The document discusses the partition coefficient, which is a measurement of a drug's lipophilicity or hydrophilicity. It defines the partition coefficient as the ratio of the amount of unionized drug distributed between the organic and aqueous phases at equilibrium. It describes how the partition coefficient is measured by dissolving a drug into two immiscible solvents - an organic and aqueous phase - and determining the amount of drug dissolved in each. It outlines a separation method using a separating funnel to dissolve and separate the drug into the two phases, then using analytical techniques like UV spectroscopy to determine the drug concentration in each phase and calculate the partition coefficient.

1. CONTENT…………..
1. Introduction
2. Definition
3. Measurement of Partition Coefficient
4. Method of measurement
5. Observation
Presented by:-
FARMAN AHMAD
B.Pharm 4th Sem.
Teerthanker Mahaveer college of pharmacy

2. PARTITION COEFFICIENT………
Introduction :-
Partition coefficient is the measurement of
lipophilicity or hydrophilicity of any unknown
sample.

3. PARTITION COEFFICIENT………
Definition:-
The partition coefficient is defined as the ratio of
unionized drug distributed between organic phase
and aqueous phase at equilibrium.
Partition coefficient (P)= Xo
Xw
Where ,
Xo= fraction of drug in organic
Xw = fraction of drug in aqueous phase.

4. PARTITION COEFFICIENT………
Measurement of Partition coefficient….
For the measurement of partition coefficient , we
take two solvents in equal quantity which are
immiscible with each other.
Now we dissolve the sample drug into
the solvents and determine the amount
of dissolved drug in both phase(aqueous
& non- aqueous).

5. PARTITION COEFFICIENT………
Method of measurement…..
Separation method :-
In this method we take a
Separating funnel, in which we fill
50 ml. oil and 50 ml. water.
 Now transfer the sample drug
Into the funnel and dissolve drug by
shaking process.
When drug is dissolved completely , open the
stopper which is below and separate both of the
solvent in different flask.

6. PARTITION COEFFICIENT………
Now we can determine the concentration of
dissolved drug in both of the solvent by various
laboratory method( e.g:- U.V spectroscopy).

7. PARTITION COEFFICIENT………
Observation…….
P= Xo
Xw
If the value of P>1 , then drug is lipophilic.
If the value of P<1 , then drug is hydrophilic.