Patellofemoral syndrome is characterized by anterior knee pain that is aggravated by activities involving weight bearing on a flexed knee. It is caused by overuse and is diagnosed when other causes have been ruled out. Risk factors include activities like running and squatting, dynamic valgus, foot abnormalities, sudden increases in activity level, patellar instability, and quadriceps weakness. Treatment focuses on activity modification, pain management, muscle stretching and strengthening exercises, orthotics, bracing, and taping. Surgery is generally not effective and the long-term prognosis is usually favorable with most patients experiencing only mild symptoms over time.