relationships – physical and graphical, markets, user
patterns, geography…
Review all market data & supply chain requirements
Have a vision of ideal solution (JIT manufacture? Print
online? Universal secondary packs? Coding/traceability?
Electronic artwork creation/approval?)

© iDi Pac Ltd 2016
Confidential
16 February 2016
in master slide)
Max 5cm x 2cm
Portfolio management of small batch programme: Typical
outcomes
Component reductions > Increase in line capacity
Contract pack volume moved in-house > Product security improved
Extended product life cycle > Increased orders
Product lead-time = super responsive > Short payback payback on capital spend
Increased segmentation > Extended sales
Exploiting Print on Demand technology:
Lead times for packaging - effectively zero
Scrap – effectively zero
Significant storage reduction
Full serialisation/anti-counterfeit capability

© iDi Pac Ltd 2016
Confidential
16 February 2016
in master slide)
Max 5cm x 2cm3D printing for customised applications
The new Proposal on Medical Device Regulation
increases standards for non custom-made 3D printed
medical devices by introducing stricter identification,
traceability and registration requirements
IP issues for organs/implants? Who owns data?

© iDi Pac Ltd 2016
Confidential
16 February 2016
in master slide)
Max 5cm x 2cmLate stage customisation: Benefits in summary
•  Needs to be part of a business strategy – not just a tactic
•  More efficient pan-continental / global supply sites by
supporting local markets
•  Can offer more variety – access to medicines for emerging
markets
•  Allows for more frequent deliveries, lower volume order size
•  Offers local language packs / more SKUs – more sales!
•  Agility in the Supply Chain

© iDi Pac Ltd 2016
Confidential
16 February 2016
in master slide)
Max 5cm x 2cmTraceability: Regain control of your property

© iDi Pac Ltd 2016
Confidential
16 February 2016
in master slide)
Max 5cm x 2cmSerialisation: Clock is ticking

© iDi Pac Ltd 2016
Confidential
16 February 2016
in master slide)
Max 5cm x 2cm
Medication errors & human cost (One in 10 patients
harmed)– preventable!
‘Pharmacovigilance’ – World Health Organisation
-Pack labelling/identification raised as issue
Vulnerability to counterfeiting
-Cost to industry in lost revenue estimated between
$75-200billion (WHO)
What’s your strategy to combat these issues?
Traceability to unit dose level
500 Dead: Glycol
Counterfeit inhaler: Bacteria in lungs

© iDi Pac Ltd 2016
Confidential
16 February 2016
in master slide)
Max 5cm x 2cm
Reduce opportunity for error:
- e-prescription
- Confirmation at dispensing
- Identification on ward
- Correct administration
…confidence in the system!
Through trust create sales and
improved outcomes - supported by
insurers
Traceability: Unit doses

© iDi Pac Ltd 2016
Confidential
16 February 2016
in master slide)
Max 5cm x 2cm
The container, called ‘Barrel’ is sized from 0.2-5mL
‘..the advantage of separating the container and it’s
application system is that filling and assembly can
occur at different places – thus the delivery chain
remains flexible..’ Sulzer Mixpac
Key to success is successful strategy of traceability/
serialisation for drug & componentry - with the
opportunity of personalisation
Unit dose technology

© iDi Pac Ltd 2016
Confidential
16 February 2016
in master slide)
Max 5cm x 2cm
Opportunities through innovation to enable greater patient
adherence via awareness, communications and delivery
Future ideas

© iDi Pac Ltd 2016
Confidential
16 February 2016
in master slide)
Max 5cm x 2cmPrinted electronics...further help for adherence?
Increased lifespan in development.. with solar panels
(battery life an issue..)
Intended use functional rather than FMCG gimmick
Early adopters in Pharma could exploit full possibilities!
(does not impact recycling stream – yet)

© iDi Pac Ltd 2016
Confidential
16 February 2016
in master slide)
Max 5cm x 2cm3D printing of medication
‘In future, the mechanism of treatment will be
inverted, with clinician feeding the diagnosis and
treatment requirements to a manufacturing suite,
who will dial up the materials required and the
structure needed to deliver the perfect treatment
profile - ready to printed locally and near to point of
care.
Through the combined efforts of science, industry
and regulatory authorities we will see this realised in
our lifetime’
Prof Ricky Wildman, University of Nottingham

© iDi Pac Ltd 2016
Confidential
16 February 2016
in master slide)
Max 5cm x 2cm
Barriers:
High temperature of printing process
Compatibility of drugs
Limited to niche applications
..compliance with regulations!
Benefits:
Tailored to individual’s needs
Dosage specific
Constructed to performance spec
3D printing

© iDi Pac Ltd 2016
Confidential
16 February 2016
in master slide)
Max 5cm x 2cmAugmented reality
FMCG brands use for fun & promotion
Opportunity for pharma industry to adopt the
right ‘tone of voice’ and encourage engagement
and connection with products/brands
Use as instructional, motivational & educational
tool to ensure correct usage of product
Choose the correct audience – medium is the
message

© iDi Pac Ltd 2016
Confidential
16 February 2016
in master slide)
Max 5cm x 2cmBroadcast holographics
Launched this January in Japan for Nestle
Kit Kat
Works via youtube clip and flat piece of
clear plastic folded into a pyramid.

© iDi Pac Ltd 2016
Confidential
16 February 2016
in master slide)
Max 5cm x 2cmInternet of things
Image courtesy of Chragokyberneticks
Concept of enabling internet-based connection
between computing devices embedded into
everyday objects
Opportunity to go beyond mandatory information
exchange & create deeper relationship

© iDi Pac Ltd 2016
Confidential
16 February 2016
in master slide)
Max 5cm x 2cm
Printable screens on flat/flexible surfaces
Content tailored to patient
Demonstration of administering drug - animation
or moving image
Content updated & broadcast to pack throughout
product lifespan?
On-pack video

© iDi Pac Ltd 2016
Confidential
16 February 2016
in master slide)
Max 5cm x 2cmThank you for your time – Any questions?
Email simon.s@idipac.com
Tel +44(0)1420 538055
www.idipac.com

PIMS Feb. 2016 Packaging Innovation

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PIMS Feb. 2016 Packaging Innovation