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The word Nuclei is derived from the latin word nucleus meaning”Kernel”
1:The nucleus was the first organelle to be discovered
2-The oldest preserved drawing dates back to the early microscopist Antonie van
Leeuwenhoek.He observed a "Lumen", the nucleus, in the red blood cells of salmon.
Scottish Botanist Robert brown observed an opaque area, which
he called the ‘areola’ or nucleus while studying Orchids under the
microscope.
Matthias Schleiden a German Botanist proposed that the nucleus
plays a role in generating cells, thus he introduced the name
"Cytoblast" (cell builder)
Discovery
Oldest known depiction of cells and
their nuclie
Nucleoproteins
Nucleo-protamine
Nucleo-histones
Acidic proteins.
Nucleic acids.
Enzymes.
Lipids.
Nucleus tends to be spherical, but may be
fusiform, ellipsoidal, flattened, depending on
cell shape
Often found at the centre of cytoplasm mass
Approximately 6 Micrometres
1-Nuclear membrane/envelope consists of two cellular membranes
arranged parallel to each other and separated by 10 to 50 nanometres
2-The space between the membranes is called the perinuclear space
and is continuous with the RER lumen
3-The outer Nuclear membrane is continuous with the membrane of
the RER and similarly has ribosomes attached on its surface
4-Nuclear pores are present on the nuclear membrane.Composed of multiple
proteins called nucleoporins,they serve as a channel for diffusion through
transport factors called karyopherins(importins and exportins).
1- It completely encloses the nucleus and separates the cell genetic
material from the surrounding cytoplasm and acts as a barrier.
1:It is a network of intermediate filaments that provide the nucleus with mechanical support
2- Provides structural support for the nuclear envelope and anchoring sites for chromosomes
and nuclear pores
3- The nuclear lamina is composed mostly of lamin proteins which are synthesized in the
cytoplasm and then incorporated into the nuclear lamina.
It is the largest sub structure found in the
nucleus of the eukaryotic cell
It is made up of Ribosomes and proteins.Three
major components of the nucleolus are
Fibrillar centers contain large amounts of RNA
polymerase I,which transcribes rRNA.
GC contains RNA bound to ribosomal proteins
that are being assembled into immature
ribosomes
DFC contains newly trancribed rRna bound to
ribosomal proteins
:The material of which the chromosomes of organisms
are composed of
The structure of Chromatin depends on the Stage of the cell cycle
Chromatin is structurally loose to allow access to RNA and DNA polymerases that transcribe and
replicate the DNA
Chromatin Forms the Chromosome structure optimized for strength and manageability
chromatin packages more tightly to facilitate segregation of the Chromosomes.
Chromatin packaging with histone proteins
Chromatinis a complex of macromolecules (DNA, protein and RNA)
Functions
1-To package DNA into a smaller volume to fit in the cell
2-To reinforce the DNA macromolecule to allow mitosis
3-To prevent DNA damage
4-To control gene expression and DNA replication
Composition
The primary protein components of chromatin are Histones that compact the
DNA
1-Chromosomes are thread-like structures located inside the nucleus of animal and
plant cells
2-Chromosomes carry DNA which is the hereditary information necessary to build a
complete organism
3-Each chromosome is made of protein and a single molecule of deoxyribonucleic acid
(DNA)
1-Chromosomes are arranged in pairs within the Nucleus
2-Humans have 22 chromosomal pairs of Autosomes.
3-Humans have a total of 46 sex chromosomes further classified as X and Y
chromosome
1-Controls all the activities of living cell
2-Cell division process and gene packaging
3-Packaging of regulatory elements and DNA
packaging to fit inside the nucleus
Physiology presentation cell nucleus
Physiology presentation cell nucleus
Physiology presentation cell nucleus

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Physiology presentation cell nucleus

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  • 3. The word Nuclei is derived from the latin word nucleus meaning”Kernel” 1:The nucleus was the first organelle to be discovered 2-The oldest preserved drawing dates back to the early microscopist Antonie van Leeuwenhoek.He observed a "Lumen", the nucleus, in the red blood cells of salmon. Scottish Botanist Robert brown observed an opaque area, which he called the ‘areola’ or nucleus while studying Orchids under the microscope. Matthias Schleiden a German Botanist proposed that the nucleus plays a role in generating cells, thus he introduced the name "Cytoblast" (cell builder) Discovery Oldest known depiction of cells and their nuclie
  • 4. Nucleoproteins Nucleo-protamine Nucleo-histones Acidic proteins. Nucleic acids. Enzymes. Lipids. Nucleus tends to be spherical, but may be fusiform, ellipsoidal, flattened, depending on cell shape Often found at the centre of cytoplasm mass Approximately 6 Micrometres
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  • 6. 1-Nuclear membrane/envelope consists of two cellular membranes arranged parallel to each other and separated by 10 to 50 nanometres 2-The space between the membranes is called the perinuclear space and is continuous with the RER lumen 3-The outer Nuclear membrane is continuous with the membrane of the RER and similarly has ribosomes attached on its surface 4-Nuclear pores are present on the nuclear membrane.Composed of multiple proteins called nucleoporins,they serve as a channel for diffusion through transport factors called karyopherins(importins and exportins). 1- It completely encloses the nucleus and separates the cell genetic material from the surrounding cytoplasm and acts as a barrier.
  • 7. 1:It is a network of intermediate filaments that provide the nucleus with mechanical support 2- Provides structural support for the nuclear envelope and anchoring sites for chromosomes and nuclear pores 3- The nuclear lamina is composed mostly of lamin proteins which are synthesized in the cytoplasm and then incorporated into the nuclear lamina.
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  • 9. It is the largest sub structure found in the nucleus of the eukaryotic cell It is made up of Ribosomes and proteins.Three major components of the nucleolus are Fibrillar centers contain large amounts of RNA polymerase I,which transcribes rRNA. GC contains RNA bound to ribosomal proteins that are being assembled into immature ribosomes DFC contains newly trancribed rRna bound to ribosomal proteins
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  • 12. :The material of which the chromosomes of organisms are composed of The structure of Chromatin depends on the Stage of the cell cycle Chromatin is structurally loose to allow access to RNA and DNA polymerases that transcribe and replicate the DNA Chromatin Forms the Chromosome structure optimized for strength and manageability chromatin packages more tightly to facilitate segregation of the Chromosomes. Chromatin packaging with histone proteins
  • 13. Chromatinis a complex of macromolecules (DNA, protein and RNA) Functions 1-To package DNA into a smaller volume to fit in the cell 2-To reinforce the DNA macromolecule to allow mitosis 3-To prevent DNA damage 4-To control gene expression and DNA replication Composition The primary protein components of chromatin are Histones that compact the DNA
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  • 15. 1-Chromosomes are thread-like structures located inside the nucleus of animal and plant cells 2-Chromosomes carry DNA which is the hereditary information necessary to build a complete organism 3-Each chromosome is made of protein and a single molecule of deoxyribonucleic acid (DNA)
  • 16. 1-Chromosomes are arranged in pairs within the Nucleus 2-Humans have 22 chromosomal pairs of Autosomes. 3-Humans have a total of 46 sex chromosomes further classified as X and Y chromosome 1-Controls all the activities of living cell 2-Cell division process and gene packaging 3-Packaging of regulatory elements and DNA packaging to fit inside the nucleus