Precision medicine is an emerging strategy that considers individual variability in genes, environment, and lifestyle to diagnose, treat, forecast, and prevent disease. As regulatory health authorities begin to develop clearer regulatory pathways in precision medicine, industries must prepare to swiftly adopt to any regulatory changes. This white paper aims to provide a broad overview on the following key topics in precision medicine:
1. Genomics and Pharmacogenetics
2. Precision Medicine vs Personalized Medicine
3. Foundation of Precision Medicine as A Treatment Tool
4. Examples of Precision Medicine as A Treatment, Predictive, and Preventative Tool
5. Precision Medicine and Cancer
6. Challenges, Next Step & Opportunities in Precision Medicine
7. Regulatory insight on Precision medicine
Emerging Technologies Shaping the Future of Precision MedicineClinosolIndia
Precision medicine, with its focus on tailoring healthcare interventions to individual characteristics, is undergoing a transformative evolution propelled by emerging technologies. From advanced genomic tools to artificial intelligence, these technologies are revolutionizing our ability to understand, diagnose, and treat diseases at an unprecedented level of specificity. This article explores the key emerging technologies shaping the future of precision medicine.
Translational Genomics towards Personalized medicine - Medhavi Vashisth.pptMedhavi27
Every individual is unique, and so is his/her body's affinity and reaction towards diseases and their treatment methods. The science of personalized takes into account biology of one individual at a time and relates it with established databases for devising or optimizing suitable treatment strategies.
Emerging Technologies and Tools in Precision Medicine ResearchClinosolIndia
Precision medicine has witnessed significant advancements with the integration of emerging technologies and innovative tools. This abstract explores the current landscape of precision medicine research, focusing on the role of cutting-edge technologies and tools in revolutionizing healthcare approaches.
Precision medicine is an emerging strategy that considers individual variability in genes, environment, and lifestyle to diagnose, treat, forecast, and prevent disease. As regulatory health authorities begin to develop clearer regulatory pathways in precision medicine, industries must prepare to swiftly adopt to any regulatory changes. This white paper aims to provide a broad overview on the following key topics in precision medicine:
1. Genomics and Pharmacogenetics
2. Precision Medicine vs Personalized Medicine
3. Foundation of Precision Medicine as A Treatment Tool
4. Examples of Precision Medicine as A Treatment, Predictive, and Preventative Tool
5. Precision Medicine and Cancer
6. Challenges, Next Step & Opportunities in Precision Medicine
7. Regulatory insight on Precision medicine
Emerging Technologies Shaping the Future of Precision MedicineClinosolIndia
Precision medicine, with its focus on tailoring healthcare interventions to individual characteristics, is undergoing a transformative evolution propelled by emerging technologies. From advanced genomic tools to artificial intelligence, these technologies are revolutionizing our ability to understand, diagnose, and treat diseases at an unprecedented level of specificity. This article explores the key emerging technologies shaping the future of precision medicine.
Translational Genomics towards Personalized medicine - Medhavi Vashisth.pptMedhavi27
Every individual is unique, and so is his/her body's affinity and reaction towards diseases and their treatment methods. The science of personalized takes into account biology of one individual at a time and relates it with established databases for devising or optimizing suitable treatment strategies.
Emerging Technologies and Tools in Precision Medicine ResearchClinosolIndia
Precision medicine has witnessed significant advancements with the integration of emerging technologies and innovative tools. This abstract explores the current landscape of precision medicine research, focusing on the role of cutting-edge technologies and tools in revolutionizing healthcare approaches.
The global precision medicine market has benefitted greatly from advancements in the life science industry. Although in its nascent stage, targeted therapies hold high chances of becoming a massive success in the coming years because of the potential to treat and cure chronic illnesses. The market is thus expected to expand at a compound annual growth rate (CAGR) of 11.60% between 2018 and 2023, generating USD 88.25 Bn in revenue by 2023.
We can aid decision making from the pre-clinical to the clinical setting, supporting line of sight to the clinic, by identifying and translating crucial biomarker approaches into the real world.
The Dawn of Personalized Healthcare A Deep Dive into Genomic Medicine Centers...aidenhitam
Genomic Medicine Centers (GMCs) are revolutionizing healthcare by integrating an individual's genetic makeup into their medical care. These specialized facilities offer genetic testing, counseling, and personalized treatment plans based on a patient's unique DNA.
