2. H.Pylori

3. Classification:
Domain Bacteria
Phylum proteobacteria
Class Epsilonproteobacteria
Order Campylobacterales
Family Helicobacteriaceae
Genus Helicobater

4. Classification:
Helicobacteraceae:
Genera:
Helicobacter, Wolinella, Flexispira,S
ulfurimonas, Thiomicrospira, and
Thiovulum

6. Microbiology of H. pylori
- Genome
-Morphology
-Cell envelope, and LPS
-Growth requirements
- Metabolism

8. CLINICAL ASPECTS OF H. PYLORI
ASSOCIATED DISEASES
• Acute and chronic gastritis
-Acute gastritis
-Chronic gastritis
• Peptic ulcer disease
-Gastric ulcers
-Duodenal ulcers
• Gastric MALT lymphoma
• Atrophic gastritis, intestinal
metaplasia, gastric cancer

10. Natural History of Helicobacter pylori Infection

13. Role of H. pylori Virulence
Factors

14. cag A (“cytotoxin associated gene A”)

15. VacA (vacuolating cytotoxin A)

18. H.pyloriPathogenesis of

19. H.pyloriPathogenesis of