This document provides an overview and summary of André Freitas' PhD thesis defense presentation on schema-agnostic queries for large schema databases using distributional semantics. The presentation motivates the need for schema-agnostic queries due to the rise of very large and dynamic database schemas. It proposes using distributional semantics to provide an accurate, comprehensive and low maintenance approach to cope with semantic heterogeneity in schema-agnostic queries. The key aspects of the approach include semantic pivoting to reduce semantic complexity, distributional semantic models to enable semantic matching, and a hybrid distributional-relational semantic model called τ-Space to support the development of a schema-agnostic query mechanism.