GMCs function as hubs for clinical care, research, and education. They provide patients with access to advanced genetic testing, helping diagnose conditions, assess disease risks, and inform treatment decisions. GMCs also play a crucial role in advancing research by collecting and analyzing patient data to unlock the secrets of how genes influence health and disease. Additionally, they educate healthcare professionals and the public about genomics and its applications in medicine.
The impact of GMCs is far-reaching. They empower patients with knowledge about their own health, pave the way for personalized medicine with targeted therapies, and contribute to the development of new diagnostic tools and drugs. However, challenges remain, including ethical considerations around privacy and discrimination, ensuring equitable access for all, and navigating the complexities of interpreting genetic data.
Looking ahead, GMCs are poised to shape the future of healthcare. As technology advances, we can expect more comprehensive genetic testing, seamless integration with electronic health records, and the development of even more precise therapies based on individual genetic profiles. Ultimately, GMCs hold immense potential for improving patient care, promoting preventative strategies, and creating a healthier future for all.
Personalized Medicine: A Utilization In Pharmaceutical Field.(A Review) Makrani Shaharukh
Personalized Medicine (PM) is an emerging exercise of medicine that uses a person‟s genetic summary to monitor judgments made in favor to the diagnosis, inhibition and treatment of diseases. Personalized medicine is presence innovative through data from the Human Genome Project. It is initial to complete its aim of “the right therapy to the right patient at the right time”. Currently PM is moving us closer to more exact, predictable and powerful medication tailored for an individual patient. By the way the genomic data is the dynamic force late PM. Combined understanding of genetics is approving us to provide greater diagnoses, safer medication advising, and more effective treatment of the diseases and conditions that have affected us throughout history. This review focus on various aspects of personalized medicine.
Personalized Medicine: Foundation, Applications, Challenges and Opportunities...The Lifesciences Magazine
Personalized medicine is a paradigm-shifting strategy that aims to give customized therapies based on individual features, genetic makeup, and distinct illness profiles in an era characterized by revolutionary developments in healthcare.
Applications of genomics and proteomics pptIbad khan
Applications of genomics and proteomics ppt
genomics and proteomics ppt
in the field of health genomics and proteomics ppt
oncology ppt
biomedical application of genomics and proteomics ppt
agriculture application of genomics and proteomics ppt
proteomics in agriculture ppt
diagnosis of infectious disease ppt
personalized medicine ppt
Personalized Medicines - Enhancers of Life's Quality and Their Future SindhBiotech
This lecture is presented by our volunteer Bushra Umer, she is from Karachi, Pakistan, and she is covering "Personalized Medicines - Enhancers of Life's Quality and Their Future ".
For video: https://www.youtube.com/watch?v=BSrgJaBYuxg
Pharmacogenomics is new science about how the systematic identification of all the human genes, their products, interindividual variation, intraindividual variation in expression and function over time affects drug response/metabolism, etc.
Improve drug safety and reduce ADRs. The presentation explained the advantages of pharmacogenomics. Explained Goals of Pharmacogen(etics)omics.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...GL Anaacs
Contact us if you are interested:
Email / Skype : kefaya1771@gmail.com
Threema: PXHY5PDH
New BATCH Ku !!! MUCH IN DEMAND FAST SALE EVERY BATCH HAPPY GOOD EFFECT BIG BATCH !
Contact me on Threema or skype to start big business!!
Hot-sale products:
NEW HOT EUTYLONE WHITE CRYSTAL!!
5cl-adba precursor (semi finished )
5cl-adba raw materials
ADBB precursor (semi finished )
ADBB raw materials
APVP powder
5fadb/4f-adb
Jwh018 / Jwh210
Eutylone crystal
Protonitazene (hydrochloride) CAS: 119276-01-6
Flubrotizolam CAS: 57801-95-3
Metonitazene CAS: 14680-51-4
Payment terms: Western Union,MoneyGram,Bitcoin or USDT.
Deliver Time: Usually 7-15days
Shipping method: FedEx, TNT, DHL,UPS etc.Our deliveries are 100% safe, fast, reliable and discreet.
