The document discusses topics in pharmaceutical chemistry including drug discovery, retrosynthetic analysis, and the synthesis of common drugs like aspirin, paracetamol, and ibuprofen. It describes how drug discovery involves identifying screening hits and optimizing them through medicinal chemistry. Retrosynthetic analysis works backwards from a target molecule to simpler precursor structures. The document provides retrosynthetic and synthetic approaches for aspirin, paracetamol, and ibuprofen as examples.

1. Pharmaceutical Chemistry
Dr. Santanu Chakravorty
Assistant Professor
Mathabhanga College

2. What is Drug Discovery
• In the fields of medicine and pharmacology, drug discovery is the process
by which new candidate medications are discovered
• Historically, drugs were discovered by identifying the active ingredient
from traditional remedies or by serendipitous discovery, as with penicillin
• Modern drug discovery involves the identification of screening
hits, medicinal Chemistry and optimization of those hits to increase
the affinity, selectivity (to reduce the potential of side effects),
efficacy/potency, metabolic stability (to increase the half-life), and
oral bioavailability. Once a compound that fulfills all of these requirements
has been identified, the process of drug development can continue. If
successful, clinical trials are developed

4. What is Retrosynthtic approach
• Retrosynthetic analysis is a technique for solving problems in the planning
of organic syntheses.
• This is achieved by transforming a target molecule into simpler precursor
structures regardless of any potential reactivity/interaction with reagents.
• Each precursor material is examined using the same method. This
procedure is repeated until simple or commercially available structures
are reached.
• These simpler/commercially available compounds can be used to form a
synthesis of the target molecule

5. Retrosynthetic and Synthetic approach of
Aspirin (common analgesic)

6. Synthetic Approach of Aspirin

7. Retrosynthesitic and synthetic approach
of Paracetamol (Anti Pyretic)

9. Ibuprofen synthesis (Anti-inflammatory
drugs)

10. Mechanism of some important steps