Samples will be sent for your evaluation!If you are interested in, please contact me, let's talk details.
We specializes in exporting high quality Research chemical, medical intermediate, Pharmaceutical chemicals and so on. Products are exported to USA, Canada, France, Korea, Japan,Russia, Southeast Asia and other countries.
More Related Content
Similar to personalized medicine its uses , application etc
The global precision medicine market has benefitted greatly from advancements in the life science industry. Although in its nascent stage, targeted therapies hold high chances of becoming a massive success in the coming years because of the potential to treat and cure chronic illnesses. The market is thus expected to expand at a compound annual growth rate (CAGR) of 11.60% between 2018 and 2023, generating USD 88.25 Bn in revenue by 2023.
We can aid decision making from the pre-clinical to the clinical setting, supporting line of sight to the clinic, by identifying and translating crucial biomarker approaches into the real world.
The Dawn of Personalized Healthcare A Deep Dive into Genomic Medicine Centers...aidenhitam
Genomic Medicine Centers (GMCs) are revolutionizing healthcare by integrating an individual's genetic makeup into their medical care. These specialized facilities offer genetic testing, counseling, and personalized treatment plans based on a patient's unique DNA.
GMCs function as hubs for clinical care, research, and education. They provide patients with access to advanced genetic testing, helping diagnose conditions, assess disease risks, and inform treatment decisions. GMCs also play a crucial role in advancing research by collecting and analyzing patient data to unlock the secrets of how genes influence health and disease. Additionally, they educate healthcare professionals and the public about genomics and its applications in medicine.
The impact of GMCs is far-reaching. They empower patients with knowledge about their own health, pave the way for personalized medicine with targeted therapies, and contribute to the development of new diagnostic tools and drugs. However, challenges remain, including ethical considerations around privacy and discrimination, ensuring equitable access for all, and navigating the complexities of interpreting genetic data.
Looking ahead, GMCs are poised to shape the future of healthcare. As technology advances, we can expect more comprehensive genetic testing, seamless integration with electronic health records, and the development of even more precise therapies based on individual genetic profiles. Ultimately, GMCs hold immense potential for improving patient care, promoting preventative strategies, and creating a healthier future for all.
Personalized Medicine: A Utilization In Pharmaceutical Field.(A Review) Makrani Shaharukh
Personalized Medicine (PM) is an emerging exercise of medicine that uses a person‟s genetic summary to monitor judgments made in favor to the diagnosis, inhibition and treatment of diseases. Personalized medicine is presence innovative through data from the Human Genome Project. It is initial to complete its aim of “the right therapy to the right patient at the right time”. Currently PM is moving us closer to more exact, predictable and powerful medication tailored for an individual patient. By the way the genomic data is the dynamic force late PM. Combined understanding of genetics is approving us to provide greater diagnoses, safer medication advising, and more effective treatment of the diseases and conditions that have affected us throughout history. This review focus on various aspects of personalized medicine.
Personalized Medicine: Foundation, Applications, Challenges and Opportunities...The Lifesciences Magazine
Personalized medicine is a paradigm-shifting strategy that aims to give customized therapies based on individual features, genetic makeup, and distinct illness profiles in an era characterized by revolutionary developments in healthcare.
Applications of genomics and proteomics pptIbad khan
Applications of genomics and proteomics ppt
genomics and proteomics ppt
in the field of health genomics and proteomics ppt
oncology ppt
biomedical application of genomics and proteomics ppt
agriculture application of genomics and proteomics ppt
proteomics in agriculture ppt
diagnosis of infectious disease ppt
personalized medicine ppt
Personalized Medicines - Enhancers of Life's Quality and Their Future SindhBiotech
This lecture is presented by our volunteer Bushra Umer, she is from Karachi, Pakistan, and she is covering "Personalized Medicines - Enhancers of Life's Quality and Their Future ".
For video: https://www.youtube.com/watch?v=BSrgJaBYuxg
Pharmacogenomics is new science about how the systematic identification of all the human genes, their products, interindividual variation, intraindividual variation in expression and function over time affects drug response/metabolism, etc.
Improve drug safety and reduce ADRs. The presentation explained the advantages of pharmacogenomics. Explained Goals of Pharmacogen(etics)omics.
Similar to personalized medicine its uses , application etc (20)
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...GL Anaacs
Contact us if you are interested:
Email / Skype : kefaya1771@gmail.com
Threema: PXHY5PDH
New BATCH Ku !!! MUCH IN DEMAND FAST SALE EVERY BATCH HAPPY GOOD EFFECT BIG BATCH !
Contact me on Threema or skype to start big business!!
Hot-sale products:
NEW HOT EUTYLONE WHITE CRYSTAL!!
5cl-adba precursor (semi finished )
5cl-adba raw materials
ADBB precursor (semi finished )
ADBB raw materials
APVP powder
5fadb/4f-adb
Jwh018 / Jwh210
Eutylone crystal
Protonitazene (hydrochloride) CAS: 119276-01-6
Flubrotizolam CAS: 57801-95-3
Metonitazene CAS: 14680-51-4
Payment terms: Western Union,MoneyGram,Bitcoin or USDT.
Deliver Time: Usually 7-15days
Shipping method: FedEx, TNT, DHL,UPS etc.Our deliveries are 100% safe, fast, reliable and discreet.
Samples will be sent for your evaluation!If you are interested in, please contact me, let's talk details.
We specializes in exporting high quality Research chemical, medical intermediate, Pharmaceutical chemicals and so on. Products are exported to USA, Canada, France, Korea, Japan,Russia, Southeast Asia and other countries.
US E-cigarette Summit: Taming the nicotine industrial complexClive Bates
I look back to 1997 and simpler time in tobacco control, then look at changes in trade, communications, technology and conclude the market is becoming ungovernable
Why invest into infodemic management in health emergenciesTina Purnat
A lecture discussing the challenge of health misinformation and information ecosystem in public health, how this impacts demand promotion in health, and how this then relates to responding to misinformation and infodemics in health emergencies. Appended with lots of tools, guidance and resources for people who want to do more reading.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
TEST BANK For Advanced Practice Nursing in the Care of Older Adults, 2nd Edit...kevinkariuki227
TEST BANK For Advanced Practice Nursing in the Care of Older Adults, 2nd Edition by Laurie Kennedy-Malone, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK For Advanced Practice Nursing in the Care of Older Adults, 2nd Edition by Laurie Kennedy-Malone, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK For Advanced Practice Nursing in the Care of Older Adults, 2nd Edit...
personalized medicine its uses , application etc
1. What if there was a single
size for shoes and
clothes?
Isn’t this unacceptable?
2. Then why do we accept
this when it comes to
our health?
3. Personalized Medicine
• Personalized medicine is an emerging practice of medicine that uses
an individual’s genetic profile to guide decisions made in regard to
the prevention, diagnosis, and treatment of disease.
• Knowledge of a patient’s genetic profile can help doctors select the
proper medication or therapy and administer it using the proper
dose or regimen.
4. • It allows the possibility of picking the right drug at the right dose for the right
person instead of the “one size fits all” approach to drug therapy.
• ultimately it will be hard to see how any kind of medicine will not be affected by
this as we learn more and more about the individual, and as many of us find our
complete genomes being sequenced and placed into our medical records to
empower that kind of personalized approach
• It is the biggest revolution in medicine in a very long time.
Personalized
Medicine
5. Development of personalized
medicine
• Since the discovery of DNA’s overall structure in 1953, the world’s scientific community has
rapidly gained a detailed knowledge of the genetic information encoded by the DNA of a cell
or organism so that today we are beginning to “personalize” this information.
• In the 1980s and 1990s, biotechnology techniques produced novel therapeutics and a
wealth of information about the mechanisms of various diseases such as cancer at the
genetic and molecular level, yet the aetiologies of other complex diseases such as obesity
and heart disease remained poorly understood.
• Researchers utilizing exciting and groundbreaking “omic” technologies and working
closely with clinicians have begun to make serious progress not only toward a molecular-
level understanding of the aetiology of complex diseases but to clearly identify that there
are actually many genetically different diseases called by the single name of cancer,
diabetes, depression, etc.
10. Process ; how it’s done :
• The ability to provide precision medicine to patients in routine clinical settings
depends on the availability of molecular profiling tests, e.g. Individual germline
DNA sequencing.
• While precision medicine currently individualizes treatment mainly on the basis of
genomic tests (clinical Exome), several promising technology modalities are being
developed, from techniques combining spectrometry and computational power to
real-time imaging of drug effects in the body.
• On the treatment side, PM can involve the use of customized medical products such
drug cocktails produced by pharmacy compounding or customized devices It can
also prevent harmful drug interactions, increase overall efficiency when prescribing
medications, and reduce costs associated with healthcare.
11. AI in personal medicine
• Artificial intelligence is a providing paradigm shift toward precision medicine
Machine learning algorithms are used for genomic sequence and to analyse and
draw inferences from the vast amounts of data patients and healthcare institutions
recorded in every moment.
• AI techniques are used in precision cardiovascular medicine to understand
genotypes and phenotypes in existing diseases, improve the quality of patient
care, enable cost-effectiveness, and reduce readmission and mortality rates.
12. • A 2021 paper reported that machine learning was able to predict the outcomes of
Phase III clinical trials (for treatment of prostate cancer) with 76% accuracy.
• 2020 paper showed that training machine learning models in a population-specific
fashion (i.e. Training models specifically for Black cancer patients) can yield
significantly superior performance than population-agnostic models
AI in personal medicine
13. Advantages of personalized medicine
• Precision medicine helps health care providers better understand the many
things—including environment, lifestyle, and heredity—that play a role in a
patient’s health, disease, or condition.
• This information lets them more accurately predict which treatments will be most
effective and safe, or possibly how to prevent the illness from starting in the first
place.
14. • Shift the emphasis in medicine from reaction to prevention
• predict susceptibility to disease
• improve disease detection
• pre-empt disease progression
• customize disease-prevention strategies
• prescribe more effective drugs
• avoid prescribing drugs with predictable negative side effects
• reduce the time, cost, and failure rate of pharmaceutical clinical trials
Advantages of personalized medicine
15. Disadvantages of personalized
Medicine
• High technology demand
• High initial cost of production and development
• Data biases that may occur along the way
• Time for treatment increases in some cases
• Patient privacy and confidentiality
16. Application and recent developments in
PM
•The detailed account of genetic information from the individual allows for appropriate
dosages, For instance, warfarin is the FDA approved oral anticoagulant commonly
prescribed to patients with blood clots. Due to warfarin’s significant inter individual
variability in pharmacokinetics and pharmacodynamics, its rate of adverse events is among
the highest of all commonly prescribed drugs.
•However, with the discovery of polymorphic variants in CYP2C9 and VKORC1 genotypes,
two genes that encode the individual anticoagulant response, physicians can use patients’
gene profile to prescribe optimum doses of warfarin to prevent side effects such as major
bleeding and to allow sooner and better therapeutic efficacy
17. Microarrays:
•The biochips known as DNA microarrays and oligonucleotide microarrays are a surface
collection of hundreds to thousands of immobilized nucleic acid sequences or
oligonucleotides in a grid created with specialized equipment that can be simultaneously
examined to conduct expression analysis .
•Biochips may contain representatives of a particular set of gene sequences (i.e.,
sequences coding for all human cytochrome P450 isozymes) or may contain sequences
representing all genes of an organism. They can produce massive amounts of genetic
information .
•Roche CYP 450 is a FDA-approved diagnostic tool able to determine a patient’s
genotype with respect to two genes that govern drug metabolism. This information
obtained may be useful by a physician to select the appropriate drug and/or dosage for a
given patient in the areas of cardiovascular disease, high blood pressure, depression,
and others (according to the company).
Application and recent developments in
PM
18. oncogenomics
• Oncogenomics is a sub-field of genomics that characterizes cancer-associated
genes. It focuses on genomic, epigenomic and transcript alterations in cancer.
• The genome of a cancer cell can also be used to stratify cancer cells identifying
one type of cancer from another or identifying a subtype of cancer within that type,
such as HER2+ breast cancer.
• Understanding the cancer genome is a step toward personalized oncology.
Numerous projects are underway around the world. Two such projects include the
US NIH Cancer Genome Atlas Project (U.S. NIH 2012) and the Sanger Institute
Cancer Genome Project (Sanger Institute 2012).
B
Application and recent developments in
PM